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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5agyGTBTau class glutathione S-transferase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5agyGTBTau class glutathione S-transferase/1.000
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.501
2lfoGCHFatty acid-binding protein, liver/0.497
4bfuZVUPantothenate kinase2.7.1.330.496
1c7oPPGHemolysin/0.495
5stdUNNScytalone dehydratase4.2.1.940.494
4uymVOR14-alpha sterol demethylase Cyp51B/0.487
2idkC2FGlycine N-methyltransferase2.1.1.200.485
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.485
1txtCAAHMG-CoA synthase/0.484
1uzwCDHIsopenicillin N synthase1.21.3.10.480
2g8yNADHydroxycarboxylate dehydrogenase B/0.478
2vo4GTB2,4-D inducible glutathione S-transferase/0.478
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.478
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.478
2gv8NDPThiol-specific monooxygenase1.14.130.477
3fhxPLPPyridoxal kinase2.7.1.350.477
4ttiFMCPurine nucleoside phosphorylase DeoD-type/0.477
3qeoLLTDeoxycytidine kinase2.7.1.740.476
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.472
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.472
1p8dCO1Oxysterols receptor LXR-beta/0.471
1zdwFLVPrenyltransferase/0.471
2lbaCHOFatty acid binding protein 6/0.471
3arvSAUChitinase A/0.471
1vf2GTXGlutathione S-transferase 32.5.1.180.470
3b9oFMNAlkane monoxygenase/0.470
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.470
3qm4PN0Cytochrome P450 2D6/0.470
4bfzZVZPantothenate kinase2.7.1.330.470
1oz0MS1Bifunctional purine biosynthesis protein PURH2.1.2.30.469
2rqfJH3Hemolymph juvenile hormone binding protein/0.469
2xvw9NRSerum albumin/0.469
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.469
1pq6965Oxysterols receptor LXR-beta/0.468
3biy01KHistone acetyltransferase p300/0.468
1rf7DHFDihydrofolate reductase1.5.1.30.467
2y60M8FIsopenicillin N synthase1.21.3.10.467
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.467
3rsv3RSBeta-secretase 13.4.23.460.467
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.466
1obnASVIsopenicillin N synthase1.21.3.10.465
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
3nx4NAPPutative oxidoreductase/0.465
3p9tTCLRepressor/0.465
3uyk0CXProbable NDP-rhamnosyltransferase/0.464
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.464
4kbn25UDihydrofolate reductase1.5.1.30.464
4ttaFMCPurine nucleoside phosphorylase DeoD-type/0.464
1q23FUAChloramphenicol acetyltransferase2.3.1.280.463
1vbiNADMalate/L-lactate dehydrogenase family protein/0.463
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.463
1fxfMJIPhospholipase A2, major isoenzyme3.1.1.40.462
2bu9HFVIsopenicillin N synthase1.21.3.10.462
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.462
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.462
4zzjCNANAD-dependent protein deacetylase sirtuin-13.5.10.462
1fm4DXCMajor pollen allergen Bet v 1-L/0.461
3dd0EZLCarbonic anhydrase 24.2.1.10.461
1hfqMOTDihydrofolate reductase1.5.1.30.460
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
1swtBTNStreptavidin/0.460
1x2hLPALipoate-protein ligase A6.3.1.200.460
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.460
3d4bDZDNAD-dependent protein deacetylase/0.460
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.460
3zeiAWHO-acetylserine sulfhydrylase/0.460
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.460
4bfwZVWPantothenate kinase2.7.1.330.460
1rx7FOLDihydrofolate reductase1.5.1.30.459
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.459
2ydoADNAdenosine receptor A2a/0.459
3gncQQQGlutaryl-CoA dehydrogenase/0.459
4a81DXCMajor pollen allergen Bet v 1-A/0.459
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.459
4ia7BIVVitamin D3 receptor A/0.459
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.458
2jb4A14Isopenicillin N synthase1.21.3.10.458
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.458
4iah1DXAlr2278 protein/0.458
1bk0ACVIsopenicillin N synthase1.21.3.10.457
1rkhVD2Vitamin D3 receptor/0.457
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.457
2vbpVB1Isopenicillin N synthase1.21.3.10.457
3dd125DGlycogen phosphorylase, liver form2.4.1.10.457
3ehjACPSensor histidine kinase DesK2.7.13.30.457
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.457
3zkyWT4Isopenicillin N synthase1.21.3.10.457
4a83DXCMajor pollen allergen Bet v 1-A/0.457
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.457
1hb3SCVIsopenicillin N synthase1.21.3.10.456
1rc4DDFDihydrofolate reductase1.5.1.30.456
2d3aADPGlutamine synthetase root isozyme 36.3.1.20.456
3b9lAZZSerum albumin/0.456
3hucG97Mitogen-activated protein kinase 14/0.456
3zoiM2WIsopenicillin N synthase1.21.3.10.456
4bfxZVXPantothenate kinase2.7.1.330.456
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.455
2zb8IMNProstaglandin reductase 21.3.1.480.455
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.455
3u9y09LTankyrase-22.4.2.300.455
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.455
1cjuFOKAdenylate cyclase type 2/0.454
1cjuFOKAdenylate cyclase type 5/0.454
1o6qR17Squalene--hopene cyclase4.2.1.1290.454
1pqc444Oxysterols receptor LXR-beta/0.454
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.454
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.454
2dxdANPNucleoside diphosphate kinase2.7.4.60.454
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.454
2ydvNECAdenosine receptor A2a/0.454
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3nu03TUDihydrofolate reductase1.5.1.30.454
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.454
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.454
4gl4NAIAlcohol dehydrogenase class-3/0.454
1w06W05Isopenicillin N synthase1.21.3.10.453
3aosJH2Hemolymph juvenile hormone binding protein/0.453
3h3r14HCollagen type IV alpha-3-binding protein/0.453
3ipuO40Oxysterols receptor LXR-alpha/0.453
3pe2E1BCasein kinase II subunit alpha2.7.11.10.453
3pqbVGPPutative oxidoreductase/0.453
3v0o4GWHisto-blood group ABO system transferase/0.453
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.453
4bb3KKAIsopenicillin N synthase1.21.3.10.453
1fx9MJIPhospholipase A2, major isoenzyme3.1.1.40.452
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.452
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.452
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.452
4rupH97Vitamin D3 receptor A/0.452
1n0uSO1Elongation factor 2/0.451
1trgCB3Thymidylate synthase/0.451
1yhjR6CPyridoxal kinase2.7.1.350.451
1zoyUQ1Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial1.3.5.10.451
1zoyUQ1Succinate dehydrogenase cytochrome b560 subunit, mitochondrial/0.451
2qc8ADPGlutamine synthetase6.3.1.20.451
2wpxACOOrf14/0.451
2xy93ESAngiotensin-converting enzyme3.2.10.451
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.451
3ekuCY9Actin-5C/0.451
3h3qH13Collagen type IV alpha-3-binding protein/0.451
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.451
3l6jZ90Alr2278 protein/0.451
3n5wXFJNitric oxide synthase, brain1.14.13.390.451
3rviRVIBeta-secretase 13.4.23.460.451
4ead0NPThymidine phosphorylase2.4.2.40.451
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.450
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.450
2pbzATPUncharacterized protein/0.450
2xvv9DNSerum albumin/0.450
3tdaPN0Cytochrome P450 2D6/0.450
4bfyZVYPantothenate kinase2.7.1.330.450
4iae1DXAlr2278 protein/0.450
4qx5CMPcGMP-dependent protein kinase 12.7.11.120.450
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.450
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.449
2vqqTFGHistone deacetylase 43.5.1.980.449
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.449
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4bis8HQLysine-specific demethylase 4A1.14.110.449
4e0u0MVCyclic dipeptide N-prenyltransferase/0.449
4g1y0VOVitamin D3 receptor A/0.449
4stdBFSScytalone dehydratase4.2.1.940.449
1pq944BOxysterols receptor LXR-beta/0.448
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.448
2vbdV10Isopenicillin N synthase1.21.3.10.448
2vd0D27Hematopoietic prostaglandin D synthase/0.448
2w3mFOLDihydrofolate reductase1.5.1.30.448
3h3t16HCollagen type IV alpha-3-binding protein/0.448
3lfeZ84Mitogen-activated protein kinase 14/0.448
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.448
4i1nFOLDihydrofolate reductase1.5.1.30.448
4v2gITCTetracycline repressor protein class D/0.448
5dp2NAPCurF/0.448
1cjkFOKAdenylate cyclase type 2/0.447
1cjkFOKAdenylate cyclase type 5/0.447
1nenDNTSuccinate dehydrogenase iron-sulfur subunit1.3.5.10.447
1nenDNTSuccinate dehydrogenase cytochrome b556 subunit/0.447
2fs4PZ1Renin3.4.23.150.447
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.447
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.447
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.447
4c77N01Phenylacetone monooxygenase1.14.13.920.447
1qtiGNTAcetylcholinesterase3.1.1.70.446
1upw444Oxysterols receptor LXR-beta/0.446
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.446
2g274LGRenin3.4.23.150.446
2xnpWCXSerine/threonine-protein kinase Nek22.7.11.10.446
3cndFADPolyamine oxidase FMS1/0.446
3eksCY9Actin-5C/0.446
3exnACOProbable acetyltransferase/0.446
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.446
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.446
3vt65YIVitamin D3 receptor/0.446
3vtdTKDVitamin D3 receptor/0.446
4zj8SUVOrexin receptor type 1/0.446
1b87ACOAac(6')-Ii protein/0.445
1rkpIBMcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.445
3c3xNAPEugenol synthase 11.1.1.3180.445
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.445
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3vi7CBDHematopoietic prostaglandin D synthase/0.445
4c6zTLE3-oxoacyl-ACP synthase/0.445
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.445
4l9q9TPSerum albumin/0.445
4oztP1AEcdysone receptor, putative/0.445
4twnB96Ephrin type-A receptor 32.7.10.10.445
3rfmCFFAdenosine receptor A2a/0.445
1i9hBNIStreptavidin/0.444
1stdBFSScytalone dehydratase4.2.1.940.444
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2iviACWIsopenicillin N synthase1.21.3.10.444
3jynNDPQuinone oxidoreductase/0.444
3kpzZNEVitamin D3 receptor/0.444
3te4ACODopamine N-acetyltransferase/0.444
3zcnATPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.444
4bftZVTPantothenate kinase2.7.1.330.444
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.444
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.444
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
4ia3BIVVitamin D3 receptor A/0.444
4zm6ACON-acetyl-beta-D glucosaminidase/0.444
5kf1COAPredicted acetyltransferase/0.444
1blzACVIsopenicillin N synthase1.21.3.10.443
1hb1OCVIsopenicillin N synthase1.21.3.10.443
1yc2NADNAD-dependent protein deacylase 2/0.443
2dhfDZFDihydrofolate reductase1.5.1.30.443
2zsdCOAPantothenate kinase2.7.1.330.443
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3eq6BCOAcyl-coenzyme A synthetase ACSM2A, mitochondrial6.2.1.20.443
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3hu2AGSTransitional endoplasmic reticulum ATPase3.6.4.60.443
3rl35GPMetallophosphoesterase MPPED23.10.443
3v2uATPProtein GAL3/0.443
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.443
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.443
4e2yJHZMethyltransferase/0.443
4g1z0VPVitamin D3 receptor A/0.443
5irnADPNucleotide binding oligomerization domain containing 2/0.443
1bucFADAcyl-CoA dehydrogenase, short-chain specific1.3.8.10.442
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.442
1puaCOAHAT A1/0.442
1u1d181Uridine phosphorylase2.4.2.30.442
1u1f183Uridine phosphorylase2.4.2.30.442
1uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.442
1ygkRRCPyridoxal kinase2.7.1.350.442
3tfyCOAN-alpha-acetyltransferase 502.3.10.442
4bj9UHBTankyrase-22.4.2.300.442
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.442
4kak06UDihydrofolate reductase1.5.1.30.442
4pzsACOHistone acetyltransferase p300/0.442
4qa0SHHHistone deacetylase 83.5.1.980.442
4utlFNRXenobiotic reductase/0.442
1rd4L08Integrin alpha-L/0.441
1uy8PU5Heat shock protein HSP 90-alpha/0.441
1w4lGL8Acetylcholinesterase3.1.1.70.441
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2qimZEAClass 10 plant pathogenesis-related protein/0.441
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.441
2y67N21UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.441
3mhcARZCarbonic anhydrase 24.2.1.10.441
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.441
4b1e6T6Beta-secretase 13.4.23.460.441
4eilUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
4h1e10JBeta-secretase 13.4.23.460.441
4kw51W6Decaprenylphosphoryl-beta-D-ribose oxidase/0.441
4phlPILPhosphodiesterase/0.441
4rh10TTSpore photoproduct lyase/0.441
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.441
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.441
5kf2ACOPredicted acetyltransferase/0.441
1dhfFOLDihydrofolate reductase1.5.1.30.440
1h36R88Squalene--hopene cyclase4.2.1.1290.440
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.440
1rx4DDFDihydrofolate reductase1.5.1.30.440
1s3uTQDDihydrofolate reductase1.5.1.30.440
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2ea4F79Methionine aminopeptidase 2/0.440
2g263LGRenin3.4.23.150.440
2vcmM11Isopenicillin N synthase1.21.3.10.440
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
2zs9ADPPantothenate kinase2.7.1.330.440
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
3ddw055Glycogen phosphorylase, liver form2.4.1.10.440
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.440
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.440
3ixp834Ecdysone receptor/0.440
3p0fBAUUridine phosphorylase 22.4.2.30.440
3w5rLOAVitamin D3 receptor/0.440
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.440
4bfvZVVPantothenate kinase2.7.1.330.440
4ej1FOLDihydrofolate reductase1.5.1.30.440
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.440
4jlk1NODeoxycytidine kinase2.7.1.740.440
4qa2SHHHistone deacetylase 83.5.1.980.440
4u9vACON-alpha-acetyltransferase 402.3.10.440