sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4idt | T28 | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4idt | T28 | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 1.000 | |
| 4dn5 | AGS | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.549 | |
| 4idv | 13V | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.540 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.535 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.523 | |
| 4l52 | 1UL | Mitogen-activated protein kinase kinase kinase 7 | 2.7.11.25 | 0.522 | |
| 4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.515 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.514 | |
| 3f69 | XDR | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.510 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.507 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.506 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.506 | |
| 4e4m | 0NH | Tyrosine-protein kinase JAK2 | / | 0.506 | |
| 2rio | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.505 | |
| 1ol5 | ADP | Aurora kinase A | 2.7.11.1 | 0.503 | |
| 4gii | 0X6 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.500 | |
| 3lxp | IZA | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.497 | |
| 5dt3 | ATP | Aurora kinase A | 2.7.11.1 | 0.497 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.494 | |
| 1om1 | IQA | Casein kinase II subunit alpha | 2.7.11.1 | 0.493 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.492 | |
| 5drd | ATP | Aurora kinase A | 2.7.11.1 | 0.491 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.489 | |
| 4gih | 0X5 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.489 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.488 | |
| 2pvh | P19 | Casein kinase II subunit alpha | 2.7.11.1 | 0.488 | |
| 4g3e | 0WC | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.488 | |
| 5dt4 | ATP | Aurora kinase A | 2.7.11.1 | 0.488 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.487 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.486 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.486 | |
| 4bie | IE6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.485 | |
| 4gj2 | 0XH | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.485 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.484 | |
| 1uv5 | BRW | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.484 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.484 | |
| 1mq4 | ADP | Aurora kinase A | 2.7.11.1 | 0.483 | |
| 3zlx | 5EZ | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.483 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.483 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.482 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.481 | |
| 1ol7 | ADP | Aurora kinase A | 2.7.11.1 | 0.481 | |
| 3zm4 | 22T | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.481 | |
| 1m2p | HNA | Casein kinase II subunit alpha | 2.7.11.1 | 0.479 | |
| 3l1s | Z92 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.479 | |
| 3le6 | 2BZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.479 | |
| 3mdd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.479 | |
| 5dr9 | SKE | Aurora kinase A | 2.7.11.1 | 0.479 | |
| 2c6t | DT5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.478 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.478 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.477 | |
| 1m2r | MNY | Casein kinase II subunit alpha | 2.7.11.1 | 0.476 | |
| 4kik | KSA | Inhibitor of nuclear factor kappa-B kinase subunit beta | 2.7.11.10 | 0.476 | |
| 2vj6 | VG5 | Beta-secretase 1 | 3.4.23.46 | 0.475 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.475 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.474 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.474 | |
| 2dwb | ANP | Aurora kinase A | 2.7.11.1 | 0.473 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.473 | |
| 2vtt | LZD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.473 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.473 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.472 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.472 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.472 | |
| 4ivc | 1J6 | Tyrosine-protein kinase JAK1 | / | 0.472 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 3zmm | F9J | Tyrosine-protein kinase JAK2 | / | 0.471 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.470 | |
| 4qbj | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.470 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.469 | |
| 1daw | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.468 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.468 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.468 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.468 | |
| 4e20 | 0MY | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.468 | |
| 4gid | 0GH | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 4gvj | ADP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.468 | |
| 4utd | ACP | Aurora kinase A | 2.7.11.1 | 0.468 | |
| 4wsq | KSA | AP2-associated protein kinase 1 | 2.7.11.1 | 0.468 | |
| 2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.467 | |
| 5dn3 | ATP | Aurora kinase A | 2.7.11.1 | 0.467 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.466 | |
| 1zys | 199 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.466 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.465 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.465 | |
| 4k6z | 1Q3 | Tyrosine-protein kinase JAK1 | / | 0.465 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.464 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.464 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 5e8y | STU | TGF-beta receptor type-2 | 2.7.11.30 | 0.464 | |
| 1nvr | STU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 2vuw | 5ID | Serine/threonine-protein kinase haspin | 2.7.11.1 | 0.463 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.463 | |
| 3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.463 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.462 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.461 | |
| 2w05 | FRT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.461 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.461 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 4fkr | 45K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.460 | |
| 2vij | C44 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3i60 | E86 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.460 | |
| 4dgm | AGI | Casein kinase II subunit alpha | 2.7.11.1 | 0.460 | |
| 4jaj | XU1 | Aurora kinase A | 2.7.11.1 | 0.460 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.460 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.460 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.459 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.459 | |
| 3zly | YSO | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.459 | |
| 4a5l | FAD | Thioredoxin reductase | / | 0.459 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.459 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.458 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 2x1n | X1N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.458 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.458 | |
| 4anm | WUL | Casein kinase II subunit alpha | 2.7.11.1 | 0.458 | |
| 4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.458 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 5dos | ATP | Aurora kinase A | 2.7.11.1 | 0.458 | |
| 1gqt | ACP | Ribokinase | / | 0.457 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.457 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.457 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.457 | |
| 2ym6 | YM6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3vs5 | VSG | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.457 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.456 | |
| 1hii | C20 | Gag-Pol polyprotein | / | 0.456 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.456 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3k5u | PFQ | Aurora kinase A | 2.7.11.1 | 0.456 | |
| 4i0s | 1B5 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.456 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.455 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.455 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.455 | |
| 3c4z | ADP | Rhodopsin kinase | / | 0.455 | |
| 3qtx | X43 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.455 | |
| 3w18 | N13 | Aurora kinase A | 2.7.11.1 | 0.455 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.455 | |
| 4cki | ADN | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.455 | |
| 4j95 | ACP | Fibroblast growth factor receptor 2 | / | 0.455 | |
| 4qo9 | 627 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.455 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.454 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.454 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.454 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.454 | |
| 4hvh | 19R | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.454 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.453 | |
| 1xkk | FMM | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 3ckx | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.453 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.453 | |
| 3tti | KBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.453 | |
| 4ach | KDI | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.453 | |
| 4o0s | ADN | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 5dpv | SKE | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 1xjd | STU | Protein kinase C theta type | 2.7.11.13 | 0.452 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.452 | |
| 2i1m | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.452 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.452 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.452 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.452 | |
| 1yvj | 4ST | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.451 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 2uzl | C94 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2wf3 | ZY3 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.451 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.451 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.451 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3rk7 | 08Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 4erw | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 4o0w | ADN | Aurora kinase A | 2.7.11.1 | 0.451 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1o6y | ACP | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.450 | |
| 2ivv | PP1 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.450 | |
| 2qak | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.450 | |
| 3lfq | A28 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3ori | AGS | Serine/threonine protein kinase | / | 0.450 | |
| 3qu0 | X40 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.450 | |
| 4hvg | 19Q | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.450 | |
| 4nwz | FAD | FAD-dependent pyridine nucleotide-disulfide oxidoreductase | / | 0.450 | |
| 4yzc | STU | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.450 | |
| 5e92 | ANP | TGF-beta receptor type-2 | 2.7.11.30 | 0.450 | |
| 1sh9 | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2xne | ASH | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 2yex | YEX | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 4r8q | ADP | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 2.7.11.1 | 0.449 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.449 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.448 | |
| 2b8l | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 2bro | DF2 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2j3k | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.448 | |
| 3rn8 | RN8 | Glutamate receptor 2 | / | 0.448 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.448 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.448 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.448 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.448 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.447 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.447 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 2h96 | 893 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.447 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.447 | |
| 2oah | QIN | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2pvl | P55 | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 2x2l | X2L | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.447 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.447 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.447 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.447 | |
| 4a06 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.447 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 4ki8 | ADP | 60 kDa chaperonin | / | 0.447 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.446 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 2xng | A0H | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 3lzu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.446 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.446 | |
| 3rk9 | 09Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 4awi | AQ2 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.446 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.445 | |
| 2vv9 | IM9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3sdi | 3SD | Proteasome subunit beta type-5 | 3.4.25.1 | 0.445 | |
| 3sdi | 3SD | Proteasome subunit beta type-6 | 3.4.25.1 | 0.445 | |
| 3sm2 | 478 | Putative gag-pro-pol polyprotein | / | 0.445 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1hsg | MK1 | Gag-Pol polyprotein | / | 0.444 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2fum | MIX | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.444 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3ddp | RC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.444 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.444 | |
| 3p4t | FAO | Putative acyl-CoA dehydrogenase | / | 0.444 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.444 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4ei4 | 0Q2 | Tyrosine-protein kinase JAK1 | / | 0.444 | |
| 4jr7 | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.443 | |
| 1ke6 | LS2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1oi9 | N20 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1ppm | 0P1 | Penicillopepsin-1 | 3.4.23.20 | 0.443 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.443 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.443 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.443 | |
| 2w1f | L0F | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3c50 | ADP | Rhodopsin kinase | / | 0.443 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.443 | |
| 4ewh | T77 | Activated CDC42 kinase 1 | / | 0.443 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.443 | |
| 4gh2 | HK0 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.443 | |
| 4k11 | 0J9 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.443 | |
| 4kio | G5K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.443 | |
| 5a3c | NAD | SIR2 family protein | / | 0.443 | |
| 5dr2 | ATP | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 1gih | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1h1r | 6CP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.442 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2q54 | MU1 | Protease | / | 0.442 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.442 | |
| 2w1g | L0G | Aurora kinase A | 2.7.11.1 | 0.442 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.442 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.442 | |
| 3zpu | M8B | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.442 | |
| 4btj | ADP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.442 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.442 | |
| 4e1z | 0MX | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.442 | |
| 4fi1 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4fkw | 62K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4ft9 | H4K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4ivd | 15T | Tyrosine-protein kinase JAK1 | / | 0.442 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.442 | |
| 5a3b | APR | SIR2 family protein | / | 0.442 | |
| 5br4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.442 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.441 | |
| 2iw9 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2qzl | IXS | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.441 | |
| 3ekp | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3gb2 | G3B | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.441 | |
| 3kfr | 3TL | Gag-Pol polyprotein | / | 0.441 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.441 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.441 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.441 | |
| 3uzp | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.441 | |
| 4afj | SJJ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 4c62 | XWW | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 4eok | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4fv5 | EK9 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 4ih8 | B43 | Calmodulin-domain protein kinase 1 | / | 0.441 | |
| 4k33 | ACP | Fibroblast growth factor receptor 3 | 2.7.10.1 | 0.441 | |
| 4k9h | 1QU | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4njv | RIT | Protease | / | 0.441 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.441 | |
| 1gij | 2PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2uze | C95 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2wf0 | ZY0 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3ohf | 3HF | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3qbh | QBH | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3rkb | 12Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3rnn | RNN | Glutamate receptor 2 | / | 0.440 | |
| 3uli | 1N3 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4g3f | 0WB | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.440 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.440 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.440 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.440 | |
| 5ijz | NAP | NADP-specific glutamate dehydrogenase | 1.4.1.4 | 0.440 |