sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.855 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.774 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.755 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.753 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.739 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.735 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.729 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.697 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.688 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.683 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.680 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.678 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.673 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.671 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.668 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.667 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.664 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.661 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.661 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.656 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.653 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.652 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.650 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.643 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.640 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.639 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.636 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.635 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.630 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.626 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.624 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.623 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.619 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.612 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.612 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.612 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.610 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.610 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.600 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.599 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.597 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.592 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.589 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.583 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.534 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.534 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.524 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.512 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.511 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.509 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.505 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.501 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.499 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.497 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.496 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.495 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.492 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.492 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.489 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.488 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.486 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.486 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.482 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.480 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.479 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.479 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.478 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.473 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.472 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.472 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.472 | |
| 3eej | 53R | Uncharacterized protein | / | 0.470 | |
| 4egn | TWO | Cytochrome P450 | / | 0.469 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.467 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.466 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.466 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.466 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.463 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.462 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.461 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.459 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.459 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.459 | |
| 2y3r | TIR | TamL | / | 0.458 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.458 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.458 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.458 | |
| 2y3s | TIR | TamL | / | 0.457 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.457 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.456 | |
| 3gob | HXX | DdmC | / | 0.456 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.455 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.455 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.454 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.453 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.453 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.451 | |
| 2c6h | PXI | Cytochrome P450 monooxygenase PikC | / | 0.451 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.451 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.451 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.451 | |
| 3u9e | COA | Lmo1369 protein | / | 0.450 | |
| 3wec | AUI | Cytochrome P450 | / | 0.450 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.449 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.448 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.448 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.448 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.448 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.447 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.447 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.446 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.446 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.446 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.446 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.445 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.445 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.445 | |
| 3zuy | TCH | Transporter | / | 0.445 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.444 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.444 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.444 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.443 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.443 | |
| 3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.443 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.443 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.442 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.442 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.442 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.442 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
| 3sls | 77D | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.442 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.442 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.442 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.442 | |
| 5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.442 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.441 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.441 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.441 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3ey9 | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.441 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.441 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.441 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.441 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.441 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.440 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.440 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.440 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.440 | |
| 3cse | N22 | Uncharacterized protein | / | 0.440 | |
| 3s1c | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.440 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.440 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.440 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.440 |