Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1vru | AAP | Gag-Pol polyprotein | 2.7.7.49 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1vru | AAP | Gag-Pol polyprotein | 2.7.7.49 | 1.000 | |
| 1tl1 | H18 | Gag-Pol polyprotein | 2.7.7.49 | 0.646 | |
| 1rt4 | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.624 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.621 | |
| 1rev | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.620 | |
| 1tkt | H12 | Gag-Pol polyprotein | 2.7.7.49 | 0.620 | |
| 1tkz | H16 | Gag-Pol polyprotein | 2.7.7.49 | 0.601 | |
| 1ikw | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.598 | |
| 2opq | HBQ | Gag-Pol polyprotein | 2.7.7.49 | 0.598 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.592 | |
| 1ikv | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.585 | |
| 1s9e | ADB | Gag-Pol polyprotein | 2.7.7.49 | 0.585 | |
| 4ko0 | JLJ | Gag-Pol polyprotein | 2.7.7.49 | 0.578 | |
| 1hni | AAA | Gag-Pol polyprotein | 2.7.7.49 | 0.577 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.575 | |
| 1s1w | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.574 | |
| 1iky | MSD | Gag-Pol polyprotein | 2.7.7.49 | 0.573 | |
| 4i2p | G73 | Gag-Pol polyprotein | 2.7.7.49 | 0.568 | |
| 2vg7 | NNI | Gag-Pol polyprotein | 2.7.7.49 | 0.566 | |
| 1ikx | PNU | Gag-Pol polyprotein | 2.7.7.49 | 0.565 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.563 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.563 | |
| 1hnv | TBO | Gag-Pol polyprotein | 2.7.7.49 | 0.562 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.562 | |
| 1tl3 | H20 | Gag-Pol polyprotein | 2.7.7.49 | 0.559 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.557 | |
| 2rf2 | MRX | Gag-Pol polyprotein | 2.7.7.49 | 0.554 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.553 | |
| 1rt5 | UC2 | Gag-Pol polyprotein | 2.7.7.49 | 0.553 | |
| 3ffi | 3OB | Gag-Pol polyprotein | 2.7.7.49 | 0.552 | |
| 2ban | 357 | Gag-Pol polyprotein | 2.7.7.49 | 0.549 | |
| 4i7f | NVE | Gag-Pol polyprotein | 2.7.7.49 | 0.549 | |
| 1rt2 | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.548 | |
| 4ig3 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.548 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.547 | |
| 3meg | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.547 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.545 | |
| 4g1q | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.543 | |
| 1jlq | SBN | Gag-Pol polyprotein | 2.7.7.49 | 0.539 | |
| 3i0s | RT7 | Gag-Pol polyprotein | 2.7.7.49 | 0.539 | |
| 4ifv | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.539 | |
| 4id5 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.538 | |
| 3lam | KRP | Gag-Pol polyprotein | 2.7.7.49 | 0.536 | |
| 1rt7 | UC4 | Gag-Pol polyprotein | 2.7.7.49 | 0.528 | |
| 2vg5 | NNC | Gag-Pol polyprotein | 2.7.7.49 | 0.528 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.524 | |
| 1fk9 | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.523 | |
| 2opp | HBQ | Gag-Pol polyprotein | 2.7.7.49 | 0.523 | |
| 3dmj | GWE | Pol protein | / | 0.518 | |
| 2hnd | NVP | Gag-Pol polyprotein | 2.7.7.49 | 0.516 | |
| 1eet | BFU | Gag-Pol polyprotein | 2.7.7.49 | 0.515 | |
| 5cyq | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.514 | |
| 2hnz | PC0 | Gag-Pol polyprotein | 2.7.7.49 | 0.513 | |
| 4i2q | 1BT | Gag-Pol polyprotein | 2.7.7.49 | 0.511 | |
| 1s1t | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.509 | |
| 3mee | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.507 | |
| 1jlc | FTC | Gag-Pol polyprotein | 2.7.7.49 | 0.506 | |
| 2opr | HBQ | Gag-Pol polyprotein | 2.7.7.49 | 0.506 | |
| 1hqu | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.501 | |
| 1tkx | GWB | Gag-Pol polyprotein | 2.7.7.49 | 0.499 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.499 | |
| 1jlg | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.496 | |
| 3nbp | JGZ | Gag-Pol polyprotein | 2.7.7.49 | 0.493 | |
| 1jla | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.492 | |
| 3m8q | DJZ | Gag-Pol polyprotein | 2.7.7.49 | 0.492 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.492 | |
| 2acw | UPG | Glycosyltransferase | / | 0.488 | |
| 4rw6 | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.488 | |
| 3p9t | TCL | Repressor | / | 0.483 | |
| 5cvf | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.483 | |
| 3di6 | PDZ | Gag-Pol polyprotein | 2.7.7.49 | 0.478 | |
| 1nde | MON | Estrogen receptor beta | / | 0.475 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.475 | |
| 3ofm | 4B0 | Casein kinase II subunit alpha' | 2.7.11.1 | 0.475 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.475 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 1rt1 | MKC | Gag-Pol polyprotein | 2.7.7.49 | 0.470 | |
| 3h0a | 9RA | Retinoic acid receptor RXR-alpha | / | 0.470 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.469 | |
| 3at4 | CCK | Casein kinase II subunit alpha | 2.7.11.1 | 0.468 | |
| 3dle | GFA | Gag-Pol polyprotein | 2.7.7.49 | 0.468 | |
| 3med | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.468 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.468 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 2nu9 | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.467 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.467 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 4lmu | QUE | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.467 | |
| 1ep4 | S11 | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.466 | |
| 1fko | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 3axw | TID | Casein kinase II subunit alpha | 2.7.11.1 | 0.466 | |
| 3u4u | LNH | Casein kinase II subunit alpha | 2.7.11.1 | 0.466 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.465 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.465 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.464 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.464 | |
| 3m8p | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.464 | |
| 3mec | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.464 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.464 | |
| 3q9x | EMO | Casein kinase II subunit alpha | 2.7.11.1 | 0.464 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.464 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.463 | |
| 2bxm | IMN | Serum albumin | / | 0.463 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.463 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.462 | |
| 4hgs | 15G | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.462 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.461 | |
| 1tqp | ATP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.461 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.461 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 4gnc | ASO | Regucalcin | 3.1.1.17 | 0.461 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.461 | |
| 5csh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.461 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 3igo | ANP | Calmodulin-domain protein kinase 1, putative | / | 0.460 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.460 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.459 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.459 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.459 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.459 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.459 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.459 | |
| 1klm | SPP | Gag-Pol polyprotein | 2.7.7.49 | 0.458 | |
| 2fk8 | SAM | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.458 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.458 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.458 | |
| 3pxy | JWS | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.458 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.458 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.458 | |
| 5cds | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.458 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.457 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.457 | |
| 4ez5 | 0RS | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.457 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 1sj0 | E4D | Estrogen receptor | / | 0.456 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.456 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.456 | |
| 4ogr | ADN | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.456 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.456 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.455 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.455 | |
| 4kfb | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.454 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.453 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.453 | |
| 2vf0 | F89 | Thymidylate synthase | / | 0.453 | |
| 3h18 | PMS | Esterase/lipase | / | 0.453 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.453 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.453 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4a95 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4m6p | 20R | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.453 | |
| 1f28 | UMP | Thymidylate synthase | 2.1.1.45 | 0.452 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.452 | |
| 1q99 | ANP | Serine/threonine-protein kinase SKY1 | 2.7.11.1 | 0.452 | |
| 2bxq | IMN | Serum albumin | / | 0.452 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.452 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 3stx | BKA | Methylketone synthase I | / | 0.452 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.452 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 3v5j | 0F2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.451 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.451 | |
| 5kjc | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.450 | |
| 3b9l | AZZ | Serum albumin | / | 0.450 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.450 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 4lm5 | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.449 | |
| 2b5j | 3AC | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 2ds1 | 1CD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.449 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.449 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.449 | |
| 3r6p | A8S | Abscisic acid receptor PYL10 | / | 0.449 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.448 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3rak | 03Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3sw4 | 18K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.448 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.448 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.448 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.448 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.447 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.447 | |
| 2g5o | DRQ | Estrogen receptor | / | 0.447 | |
| 2h96 | 893 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.447 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.447 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.447 | |
| 2w17 | I19 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.447 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.447 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.447 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.447 | |
| 1e7a | PFL | Serum albumin | / | 0.446 | |
| 1e8w | QUE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1s1v | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.446 | |
| 1uom | PTI | Estrogen receptor | / | 0.446 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.446 | |
| 2pvl | P55 | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.446 | |
| 3cse | N22 | Uncharacterized protein | / | 0.446 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3ldf | SAH | Uncharacterized protein | / | 0.446 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4egn | TWO | Cytochrome P450 | / | 0.446 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 4gg5 | 0J3 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.446 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.445 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.445 | |
| 2j0v | GDP | Rac-like GTP-binding protein ARAC7 | / | 0.445 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.445 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3dol | GWI | Pol protein | / | 0.445 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.445 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.445 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.445 | |
| 4em9 | TCE | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.445 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.445 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.444 | |
| 1lrh | NLA | Auxin-binding protein 1 | / | 0.444 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.444 | |
| 2jfg | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.444 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.444 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.444 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.444 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.444 | |
| 4l23 | X6K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.444 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2xvv | 9DN | Serum albumin | / | 0.443 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3nef | PYV | Abscisic acid receptor PYL1 | / | 0.443 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.443 | |
| 3qqk | X02 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3vet | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.443 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.443 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4ezl | 0SE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.443 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.443 | |
| 4p6w | MOF | Glucocorticoid receptor | / | 0.443 | |
| 4xwt | U5P | Ribonuclease J | / | 0.443 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.442 | |
| 1kyo | SMA | Cytochrome b | / | 0.442 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.442 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2jf9 | OHT | Estrogen receptor | / | 0.442 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 2rht | C1E | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | 3.7.1.8 | 0.442 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.442 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3pej | BC2 | Endoplasmin homolog, putative | / | 0.442 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.442 | |
| 4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.442 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.442 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 1osv | CHC | Bile acid receptor | / | 0.441 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.441 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.441 | |
| 1v79 | FR7 | Adenosine deaminase | 3.5.4.4 | 0.441 | |
| 1xqc | AEJ | Estrogen receptor | / | 0.441 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 2vtq | LZA | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3c4e | C4E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3cy3 | JN5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3g8e | IS1 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.441 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.441 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.441 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.441 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.441 | |
| 1g67 | TZP | Thiamine-phosphate synthase | / | 0.440 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.440 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.440 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2ay9 | 5PV | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.440 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2ibz | SMA | Cytochrome b | / | 0.440 | |
| 2puu | G2G | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.440 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.440 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3ox3 | 4X4 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3uwq | U5P | Orotidine 5'-phosphate decarboxylase | / | 0.440 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.440 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.440 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.440 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 | |
| 4h38 | 0YX | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.440 | |
| 4jvm | XDI | Estrogen sulfotransferase | 2.8.2.4 | 0.440 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.440 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.440 | |
| 4ylh | YE1 | (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase | / | 0.440 | |
| 5a3b | APR | SIR2 family protein | / | 0.440 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.440 |