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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4aqc88ATyrosine-protein kinase JAK2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4aqc88ATyrosine-protein kinase JAK2/1.000
3lpbNVBTyrosine-protein kinase JAK2/0.634
4hge15VTyrosine-protein kinase JAK2/0.607
4ji91M3Tyrosine-protein kinase JAK2/0.577
4e6d0NUTyrosine-protein kinase JAK2/0.570
4f081RSTyrosine-protein kinase JAK2/0.565
2b7aIZATyrosine-protein kinase JAK2/0.558
3iok1P6Tyrosine-protein kinase JAK2/0.556
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.545
4jia1K3Tyrosine-protein kinase JAK2/0.535
4i5cC5ITyrosine-protein kinase JAK1/0.531
2xa4AZ5Tyrosine-protein kinase JAK2/0.527
4hvi19STyrosine-protein kinase JAK32.7.10.20.527
4iva1J5Tyrosine-protein kinase JAK2/0.523
5e8ySTUTGF-beta receptor type-22.7.11.300.523
3be9P04Casein kinase II subunit alpha2.7.11.10.522
2pvmP29Casein kinase II subunit alpha2.7.11.10.520
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.519
3s1h56ZCyclin-dependent kinase 22.7.11.220.519
3zmmF9JTyrosine-protein kinase JAK2/0.519
4c61LMMTyrosine-protein kinase JAK2/0.513
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.512
3rvg17PTyrosine-protein kinase JAK2/0.511
2pvnP63Casein kinase II subunit alpha2.7.11.10.510
3rak03ZCyclin-dependent kinase 22.7.11.220.509
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.507
4ivb1J5Tyrosine-protein kinase JAK1/0.506
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.504
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.504
1g5sI17Cyclin-dependent kinase 22.7.11.220.501
3gxlQIGTGF-beta receptor type-12.7.11.300.497
4e5w0NTTyrosine-protein kinase JAK1/0.495
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.494
4e6q0NVTyrosine-protein kinase JAK2/0.494
4qnyANPMitogen activated protein kinase, putative/0.493
2vv9IM9Cyclin-dependent kinase 22.7.11.220.490
4anmWULCasein kinase II subunit alpha2.7.11.10.490
4e4n0NLTyrosine-protein kinase JAK1/0.490
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.489
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.489
2pvhP19Casein kinase II subunit alpha2.7.11.10.488
4btjATPTau-tubulin kinase 12.7.11.10.488
4ehzJAKTyrosine-protein kinase JAK1/0.488
1yvj4STTyrosine-protein kinase JAK32.7.10.20.487
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.487
4ivc1J6Tyrosine-protein kinase JAK1/0.487
1m2pHNACasein kinase II subunit alpha2.7.11.10.485
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.485
4wsqKSAAP2-associated protein kinase 12.7.11.10.485
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.484
4bbfO19Tyrosine-protein kinase JAK2/0.484
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.484
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.483
4fkv61KCyclin-dependent kinase 22.7.11.220.483
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.483
1eh4IC1Casein kinase I homolog 12.7.11.10.482
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.482
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.482
4btjADPTau-tubulin kinase 12.7.11.10.482
3eyhIZATyrosine-protein kinase JAK1/0.481
3lxkMI1Tyrosine-protein kinase JAK32.7.10.20.481
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.481
3zep1NXTyrosine-protein kinase JAK32.7.10.20.479
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.477
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.477
4fv6E57Mitogen-activated protein kinase 12.7.11.240.477
2c6lDT4Cyclin-dependent kinase 22.7.11.220.476
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.476
2j0m4STFocal adhesion kinase 12.7.10.20.475
4j95ACPFibroblast growth factor receptor 2/0.475
2vu3LZECyclin-dependent kinase 22.7.11.220.474
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.474
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.474
4fk60UJTyrosine-protein kinase JAK1/0.474
3kvxFMYMitogen-activated protein kinase 102.7.11.240.473
4y93746Tyrosine-protein kinase/0.473
1y91CT9Cyclin-dependent kinase 22.7.11.220.472
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.472
4gmy0X5Tyrosine-protein kinase JAK2/0.472
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.471
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.470
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.470
2pvlP55Casein kinase II subunit alpha2.7.11.10.470
3i60E86Mitogen-activated protein kinase 12.7.11.240.470
3zewSTUEphrin type-B receptor 42.7.10.10.470
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.470
1pxmCK5Cyclin-dependent kinase 22.7.11.220.469
2w05FRTCyclin-dependent kinase 22.7.11.220.469
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.469
4hvg19QTyrosine-protein kinase JAK32.7.10.20.469
4dgnLU2Casein kinase II subunit alpha2.7.11.10.468
1bygSTUTyrosine-protein kinase CSK/0.467
3hmm855TGF-beta receptor type-12.7.11.300.467
5cnnANPEpidermal growth factor receptor2.7.10.10.467
4ux9ANPMitogen-activated protein kinase 82.7.11.240.466
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.466
1dawANPCasein kinase II subunit alpha2.7.11.10.465
3le62BZCyclin-dependent kinase 22.7.11.220.465
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.465
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.465
2w17I19Cyclin-dependent kinase 22.7.11.220.464
3zh8C58Protein kinase C iota type2.7.11.130.464
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.464
4lfiGNPCasein kinase II subunit alpha2.7.11.10.464
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.464
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.463
5cvfATPCasein kinase II subunit alpha2.7.11.10.463
5dr6SKEAurora kinase A2.7.11.10.463
1aq1STUCyclin-dependent kinase 22.7.11.220.462
1fvv107Cyclin-dependent kinase 22.7.11.220.462
1p2a5BNCyclin-dependent kinase 22.7.11.220.462
3at4CCKCasein kinase II subunit alpha2.7.11.10.462
3gu83GUDeath-associated protein kinase 12.7.11.10.462
4c62XWWTyrosine-protein kinase JAK2/0.462
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.462
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.461
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3rkb12ZCyclin-dependent kinase 22.7.11.220.461
3sw418KCyclin-dependent kinase 22.7.11.220.461
4btmF8ETau-tubulin kinase 12.7.11.10.461
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.460
3nynSGVG protein-coupled receptor kinase 62.7.11.160.460
5dr9SKEAurora kinase A2.7.11.10.460
1di8DTQCyclin-dependent kinase 22.7.11.220.458
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4e4m0NHTyrosine-protein kinase JAK2/0.458
4fko20KCyclin-dependent kinase 22.7.11.220.458
4iwd1JCHepatocyte growth factor receptor2.7.10.10.458
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.457
1ykr628Cyclin-dependent kinase 22.7.11.220.457
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.457
2vttLZDCyclin-dependent kinase 22.7.11.220.457
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.457
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.457
3rmf20ZCyclin-dependent kinase 22.7.11.220.457
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.457
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.457
4qmpDKISerine/threonine-protein kinase 242.7.11.10.457
1w8cN69Cyclin-dependent kinase 22.7.11.220.456
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.456
4o1pANPRibonuclease L/0.456
5e92ANPTGF-beta receptor type-22.7.11.300.456
2uzbC75Cyclin-dependent kinase 22.7.11.220.455
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.455
4eooATPCyclin-dependent kinase 22.7.11.220.455
1dayGNPCasein kinase II subunit alpha2.7.11.10.454
1gii1PUCyclin-dependent kinase 22.7.11.220.454
1om1IQACasein kinase II subunit alpha2.7.11.10.454
3ggfGVDSerine/threonine-protein kinase 26/0.454
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3cgfJNFMitogen-activated protein kinase 102.7.11.240.453
3orkAGSSerine/threonine protein kinase/0.453
4dt9GMPAPH(2'')-Id/0.453
5cnoANPEpidermal growth factor receptor2.7.10.10.453
1m2rMNYCasein kinase II subunit alpha2.7.11.10.452
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.452
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.452
2v7a627Tyrosine-protein kinase ABL12.7.10.20.452
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.452
4o0wADNAurora kinase A2.7.11.10.452
4dymIYZActivin receptor type-12.7.11.300.451
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
4ocvANPAminoglycoside phosphotransferase/0.450
2cchATPCyclin-dependent kinase 22.7.11.220.449
2iw84SPCyclin-dependent kinase 22.7.11.220.449
4ez50RSCyclin-dependent kinase 62.7.11.220.449
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.449
4k771Q4Tyrosine-protein kinase JAK1/0.449
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.449
2c6iDT1Cyclin-dependent kinase 22.7.11.220.448
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.448
3a4vNADNDP-sugar epimerase/0.448
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.447
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.447
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.447
3sheI85MAP kinase-activated protein kinase 32.7.11.10.447
4aguD15Cyclin-dependent kinase-like 1/0.447
4lrjANPUncharacterized protein/0.447
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.446
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.446
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.446
2xb7GUIALK tyrosine kinase receptor2.7.10.10.446
3eljGS7Mitogen-activated protein kinase 82.7.11.240.446
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.446
1h1s4SPCyclin-dependent kinase 22.7.11.220.445
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.445
2eufLQQCyclin-dependent kinase 62.7.11.220.445
2xrwANPMitogen-activated protein kinase 82.7.11.240.445
3qtuX44Cyclin-dependent kinase 22.7.11.220.445
5e8wSTUTGF-beta receptor type-12.7.11.300.445
1xjdSTUProtein kinase C theta type2.7.11.130.444
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.444
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.444
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.444
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.444
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.444
4ockANPN-acetylhexosamine 1-kinase2.7.1.1620.444
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
1e9hINRCyclin-dependent kinase 22.7.11.220.443
1me6IVSPlasmepsin-23.4.23.390.443
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.443
3ezvEZVCyclin-dependent kinase 22.7.11.220.443
3pxkPXKFocal adhesion kinase 12.7.10.20.443
4dfg0JVGag-Pol polyprotein3.4.23.160.443
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.443
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.443
2qoqANPEphrin type-A receptor 32.7.10.10.442
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.442
3ortAGSSerine/threonine protein kinase/0.442
3qx2X63Cyclin-dependent kinase 22.7.11.220.442
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.442
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.442
4ii5ADPCyclin-dependent kinase 22.7.11.220.442
5dnrATPAurora kinase A2.7.11.10.442
2cciATPCyclin-dependent kinase 22.7.11.220.441
2h96893Mitogen-activated protein kinase 82.7.11.240.441
2qfxNDPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.441
2x1nX1NCyclin-dependent kinase 22.7.11.220.441
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3gu7ADPDeath-associated protein kinase 12.7.11.10.441
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.441
3wblPDYCyclin-dependent kinase 22.7.11.220.441
4bcmT7ZCyclin-dependent kinase 22.7.11.220.441
4erwSTUCyclin-dependent kinase 22.7.11.220.441
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.441
4qmlANPSerine/threonine-protein kinase 242.7.11.10.441
4y95746Tyrosine-protein kinase/0.441
1pmn984Mitogen-activated protein kinase 102.7.11.240.440
2fvdLIACyclin-dependent kinase 22.7.11.220.440
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3gubGUBDeath-associated protein kinase 12.7.11.10.440
4ivd15TTyrosine-protein kinase JAK1/0.440
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.440