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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1l0lFMXCytochrome b

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
1l0lFMXCytochrome b/1.000
2fyuFDNCytochrome b/0.526
3vtdTKDVitamin D3 receptor/0.492
3uvvREARetinoic acid receptor RXR-alpha/0.489
1olmVTQSEC14-like protein 2/0.486
2p1u4TNRetinoic acid receptor RXR-alpha/0.485
3vtcTK3Vitamin D3 receptor/0.485
3emlZMAAdenosine receptor A2a/0.483
1rdtL79Retinoic acid receptor RXR-alpha/0.482
2bxqIMNSerum albumin/0.482
1fmjRTLRetinol dehydratase/0.481
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.481
3vrwYS5Vitamin D3 receptor/0.481
4rujVDXVitamin D3 receptor A/0.480
3kpzZNEVitamin D3 receptor/0.479
3v1mHPK2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase3.7.1.80.479
4iarERM5-hydroxytryptamine receptor 1B/0.479
1kb9SMACytochrome b/0.478
2pnuENMAndrogen receptor/0.478
1rkhVD2Vitamin D3 receptor/0.477
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.476
3tguWF3Cytochrome b/0.476
1db1VDXVitamin D3 receptor/0.474
1txiTX5Vitamin D3 receptor/0.474
2ydoADNAdenosine receptor A2a/0.473
4g1z0VPVitamin D3 receptor A/0.473
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.470
1p8dCO1Oxysterols receptor LXR-beta/0.470
3w5p4OAVitamin D3 receptor/0.470
4klaCHDFerrochelatase, mitochondrial4.99.1.10.470
2op18PCEnoyl-ACP reductase/0.469
2p1t3TNRetinoic acid receptor RXR-alpha/0.469
2fpcSCGStrictosidine synthase4.3.3.20.468
3e5aVX6Aurora kinase A2.7.11.10.468
3njoPYVAbscisic acid receptor PYR1/0.468
3vt65YIVitamin D3 receptor/0.468
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
4g1y0VOVitamin D3 receptor A/0.468
4q0a4OAVitamin D3 receptor A/0.468
1rk3VDXVitamin D3 receptor/0.467
1ybgTAVUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.467
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.467
4equG6ISerine/threonine-protein kinase 102.7.11.10.467
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
1ezvSMACytochrome b/0.465
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.465
2hbhXE4Vitamin D3 receptor A/0.465
3is9AC7Gag-Pol polyprotein2.7.7.490.465
4fhh0U3Vitamin D3 receptor A/0.465
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.464
3vt5YI2Vitamin D3 receptor/0.464
4g20484Vitamin D3 receptor A/0.464
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
2p1v5TNRetinoic acid receptor RXR-alpha/0.463
3dr1C5DVitamin D3 receptor A/0.462
5k2aZMAAdenosine receptor A2a/0.462
2xvv9DNSerum albumin/0.461
3w5rLOAVitamin D3 receptor/0.461
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
5dq8FLFTranscriptional enhancer factor TEF-4/0.461
4ruoBIVVitamin D3 receptor A/0.460
2acwUPGGlycosyltransferase/0.459
2hb7O1CVitamin D3 receptor/0.459
2qjySMACytochrome b/0.459
2zlaVDBVitamin D3 receptor/0.459
3b9lAZZSerum albumin/0.459
3tkyN7I(Iso)eugenol O-methyltransferase2.1.1.1460.459
4iui1GQEstrogen receptor/0.459
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.458
1x8lOXRRetinol dehydratase/0.458
2r0pK2CPutative FAD-monooxygenase/0.458
2xvw9NRSerum albumin/0.458
3nxtD2EDihydrofolate reductase1.5.1.30.458
3wv9FEGHmd co-occurring protein HcgE/0.458
4dvi2IWTankyrase-12.4.2.300.458
1fbyREARetinoic acid receptor RXR-alpha/0.457
1fmlRTLRetinol dehydratase/0.457
1gpeFADGlucose oxidase1.1.3.40.457
1kkq471Peroxisome proliferator-activated receptor alpha/0.457
2p15EZTEstrogen receptor/0.457
2ydvNECAdenosine receptor A2a/0.457
3qtrX36Cyclin-dependent kinase 22.7.11.220.457
3vrvYSDVitamin D3 receptor/0.457
3w0aDS5Vitamin D3 receptor/0.457
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.456
1mznBM6Retinoic acid receptor RXR-alpha/0.456
2aclREARetinoic acid receptor RXR-alpha/0.456
2hw2RFPRifampin ADP-ribosyl transferase/0.456
3reoEUG(Iso)eugenol O-methyltransferase2.1.1.1460.456
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
3t8xT8XT-cell surface glycoprotein CD1b/0.456
3v1s0LHStrictosidine synthase4.3.3.20.456
3vt45YIVitamin D3 receptor/0.456
4apuA2KProgesterone receptor/0.456
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4mubOAQSulfotransferase oxamniquine resistance protein/0.456
5g53NECAdenosine receptor A2a/0.456
1s19MC9Vitamin D3 receptor/0.455
2zlcVDXVitamin D3 receptor/0.455
3cxhSMACytochrome b/0.455
3ipq965Oxysterols receptor LXR-alpha/0.455
1dkfBMSRetinoic acid receptor alpha/0.454
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.454
1mvcBM6Retinoic acid receptor RXR-alpha/0.454
1o1vTCHGastrotropin/0.454
1osvCHCBile acid receptor/0.454
1xlsREARetinoic acid receptor RXR-alpha/0.454
2fziDH3Dihydrofolate reductase1.5.1.30.454
2hasC3OVitamin D3 receptor/0.454
2hc4VDXVitamin D3 receptor A/0.454
2z7gEH9Adenosine deaminase3.5.4.40.454
3c3xNAPEugenol synthase 11.1.1.3180.454
3jynNDPQuinone oxidoreductase/0.454
3l0lHC3Nuclear receptor ROR-gamma/0.454
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.454
4kfj1R0Dihydrofolate reductase1.5.1.30.454
5uviZMAAdenosine receptor A2a/0.454
1x2hLPALipoate-protein ligase A6.3.1.200.453
2gpvOHTEstrogen-related receptor gamma/0.453
2ibzSMACytochrome b/0.453
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
2zb45OPProstaglandin reductase 21.3.1.480.453
3oapREARetinoic acid receptor RXR-alpha/0.453
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
4ia1BIVVitamin D3 receptor A/0.453
3pwhZMAAdenosine receptor A2a/0.453
1fm69CRRetinoic acid receptor RXR-alpha/0.452
1ie8KH1Vitamin D3 receptor/0.452
3bfa9ODOdorant binding protein ASP1/0.452
3gkjHC3Niemann-Pick C1 protein/0.452
3w0jT08Vitamin D3 receptor/0.452
3w5tLHPVitamin D3 receptor/0.452
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
4iteTEYVitamin D3 receptor/0.452
1rjkVDZVitamin D3 receptor/0.451
2hamC33Vitamin D3 receptor/0.451
3cx5SMACytochrome b/0.451
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
3vrtYS2Vitamin D3 receptor/0.451
3vtbTKAVitamin D3 receptor/0.451
1ndzFR5Adenosine deaminase3.5.4.40.450
2pogWSTEstrogen receptor/0.450
3eta351Insulin receptor2.7.10.10.450
3k9uACOSpermidine N(1)-acetyltransferase/0.450
3p9tTCLRepressor/0.450
3qly55VUncharacterized protein/0.450
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
3s79ASDAromatase1.14.14.140.450
4a84DXCMajor pollen allergen Bet v 1-A/0.450
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
5iubCLRAdenosine receptor A2a/0.450
1l2jETCEstrogen receptor beta/0.449
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.449
2ol4JPNEnoyl-ACP reductase/0.449
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
2xlsFADPutative flavin-containing monooxygenase/0.449
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.449
3bfb9ODPheromone-binding protein ASP1/0.449
3fu9KIBLaccase-11.10.3.20.449
4ia3BIVVitamin D3 receptor A/0.449
4ia7BIVVitamin D3 receptor A/0.449
1khrVIRStreptogramin A acetyltransferase2.3.10.448
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
1ygjRMCPyridoxal kinase2.7.1.350.448
2uxoTACHTH-type transcriptional regulator TtgR/0.448
2uxpCLMHTH-type transcriptional regulator TtgR/0.448
2yiuSMACytochrome b/0.448
3cyz9ODPheromone-binding protein ASP1/0.448
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3pqbVGPPutative oxidoreductase/0.448
3w5q3KLVitamin D3 receptor/0.448
4m8e29VRetinoic acid receptor RXR-alpha/0.448
4xymCOAAcyl-CoA synthetase (NDP forming)/0.448
1fvpFMANon-fluorescent flavoprotein/0.447
1ly3COGDihydrofolate reductase1.5.1.30.447
1ly4COQDihydrofolate reductase1.5.1.30.447
2aclL05Oxysterols receptor LXR-alpha/0.447
2o12FMNChorismate synthase/0.447
2po7CHDFerrochelatase, mitochondrial4.99.1.10.447
2uxxFAJLysine-specific histone demethylase 1A10.447
3elm24FCollagenase 33.4.240.447
3ipuO40Oxysterols receptor LXR-alpha/0.447
4iaq2GM5-hydroxytryptamine receptor 1B/0.447
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
3qakUKAAdenosine receptor A2a/0.447
1gt5BZQOdorant-binding protein/0.446
1xp6AIUEstrogen receptor/0.446
2o4jVD4Vitamin D3 receptor/0.446
2p4iMR9Angiopoietin-1 receptor2.7.10.10.446
3fu83DMLaccase-11.10.3.20.446
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3ntdFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.446
4ead0NPThymidine phosphorylase2.4.2.40.446
4okb198Androgen receptor/0.446
4z44FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.446
5iu86DZAdenosine receptor A2a/0.446
5k2cZMAAdenosine receptor A2a/0.446
5k2bZMAAdenosine receptor A2a/0.446
3rfmCFFAdenosine receptor A2a/0.446
3w0yDS4Vitamin D3 receptor/0.445
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.445
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.445
4k4j1O8Retinoic acid receptor RXR-alpha/0.445
7catNDPCatalase1.11.1.60.445
5k2dZMAAdenosine receptor A2a/0.445
3uzcT4EAdenosine receptor A2a/0.445
1crbRTLRetinol-binding protein 1/0.444
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1rkgVD1Vitamin D3 receptor/0.444
1sqqOSTCytochrome b/0.444
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.444
2z3uCRRCytochrome P450/0.444
3a783EVVitamin D3 receptor/0.444
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3stv3HOMethylketone synthase I/0.444
4ceqQCHIntegrase/0.444
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.444
4iah1DXAlr2278 protein/0.444
5dozNDPJamJ/0.444
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3qri919Tyrosine-protein kinase ABL12.7.10.20.443
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4g2h0VQVitamin D3 receptor A/0.443
4m8hR4MRetinoic acid receptor RXR-alpha/0.443
5bt42LOBromodomain-containing protein 4/0.443
1ci7UMPThymidylate synthase2.1.1.450.442
1e1kFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.442
1q1rFADPutidaredoxin reductase1.18.1.50.442
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2bxmIMNSerum albumin/0.442
2r5nTPPTransketolase 1/0.442
3bejMUFBile acid receptor/0.442
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.442
3mbgFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.442
3vt3VDXVitamin D3 receptor/0.442
4fhi0S4Vitamin D3 receptor A/0.442
4g210VPVitamin D3 receptor A/0.442
5jtbZMAAdenosine receptor A2a/0.442
1fm99CRRetinoic acid receptor RXR-alpha/0.441
1t7o152Carnitine O-acetyltransferase2.3.1.70.441
1xu9CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
2pncCLUPrimary amine oxidase, liver isozyme/0.441
3abaFLICytochrome P450/0.441
3w0c6DSVitamin D3 receptor/0.441
4fhd0TTSpore photoproduct lyase/0.441
4o701QKBromodomain-containing protein 4/0.441
4rupH97Vitamin D3 receptor A/0.441
1jujLYAThymidylate synthase2.1.1.450.440
1kyoSMACytochrome b/0.440
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.440
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.440
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
2zl9VDAVitamin D3 receptor/0.440
3cz09ODPheromone-binding protein ASP1/0.440
3dd125DGlycogen phosphorylase, liver form2.4.1.10.440
3ntaFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.440
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
4eiyZMAAdenosine receptor A2a/0.440
4phlPILPhosphodiesterase/0.440
5iua6DXAdenosine receptor A2a/0.440