Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3vs4 | VSF | Tyrosine-protein kinase HCK | 2.7.10.2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3vs4 | VSF | Tyrosine-protein kinase HCK | 2.7.10.2 | 1.000 | |
| 3vs6 | VSH | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.681 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.674 | |
| 1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.654 | |
| 2c0t | L3G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.647 | |
| 3vs2 | VSB | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.643 | |
| 3vs5 | VSG | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.642 | |
| 3vs0 | VS0 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.625 | |
| 2c0i | L1G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.621 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.621 | |
| 3vs3 | VSE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.618 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.614 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.614 | |
| 4dgg | I76 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.614 | |
| 3vry | B43 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.589 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.584 | |
| 3vs1 | VSA | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.584 | |
| 4k11 | 0J9 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.574 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.571 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.560 | |
| 4id7 | 1G0 | Activated CDC42 kinase 1 | / | 0.550 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.544 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.544 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.542 | |
| 4otw | DB8 | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.542 | |
| 3w2s | W2R | Epidermal growth factor receptor | 2.7.10.1 | 0.538 | |
| 2bdj | HET | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.532 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.530 | |
| 4yuq | KS1 | Calmodulin-like domain protein kinase | / | 0.530 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.529 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.526 | |
| 4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.526 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.523 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.522 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.521 | |
| 2zm1 | KSF | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.521 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.519 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.518 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.516 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.515 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.514 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.511 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.511 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.511 | |
| 2zv9 | PP2 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.510 | |
| 4lgh | 0JN | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.508 | |
| 4mxo | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.508 | |
| 1yol | S03 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.507 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.507 | |
| 4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.506 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.505 | |
| 2of2 | 547 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.504 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.503 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.503 | |
| 3b2w | 9NH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.502 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.502 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.501 | |
| 2zva | 1N1 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.500 | |
| 4lgg | VGG | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.499 | |
| 3ac5 | KZM | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.498 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.497 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.496 | |
| 2gs7 | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.496 | |
| 3qlg | 1N1 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.496 | |
| 3js2 | VM1 | Fibroblast growth factor receptor 1 | / | 0.495 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.495 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.495 | |
| 1xkk | FMM | Epidermal growth factor receptor | 2.7.10.1 | 0.493 | |
| 4mxa | BK7 | Calmodulin-like domain protein kinase isoenzyme gamma, related | / | 0.493 | |
| 4xli | 1N1 | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.493 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.492 | |
| 3ncg | BK1 | Calmodulin-domain protein kinase 1, putative | / | 0.491 | |
| 4l7s | G7K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.491 | |
| 4bb4 | 32W | Ephrin type-B receptor 4 | 2.7.10.1 | 0.490 | |
| 2bal | PQA | Mitogen-activated protein kinase 14 | / | 0.489 | |
| 2c6e | HPM | Aurora kinase A | 2.7.11.1 | 0.489 | |
| 4kiq | 1RA | Mitogen-activated protein kinase 14 | / | 0.489 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.489 | |
| 4nk9 | 2K5 | Fibroblast growth factor receptor 1 | / | 0.489 | |
| 2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.488 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.488 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.488 | |
| 2itn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.487 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.487 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.487 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.487 | |
| 4mxy | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.487 | |
| 4mxz | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.487 | |
| 4hvh | 19R | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.486 | |
| 1qpe | PP2 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.485 | |
| 2vww | 7X2 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.485 | |
| 2xvd | AS6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.485 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.484 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.484 | |
| 2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.484 | |
| 2of4 | 979 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.484 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.484 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.484 | |
| 3ac2 | KSE | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.483 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.483 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.482 | |
| 2qoc | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.481 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.481 | |
| 2vx0 | 7X7 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.480 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.480 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.480 | |
| 3uvq | FS8 | Mitogen-activated protein kinase 14 | / | 0.480 | |
| 4jr3 | KJR | Epidermal growth factor receptor | 2.7.10.1 | 0.480 | |
| 2vwu | 7X1 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.479 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.479 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.478 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.478 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.477 | |
| 2vx1 | 7X8 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.477 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.477 | |
| 4c4g | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.477 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.476 | |
| 2vwz | 7X6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.476 | |
| 4i23 | 1C9 | Epidermal growth factor receptor | 2.7.10.1 | 0.476 | |
| 4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.475 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.475 | |
| 2p2h | 994 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.473 | |
| 4kip | 1R9 | Mitogen-activated protein kinase 14 | / | 0.473 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.472 | |
| 3w2r | W2R | Epidermal growth factor receptor | 2.7.10.1 | 0.472 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.472 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.471 | |
| 2ycq | UPX | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.471 | |
| 3ac3 | KSH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.471 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.471 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.471 | |
| 4feq | 0T8 | Tyrosine-protein kinase receptor TYRO3 | 2.7.10.1 | 0.471 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.471 | |
| 2ivv | PP1 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.470 | |
| 2vwy | 7X5 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.470 | |
| 2x2l | X2L | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.470 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.470 | |
| 3dtc | VIN | Mitogen-activated protein kinase kinase kinase 9 | 2.7.11.25 | 0.470 | |
| 3f88 | 3HT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.470 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.469 | |
| 2x9f | X9F | Ephrin type-B receptor 4 | 2.7.10.1 | 0.469 | |
| 3w18 | N13 | Aurora kinase A | 2.7.11.1 | 0.469 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.469 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.468 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.468 | |
| 1osv | CHC | Bile acid receptor | / | 0.467 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.467 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.467 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.467 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.466 | |
| 3lcd | BDY | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.466 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.466 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.466 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.466 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.466 | |
| 2itv | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.465 | |
| 3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 4dfl | 0K0 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.465 | |
| 4ih8 | B43 | Calmodulin-domain protein kinase 1 | / | 0.465 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.464 | |
| 2fgi | PD1 | Fibroblast growth factor receptor 1 | / | 0.464 | |
| 3zdi | UGJ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.464 | |
| 4j97 | ACP | Fibroblast growth factor receptor 2 | / | 0.464 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.463 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.463 | |
| 3icr | COA | Coenzyme A disulfide reductase | / | 0.463 | |
| 4c4h | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.463 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.462 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.462 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 3v5j | 0F2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.462 | |
| 1ie4 | T44 | Transthyretin | / | 0.461 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.461 | |
| 2eb3 | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.461 | |
| 3ad6 | KSC | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.461 | |
| 3o96 | IQO | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.461 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.461 | |
| 2zyb | KSL | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.460 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 3f69 | XDR | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.460 | |
| 3mwu | BK3 | Calmodulin-domain protein kinase 1, putative | / | 0.460 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.459 | |
| 2ycs | NXP | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.459 | |
| 3c7q | XIN | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.459 | |
| 3h0s | B38 | Acetyl-CoA carboxylase | / | 0.459 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.459 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 2hen | ADP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.458 | |
| 3f5p | 741 | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.458 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.458 | |
| 1pn3 | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.457 | |
| 2py3 | ACP | Fibroblast growth factor receptor 2 | / | 0.457 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.457 | |
| 4c8b | 0LI | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.457 | |
| 5aaa | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.457 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.456 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.456 | |
| 4aac | AAV | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.455 | |
| 4e4m | 0NH | Tyrosine-protein kinase JAK2 | / | 0.455 | |
| 4l52 | 1UL | Mitogen-activated protein kinase kinase kinase 7 | 2.7.11.25 | 0.455 | |
| 2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.454 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.454 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.454 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.454 | |
| 2yaa | ATP | Death-associated protein kinase 2 | / | 0.454 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.454 | |
| 4aa4 | QC0 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 4yzc | STU | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.454 | |
| 1pme | SB2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.453 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.453 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.453 | |
| 3k5u | PFQ | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 4a9t | A9T | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.453 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.452 | |
| 2xyn | VX6 | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.452 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 2zm4 | KSM | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.452 | |
| 4aa5 | NQB | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.452 | |
| 4z35 | ON9 | Lysophosphatidic acid receptor 1 | / | 0.452 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.451 | |
| 2pzp | ACP | Fibroblast growth factor receptor 2 | / | 0.451 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 4aw5 | 30K | Ephrin type-B receptor 4 | 2.7.10.1 | 0.451 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.451 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 4wkq | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.451 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.451 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.450 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.450 | |
| 4c62 | XWW | Tyrosine-protein kinase JAK2 | / | 0.450 | |
| 4nj3 | 2KD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3l8x | N4D | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3mvl | 38P | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.449 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.449 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.448 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.448 | |
| 2o0u | C0M | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.448 | |
| 2uy0 | HV1 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.448 | |
| 3qp0 | NI8 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4btk | DTQ | Tau-tubulin kinase 1 | 2.7.11.1 | 0.448 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.448 | |
| 4mcv | 29K | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.448 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 1yi3 | LY2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 3upj | U03 | Gag-Pol polyprotein | / | 0.447 | |
| 4bdb | ODO | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.447 | |
| 4f63 | 0S7 | Fibroblast growth factor receptor 1 | / | 0.447 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4zse | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 5amn | DTQ | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.447 | |
| 1py5 | PY1 | TGF-beta receptor type-1 | 2.7.11.30 | 0.446 | |
| 1wvx | BD4 | Death-associated protein kinase 1 | 2.7.11.1 | 0.446 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.446 | |
| 3s2p | PMU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.446 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.445 | |
| 1u5r | ATP | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.445 | |
| 1yvj | 4ST | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.445 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2wmq | ZYQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2xp2 | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.445 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.445 | |
| 3aox | EMH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.445 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3m8q | DJZ | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.445 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4g17 | 0VN | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.445 | |
| 1xr1 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 2gtn | LIE | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 2x2m | X2M | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.444 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.444 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.444 | |
| 4erw | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 1gqt | ACP | Ribokinase | / | 0.443 | |
| 2yiq | YIQ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 3gfe | P37 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3ogq | AB1 | Pol polyprotein | / | 0.443 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.443 | |
| 4cki | ADN | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.443 | |
| 4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.443 | |
| 4ic7 | ANP | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.443 | |
| 4j36 | FAD | Kynurenine 3-monooxygenase | / | 0.443 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.442 | |
| 1mes | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2c47 | 5ID | Casein kinase I isoform gamma-2 | / | 0.442 | |
| 2cmv | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.442 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2j0m | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.442 | |
| 2ym6 | YM6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.442 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.442 | |
| 3qlf | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 4bc6 | XZN | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.442 | |
| 4idv | 13V | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.442 | |
| 4wsq | KSA | AP2-associated protein kinase 1 | 2.7.11.1 | 0.442 | |
| 5f0a | 1FB | cGMP-dependent protein kinase, putative | / | 0.442 | |
| 1bve | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.441 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2v7a | 627 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.441 | |
| 2xm9 | LWH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.441 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.441 | |
| 3bkb | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.441 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.441 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.441 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.441 | |
| 3umx | Q18 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.441 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 4bdf | H3R | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.441 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.441 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.441 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.441 | |
| 4i0t | 1B6 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.441 | |
| 4jrv | KJV | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 1bvg | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1npa | 3NH | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1npw | LGZ | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.440 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.440 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.440 | |
| 3ggf | GVD | Serine/threonine-protein kinase 26 | / | 0.440 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.440 | |
| 3tti | KBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.440 | |
| 4a61 | ANP | Plasmid segregation protein ParM | / | 0.440 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4f9w | LM4 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.440 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.440 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.440 |