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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4c73TLH3-oxoacyl-ACP synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4c73TLH3-oxoacyl-ACP synthase/1.000
4c72TLG3-oxoacyl-ACP synthase/0.816
4c6zTLE3-oxoacyl-ACP synthase/0.762
2wggTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.613
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.599
4c717RD3-oxoacyl-ACP synthase/0.599
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.588
4jv3N32Beta-ketoacyl synthase/0.563
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.555
3g11P9C3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.555
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.554
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.550
2vb8TLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.548
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.537
3hnzPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.523
3ho9N3A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.523
4c6uTLG3-oxoacyl-ACP synthase/0.506
2pksG44Prothrombin3.4.21.50.485
5irnADPNucleotide binding oligomerization domain containing 2/0.485
3ho2N323-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.483
2gevCOKPantothenate kinase2.7.1.330.481
5dp2NAPCurF/0.479
3zkyWT4Isopenicillin N synthase1.21.3.10.478
2iviACWIsopenicillin N synthase1.21.3.10.477
1crbRTLRetinol-binding protein 1/0.476
4bfyZVYPantothenate kinase2.7.1.330.475
1lkeDOGBilin-binding protein/0.470
4bfxZVXPantothenate kinase2.7.1.330.470
4bftZVTPantothenate kinase2.7.1.330.468
4mlp2CXCryptochrome-2/0.468
2zi224UProthrombin3.4.21.50.467
1d6w00RProthrombin3.4.21.50.466
1xm1GAHProthrombin3.4.21.50.466
2zc922UProthrombin3.4.21.50.464
3gwfFADCyclohexanone monooxygenase/0.464
4n3l2FNProthrombin3.4.21.50.464
2zhq27UProthrombin3.4.21.50.463
1d3dBZTProthrombin3.4.21.50.462
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.462
5fd8A5APutative carboxypeptidase yocD/0.462
5fm7ADPRuvB-like helicase/0.462
1nm6L86Prothrombin3.4.21.50.461
2a9z26AAdenosine kinase2.7.1.200.460
4bamMM9Prothrombin3.4.21.50.460
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.460
1z71L17Prothrombin3.4.21.50.459
3c3xNAPEugenol synthase 11.1.1.3180.459
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.459
1fmjRTLRetinol dehydratase/0.458
2v3oI26Prothrombin3.4.21.50.458
1c4uIH1Prothrombin3.4.21.50.457
3biz61EWee1-like protein kinase2.7.10.20.457
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1qiqACCIsopenicillin N synthase1.21.3.10.456
1xddAAYIntegrin alpha-L/0.456
2ed3SAHDiphthine synthase/0.456
2r2mI50Prothrombin3.4.21.50.456
2znk31UProthrombin3.4.21.50.456
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.456
1mueCDDProthrombin3.4.21.50.455
2anmCDOProthrombin3.4.21.50.455
2zhf49UProthrombin3.4.21.50.455
3kp4MIITranscriptional regulator TcaR/0.455
4jlm1NNDeoxycytidine kinase2.7.1.740.455
2ab8MTPAdenosine kinase2.7.1.200.454
2gv8NDPThiol-specific monooxygenase1.14.130.454
2zda32UProthrombin3.4.21.50.454
2zhe13UProthrombin3.4.21.50.454
1cjtFOKAdenylate cyclase type 2/0.453
1cjtFOKAdenylate cyclase type 5/0.453
1cs4FOKAdenylate cyclase type 2/0.453
1cs4FOKAdenylate cyclase type 5/0.453
2hxzH7JCathepsin S3.4.22.270.453
2wgeTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.453
2zgx29UProthrombin3.4.21.50.453
3br3ETHTH-type transcriptional regulator QacR/0.453
3ig6438Urokinase-type plasminogen activator3.4.21.730.453
3qt62P0Mevalonate diphosphate decarboxylase/0.453
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.453
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.453
2dxiATPGlutamate--tRNA ligase6.1.1.170.452
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.452
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.452
1kceCB3Thymidylate synthase/0.451
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.451
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.451
2uuk897Prothrombin3.4.21.50.450
2z3uCRRCytochrome P450/0.450
4ho6UTPGlucose-1-phosphate thymidylyltransferase/0.450
1qorNDPQuinone oxidoreductase 1/0.449
2nr4FMNConserved protein/0.449
4guuFA9Lysine-specific histone demethylase 1B10.449
2cv1ATPGlutamate--tRNA ligase6.1.1.170.448
2ffqGSPRas-related protein Rab-6B/0.448
2zfr46UProthrombin3.4.21.50.448
2zhw12UProthrombin3.4.21.50.448
1d3pBT3Prothrombin3.4.21.50.447
1zrb062Prothrombin3.4.21.50.447
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.447
3gb4D3MDdmC/0.447
4ax9N5NProthrombin3.4.21.50.447
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.447
4bfsZVSPantothenate kinase2.7.1.330.447
4bfvZVVPantothenate kinase2.7.1.330.447
4j6bPLOCytochrome P450 monooxygenase/0.447
1cjuFOKAdenylate cyclase type 2/0.446
1cjuFOKAdenylate cyclase type 5/0.446
1culFOKAdenylate cyclase type 2/0.446
1culFOKAdenylate cyclase type 5/0.446
1ta6177Prothrombin3.4.21.50.446
3rdqDTBStreptavidin/0.446
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.446
3biu10UProthrombin3.4.21.50.445
3fhxPXLPyridoxal kinase2.7.1.350.445
3p62FMNPentaerythritol tetranitrate reductase/0.445
1eqaMG7Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase2.1.1.570.444
1j9zFADNADPH--cytochrome P450 reductase/0.444
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.444
2c12FADNitroalkane oxidase1.7.3.10.444
2ym1FADPhenylacetone monooxygenase1.14.13.920.444
3uleC69Actin-related protein 3/0.444
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.444
4b1jA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.444
4uugPXGBranched-chain amino acid aminotransferase, putative/0.444
1bk0ACVIsopenicillin N synthase1.21.3.10.443
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.443
1sq5ADPPantothenate kinase2.7.1.330.443
1x1bSAHC-20 methyltransferase/0.443
1ygkRRCPyridoxal kinase2.7.1.350.443
2xlpNAPPutative flavin-containing monooxygenase/0.443
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.443
3ol5SAWCamphor 5-monooxygenase1.14.15.10.443
4bb3KKAIsopenicillin N synthase1.21.3.10.443
1lb9DNQGlutamate receptor 2/0.442
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.442
1w0kADPATP synthase subunit alpha, mitochondrial/0.442
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.442
2jh0701Prothrombin3.4.21.50.442
2vbdV10Isopenicillin N synthase1.21.3.10.442
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.442
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.442
1cjkFOKAdenylate cyclase type 2/0.441
1cjkFOKAdenylate cyclase type 5/0.441
1yhjR6CPyridoxal kinase2.7.1.350.441
2e07SAHDiphthine synthase/0.441
2j08FADDeoxyribodipyrimidine photo-lyase4.1.99.30.441
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.441
2w6qOA5Biotin carboxylase6.3.4.140.441
3eq02TSProthrombin3.4.21.50.441
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.440
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.440
2eh5SAHDiphthine synthase/0.440
2owuSAHDiphthine synthase/0.440
3d4bDZDNAD-dependent protein deacetylase/0.440
3q9bB3NAcetylpolyamine amidohydrolase/0.440
4c77N01Phenylacetone monooxygenase1.14.13.920.440
4li81XQTankyrase-12.4.2.300.440
4n1gCEIObelin/0.440