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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3rs4GNPGTPase HRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3rs4GNPGTPase HRas/1.000
4dltGNPGTPase HRas/0.868
3lbhGNPGTPase HRas/0.840
3lbiGNPGTPase HRas/0.835
3lbnGNPGTPase HRas/0.793
3k8yGNPGTPase HRas/0.704
4g0nGNPGTPase HRas/0.693
4l9wGNPGTPase HRas/0.693
3rslGNPGTPase HRas/0.689
3rs0GNPGTPase HRas/0.685
4dlwGNPGTPase HRas/0.680
3rs7GNPGTPase HRas/0.677
4dsnGCPGTPase KRas/0.673
3l8yGNPGTPase HRas/0.670
2rgeGNPGTPase HRas/0.669
3oiwGNPGTPase HRas/0.662
3pitGNPRas-related protein M-Ras/0.662
3i3sGNPGTPase HRas/0.660
4dlzGNPGTPase HRas/0.658
5dhaGNPGTP-binding nuclear protein Ran/0.658
3kkoGNPRas-related protein M-Ras/0.653
2rgcGNPGTPase HRas/0.651
2c5lGTPGTPase HRas/0.649
5b2zGNPGTPase HRas/0.645
4rkfGNPRas-related protein Rab-3/0.642
5difGNPGTP-binding nuclear protein Ran/0.642
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.640
3ddcGNPGTPase HRas/0.640
4nyiGNPGTPase HRas/0.635
4dlsGNPGTPase HRas/0.633
1g17GNPRas-related protein SEC4/0.632
3x1zGNPRas-related protein Rap-1b/0.629
3v4fGNPGTPase HRas/0.628
4hdoGNPRas-related protein Rap-1b/0.625
4lhwGNPRas-related protein Rab-8A/0.625
4nyjGNPGTPase HRas/0.625
3oiuGNPGTPase HRas/0.624
4k81GTPGTPase HRas/0.624
1t91GTPRas-related protein Rab-7a/0.622
1ibrGNPGTP-binding nuclear protein Ran/0.621
3a58GNPGTP-binding protein RHO1/0.620
2rgbGNPGTPase HRas/0.617
3kudGDPGTPase HRas/0.617
1e96GTPRas-related C3 botulinum toxin substrate 1/0.612
3a6pGTPGTP-binding nuclear protein Ran/0.611
4l9sGDPGTPase HRas/0.611
1yzqGNPRas-related protein Rab-6A/0.608
4qxaGTPRas-related protein Rab-9A/0.608
3kucGDPRas-related protein Rap-1A/0.606
5jljGNPGTP-binding nuclear protein Ran/0.604
3e5hGNPRas-related protein Rab-28/0.602
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.597
4tq9GDPGTPase KRas/0.597
3tsoGNPRas-related protein Rab-25/0.594
1xtsGTPGTP-binding protein Rheb/0.593
3w3zGTPGTP-binding nuclear protein Ran/0.592
4dlxGNPGTPase HRas/0.592
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.591
2bkuGTPGTP-binding nuclear protein Ran/0.589
1kmqGNPTransforming protein RhoA/0.588
4mitGTPRho-related protein racC/0.588
4hdqGNPRas-related protein Rap-1b/0.587
4lv6GDPGTPase KRas/0.587
2zetGTPRas-related protein Rab-27B/0.585
3rabGNPRas-related protein Rab-3A/0.585
4lpkGDPGTPase KRas/0.585
1zc4GNPRas-related protein Ral-A/0.584
3tgpGNPGTPase HRas/0.583
1xtrGNPGTP-binding protein Rheb/0.582
4l8gGDPGTPase KRas/0.582
1a2bGSPTransforming protein RhoA/0.579
1cxzGSPTransforming protein RhoA/0.579
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.579
3ea5GDPGTP-binding nuclear protein Ran/0.579
1zd9GDPADP-ribosylation factor-like protein 8A/0.577
2gcpGSPRho-related GTP-binding protein RhoC/0.576
1zc3GNPRas-related protein Ral-A/0.575
2fe4GDPRas-related protein Rab-6B/0.575
4epwGDPGTPase KRas/0.574
2gilGTPRas-related protein Rab-6A/0.572
1s1cGNPTransforming protein RhoA/0.571
1zbdGTPRas-related protein Rab-3A/0.571
2ce2GDPGTPase HRas/0.571
3nbzGTPGTP-binding nuclear protein Ran/0.571
4wa7GDPGTPase KRas/0.571
3kkqGDPRas-related protein M-Ras/0.570
3oesGNPGTPase RhebL1/0.570
4dlvGNPGTPase HRas/0.570
4dsoGSPGTPase KRas/0.566
1vg8GNPRas-related protein Rab-7a/0.564
3bbpGTPRas-related protein Rab-6A/0.564
4o2lGTPGTP-binding protein Rheb/0.564
3th5GNPRas-related C3 botulinum toxin substrate 1/0.560
4q03GDPGTPase KRas/0.559
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.557
4o2rGDPGTP-binding protein Rheb/0.557
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.556
3rs5GNPGTPase HRas/0.556
4o25GTPGTP-binding protein Rheb/0.556
4obeGDPGTPase KRas/0.556
3wyfGTPGTP-binding nuclear protein/0.555
4kvgGTPRas-related protein Rap-1A/0.555
4lrwGDPGTPase KRas/0.554
1yu9GNPRas-related protein Rab-4A/0.551
4uj3GNPRas-related protein Rab-11A/0.551
3x1wGDPRas-related protein Rap-1b/0.550
4epxGDPGTPase KRas/0.548
3oivGNPGTPase HRas/0.547
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.546
1x1rGDPRas-related protein M-Ras/0.545
2ffqGSPRas-related protein Rab-6B/0.545
4lucGDPGTPase KRas/0.545
1z0aGDPRas-related protein Rab-2A/0.544
3tnfGNPRas-related protein Rab-8A/0.543
3k9lGNPGTPase HRas/0.542
1yhnGTPRas-related protein Rab-7a/0.540
4q02GDPGTPase KRas/0.540
3mjhGTPRas-related protein Rab-5A/0.537
1d5cGDPGTPase (Rab6)/0.535
3kz1GSPTransforming protein RhoA/0.535
4ql3GDPGTPase KRas/0.533
1z0dGDPRas-related protein Rab-5C/0.532
3lawGNPRas-related protein Rab-7a/0.531
4ol0GTPGTP-binding nuclear protein Ran/0.531
4xvqGNPGTPase HRas/0.530
1ow3GDPTransforming protein RhoA/0.529
1z2aGDPRas-related protein Rab-23/0.529
4js0GNPCell division control protein 42 homolog/0.529
3bc1GNPRas-related protein Rab-27A/0.527
1n6lGTPRas-related protein Rab-5A/0.525
1oixGDPRas-related protein Rab-11A/0.525
2fg5GNPRas-related protein Rab-31/0.524
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.524
1m7bGTPRho-related GTP-binding protein RhoE/0.523
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.523
4ldjGDPGTPase KRas/0.523
2mscGDPMHC class I alpha chain/0.521
4xvrGNPGTPase HRas/0.521
5c46GSPRas-related protein Rab-11A/0.520
2bmeGNPRas-related protein Rab-4A/0.519
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.519
3qbtGNPRas-related protein Rab-8A/0.519
1k5dGNPGTP-binding nuclear protein Ran/0.518
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.518
4dxaGSPRas-related protein Rap-1b/0.518
2msdGNPMHC class I alpha chain/0.515
4dsuGDPGTPase KRas/0.515
1lfdGNPGTPase HRas/0.514
2rggGNPGTPase HRas/0.514
4xoiGTPTransforming protein RhoA/0.509
2cl6CAGGTPase HRas/0.507
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.506
3eg5GNPCell division control protein 42 homolog/0.506
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.506
1z2cGNPRho-related GTP-binding protein RhoC/0.502
4cidANPEH domain-containing protein 2/0.501
1gwnGTPRho-related GTP-binding protein RhoE/0.500
4g2i0VQVitamin D3 receptor/0.498
3cphGDPRas-related protein SEC4/0.497
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.496
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.495
3tklGTPRas-related protein Rab-1A/0.495
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.495
1x1cSAHC-20 methyltransferase/0.494
5hpyGDPTransforming protein RhoA/0.493
1uadGNPRas-related protein Ral-A/0.488
2q3fGNPRas-related GTP-binding protein D/0.488
2j5xGSPADP-ribosylation factor 6/0.487
4ead0NPThymidine phosphorylase2.4.2.40.486
2a9z26AAdenosine kinase2.7.1.200.485
2j0vGDPRac-like GTP-binding protein ARAC7/0.485
1g16GDPRas-related protein SEC4/0.483
1tu3GNPRas-related protein Rab-5A/0.482
2o4jVD4Vitamin D3 receptor/0.482
2a9y26AAdenosine kinase2.7.1.200.480
2mseGNPMHC class I alpha chain/0.479
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.478
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.477
3vhxGTPADP-ribosylation factor 6/0.476
4uj5GNPRas-related protein Rab-11A/0.476
4edz0O5Hematopoietic prostaglandin D synthase/0.475
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.475
2o4rVD5Vitamin D3 receptor/0.472
2zlcVDXVitamin D3 receptor/0.472
4lzwTHMUridine phosphorylase/0.472
2fhjMFNFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.470
2hb8MVDVitamin D3 receptor/0.470
4k5o1OTM1 family aminopeptidase3.4.110.470
1giaGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.469
1ay0TPPTransketolase 12.2.1.10.467
3dvlATPCircadian clock protein kinase KaiC2.7.11.10.467
2clsGTPRho-related GTP-binding protein Rho6/0.466
1v8kANPKinesin-like protein KIF2C/0.465
2harOCCVitamin D3 receptor/0.464
4mv1ADPBiotin carboxylase6.3.4.140.464
4mv3ACPBiotin carboxylase6.3.4.140.464
3pqbVGPPutative oxidoreductase/0.463
3r9xGNPGTPase Era/0.463
4qzuRTLRetinol-binding protein 2/0.462
4xymCOAAcyl-CoA synthetase (NDP forming)/0.462
4d0lGSPRas-related protein Rab-11A/0.461
1pwyAC2Purine nucleoside phosphorylase2.4.2.10.460
1culGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.459
1db1VDXVitamin D3 receptor/0.459
1xmmM7Gm7GpppX diphosphatase3.6.1.590.459
4lb2DM5Serum albumin/0.459
1tkaN3TTransketolase 12.2.1.10.458
5kf1COAPredicted acetyltransferase/0.458
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.457
4iteTEYVitamin D3 receptor/0.457
2rbeZMGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.456
3dgeADPSensor histidine kinase/0.456
1x1dSAHC-20 methyltransferase/0.455
3w0aDS5Vitamin D3 receptor/0.455
4y0vGDPADP-ribosylation factor 1, putative/0.455
1kqwRTLCellular retinol-binding protein type II/0.454
1wdtGTPElongation factor G (EF-G-2)/0.454
2wu2CBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.454
2wu2CBESuccinate dehydrogenase cytochrome b556 subunit/0.454
3dh8B4NUncharacterized protein PA1000/0.454
3zeiAWHO-acetylserine sulfhydrylase/0.454
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.454
5e8jSAHmRNA cap guanine-N7 methyltransferase2.1.1.560.454
1bcpATPPertussis toxin subunit 4/0.453
1bcpATPPertussis toxin subunit 5/0.453
1m2oGNPSmall COPII coat GTPase SAR13.6.50.453
1txiTX5Vitamin D3 receptor/0.453
1vhnFMNtRNA-dihydrouridine synthase/0.453
2oegUPGUDP-glucose pyrophosphorylase/0.453
2yloTESAndrogen receptor/0.453
3w0c6DSVitamin D3 receptor/0.453
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.453
4l0qNADAlcohol dehydrogenase class-3/0.453
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
2gvdFKPAdenylate cyclase type 2/0.452
2gvdFKPAdenylate cyclase type 5/0.452
3kxoKXOHematopoietic prostaglandin D synthase/0.452
3nh8DC2N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)3.5.1.1140.452
3vrbFTNSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial/0.452
3vrbFTNCytochrome b-large subunit/0.452
4k5p1OSM1 family aminopeptidase3.4.110.452
1g2vTTPGlucose-1-phosphate thymidylyltransferase/0.451
1ky2GNPGTP-binding protein YPT7/0.451
2p1u4TNRetinoic acid receptor RXR-alpha/0.451
3adaNADSubunit alpha of sarocosine oxidase/0.451
3da24MDCarbonic anhydrase 134.2.1.10.451
3refGDPRho family GTPase/0.451
4cf7ADPAdenylate kinase/0.451
4dvi2IWTankyrase-12.4.2.300.451
4ylgGDPADP-ribosylation factor 1, putative/0.451
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
1s0zEB1Vitamin D3 receptor/0.450
1towCRZFatty acid-binding protein, adipocyte/0.450
1x1aSAMC-20 methyltransferase/0.450
1z7yAA5Cysteine synthase 12.5.1.470.450
2bxqIMNSerum albumin/0.450
3vmmP0DAlanine--anticapsin ligase/0.450
4c6uTLG3-oxoacyl-ACP synthase/0.450
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.450
4xybNDPFormate dehydrogenase/0.450
2wu5CBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.449
2wu5CBESuccinate dehydrogenase cytochrome b556 subunit/0.449
2x06NADL-sulfolactate dehydrogenase/0.449
3m7rVDXVitamin D3 receptor/0.449
3x025GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.449
4fhi0S4Vitamin D3 receptor A/0.449
4itrGDPCell division control protein 42 homolog/0.449
4xg1LLPDiaminopimelate decarboxylase/0.449
1am4GNPCell division control protein 42 homolog/0.448
1mczRMNBenzoylformate decarboxylase4.1.1.70.448
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.448
3akm11DFatty acid-binding protein, intestinal/0.448
4dzzADPPlasmid partitioning protein ParF/0.448
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.448
1culFOKAdenylate cyclase type 2/0.447
1culFOKAdenylate cyclase type 5/0.447
1s19MC9Vitamin D3 receptor/0.447
2iutAGSDNA translocase FtsK/0.447
2vcxD26Hematopoietic prostaglandin D synthase/0.447
3cx8GSPGuanine nucleotide-binding protein subunit alpha-13/0.447
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3k7mFAD6-hydroxy-L-nicotine oxidase/0.447
3n8xNIMProstaglandin G/H synthase 11.14.99.10.447
4bn1ADPAurora kinase A2.7.11.10.447
4g0k0VSGlutathionyl-hydroquinone reductase YqjG1.80.447
1aqxGTDGlutathione S-transferase P2.5.1.180.446
1aztGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.446
2dy9ADPNucleoside diphosphate kinase2.7.4.60.446
2xvv9DNSerum albumin/0.446
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.446
3ddw055Glycogen phosphorylase, liver form2.4.1.10.446
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.446
4ihjGTPTubulin alpha-1B chain/0.446
4itfTFYVitamin D3 receptor/0.446
4m8e29VRetinoic acid receptor RXR-alpha/0.446
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.446
1r2jFADFkbI/0.445
2r6jNDPEugenol synthase 11.1.1.3180.445
3hpqAP5Adenylate kinase/0.445
3tifADPUncharacterized ABC transporter ATP-binding protein MJ0796/0.445
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2ydd2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.444
3c16GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.444
3mjrAC2Deoxycytidine kinase2.7.1.740.444
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.444
4bfzZVZPantothenate kinase2.7.1.330.444
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.444
2hb7O1CVitamin D3 receptor/0.443
2xvw9NRSerum albumin/0.443
3v2uATPProtein GAL3/0.443
4ao4PLKBeta-transaminase/0.443
5c80URIUridine phosphorylase/0.443
5iqdGNPBifunctional AAC/APH2.3.10.443
5je3SAHMethyl transferase/0.443
5li5THR_ALA_ASN_PRO_SEPKLTH0G14146p/0.443
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1t65DHTAndrogen receptor/0.442
2rqfJH3Hemolymph juvenile hormone binding protein/0.442
2vbdV10Isopenicillin N synthase1.21.3.10.442
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.442
3maaFKPAdenylate cyclase type 2/0.442
3maaFKPAdenylate cyclase type 5/0.442
5c3jUQ1Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial/0.442
5c3jUQ1Succinate dehydrogenase cytochrome b560/0.442
5jtbZMAAdenosine receptor A2a/0.442
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.441
3a783EVVitamin D3 receptor/0.441
3wquATPCell division protein FtsA/0.441
1klkPMDDihydrofolate reductase1.5.1.30.440
2aa2AS4Mineralocorticoid receptor/0.440
2qzrS79Queuine tRNA-ribosyltransferase2.4.2.290.440
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.440
3q7dNPXProstaglandin G/H synthase 21.14.99.10.440
3t1tGDPProbable gliding protein mglA/0.440
3up0D7SaceDAF-12/0.440
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
4gojGNPADP-ribosylation factor-like protein 3/0.440
4ybnFADFlavin-nucleotide-binding protein/0.440