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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.634
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.631
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.631
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.630
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.629
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.625
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.625
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.613
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.613
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.613
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.611
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.608
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.604
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.603
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.598
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.597
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.597
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.594
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.591
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.589
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.585
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.582
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.581
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.577
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.577
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.576
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.574
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.572
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.571
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.569
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.566
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.564
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.563
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.561
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.560
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.559
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.554
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.553
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.551
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.544
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.544
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.539
2uvzGVJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.537
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.529
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.524
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.517
3nynSGVG protein-coupled receptor kinase 62.7.11.160.516
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.512
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.506
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.499
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
3dfcANPDeath-associated protein kinase 12.7.11.10.485
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.484
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.483
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.481
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.480
4otiMI1Serine/threonine-protein kinase N1/0.480
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.477
2ijmADPFocal adhesion kinase 12.7.10.20.476
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.476
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.474
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.473
3mvjXFEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
2ckeIQUDeath-associated protein kinase 2/0.470
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.470
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
3gu6ADPDeath-associated protein kinase 12.7.11.10.468
3s1h56ZCyclin-dependent kinase 22.7.11.220.468
3a62STURibosomal protein S6 kinase beta-12.7.11.10.467
5auvAGIDeath-associated protein kinase 12.7.11.10.467
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.466
3gubGUBDeath-associated protein kinase 12.7.11.10.466
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.465
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.465
4ic7ANPMitogen-activated protein kinase 72.7.11.240.465
5av2KMPDeath-associated protein kinase 12.7.11.10.465
4axdANPInositol-pentakisphosphate 2-kinase2.7.1.1580.464
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.462
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.462
1g5sI17Cyclin-dependent kinase 22.7.11.220.461
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
3nieANPMitogen-activated protein kinase/0.459
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.459
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.459
4qnyANPMitogen activated protein kinase, putative/0.458
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2uvyGVIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.457
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4j95ACPFibroblast growth factor receptor 2/0.457
2y9qANPMitogen-activated protein kinase 12.7.11.240.456
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.456
5auxKMPDeath-associated protein kinase 12.7.11.10.456
4bebATPType I restriction enzyme EcoR124II R protein3.1.21.30.455
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.454
4hvi19STyrosine-protein kinase JAK32.7.10.20.453
4jia1K3Tyrosine-protein kinase JAK2/0.453
3eyhIZATyrosine-protein kinase JAK1/0.452
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.452
2pvnP63Casein kinase II subunit alpha2.7.11.10.451
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.451
2gciMRRProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.450
2w05FRTCyclin-dependent kinase 22.7.11.220.450
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.450
4anmWULCasein kinase II subunit alpha2.7.11.10.450
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.450
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.450
2uzbC75Cyclin-dependent kinase 22.7.11.220.449
4axfANPInositol-pentakisphosphate 2-kinase2.7.1.1580.449
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.449
4y95746Tyrosine-protein kinase/0.449
1aq1STUCyclin-dependent kinase 22.7.11.220.448
1g2kNM1Gag-Pol polyprotein3.4.23.160.448
2f2uM77Rho-associated protein kinase 22.7.11.10.448
3qn8NI7Gag-Pol polyprotein3.4.23.160.448
1hpoUNIGag-Pol polyprotein3.4.23.160.447
4dtaADNAPH(2'')-Id/0.447
4o8aFADBifunctional protein PutA1.2.1.880.447
1h1r6CPCyclin-dependent kinase 22.7.11.220.446
1pxoCK7Cyclin-dependent kinase 22.7.11.220.446
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.446
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.446
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
2vtqLZACyclin-dependent kinase 22.7.11.220.445
1w8cN69Cyclin-dependent kinase 22.7.11.220.444
3dneLL1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3qp0NI8Gag-Pol polyprotein3.4.23.160.444
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.444
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.444
5auzGENDeath-associated protein kinase 12.7.11.10.444
1ec3MS3Gag-Pol polyprotein3.4.23.160.443
1p2a5BNCyclin-dependent kinase 22.7.11.220.443
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.443
2etrY27Rho-associated protein kinase 12.7.11.10.443
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.443
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.443
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.442
4fv6E57Mitogen-activated protein kinase 12.7.11.240.442
1i9c5ADGlutamate mutase epsilon subunit/0.441
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.441
2c6lDT4Cyclin-dependent kinase 22.7.11.220.441
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.441
4eon1ROCyclin-dependent kinase 22.7.11.220.441
4j54G52Gag-Pol polyprotein3.4.23.160.441
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.440
2gd2CAAProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.440
3m0wP77Protein S100-A4/0.440