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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gfeP37Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3gfeP37Mitogen-activated protein kinase 14/1.000
3s4qNK0Mitogen-activated protein kinase 14/0.620
3itzP66Mitogen-activated protein kinase 14/0.603
3iphG11Mitogen-activated protein kinase 14/0.597
2zb0GK3Mitogen-activated protein kinase 14/0.588
3l8xN4DMitogen-activated protein kinase 14/0.579
3fskRO6Mitogen-activated protein kinase 14/0.573
3fklFKLMitogen-activated protein kinase 14/0.566
3flyFLYMitogen-activated protein kinase 14/0.566
3fmn530Mitogen-activated protein kinase 14/0.565
3fi4FI4Mitogen-activated protein kinase 14/0.564
3uvqFS8Mitogen-activated protein kinase 14/0.557
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.556
4aa4QC0Mitogen-activated protein kinase 14/0.555
1ouy094Mitogen-activated protein kinase 14/0.553
2balPQAMitogen-activated protein kinase 14/0.553
3dt1P40Mitogen-activated protein kinase 14/0.553
1di9MSQMitogen-activated protein kinase 14/0.551
1zyjBI5Mitogen-activated protein kinase 14/0.546
3nww3NWMitogen-activated protein kinase 14/0.545
2rg6287Mitogen-activated protein kinase 14/0.543
3fln3FNMitogen-activated protein kinase 14/0.543
3flzFLZMitogen-activated protein kinase 14/0.543
3uvp048Mitogen-activated protein kinase 14/0.540
2zazGK1Mitogen-activated protein kinase 14/0.539
4kin1M8Mitogen-activated protein kinase 14/0.539
4nks2M2Fibroblast growth factor receptor 1/0.539
4nka2K7Fibroblast growth factor receptor 1/0.536
3fmh533Mitogen-activated protein kinase 14/0.535
3mpt1GKMitogen-activated protein kinase 14/0.532
3ha85JZMitogen-activated protein kinase 14/0.531
3roc29AMitogen-activated protein kinase 14/0.528
3mvl38PMitogen-activated protein kinase 14/0.527
3uibSB2Putative mitogen-activated protein kinase/0.527
2gfsPQBMitogen-activated protein kinase 14/0.526
2itqITQEpidermal growth factor receptor2.7.10.10.525
3hllI45Mitogen-activated protein kinase 14/0.525
4kip1R9Mitogen-activated protein kinase 14/0.525
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.524
4aa5NQBMitogen-activated protein kinase 14/0.522
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.520
3fsfFSSMitogen-activated protein kinase 14/0.520
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.519
4lopSB4Mitogen-activated protein kinase 14/0.518
2of2547Tyrosine-protein kinase Lck2.7.10.20.517
4eh60ONMitogen-activated protein kinase 14/0.517
3fmlFMLMitogen-activated protein kinase 14/0.516
3flwFLWMitogen-activated protein kinase 14/0.515
4f640S8Fibroblast growth factor receptor 1/0.514
3hl7I47Mitogen-activated protein kinase 14/0.513
1ywrLI9Mitogen-activated protein kinase 14/0.512
3fkoFKOMitogen-activated protein kinase 14/0.512
3mpaSB2Mitogen-activated protein kinase 14/0.511
1ouk084Mitogen-activated protein kinase 14/0.510
2rg5279Mitogen-activated protein kinase 14/0.510
3fmkFMKMitogen-activated protein kinase 14/0.510
3fl4FL4Mitogen-activated protein kinase 14/0.509
4kiq1RAMitogen-activated protein kinase 14/0.509
1m7qDQOMitogen-activated protein kinase 14/0.508
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.507
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.506
3bv2P38Mitogen-activated protein kinase 14/0.505
3rinI2OMitogen-activated protein kinase 14/0.504
2hk51BMTyrosine-protein kinase HCK2.7.10.20.503
2itwITQEpidermal growth factor receptor2.7.10.10.503
2of4979Tyrosine-protein kinase Lck2.7.10.20.503
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.503
3flsFLSMitogen-activated protein kinase 14/0.503
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.503
4f630S7Fibroblast growth factor receptor 1/0.502
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.501
3ocgOCGMitogen-activated protein kinase 14/0.500
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.498
3gc7B45Mitogen-activated protein kinase 14/0.497
3hp552PMitogen-activated protein kinase 14/0.497
3o8tBMUMitogen-activated protein kinase 14/0.497
3vjoANPEpidermal growth factor receptor2.7.10.10.496
3ds6A17Mitogen-activated protein kinase 14/0.495
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.494
3bv3P39Mitogen-activated protein kinase 14/0.494
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.493
3mvm39PMitogen-activated protein kinase 14/0.493
1ove358Mitogen-activated protein kinase 14/0.491
2zb1GK4Mitogen-activated protein kinase 14/0.491
2i0ePDSProtein kinase C beta type2.7.11.130.490
3fknFKNMitogen-activated protein kinase 14/0.490
3fmmXI2Mitogen-activated protein kinase 14/0.490
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.490
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.488
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.486
2qd9LGFMitogen-activated protein kinase 14/0.485
4nk92K5Fibroblast growth factor receptor 1/0.485
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.484
3ac2KSETyrosine-protein kinase Lck2.7.10.20.483
3bx5304Mitogen-activated protein kinase 14/0.483
4fob0USALK tyrosine kinase receptor2.7.10.10.483
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.482
1bl6SB6Mitogen-activated protein kinase 14/0.481
2y6o1N1Ephrin type-A receptor 42.7.10.10.480
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.480
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.480
1agwSU2Fibroblast growth factor receptor 1/0.479
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.479
4jr3KJREpidermal growth factor receptor2.7.10.10.479
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.478
4fnzNZFALK tyrosine kinase receptor2.7.10.10.478
1k6cMK1Gag-Pol polyprotein3.4.23.160.477
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.477
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.477
3fc152PMitogen-activated protein kinase 14/0.476
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.475
4cd2FOLDihydrofolate reductase1.5.1.30.475
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.475
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.474
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.474
4j97ACPFibroblast growth factor receptor 2/0.474
1m17AQ4Epidermal growth factor receptor2.7.10.10.473
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.473
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.473
2vwx7X4Ephrin type-B receptor 42.7.10.10.472
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.471
5f0a1FBcGMP-dependent protein kinase, putative/0.471
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.470
2zybKSLTyrosine-protein kinase Lck2.7.10.20.470
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.468
3opdHIEHeat shock protein 83/0.468
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.467
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
4eh50OMMitogen-activated protein kinase 14/0.466
4gk2L66Ephrin type-A receptor 32.7.10.10.466
4i231C9Epidermal growth factor receptor2.7.10.10.466
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.465
4looSB4Mitogen-activated protein kinase 14/0.465
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.464
4hys1BJMitogen-activated protein kinase 82.7.11.240.464
2pvyACPFibroblast growth factor receptor 2/0.463
3ac1KZITyrosine-protein kinase Lck2.7.10.20.463
3drcMTXDihydrofolate reductase1.5.1.30.463
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.462
2vx07X7Ephrin type-B receptor 42.7.10.10.462
3e92G6AMitogen-activated protein kinase 14/0.462
1gebCAMCamphor 5-monooxygenase1.14.15.10.461
1rbmKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.461
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.461
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.461
3lfa1N1Mitogen-activated protein kinase 14/0.461
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.461
3t2kFADSulfide-quinone reductase/0.461
4eh70OOMitogen-activated protein kinase 14/0.461
4ic7ANPMitogen-activated protein kinase 72.7.11.240.461
2eb3ANPEpidermal growth factor receptor2.7.10.10.460
3fmjFMJMitogen-activated protein kinase 14/0.460
3hvcGG5Mitogen-activated protein kinase 14/0.460
3zsh469Mitogen-activated protein kinase 14/0.460
4gk3L87Ephrin type-A receptor 32.7.10.10.460
5c8yACPTubulin tyrosine ligase/0.460
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.459
4nc3ERM5-hydroxytryptamine receptor 2B/0.459
1oecAA2Fibroblast growth factor receptor 2/0.458
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.458
3eigMTXDihydrofolate reductase1.5.1.30.458
3iqeH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.458
3obgSB2Mitogen-activated protein kinase 14/0.458
3oc1BMUMitogen-activated protein kinase 14/0.458
4dlj6RGMitogen-activated protein kinase 14/0.458
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.458
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.457
4jq7KJQEpidermal growth factor receptor2.7.10.10.457
1yqj6NPMitogen-activated protein kinase 14/0.456
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.456
2vwz7X6Ephrin type-B receptor 42.7.10.10.456
3acjKSSTyrosine-protein kinase Lck2.7.10.20.456
3bhy7CPDeath-associated protein kinase 3/0.456
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.456
4l4xNDPAmphI/0.456
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
2ghmLICMitogen-activated protein kinase 14/0.454
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.454
3gcq1BUMitogen-activated protein kinase 14/0.454
3vrwYS5Vitamin D3 receptor/0.454
1j39UPGDNA beta-glucosyltransferase/0.453
2vd5BI8Myotonin-protein kinase2.7.11.10.453
2vzmNRBCytochrome P450 monooxygenase PikC/0.453
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.453
1w84L12Mitogen-activated protein kinase 14/0.452
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.452
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.452
2itpAEEEpidermal growth factor receptor2.7.10.10.452
2izrBRKCasein kinase I isoform gamma-32.7.11.10.452
2oz6CMPCyclic AMP receptor-like protein/0.452
2vx17X8Ephrin type-B receptor 42.7.10.10.452
4dpwAGSMevalonate diphosphate decarboxylase/0.452
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.452
1ie8KH1Vitamin D3 receptor/0.451
1sg6NADPentafunctional AROM polypeptide/0.451
2cppCAMCamphor 5-monooxygenase1.14.15.10.451
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.451
3w33W19Epidermal growth factor receptor2.7.10.10.451
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.451
4z34ON7Lysophosphatidic acid receptor 1/0.451
2cmvNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.450
2itzIREEpidermal growth factor receptor2.7.10.10.450
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.450
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.450
4jin1L7RIO-type serine/threonine-protein kinase Rio12.7.11.10.450
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.450
1bveDMPGag-Pol polyprotein3.4.23.160.449
2x7gPVBSRSF protein kinase 22.7.11.10.449
3hv3R49Mitogen-activated protein kinase 14/0.449
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.449
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.449
1meiXMPInosine-5'-monophosphate dehydrogenase/0.448
2baqPQBMitogen-activated protein kinase 14/0.448
3a62STURibosomal protein S6 kinase beta-12.7.11.10.448
3lfqA28Cyclin-dependent kinase 22.7.11.220.448
3och2MXDihydrofolate reductase1.5.1.30.448
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.448
4iteTEYVitamin D3 receptor/0.448
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.447
1u3dFADCryptochrome-1/0.447
2cgpCMPcAMP-activated global transcriptional regulator CRP/0.447
3l8sBFFMitogen-activated protein kinase 14/0.447
3qaiXNNKetohexokinase/0.447
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.447
4gt3ATPMitogen-activated protein kinase 12.7.11.240.447
4qnaX11Serine/threonine-protein kinase 242.7.11.10.447
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.447
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.446
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
3fpjSAMUncharacterized protein/0.446
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.446
4b99R4LMitogen-activated protein kinase 72.7.11.240.446
4gk4L90Ephrin type-A receptor 32.7.10.10.446
2a0cCK9Cyclin-dependent kinase 22.7.11.220.445
2feuCAMCamphor 5-monooxygenase1.14.15.10.445
2xvdAS6Ephrin type-B receptor 42.7.10.10.445
2zawCAMCamphor 5-monooxygenase1.14.15.10.445
3iqeF42F420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.445
3iqzH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.445
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.445
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.445
4aotGW8Serine/threonine-protein kinase 102.7.11.10.445
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.445
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.445
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
4zolACPTubulin tyrosine ligase/0.445
1ie3NADMalate dehydrogenase/0.444
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
2j7t274Serine/threonine-protein kinase 102.7.11.10.444
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.444
2yfxVGHALK tyrosine kinase receptor2.7.10.10.444
2z97CAMCamphor 5-monooxygenase1.14.15.10.444
3hx4ANPCalmodulin-domain protein kinase 1/0.444
3nbwTR4Ketohexokinase/0.444
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.444
1g6cIFPThiamine-phosphate synthase/0.443
1k6pXN3Gag-Pol polyprotein3.4.23.160.443
1rf9DBRCamphor 5-monooxygenase1.14.15.10.443
1sxjAGSReplication factor C subunit 1/0.443
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.443
2vtrLZBCyclin-dependent kinase 22.7.11.220.443
3gstGPRGlutathione S-transferase Mu 12.5.1.180.443
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1zzlTZYMitogen-activated protein kinase 14/0.442
2vwy7X5Ephrin type-B receptor 42.7.10.10.442
3b2tM33Fibroblast growth factor receptor 2/0.442
3fwjCAMCamphor 5-monooxygenase1.14.15.10.442
3vryB43Tyrosine-protein kinase HCK2.7.10.20.442
3zewSTUEphrin type-B receptor 42.7.10.10.442
4dce0JFALK tyrosine kinase receptor2.7.10.10.442
4fuxE75Mitogen-activated protein kinase 12.7.11.240.442
4nfn2KCTau-tubulin kinase 12.7.11.10.442
1iwiCAMCamphor 5-monooxygenase1.14.15.10.441
1k6vXN2Gag-Pol polyprotein3.4.23.160.441
1nzdUPGDNA beta-glucosyltransferase/0.441
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.441
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.441
3dafFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.441
3gubGUBDeath-associated protein kinase 12.7.11.10.441
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
3oagLPQRenin3.4.23.150.441
3w2rW2REpidermal growth factor receptor2.7.10.10.441
4aicNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.441
4qmuSKESerine/threonine-protein kinase 242.7.11.10.441
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.440
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3da1FADGlycerol-3-phosphate dehydrogenase/0.440
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.440
3w9rA8SAbscisic acid receptor PYL9/0.440
4c9pCAMCytochrome P450/0.440
4ejmNAPPutative zinc-binding dehydrogenase/0.440
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440
6gsxGPSGlutathione S-transferase Mu 12.5.1.180.440