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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fcq2N6Heat shock protein HSP 90-alpha

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4fcq2N6Heat shock protein HSP 90-alpha/1.000
2vci2GJHeat shock protein HSP 90-alpha/0.758
2wi5ZZ5Heat shock protein HSP 90-alpha/0.741
2bsmBSMHeat shock protein HSP 90-alpha/0.655
2wi1ZZ2Heat shock protein HSP 90-alpha/0.647
2cct2E1Heat shock protein HSP 90-alpha/0.644
4egh0OYHeat shock protein HSP 90-alpha/0.643
2yi66QMHeat shock protein HSP 90-alpha/0.639
2vcj2EQHeat shock protein HSP 90-alpha/0.623
2uwd2GGHeat shock protein HSP 90-alpha/0.615
2yjwYJWHeat shock protein HSP 90-alpha/0.612
2ye42FYHeat shock protein HSP 90-alpha/0.607
3ft5MO8Heat shock protein HSP 90-alpha/0.606
2yi7BZ8Heat shock protein HSP 90-alpha/0.600
2ye92D4Heat shock protein HSP 90-alpha/0.590
2yee2ECHeat shock protein HSP 90-alpha/0.572
2wi2ZZ3Heat shock protein HSP 90-alpha/0.570
1uy7PU4Heat shock protein HSP 90-alpha/0.564
3ekrPY9Heat shock protein HSP 90-alpha/0.562
2wi6ZZ6Heat shock protein HSP 90-alpha/0.561
2yefANPHeat shock protein HSP 90-alpha/0.559
2yecXQ0Heat shock protein HSP 90-alpha/0.555
2yejZZ3Heat shock protein HSP 90-alpha/0.554
4ipeANPTNF receptor-associated protein 1/0.552
1uyePU9Heat shock protein HSP 90-alpha/0.551
3d0bSNXHeat shock protein HSP 90-alpha/0.551
4jqlVJ6Heat shock protein HSP 90-alpha/0.551
3hyz42CHeat shock protein HSP 90-alpha/0.550
4egkRDCHeat shock protein HSP 90-alpha/0.538
3ft8MOJHeat shock protein HSP 90-alpha/0.536
1yetGDMHeat shock protein HSP 90-alpha/0.535
2gqpPA7Endoplasmin/0.535
1byqADPHeat shock protein HSP 90-alpha/0.532
3r4oFU3Heat shock protein HSP 90-alpha/0.532
4xcjADPHeat shock cognate 90 kDa protein/0.530
1osfKOSHeat shock protein HSP 90-alpha/0.529
2yegXQGHeat shock protein HSP 90-alpha/0.528
2qg0A94Heat shock protein HSP 90-alpha/0.526
2xhtC0YHeat shock protein HSP 90-alpha/0.525
4bqjXKLHeat shock protein HSP 90-alpha/0.525
3vhaVHAHeat shock protein HSP 90-alpha/0.524
1uy8PU5Heat shock protein HSP 90-alpha/0.521
4xdmGDMHeat shock cognate 90 kDa protein/0.521
4egiB2JHeat shock protein HSP 90-alpha/0.517
1uyhPU0Heat shock protein HSP 90-alpha/0.516
4b7p9UNHeat shock protein HSP 90-alpha/0.516
2qg2A91Heat shock protein HSP 90-alpha/0.515
3ekoPYUHeat shock protein HSP 90-alpha/0.515
2fypRDEEndoplasmin/0.511
3hz142CHeat shock protein HSP 90-alpha/0.511
1yc14BCHeat shock protein HSP 90-alpha/0.509
3o0iP54Heat shock protein HSP 90-alpha/0.509
2gfdRDAEndoplasmin/0.508
4xclAGSHeat shock cognate 90 kDa protein/0.508
1qy8RDIEndoplasmin/0.507
3hhu819Heat shock protein HSP 90-alpha/0.506
2o1uANPEndoplasmin/0.505
3inwJZBHeat shock protein HSP 90-alpha/0.504
2xabVHDHeat shock protein HSP 90-alpha/0.503
2xd6XD6ATP-dependent molecular chaperone HSP82/0.503
1uyiPUZHeat shock protein HSP 90-alpha/0.498
2xk2ADPHeat shock protein HSP 90-alpha/0.497
2byh2D7Heat shock protein HSP 90-alpha/0.496
2hg1N5OEndoplasmin/0.496
4ivgANPTNF receptor-associated protein 1/0.496
2iwuNP5ATP-dependent molecular chaperone HSP82/0.495
2yk2YJWHeat shock protein HSP 90-alpha/0.494
3t10ACPHeat shock protein HSP 90-alpha/0.493
2xjxXJXHeat shock protein HSP 90-alpha/0.492
3k974CDHeat shock protein HSP 90-alpha/0.492
3rlp3RPHeat shock protein HSP 90-alpha/0.490
4gqtADPHeat shock protein 90/0.490
3q5kD1UHeat shock protein 83-1/0.488
2xcmADPCytosolic heat shock protein 90/0.487
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.487
3k99PFTHeat shock protein HSP 90-alpha/0.486
3rlr3RRHeat shock protein HSP 90-alpha/0.486
3d8vUD1Bifunctional protein GlmU/0.485
4xc0ACPHeat shock cognate 90 kDa protein/0.485
3cukFADD-amino-acid oxidase1.4.3.30.481
2hchN5AEndoplasmin/0.479
2xx213CATP-dependent molecular chaperone HSP82/0.479
1i59ANPChemotaxis protein CheA2.7.13.30.476
1zeoC01Peroxisome proliferator-activated receptor gamma/0.476
2fxsRDAATP-dependent molecular chaperone HSP82/0.476
4efuEFUHeat shock protein HSP 90-alpha/0.476
2yeiXQIHeat shock protein HSP 90-alpha/0.474
2wi72KLHeat shock protein HSP 90-alpha/0.472
2iorADPChaperone protein HtpG/0.469
3t0zATPHeat shock protein HSP 90-alpha/0.469
2esaGDMEndoplasmin/0.468
3whaWHAHeat shock protein HSP 90-alpha/0.468
1heuNADAlcohol dehydrogenase E chain1.1.1.10.467
2iwsNP4ATP-dependent molecular chaperone HSP82/0.467
2vwcBC2ATP-dependent molecular chaperone HSP82/0.467
4bfsZVSPantothenate kinase2.7.1.330.467
1dj2GDPAdenylosuccinate synthetase, chloroplastic/0.466
3t1kANPHeat shock protein HSP 90-alpha/0.466
2bu8ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.465
4asg814ATP-dependent molecular chaperone HSP82/0.465
1t09NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.464
1u2oNECEndoplasmin/0.464
1yc443PHeat shock protein HSP 90-alpha/0.464
2werRDCATP-dependent molecular chaperone HSP82/0.464
1i5aACPChemotaxis protein CheA2.7.13.30.463
1u0zRDCEndoplasmin/0.463
2wi4ZZ4Heat shock protein HSP 90-alpha/0.463
2xjgXJGHeat shock protein HSP 90-alpha/0.463
3o6o94MHeat shock protein 83/0.463
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
4s32ANPMitogen-activated protein kinase 12.7.11.240.462
1o76CAMCamphor 5-monooxygenase1.14.15.10.461
2q6sPLBPeroxisome proliferator-activated receptor gamma/0.461
2yyuC5POrotidine 5'-phosphate decarboxylase/0.461
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
5kcpNAJAlcohol dehydrogenase E chain1.1.1.10.461
2xjjL81Heat shock protein HSP 90-alpha/0.460
2z6dFMNPhototropin-22.7.11.10.460
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.460
4ce2BO5ATP-dependent molecular chaperone HSP82/0.460
2bz5AB4Heat shock protein HSP 90-alpha/0.459
2hkjRDCType 2 DNA topoisomerase 6 subunit B/0.459
3hx4ANPCalmodulin-domain protein kinase 1/0.459
3pehIBDEndoplasmin homolog, putative/0.459
4s26SAHPhosphomethylpyrimidine synthase, chloroplastic4.1.99.170.459
2oxiNADAlcohol dehydrogenase E chain1.1.1.10.458
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.458
3wdlATP4-phosphopantoate--beta-alanine ligase6.3.2.360.458
1towCRZFatty acid-binding protein, adipocyte/0.457
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.457
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
2xhrC0PHeat shock protein HSP 90-alpha/0.456
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.456
3otwCOAPhosphopantetheine adenylyltransferase/0.456
4xivADPChemotaxis protein CheA2.7.13.30.456
5cdgNAJAlcohol dehydrogenase E chain1.1.1.10.456
2uzlC94Cyclin-dependent kinase 22.7.11.220.455
3b28B2XHeat shock protein HSP 90-alpha/0.455
3d3wNAPL-xylulose reductase1.1.1.100.455
3hekBD0Heat shock protein HSP 90-alpha/0.455
3is2FADVivid PAS protein VVD/0.455
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.455
4r1lADPPhenylacetate-coenzyme A ligase/0.455
1i58ACPChemotaxis protein CheA2.7.13.30.454
1ipeNDPTropinone reductase 21.1.1.2360.454
1tj0FADBifunctional protein PutA1.5.5.20.454
3tjzGNPADP-ribosylation factor 1/0.454
5kjcNAJAlcohol dehydrogenase E chain1.1.1.10.454
1p0hACOMycothiol acetyltransferase2.3.1.1890.453
2breKJ2ATP-dependent molecular chaperone HSP82/0.453
3r4nFU5Heat shock protein HSP 90-alpha/0.453
2bt0CT5Heat shock protein HSP 90-alpha/0.452
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.452
4a4wYFBPeroxisome proliferator-activated receptor gamma/0.452
4briUNPEctonucleoside triphosphate diphosphohydrolase I/0.452
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.452
1am1ADPATP-dependent molecular chaperone HSP82/0.451
1n9nFMNPutative blue light receptor/0.451
2i5bADPPyridoxine kinase/0.451
3zc3NAPFerredoxin--NADP reductase1.18.1.20.451
4gk3L87Ephrin type-A receptor 32.7.10.10.451
1i5bANPChemotaxis protein CheA2.7.13.30.450
1z5aADPType 2 DNA topoisomerase 6 subunit B/0.450
3k981RCHeat shock protein HSP 90-alpha/0.450
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.450
4dxhNAJAlcohol dehydrogenase E chain1.1.1.10.450
1i59ADPChemotaxis protein CheA2.7.13.30.449
1l4mNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.449
1ykdCMPAdenylate cyclase/0.449
3r9iADPSeptum site-determining protein MinD/0.449
4as94QSATP-dependent molecular chaperone HSP82/0.449
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.449
1bgqRDCATP-dependent molecular chaperone HSP82/0.448
1tv8SAMGTP 3',8-cyclase4.1.99.180.448
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.448
2wq7FADRE11660p/0.448
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.448
4b5pACOAlpha-tubulin N-acetyltransferase 1/0.448
4fvqATPTyrosine-protein kinase JAK2/0.448
4hi0GDPUrease accessory protein UreG/0.448
5fklTDCTetracycline repressor protein class D/0.448
1ju9NADAlcohol dehydrogenase E chain1.1.1.10.447
2znq401Peroxisome proliferator-activated receptor delta/0.447
3tr05GPGuanylate kinase/0.447
4asf62UATP-dependent molecular chaperone HSP82/0.446
4dgo0JWCasein kinase II subunit alpha2.7.11.10.446
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.446
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.446
5i4nATPTyrosine-protein kinase JAK2/0.446
5kjeNAJAlcohol dehydrogenase E chain1.1.1.10.446
1cjkFOKAdenylate cyclase type 2/0.445
1cjkFOKAdenylate cyclase type 5/0.445
1ei1ANPDNA gyrase subunit B/0.445
1w87NAPFerredoxin--NADP reductase1.18.1.20.445
2yxuATPPyridoxal kinase2.7.1.350.445
3p7nFMNLight-activated DNA-binding protein EL222/0.445
4l78ADPPhosphoribosylformylglycinamidine synthase/0.445
1y4sADPChaperone protein HtpG/0.444
2uzeC95Cyclin-dependent kinase 22.7.11.220.444
2zdxP4A[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.444
3c11GDMATP-dependent molecular chaperone HSP82/0.444
3r4pFU7Heat shock protein HSP 90-alpha/0.444
4aicNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.444
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.444
4kgmATPUncharacterized protein/0.444
4rpgFADUDP-galactopyranose mutase5.4.99.90.444
4yerADPAntibiotic ABC transporter, ATP-binding protein, putative/0.444
5l3rGCPCell division protein FtsY homolog, chloroplastic/0.444
1dz8CAMCamphor 5-monooxygenase1.14.15.10.443
1hzzNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.443
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.443
1i2lDCSAminodeoxychorismate lyase4.1.3.380.443
1snyNAPLD36273p/0.443
2yhyADPBifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase2.7.1.600.443
2yx6ADPUncharacterized protein/0.443
3dogNNNCyclin-dependent kinase 22.7.11.220.443
4hwkNAPSepiapterin reductase1.1.1.1530.443
4ma628EAra h 8 allergen/0.443
4zohFADPutative oxidoreductase FAD-binding subunit/0.443
5cdtNAJAlcohol dehydrogenase E chain1.1.1.10.443
1hdgNADGlyceraldehyde-3-phosphate dehydrogenase/0.442
1qrrUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.442
2qbmCAMCamphor 5-monooxygenase1.14.15.10.442
2qjoNADBifunctional NMN adenylyltransferase/Nudix hydrolase2.7.7.10.442
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2vkeTACTetracycline repressor protein class D/0.442
3a8tATPAdenylate isopentenyltransferase/0.442
4ce3L4VATP-dependent molecular chaperone HSP82/0.442
4fvrATPTyrosine-protein kinase JAK2/0.442
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.442
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.442
4j7xNAPSepiapterin reductase1.1.1.1530.442
5d3qGDPDynamin-13.6.5.50.442
1ebuNDAHomoserine dehydrogenase1.1.1.30.441
1p3dUMAUDP-N-acetylmuramate--L-alanine ligase6.3.2.80.441
1x2hLPALipoate-protein ligase A6.3.1.200.441
2itvANPEpidermal growth factor receptor2.7.10.10.441
2r9eSDXCitrate synthase2.3.3.160.441
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.441
3ad9NADSubunit alpha of sarocosine oxidase/0.441
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.441
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.441
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4du82P0Mevalonate diphosphate decarboxylase/0.441
4umxNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
5kgpACOPredicted acetyltransferase/0.441
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.440
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.440
1gy3ATPCyclin-dependent kinase 22.7.11.220.440
1i58ADPChemotaxis protein CheA2.7.13.30.440
2ad5ADPCTP synthase/0.440
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.440
2o1vADPEndoplasmin/0.440
2qocANPEphrin type-A receptor 32.7.10.10.440
2vojNADAlanine dehydrogenase1.4.1.10.440
2wepADPATP-dependent molecular chaperone HSP82/0.440
2yltNAPPhenylacetone monooxygenase1.14.13.920.440
4ffmADPUncharacterized protein/0.440