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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1h0vUN4Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1h0vUN4Cyclin-dependent kinase 22.7.11.221.000
2r3iSCFCyclin-dependent kinase 22.7.11.220.644
1b39ATPCyclin-dependent kinase 22.7.11.220.619
2btrU73Cyclin-dependent kinase 22.7.11.220.616
2r3gSC9Cyclin-dependent kinase 22.7.11.220.610
2c6iDT1Cyclin-dependent kinase 22.7.11.220.607
4ek816KCyclin-dependent kinase 22.7.11.220.603
2r3r6SCCyclin-dependent kinase 22.7.11.220.585
2r3o2SCCyclin-dependent kinase 22.7.11.220.583
3qqhX0ACyclin-dependent kinase 22.7.11.220.579
1e1xNW1Cyclin-dependent kinase 22.7.11.220.576
1h0w207Cyclin-dependent kinase 22.7.11.220.575
3rjc06ZCyclin-dependent kinase 22.7.11.220.575
2a4lRRCCyclin-dependent kinase 22.7.11.220.574
5aniES4Cyclin-dependent kinase 22.7.11.220.570
3r1yX76Cyclin-dependent kinase 22.7.11.220.569
3rm618ZCyclin-dependent kinase 22.7.11.220.569
1w8cN69Cyclin-dependent kinase 22.7.11.220.562
4fklCK2Cyclin-dependent kinase 22.7.11.220.555
3iggEFQCyclin-dependent kinase 22.7.11.220.554
4fkr45KCyclin-dependent kinase 22.7.11.220.554
2uznC96Cyclin-dependent kinase 22.7.11.220.551
4fkt48KCyclin-dependent kinase 22.7.11.220.550
3s00Z60Cyclin-dependent kinase 22.7.11.220.549
3r7vZ02Cyclin-dependent kinase 22.7.11.220.548
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.546
3qwjX6ACyclin-dependent kinase 22.7.11.220.545
4fkg4CKCyclin-dependent kinase 22.7.11.220.545
2exmZIPCyclin-dependent kinase 22.7.11.220.543
2r3fSC8Cyclin-dependent kinase 22.7.11.220.543
3qx2X63Cyclin-dependent kinase 22.7.11.220.543
1ke6LS2Cyclin-dependent kinase 22.7.11.220.541
3r7yZ04Cyclin-dependent kinase 22.7.11.220.541
4fki09KCyclin-dependent kinase 22.7.11.220.541
1ckpPVBCyclin-dependent kinase 22.7.11.220.539
2r3p3SCCyclin-dependent kinase 22.7.11.220.539
4ez30S0Cyclin-dependent kinase 22.7.11.220.539
3pj8404Cyclin-dependent kinase 22.7.11.220.538
3raiX85Cyclin-dependent kinase 22.7.11.220.538
3qxoX65Cyclin-dependent kinase 22.7.11.220.537
4fkq42KCyclin-dependent kinase 22.7.11.220.537
2c69CT8Cyclin-dependent kinase 22.7.11.220.536
3r73X87Cyclin-dependent kinase 22.7.11.220.535
3rm719ZCyclin-dependent kinase 22.7.11.220.535
3rpv26ZCyclin-dependent kinase 22.7.11.220.535
3qtzX42Cyclin-dependent kinase 22.7.11.220.534
3r1sX73Cyclin-dependent kinase 22.7.11.220.534
1h1r6CPCyclin-dependent kinase 22.7.11.220.533
4fkpLS5Cyclin-dependent kinase 22.7.11.220.531
1b38ATPCyclin-dependent kinase 22.7.11.220.529
2b52D42Cyclin-dependent kinase 22.7.11.220.529
3qzhX69Cyclin-dependent kinase 22.7.11.220.529
2b54D05Cyclin-dependent kinase 22.7.11.220.526
4kd11QKCyclin-dependent kinase 22.7.11.220.526
1gih1PUCyclin-dependent kinase 22.7.11.220.524
2w05FRTCyclin-dependent kinase 22.7.11.220.524
3qtxX43Cyclin-dependent kinase 22.7.11.220.524
3s2pPMUCyclin-dependent kinase 22.7.11.220.524
3rahO1ZCyclin-dependent kinase 22.7.11.220.523
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.520
3r9hZ67Cyclin-dependent kinase 22.7.11.220.520
4acm7YGCyclin-dependent kinase 22.7.11.220.520
2r64740Cyclin-dependent kinase 22.7.11.220.519
1ke7LS3Cyclin-dependent kinase 22.7.11.220.517
3qtuX44Cyclin-dependent kinase 22.7.11.220.516
3r6xX84Cyclin-dependent kinase 22.7.11.220.516
4nj32KDCyclin-dependent kinase 22.7.11.220.515
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.513
3pxyJWSCyclin-dependent kinase 22.7.11.220.513
3rk909ZCyclin-dependent kinase 22.7.11.220.513
1ke9LS5Cyclin-dependent kinase 22.7.11.220.512
3r28XA0Cyclin-dependent kinase 22.7.11.220.512
3r83Z14Cyclin-dependent kinase 22.7.11.220.511
2btsU32Cyclin-dependent kinase 22.7.11.220.510
3unj0BXCyclin-dependent kinase 22.7.11.220.510
1ke5LS1Cyclin-dependent kinase 22.7.11.220.509
4bcpT3CCyclin-dependent kinase 22.7.11.220.509
3rni21ZCyclin-dependent kinase 22.7.11.220.508
3sqq99ZCyclin-dependent kinase 22.7.11.220.508
3sw418KCyclin-dependent kinase 22.7.11.220.508
1di8DTQCyclin-dependent kinase 22.7.11.220.507
1h1q2A6Cyclin-dependent kinase 22.7.11.220.507
2vtsLZCCyclin-dependent kinase 22.7.11.220.506
3fz1B98Cyclin-dependent kinase 22.7.11.220.506
3qu0X40Cyclin-dependent kinase 22.7.11.220.506
3qqlX03Cyclin-dependent kinase 22.7.11.220.505
1e1vCMGCyclin-dependent kinase 22.7.11.220.504
2bhhRYUCyclin-dependent kinase 22.7.11.220.504
3roy22ZCyclin-dependent kinase 22.7.11.220.504
4fkj11KCyclin-dependent kinase 22.7.11.220.504
1oguST8Cyclin-dependent kinase 22.7.11.220.503
1vyzN5BCyclin-dependent kinase 22.7.11.220.503
2r3mSCXCyclin-dependent kinase 22.7.11.220.503
3lfnA27Cyclin-dependent kinase 22.7.11.220.503
4ek610KCyclin-dependent kinase 22.7.11.220.502
1pxmCK5Cyclin-dependent kinase 22.7.11.220.501
3qwkX62Cyclin-dependent kinase 22.7.11.220.501
3r8uZ31Cyclin-dependent kinase 22.7.11.220.501
3unk0BYCyclin-dependent kinase 22.7.11.220.501
4bgh3I6Cyclin-dependent kinase 22.7.11.220.501
2r3q5SCCyclin-dependent kinase 22.7.11.220.500
2uzoC62Cyclin-dependent kinase 22.7.11.220.500
3lfsA07Cyclin-dependent kinase 22.7.11.220.500
3qziX72Cyclin-dependent kinase 22.7.11.220.500
3rpo24ZCyclin-dependent kinase 22.7.11.220.500
3s0o50ZCyclin-dependent kinase 22.7.11.220.500
1oitHDTCyclin-dependent kinase 22.7.11.220.499
2c6mDT5Cyclin-dependent kinase 22.7.11.220.499
2r3lSCWCyclin-dependent kinase 22.7.11.220.499
2iw84SPCyclin-dependent kinase 22.7.11.220.498
2w06FRVCyclin-dependent kinase 22.7.11.220.498
3r9dX6BCyclin-dependent kinase 22.7.11.220.498
3rak03ZCyclin-dependent kinase 22.7.11.220.498
1w0xOLOCyclin-dependent kinase 22.7.11.220.497
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.496
3qqfX07Cyclin-dependent kinase 22.7.11.220.496
3r7iX9ICyclin-dependent kinase 22.7.11.220.496
4lyn1YGCyclin-dependent kinase 22.7.11.220.496
2c6o4SPCyclin-dependent kinase 22.7.11.220.495
3qzgX67Cyclin-dependent kinase 22.7.11.220.495
4eor4SPCyclin-dependent kinase 22.7.11.220.495
3qruX19Cyclin-dependent kinase 22.7.11.220.494
4fks46KCyclin-dependent kinase 22.7.11.220.494
1pxkCK3Cyclin-dependent kinase 22.7.11.220.493
3ddpRC8Cyclin-dependent kinase 22.7.11.220.493
1vyw292Cyclin-dependent kinase 22.7.11.220.492
3ddqRRCCyclin-dependent kinase 22.7.11.220.492
3ti1B49Cyclin-dependent kinase 22.7.11.220.492
1pxoCK7Cyclin-dependent kinase 22.7.11.220.491
3r7eX88Cyclin-dependent kinase 22.7.11.220.490
1gz8MBPCyclin-dependent kinase 22.7.11.220.489
2wpa889Cyclin-dependent kinase 22.7.11.220.489
3ezrEZRCyclin-dependent kinase 22.7.11.220.489
3r8lZ30Cyclin-dependent kinase 22.7.11.220.489
3ig7EFPCyclin-dependent kinase 22.7.11.220.488
3r7uX96Cyclin-dependent kinase 22.7.11.220.488
4eon1ROCyclin-dependent kinase 22.7.11.220.488
4eos1ROCyclin-dependent kinase 22.7.11.220.488
3lfqA28Cyclin-dependent kinase 22.7.11.220.486
1h1pCMGCyclin-dependent kinase 22.7.11.220.484
1unlRRCCyclin-dependent-like kinase 52.7.11.10.483
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.483
3s1h56ZCyclin-dependent kinase 22.7.11.220.482
1g5sI17Cyclin-dependent kinase 22.7.11.220.481
1urwI1PCyclin-dependent kinase 22.7.11.220.481
1ke8LS4Cyclin-dependent kinase 22.7.11.220.479
1v1k3FPCyclin-dependent kinase 22.7.11.220.479
3r8pZ46Cyclin-dependent kinase 22.7.11.220.479
2b55D31Cyclin-dependent kinase 22.7.11.220.478
2vttLZDCyclin-dependent kinase 22.7.11.220.478
3qtrX36Cyclin-dependent kinase 22.7.11.220.478
3r1qX75Cyclin-dependent kinase 22.7.11.220.477
3py0SU9Cyclin-dependent kinase 22.7.11.220.475
2iw94SPCyclin-dependent kinase 22.7.11.220.474
2r3kSCQCyclin-dependent kinase 22.7.11.220.474
1h1s4SPCyclin-dependent kinase 22.7.11.220.473
1oiuN76Cyclin-dependent kinase 22.7.11.220.473
3rk507ZCyclin-dependent kinase 22.7.11.220.472
1gy3ATPCyclin-dependent kinase 22.7.11.220.471
1oiqHDUCyclin-dependent kinase 22.7.11.220.471
2wotZZGTGF-beta receptor type-12.7.11.300.471
3bhtMFRCyclin-dependent kinase 22.7.11.220.471
3qtqX35Cyclin-dependent kinase 22.7.11.220.471
3rpr25ZCyclin-dependent kinase 22.7.11.220.471
2a0cCK9Cyclin-dependent kinase 22.7.11.220.470
1oi9N20Cyclin-dependent kinase 22.7.11.220.468
3qqkX02Cyclin-dependent kinase 22.7.11.220.468
4fko20KCyclin-dependent kinase 22.7.11.220.468
2xmyCDKCyclin-dependent kinase 22.7.11.220.467
3ezvEZVCyclin-dependent kinase 22.7.11.220.467
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.466
4bcnT9NCyclin-dependent kinase 22.7.11.220.466
4fx360KCyclin-dependent kinase 22.7.11.220.466
1fvt106Cyclin-dependent kinase 22.7.11.220.465
2vv9IM9Cyclin-dependent kinase 22.7.11.220.464
2xnbY8LCyclin-dependent kinase 22.7.11.220.464
3ql8X01Cyclin-dependent kinase 22.7.11.220.464
2c4g514Cyclin-dependent kinase 22.7.11.220.463
4eomATPCyclin-dependent kinase 22.7.11.220.463
1y8yCT7Cyclin-dependent kinase 22.7.11.220.462
3rk708ZCyclin-dependent kinase 22.7.11.220.462
1ykr628Cyclin-dependent kinase 22.7.11.220.461
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.461
1p2a5BNCyclin-dependent kinase 22.7.11.220.460
2c68CT6Cyclin-dependent kinase 22.7.11.220.460
1r78FMDCyclin-dependent kinase 22.7.11.220.459
2r3jSCJCyclin-dependent kinase 22.7.11.220.459
1e9hINRCyclin-dependent kinase 22.7.11.220.458
3rzb02ZCyclin-dependent kinase 22.7.11.220.457
4eop1ROCyclin-dependent kinase 22.7.11.220.457
3ral04ZCyclin-dependent kinase 22.7.11.220.456
1pyePM1Cyclin-dependent kinase 22.7.11.220.453
2duv371Cyclin-dependent kinase 22.7.11.220.453
4fkw62KCyclin-dependent kinase 22.7.11.220.453
2wxvWXVCyclin-dependent kinase 22.7.11.220.452
3rkb12ZCyclin-dependent kinase 22.7.11.220.451
4fkv61KCyclin-dependent kinase 22.7.11.220.451
2c5yMTWCyclin-dependent kinase 22.7.11.220.450
3sheI85MAP kinase-activated protein kinase 32.7.11.10.450
1gij2PUCyclin-dependent kinase 22.7.11.220.449
2vthLZ2Cyclin-dependent kinase 22.7.11.220.449
1gii1PUCyclin-dependent kinase 22.7.11.220.447
3qtsX46Cyclin-dependent kinase 22.7.11.220.447
4bcoT6QCyclin-dependent kinase 22.7.11.220.445
1y91CT9Cyclin-dependent kinase 22.7.11.220.444
4i3zADPCyclin-dependent kinase 22.7.11.220.444
3tiz3TICyclin-dependent kinase 22.7.11.220.443
3qzfX66Cyclin-dependent kinase 22.7.11.220.442
4eok4SPCyclin-dependent kinase 22.7.11.220.442
4qmpDKISerine/threonine-protein kinase 242.7.11.10.442
3my5RFZCyclin-dependent kinase 22.7.11.220.441
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.440
2w1hL0FCyclin-dependent kinase 22.7.11.220.440
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3r9nZ68Cyclin-dependent kinase 22.7.11.220.440
3r9oZ71Cyclin-dependent kinase 22.7.11.220.440
4k8aK8AFocal adhesion kinase 12.7.10.20.440