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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4btjADPTau-tubulin kinase 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4btjADPTau-tubulin kinase 12.7.11.11.000
4btjATPTau-tubulin kinase 12.7.11.10.602
4btmF8ETau-tubulin kinase 12.7.11.10.528
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.520
3i60E86Mitogen-activated protein kinase 12.7.11.240.518
4fv6E57Mitogen-activated protein kinase 12.7.11.240.518
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.515
4qnyANPMitogen activated protein kinase, putative/0.505
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.504
5dnrATPAurora kinase A2.7.11.10.502
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.497
4anmWULCasein kinase II subunit alpha2.7.11.10.491
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.488
3be9P04Casein kinase II subunit alpha2.7.11.10.487
1dawANPCasein kinase II subunit alpha2.7.11.10.485
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.485
4eooATPCyclin-dependent kinase 22.7.11.220.484
4k33ACPFibroblast growth factor receptor 32.7.10.10.484
3bu5ATPInsulin receptor2.7.10.10.483
1pmn984Mitogen-activated protein kinase 102.7.11.240.482
4hvi19STyrosine-protein kinase JAK32.7.10.20.482
5e8ySTUTGF-beta receptor type-22.7.11.300.482
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.481
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.480
4hge15VTyrosine-protein kinase JAK2/0.477
4aqc88ATyrosine-protein kinase JAK2/0.476
2j0lANPFocal adhesion kinase 12.7.10.20.475
3kvxFMYMitogen-activated protein kinase 102.7.11.240.474
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.474
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.474
3gu7ADPDeath-associated protein kinase 12.7.11.10.473
1jnkANPMitogen-activated protein kinase 102.7.11.240.472
5dosATPAurora kinase A2.7.11.10.472
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.471
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.471
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.470
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
2pvnP63Casein kinase II subunit alpha2.7.11.10.468
4ii5ADPCyclin-dependent kinase 22.7.11.220.468
5ap7SVEDual specificity protein kinase TTK2.7.12.10.468
1i44ACPInsulin receptor2.7.10.10.467
2ijmATPFocal adhesion kinase 12.7.10.20.467
3ttjJBIMitogen-activated protein kinase 102.7.11.240.467
4j99ACPFibroblast growth factor receptor 2/0.467
4ji91M3Tyrosine-protein kinase JAK2/0.467
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.466
2pvmP29Casein kinase II subunit alpha2.7.11.10.466
2v7a627Tyrosine-protein kinase ABL12.7.10.20.466
2xrwANPMitogen-activated protein kinase 82.7.11.240.466
3cgfJNFMitogen-activated protein kinase 102.7.11.240.466
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.466
4h3qANPMitogen-activated protein kinase 12.7.11.240.466
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.464
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.464
2p33J07Mitogen-activated protein kinase 102.7.11.240.463
4ysjADPCalmodulin-like domain protein kinase/0.463
4o0wADNAurora kinase A2.7.11.10.461
1yvj4STTyrosine-protein kinase JAK32.7.10.20.460
3lpbNVBTyrosine-protein kinase JAK2/0.460
4lfiGNPCasein kinase II subunit alpha2.7.11.10.460
4lrjANPUncharacterized protein/0.460
1dayGNPCasein kinase II subunit alpha2.7.11.10.459
4qmlANPSerine/threonine-protein kinase 242.7.11.10.459
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.458
4j95ACPFibroblast growth factor receptor 2/0.458
3ttiKBIMitogen-activated protein kinase 102.7.11.240.457
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.457
5cnnANPEpidermal growth factor receptor2.7.10.10.457
4nifANPMitogen-activated protein kinase 12.7.11.240.456
4ux9ANPMitogen-activated protein kinase 82.7.11.240.456
5cvfATPCasein kinase II subunit alpha2.7.11.10.456
1m2pHNACasein kinase II subunit alpha2.7.11.10.455
3eljGS7Mitogen-activated protein kinase 82.7.11.240.455
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.455
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.454
3zewSTUEphrin type-B receptor 42.7.10.10.454
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.454
1qmzATPCyclin-dependent kinase 22.7.11.220.452
3lltANPProtein serine/threonine kinase-1/0.452
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.452
3t8oATPRhodopsin kinase/0.451
2henADPEphrin type-B receptor 22.7.10.10.450
3orpAGSSerine/threonine protein kinase/0.450
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
3sheI85MAP kinase-activated protein kinase 32.7.11.10.450
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
2c6lDT4Cyclin-dependent kinase 22.7.11.220.449
2yaaATPDeath-associated protein kinase 2/0.449
4aguD15Cyclin-dependent kinase-like 1/0.449
3at4CCKCasein kinase II subunit alpha2.7.11.10.448
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.448
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.447
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.447
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.447
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.447
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.447
2j0m4STFocal adhesion kinase 12.7.10.20.446
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.446
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.446
4enhFVXCholesterol 24-hydroxylase/0.446
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.446
2vv9IM9Cyclin-dependent kinase 22.7.11.220.445
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.445
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.444
3s1h56ZCyclin-dependent kinase 22.7.11.220.444
4deeADPAurora kinase A2.7.11.10.444
4g3jVNTLanosterol 14-alpha-demethylase/0.444
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.444
4y93746Tyrosine-protein kinase/0.444
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.443
3nynSGVG protein-coupled receptor kinase 62.7.11.160.443
4ocvANPAminoglycoside phosphotransferase/0.443
2q9fC3SCholesterol 24-hydroxylase/0.442
2uzbC75Cyclin-dependent kinase 22.7.11.220.442
2x1nX1NCyclin-dependent kinase 22.7.11.220.442
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.442
4xlvACPInsulin receptor2.7.10.10.442
3hmm855TGF-beta receptor type-12.7.11.300.441
4btkDTQTau-tubulin kinase 12.7.11.10.441
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.441
4wsqKSAAP2-associated protein kinase 12.7.11.10.441
1eh4IC1Casein kinase I homolog 12.7.11.10.440
2qoqANPEphrin type-A receptor 32.7.10.10.440
2w4jADPDeath-associated protein kinase 12.7.11.10.440
3w8qAGSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
4o1pANPRibonuclease L/0.440