sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2q9c | GNP | Signal recognition particle receptor FtsY |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2q9c | GNP | Signal recognition particle receptor FtsY | / | 1.000 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.512 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.498 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.488 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.486 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.485 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.485 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.483 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.483 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.483 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.481 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.481 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.480 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.478 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.478 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.478 | |
| 4blr | UTP | NTPase P4 | / | 0.478 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.477 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.476 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.476 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.475 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.475 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.475 | |
| 1s20 | NAD | 2,3-diketo-L-gulonate reductase | 1.1.1.130 | 0.474 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.474 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.471 | |
| 3t70 | DU4 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.471 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.471 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.471 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.469 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.468 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.468 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.468 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.467 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.467 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.466 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.466 | |
| 3t64 | DU3 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.466 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.466 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.466 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.465 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.464 | |
| 2f3e | AXQ | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.464 | |
| 3k4c | FAD | Pyranose 2-oxidase | / | 0.464 | |
| 3kpb | SAM | Uncharacterized protein MJ0100 | / | 0.464 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.464 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.464 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.464 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.463 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.463 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.463 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.462 | |
| 3duy | AFJ | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.461 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.461 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.461 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.461 | |
| 3daa | PDD | D-alanine aminotransferase | 2.6.1.21 | 0.460 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.460 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.459 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 3l9h | EMQ | Kinesin-like protein KIF11 | / | 0.459 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.459 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.459 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.458 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.458 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.458 | |
| 1daa | PLP | D-alanine aminotransferase | 2.6.1.21 | 0.457 | |
| 1m6i | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.457 | |
| 2cfy | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.457 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.457 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.457 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.457 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.457 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.457 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.457 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.456 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3opm | LUI | Dipeptidyl peptidase 4 | / | 0.456 | |
| 4ytn | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.456 | |
| 1i6k | TYM | Tryptophan--tRNA ligase | 6.1.1.2 | 0.455 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.455 | |
| 2dgn | DOI | Adenylosuccinate synthetase isozyme 1 | / | 0.455 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.455 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.455 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.455 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.454 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.454 | |
| 1ld7 | U66 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.454 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.454 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.454 | |
| 3k5f | AYH | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.454 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.454 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.454 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.454 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.453 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.453 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.453 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3r2f | PB0 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.453 | |
| 4hxy | NDP | Plm1 | / | 0.453 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1typ | FAD | Trypanothione reductase | 1.8.1.12 | 0.452 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.452 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.452 | |
| 2ex1 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.452 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.452 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.452 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.452 | |
| 3toz | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.452 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.452 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.452 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.451 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.451 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.451 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.451 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.451 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.451 | |
| 3zks | WZV | Beta-secretase 2 | 3.4.23.45 | 0.451 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.450 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.449 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.449 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.449 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.449 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3a3g | DLZ | Lumazine protein | / | 0.449 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.449 | |
| 4fdu | IHS | Putative multiple inositol polyphosphate histidine phosphatase 1 | / | 0.449 | |
| 4l4x | NDP | AmphI | / | 0.449 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.448 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.448 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.448 | |
| 2gqt | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.448 | |
| 2oah | QIN | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 2vkm | BSD | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.448 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.448 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.448 | |
| 5ftf | ADP | TPR domain protein | / | 0.448 | |
| 1ld8 | U49 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 1ndi | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.447 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.447 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.447 | |
| 3dk8 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.447 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.447 | |
| 3lzx | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.447 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.447 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.447 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.446 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1sa4 | JAN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.446 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.446 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.446 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.446 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.446 | |
| 2ph6 | 712 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2qtc | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.446 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.446 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.446 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.446 | |
| 4h3i | 10V | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.446 | |
| 1d4c | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.445 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.445 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.445 | |
| 2zu8 | GDD | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.445 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.445 | |
| 3dm5 | GDP | Signal recognition particle 54 kDa protein | / | 0.445 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.445 | |
| 3pft | FMN | Flavin reductase | / | 0.445 | |
| 3vuc | HHE | Renin | 3.4.23.15 | 0.445 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.445 | |
| 4dja | FAD | (6-4) photolyase | / | 0.445 | |
| 4oaq | NDP | R-specific carbonyl reductase | / | 0.445 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.445 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.445 | |
| 5er0 | FAD | Uncharacterized NAD(FAD)-dependent dehydrogenase | / | 0.445 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.444 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.444 | |
| 2iwh | ANP | Elongation factor 3A | / | 0.444 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3g0d | XIH | Dipeptidyl peptidase 4 | / | 0.444 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.444 | |
| 3qfb | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.444 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.443 | |
| 2daa | DCS | D-alanine aminotransferase | 2.6.1.21 | 0.443 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.443 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.443 | |
| 3grs | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.443 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.443 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.443 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.443 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.442 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.442 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.442 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.442 | |
| 2gsd | NAD | Formate dehydrogenase | / | 0.442 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.442 | |
| 3dv1 | AR9 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.442 | |
| 3g0g | RUM | Dipeptidyl peptidase 4 | / | 0.442 | |
| 3i12 | ADP | D-alanine--D-alanine ligase A | 6.3.2.4 | 0.442 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.442 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.442 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4lut | DCS | Alanine racemase | / | 0.442 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.441 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.441 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.441 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.441 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.441 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.441 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.441 | |
| 4qed | NAP | ElxO | / | 0.441 | |
| 4tlz | NAP | KtzI | / | 0.441 | |
| 4xr9 | NAD | CalS8 | / | 0.441 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.440 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1yqx | NAP | Sinapyl alcohol dehydrogenase | / | 0.440 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.440 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.440 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.440 | |
| 3r7w | GNP | GTP-binding protein GTR2 | / | 0.440 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.440 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.440 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4l7j | 1W2 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4wzh | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.440 |