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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3rmf20ZCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3rmf20ZCyclin-dependent kinase 22.7.11.221.000
3s1h56ZCyclin-dependent kinase 22.7.11.220.663
3ral04ZCyclin-dependent kinase 22.7.11.220.660
3rpy27ZCyclin-dependent kinase 22.7.11.220.657
3rak03ZCyclin-dependent kinase 22.7.11.220.633
3uli1N3Cyclin-dependent kinase 22.7.11.220.606
1y91CT9Cyclin-dependent kinase 22.7.11.220.602
3rk708ZCyclin-dependent kinase 22.7.11.220.595
2w06FRVCyclin-dependent kinase 22.7.11.220.589
3sw418KCyclin-dependent kinase 22.7.11.220.579
3qtuX44Cyclin-dependent kinase 22.7.11.220.577
4fkv61KCyclin-dependent kinase 22.7.11.220.572
3qtzX42Cyclin-dependent kinase 22.7.11.220.566
1gih1PUCyclin-dependent kinase 22.7.11.220.564
3rni21ZCyclin-dependent kinase 22.7.11.220.564
4fkw62KCyclin-dependent kinase 22.7.11.220.562
3qxpX64Cyclin-dependent kinase 22.7.11.220.561
3r9dX6BCyclin-dependent kinase 22.7.11.220.560
2w17I19Cyclin-dependent kinase 22.7.11.220.559
3rk507ZCyclin-dependent kinase 22.7.11.220.559
4acm7YGCyclin-dependent kinase 22.7.11.220.559
3qtxX43Cyclin-dependent kinase 22.7.11.220.557
3qu0X40Cyclin-dependent kinase 22.7.11.220.556
3rpv26ZCyclin-dependent kinase 22.7.11.220.555
2bhhRYUCyclin-dependent kinase 22.7.11.220.551
1v1k3FPCyclin-dependent kinase 22.7.11.220.547
3qzgX67Cyclin-dependent kinase 22.7.11.220.547
1pxmCK5Cyclin-dependent kinase 22.7.11.220.546
1urwI1PCyclin-dependent kinase 22.7.11.220.545
2xmyCDKCyclin-dependent kinase 22.7.11.220.545
1p2a5BNCyclin-dependent kinase 22.7.11.220.543
3qqkX02Cyclin-dependent kinase 22.7.11.220.543
4fkr45KCyclin-dependent kinase 22.7.11.220.543
3r71X86Cyclin-dependent kinase 22.7.11.220.542
2w1hL0FCyclin-dependent kinase 22.7.11.220.541
3rjc06ZCyclin-dependent kinase 22.7.11.220.540
3sw719KCyclin-dependent kinase 22.7.11.220.540
1aq1STUCyclin-dependent kinase 22.7.11.220.539
3r9oZ71Cyclin-dependent kinase 22.7.11.220.538
3sqq99ZCyclin-dependent kinase 22.7.11.220.537
2vv9IM9Cyclin-dependent kinase 22.7.11.220.535
2c6o4SPCyclin-dependent kinase 22.7.11.220.533
2w05FRTCyclin-dependent kinase 22.7.11.220.531
3lfnA27Cyclin-dependent kinase 22.7.11.220.531
3rk909ZCyclin-dependent kinase 22.7.11.220.531
1oiyN41Cyclin-dependent kinase 22.7.11.220.530
2a0cCK9Cyclin-dependent kinase 22.7.11.220.529
3unk0BYCyclin-dependent kinase 22.7.11.220.529
4fko20KCyclin-dependent kinase 22.7.11.220.528
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.527
4bgh3I6Cyclin-dependent kinase 22.7.11.220.527
4fx360KCyclin-dependent kinase 22.7.11.220.525
3s0o50ZCyclin-dependent kinase 22.7.11.220.524
1oi9N20Cyclin-dependent kinase 22.7.11.220.523
1pkdUCNCyclin-dependent kinase 22.7.11.220.523
1oitHDTCyclin-dependent kinase 22.7.11.220.522
2r64740Cyclin-dependent kinase 22.7.11.220.521
3wblPDYCyclin-dependent kinase 22.7.11.220.521
1ke6LS2Cyclin-dependent kinase 22.7.11.220.519
1w0xOLOCyclin-dependent kinase 22.7.11.220.519
3qtrX36Cyclin-dependent kinase 22.7.11.220.519
1di8DTQCyclin-dependent kinase 22.7.11.220.518
1gii1PUCyclin-dependent kinase 22.7.11.220.518
2r3lSCWCyclin-dependent kinase 22.7.11.220.517
3py0SU9Cyclin-dependent kinase 22.7.11.220.517
3ezvEZVCyclin-dependent kinase 22.7.11.220.516
3qtwX3ACyclin-dependent kinase 22.7.11.220.516
2iw84SPCyclin-dependent kinase 22.7.11.220.515
2bheBRYCyclin-dependent kinase 22.7.11.220.511
3r73X87Cyclin-dependent kinase 22.7.11.220.510
1oirHDYCyclin-dependent kinase 22.7.11.220.509
1g5sI17Cyclin-dependent kinase 22.7.11.220.508
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.508
3ti1B49Cyclin-dependent kinase 22.7.11.220.506
2vttLZDCyclin-dependent kinase 22.7.11.220.503
1h1r6CPCyclin-dependent kinase 22.7.11.220.501
2pvnP63Casein kinase II subunit alpha2.7.11.10.501
4ek816KCyclin-dependent kinase 22.7.11.220.501
1fvv107Cyclin-dependent kinase 22.7.11.220.500
2uznC96Cyclin-dependent kinase 22.7.11.220.500
3r1sX73Cyclin-dependent kinase 22.7.11.220.500
4erwSTUCyclin-dependent kinase 22.7.11.220.500
2b55D31Cyclin-dependent kinase 22.7.11.220.499
4qmpDKISerine/threonine-protein kinase 242.7.11.10.499
3rkb12ZCyclin-dependent kinase 22.7.11.220.498
1ke7LS3Cyclin-dependent kinase 22.7.11.220.497
1ke9LS5Cyclin-dependent kinase 22.7.11.220.497
4fkq42KCyclin-dependent kinase 22.7.11.220.497
1oguST8Cyclin-dependent kinase 22.7.11.220.496
3le62BZCyclin-dependent kinase 22.7.11.220.496
1pxlCK4Cyclin-dependent kinase 22.7.11.220.494
2btsU32Cyclin-dependent kinase 22.7.11.220.494
2i40BLZCyclin-dependent kinase 22.7.11.220.494
3lfqA28Cyclin-dependent kinase 22.7.11.220.494
3ql8X01Cyclin-dependent kinase 22.7.11.220.494
3s2pPMUCyclin-dependent kinase 22.7.11.220.493
3r9hZ67Cyclin-dependent kinase 22.7.11.220.492
4fkj11KCyclin-dependent kinase 22.7.11.220.492
1h1s4SPCyclin-dependent kinase 22.7.11.220.491
3be9P04Casein kinase II subunit alpha2.7.11.10.491
1pyePM1Cyclin-dependent kinase 22.7.11.220.490
2c6tDT5Cyclin-dependent kinase 22.7.11.220.490
2r3kSCQCyclin-dependent kinase 22.7.11.220.490
2c6iDT1Cyclin-dependent kinase 22.7.11.220.489
3qxoX65Cyclin-dependent kinase 22.7.11.220.489
3qqfX07Cyclin-dependent kinase 22.7.11.220.488
3unj0BXCyclin-dependent kinase 22.7.11.220.488
4fkt48KCyclin-dependent kinase 22.7.11.220.488
1fvt106Cyclin-dependent kinase 22.7.11.220.487
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.487
4fks46KCyclin-dependent kinase 22.7.11.220.486
2duv371Cyclin-dependent kinase 22.7.11.220.484
2wxvWXVCyclin-dependent kinase 22.7.11.220.484
3rpo24ZCyclin-dependent kinase 22.7.11.220.484
2wihP48Cyclin-dependent kinase 22.7.11.220.483
3r7yZ04Cyclin-dependent kinase 22.7.11.220.483
1dm2HMDCyclin-dependent kinase 22.7.11.220.482
3r7iX9ICyclin-dependent kinase 22.7.11.220.482
1ykr628Cyclin-dependent kinase 22.7.11.220.481
4fkg4CKCyclin-dependent kinase 22.7.11.220.481
1e9hINRCyclin-dependent kinase 22.7.11.220.480
3qruX19Cyclin-dependent kinase 22.7.11.220.480
1ke5LS1Cyclin-dependent kinase 22.7.11.220.479
2eufLQQCyclin-dependent kinase 62.7.11.220.479
2r3jSCJCyclin-dependent kinase 22.7.11.220.479
3qzhX69Cyclin-dependent kinase 22.7.11.220.479
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.479
1ke8LS4Cyclin-dependent kinase 22.7.11.220.478
3ddpRC8Cyclin-dependent kinase 22.7.11.220.477
4eok4SPCyclin-dependent kinase 22.7.11.220.477
1pxpCK8Cyclin-dependent kinase 22.7.11.220.476
2iw94SPCyclin-dependent kinase 22.7.11.220.476
3r7uX96Cyclin-dependent kinase 22.7.11.220.476
4ez50RSCyclin-dependent kinase 62.7.11.220.476
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.476
2vu3LZECyclin-dependent kinase 22.7.11.220.475
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.475
3r8zZ63Cyclin-dependent kinase 22.7.11.220.475
2fvdLIACyclin-dependent kinase 22.7.11.220.474
3qrtX14Cyclin-dependent kinase 22.7.11.220.474
3roy22ZCyclin-dependent kinase 22.7.11.220.474
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.473
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.471
3r8lZ30Cyclin-dependent kinase 22.7.11.220.470
1h1pCMGCyclin-dependent kinase 22.7.11.220.469
3qqhX0ACyclin-dependent kinase 22.7.11.220.468
3qtqX35Cyclin-dependent kinase 22.7.11.220.468
3r6xX84Cyclin-dependent kinase 22.7.11.220.468
3pxyJWSCyclin-dependent kinase 22.7.11.220.467
3r83Z14Cyclin-dependent kinase 22.7.11.220.467
3rm618ZCyclin-dependent kinase 22.7.11.220.467
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.467
4ek610KCyclin-dependent kinase 22.7.11.220.466
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.466
1gij2PUCyclin-dependent kinase 22.7.11.220.465
3ddqRRCCyclin-dependent kinase 22.7.11.220.465
3qwkX62Cyclin-dependent kinase 22.7.11.220.465
1h0w207Cyclin-dependent kinase 22.7.11.220.464
2uzoC62Cyclin-dependent kinase 22.7.11.220.464
4ez30S0Cyclin-dependent kinase 22.7.11.220.464
2c5nCK8Cyclin-dependent kinase 22.7.11.220.463
2cchATPCyclin-dependent kinase 22.7.11.220.463
3lfsA07Cyclin-dependent kinase 22.7.11.220.463
4eor4SPCyclin-dependent kinase 22.7.11.220.463
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.462
2x1nX1NCyclin-dependent kinase 22.7.11.220.462
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.462
3r8vZ62Cyclin-dependent kinase 22.7.11.220.462
4fkpLS5Cyclin-dependent kinase 22.7.11.220.462
2b52D42Cyclin-dependent kinase 22.7.11.220.460
2c6lDT4Cyclin-dependent kinase 22.7.11.220.460
4bcpT3CCyclin-dependent kinase 22.7.11.220.460
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.459
4anmWULCasein kinase II subunit alpha2.7.11.10.459
1v0oINRCell division control protein 2 homolog2.7.11.220.458
2b53D23Cyclin-dependent kinase 22.7.11.220.457
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.457
2uzeC95Cyclin-dependent kinase 22.7.11.220.457
2vtsLZCCyclin-dependent kinase 22.7.11.220.457
3r1qX75Cyclin-dependent kinase 22.7.11.220.457
2uzbC75Cyclin-dependent kinase 22.7.11.220.456
2vthLZ2Cyclin-dependent kinase 22.7.11.220.456
3dogNNNCyclin-dependent kinase 22.7.11.220.456
3r7vZ02Cyclin-dependent kinase 22.7.11.220.456
1pxkCK3Cyclin-dependent kinase 22.7.11.220.455
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.455
3ezrEZRCyclin-dependent kinase 22.7.11.220.455
3ig7EFPCyclin-dependent kinase 22.7.11.220.455
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.453
4lfiGNPCasein kinase II subunit alpha2.7.11.10.453
4lyn1YGCyclin-dependent kinase 22.7.11.220.453
1oiuN76Cyclin-dependent kinase 22.7.11.220.452
2b7aIZATyrosine-protein kinase JAK2/0.452
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.452
3pj8404Cyclin-dependent kinase 22.7.11.220.452
3fz1B98Cyclin-dependent kinase 22.7.11.220.451
1pxoCK7Cyclin-dependent kinase 22.7.11.220.450
2r3mSCXCyclin-dependent kinase 22.7.11.220.450
1r78FMDCyclin-dependent kinase 22.7.11.220.448
1w8cN69Cyclin-dependent kinase 22.7.11.220.448
2r3iSCFCyclin-dependent kinase 22.7.11.220.448
2uzdC85Cyclin-dependent kinase 22.7.11.220.448
2wpa889Cyclin-dependent kinase 22.7.11.220.448
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.448
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.448
3qx2X63Cyclin-dependent kinase 22.7.11.220.448
2xnbY8LCyclin-dependent kinase 22.7.11.220.447
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.447
2a4lRRCCyclin-dependent kinase 22.7.11.220.446
3my5RFZCyclin-dependent kinase 22.7.11.220.446
4bcmT7ZCyclin-dependent kinase 22.7.11.220.446
1ckpPVBCyclin-dependent kinase 22.7.11.220.445
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.445
1vyw292Cyclin-dependent kinase 22.7.11.220.445
2pvhP19Casein kinase II subunit alpha2.7.11.10.445
2r3p3SCCyclin-dependent kinase 22.7.11.220.445
3ggfGVDSerine/threonine-protein kinase 26/0.445
4dgnLU2Casein kinase II subunit alpha2.7.11.10.445
1oiqHDUCyclin-dependent kinase 22.7.11.220.444
3i60E86Mitogen-activated protein kinase 12.7.11.240.444
2uzlC94Cyclin-dependent kinase 22.7.11.220.443
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.443
5e8wSTUTGF-beta receptor type-12.7.11.300.443
2j9mPY8Cyclin-dependent kinase 22.7.11.220.442
4hge15VTyrosine-protein kinase JAK2/0.442
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
1y8yCT7Cyclin-dependent kinase 22.7.11.220.441
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.441
2pvlP55Casein kinase II subunit alpha2.7.11.10.441
3qwjX6ACyclin-dependent kinase 22.7.11.220.441
3r8pZ46Cyclin-dependent kinase 22.7.11.220.441
1h1q2A6Cyclin-dependent kinase 22.7.11.220.440
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.440
4aqc88ATyrosine-protein kinase JAK2/0.440
4fki09KCyclin-dependent kinase 22.7.11.220.440
5e8ySTUTGF-beta receptor type-22.7.11.300.440