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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3mpt1GKMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3mpt1GKMitogen-activated protein kinase 14/1.000
3iphG11Mitogen-activated protein kinase 14/0.688
4aa5NQBMitogen-activated protein kinase 14/0.603
4kin1M8Mitogen-activated protein kinase 14/0.598
3fklFKLMitogen-activated protein kinase 14/0.595
3fskRO6Mitogen-activated protein kinase 14/0.594
3fln3FNMitogen-activated protein kinase 14/0.592
2balPQAMitogen-activated protein kinase 14/0.590
2rg6287Mitogen-activated protein kinase 14/0.590
3flyFLYMitogen-activated protein kinase 14/0.581
4aacAAVMitogen-activated protein kinase 14/0.580
4aa4QC0Mitogen-activated protein kinase 14/0.566
4kiq1RAMitogen-activated protein kinase 14/0.566
3flzFLZMitogen-activated protein kinase 14/0.559
3s4qNK0Mitogen-activated protein kinase 14/0.559
2rg5279Mitogen-activated protein kinase 14/0.557
3dt1P40Mitogen-activated protein kinase 14/0.557
4kip1R9Mitogen-activated protein kinase 14/0.551
3l8xN4DMitogen-activated protein kinase 14/0.548
3fmh533Mitogen-activated protein kinase 14/0.547
3nww3NWMitogen-activated protein kinase 14/0.547
3fi4FI4Mitogen-activated protein kinase 14/0.538
3ocgOCGMitogen-activated protein kinase 14/0.537
3hl7I47Mitogen-activated protein kinase 14/0.536
3u8w09JMitogen-activated protein kinase 14/0.536
4lopSB4Mitogen-activated protein kinase 14/0.532
3flwFLWMitogen-activated protein kinase 14/0.529
2ghlLIBMitogen-activated protein kinase 14/0.525
3mvm39PMitogen-activated protein kinase 14/0.517
2zazGK1Mitogen-activated protein kinase 14/0.514
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.514
1zz2B11Mitogen-activated protein kinase 14/0.511
2qd9LGFMitogen-activated protein kinase 14/0.508
3d7zGK5Mitogen-activated protein kinase 14/0.504
2zb0GK3Mitogen-activated protein kinase 14/0.503
2zb1GK4Mitogen-activated protein kinase 14/0.503
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.500
3hvcGG5Mitogen-activated protein kinase 14/0.499
4looSB4Mitogen-activated protein kinase 14/0.498
3gfeP37Mitogen-activated protein kinase 14/0.497
3bv2P38Mitogen-activated protein kinase 14/0.495
1ywnLIFVascular endothelial growth factor receptor 22.7.10.10.494
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.490
2w3bNDPDihydrofolate reductase1.5.1.30.489
3fmkFMKMitogen-activated protein kinase 14/0.486
3bv3P39Mitogen-activated protein kinase 14/0.485
3vjoANPEpidermal growth factor receptor2.7.10.10.483
1fm4DXCMajor pollen allergen Bet v 1-L/0.482
1ouk084Mitogen-activated protein kinase 14/0.482
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.482
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
4eh60ONMitogen-activated protein kinase 14/0.480
3gbuATPUncharacterized sugar kinase PH14592.7.10.478
2gtnLIEMitogen-activated protein kinase 14/0.477
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.477
2y6o1N1Ephrin type-A receptor 42.7.10.10.476
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.476
3gc9B45Mitogen-activated protein kinase 112.7.11.240.475
3uvqFS8Mitogen-activated protein kinase 14/0.475
3uyt0CKCasein kinase I isoform delta2.7.11.10.474
4i231C9Epidermal growth factor receptor2.7.10.10.473
1agwSU2Fibroblast growth factor receptor 1/0.472
1zyjBI5Mitogen-activated protein kinase 14/0.470
3ac2KSETyrosine-protein kinase Lck2.7.10.20.470
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.469
4loqSB4Mitogen-activated protein kinase 14/0.469
1py5PY1TGF-beta receptor type-12.7.11.300.468
3e92G6AMitogen-activated protein kinase 14/0.468
2he5NDPAldo-keto reductase family 1 member C211.1.10.467
1xddAAYIntegrin alpha-L/0.466
3itzP66Mitogen-activated protein kinase 14/0.466
4xr9NADCalS8/0.466
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.465
1vjy460TGF-beta receptor type-12.7.11.300.464
1zrzBI1Protein kinase C iota type2.7.11.130.464
3tk3CPZCytochrome P450 2B41.14.14.10.464
4dbzNDPPutative ketoacyl reductase1.3.10.464
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.464
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.463
2qo9ANPEphrin type-A receptor 32.7.10.10.463
3nxxNDPDihydrofolate reductase1.5.1.30.463
3qlsNDPDihydrofolate reductase1.5.1.30.463
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.463
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
2itwITQEpidermal growth factor receptor2.7.10.10.462
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.462
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.462
4a8v2ANMajor pollen allergen Bet v 1-J/0.462
4g7gVFVLanosterol 14-alpha-demethylase/0.462
4gk3L87Ephrin type-A receptor 32.7.10.10.462
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.461
2wouZZFTGF-beta receptor type-12.7.11.300.461
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.461
3d84NDPDihydrofolate reductase1.5.1.30.461
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.461
3tjzGNPADP-ribosylation factor 1/0.461
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.460
2rlcCHDCholoylglycine hydrolase3.5.1.240.460
3m6iNADL-arabinitol 4-dehydrogenase1.1.1.120.460
1rw8580TGF-beta receptor type-12.7.11.300.459
2itxANPEpidermal growth factor receptor2.7.10.10.459
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.459
3qlrNDPDihydrofolate reductase1.5.1.30.459
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.459
5c1mCLRMu-type opioid receptor/0.459
1bwsNDPGDP-L-fucose synthase/0.458
3fp0FP015-O-acetyltransferase/0.458
3h3cP1EProtein-tyrosine kinase 2-beta2.7.10.20.458
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4jr3KJREpidermal growth factor receptor2.7.10.10.458
4y8wSTRSteroid 21-hydroxylase/0.458
1ezvUQ6Cytochrome b/0.457
1hncGDNGlutathione S-transferase Mu 22.5.1.180.457
2x8hFADThioredoxin glutathione reductase/0.457
3b6zCO7Enoyl reductase LovC10.457
3gw9VNILanosterol 14-alpha-demethylase/0.457
4ipw1G7Mycocyclosin synthase1.14.21.90.457
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.456
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.456
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.456
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
4jq7KJQEpidermal growth factor receptor2.7.10.10.456
1h73ANPHomoserine kinase2.7.1.390.455
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.455
2eb3ANPEpidermal growth factor receptor2.7.10.10.455
2jcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.455
2nniMTKCytochrome P450 2C8/0.455
2oc4IMHPurine nucleoside phosphorylase2.4.2.10.455
2of2547Tyrosine-protein kinase Lck2.7.10.20.455
2y3sTIRTamL/0.455
4tuvCPZCytochrome P450 1191.140.455
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.455
2aa3AP0L-lactate dehydrogenase/0.454
4jq8KJ8Epidermal growth factor receptor2.7.10.10.454
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.454
1tqf32PBeta-secretase 13.4.23.460.453
1v9aSAHUncharacterized protein/0.453
2jb4A14Isopenicillin N synthase1.21.3.10.453
4a87NARMajor pollen allergen Bet v 1-A/0.453
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.453
4ji91M3Tyrosine-protein kinase JAK2/0.453
1trgCB3Thymidylate synthase/0.452
2a94AP0L-lactate dehydrogenase1.1.1.270.452
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.452
3hx4ANPCalmodulin-domain protein kinase 1/0.452
3tucFPWTyrosine-protein kinase SYK2.7.10.20.452
3uvp048Mitogen-activated protein kinase 14/0.452
3zuyTCHTransporter/0.452
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.452
4y93746Tyrosine-protein kinase/0.452
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.451
1u4dDBQActivated CDC42 kinase 1/0.451
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.451
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4fod0UVALK tyrosine kinase receptor2.7.10.10.451
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.451
4q73FADBifunctional protein PutA/0.451
1di9MSQMitogen-activated protein kinase 14/0.450
1eioGCHGastrotropin/0.450
1osvCHCBile acid receptor/0.450
1t2cNAIL-lactate dehydrogenase1.1.1.270.450
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.450
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.450
2gfsPQBMitogen-activated protein kinase 14/0.450
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.450
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.450
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.450
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.90.450
4bfzZVZPantothenate kinase2.7.1.330.450
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.450
4du82P0Mevalonate diphosphate decarboxylase/0.450
1ia1NDPDihydrofolate reductase1.5.1.30.449
2itvANPEpidermal growth factor receptor2.7.10.10.449
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.449
2oegUPGUDP-glucose pyrophosphorylase/0.449
2ozuACOHistone acetyltransferase KAT6A/0.449
2vwqNAPGlucose 1-dehydrogenase/0.449
2y99NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.449
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.449
3ibqATPPyridoxal kinase/0.449
3lzs017Gag-Pol polyprotein3.4.23.160.449
3uleC69Actin-related protein 3/0.449
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.449
4c02TAKActivin receptor type-12.7.11.300.449
4fv7E94Mitogen-activated protein kinase 12.7.11.240.449
4g2fC07Ephrin type-A receptor 32.7.10.10.449
4jx1CAHCamphor 5-monooxygenase1.14.15.10.449
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.449
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
1phgMYTCamphor 5-monooxygenase1.14.15.10.448
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.448
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.448
3dxmN24Actin-related protein 3/0.448
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.448
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.448
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.448
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.448
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1pjcNADAlanine dehydrogenase/0.447
2itnANPEpidermal growth factor receptor2.7.10.10.447
2itpAEEEpidermal growth factor receptor2.7.10.10.447
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.447
2xtnGTPGTPase IMAP family member 2/0.447
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.447
3b70NAPEnoyl reductase LovC10.447
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
3fsfFSSMitogen-activated protein kinase 14/0.447
3hllI45Mitogen-activated protein kinase 14/0.447
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.447
3w32W32Epidermal growth factor receptor2.7.10.10.447
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
4i8zG08Gag-Pol polyprotein3.4.23.160.447
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.446
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.446
2ad5ADPCTP synthase/0.446
2ien017Gag-Pol polyprotein3.4.23.160.446
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
2qn7HBZGlycogen phosphorylase, muscle form2.4.1.10.446
3ac1KZITyrosine-protein kinase Lck2.7.10.20.446
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.446
4g3jVNTLanosterol 14-alpha-demethylase/0.446
4riyADPEpidermal growth factor receptor2.7.10.10.446
4rww2BALmo2692 protein/0.446
1adfTADAlcohol dehydrogenase E chain1.1.1.10.445
1cx4CMPcAMP-dependent protein kinase type II-beta regulatory subunit/0.445
1k6cMK1Gag-Pol polyprotein3.4.23.160.445
1nptNADGlyceraldehyde-3-phosphate dehydrogenase/0.445
1sxjAGSReplication factor C subunit 1/0.445
2cig1DGDihydrofolate reductase1.5.1.30.445
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.445
2vwx7X4Ephrin type-B receptor 42.7.10.10.445
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.445
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.445
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.445
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.445
4appN53Serine/threonine-protein kinase PAK 42.7.11.10.445
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.445
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.444
1kp2ATPArgininosuccinate synthase6.3.4.50.444
1kzjCB3Thymidylate synthase/0.444
1ot7IU5Bile acid receptor/0.444
2iviACWIsopenicillin N synthase1.21.3.10.444
2uzfCAA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.444
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.444
2yyuC5POrotidine 5'-phosphate decarboxylase/0.444
3bgxTMPThymidylate synthase/0.444
3pm9FADPutative oxidoreductase/0.444
3qt62P0Mevalonate diphosphate decarboxylase/0.444
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.444
4g3pUD1Bifunctional protein GlmU/0.444
4m4922YL-lactate dehydrogenase A chain1.1.1.270.444
4nieNBHNuclear receptor ROR-gamma/0.444
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.443
1llzFMNFerredoxin-dependent glutamate synthase 21.4.7.10.443
1rrmAPRLactaldehyde reductase1.1.1.770.443
1ywrLI9Mitogen-activated protein kinase 14/0.443
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.443
2dteNAIGlucose 1-dehydrogenase related protein/0.443
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.443
3ds6A17Mitogen-activated protein kinase 14/0.443
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.443
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.443
4cjfRVNIntegrase/0.443
4g6gFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.443
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.442
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
1qvrANPChaperone protein ClpB/0.442
1xefATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.442
2a7r5GPGMP reductase 2/0.442
2bjfDXCCholoylglycine hydrolase3.5.1.240.442
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2c29NAPDihydroflavonol 4-reductase/0.442
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.442
2vn0TDZCytochrome P450 2C8/0.442
2xyuQ9GEphrin type-A receptor 42.7.10.10.442
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.442
3d8vUD1Bifunctional protein GlmU/0.442
3k4cFADPyranose 2-oxidase/0.442
3lfeZ84Mitogen-activated protein kinase 14/0.442
3lqfNADGalactitol dehydrogenase/0.442
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.442
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.442
4a99FADTetX family tetracycline inactivation enzyme/0.442
4mv8ACPBiotin carboxylase6.3.4.140.442
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.442
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
1gd1NADGlyceraldehyde-3-phosphate dehydrogenase/0.441
1ie3NADMalate dehydrogenase/0.441
1nboNADGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.441
1nhhANPDNA mismatch repair protein MutL/0.441
1p84UQ6Cytochrome b/0.441
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2hckQUETyrosine-protein kinase HCK2.7.10.20.441
2ibzUQ6Cytochrome b/0.441
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.441
2zjmF1MBeta-secretase 13.4.23.460.441
2zjwREFCasein kinase II subunit alpha2.7.11.10.441
3nbvANPKetohexokinase/0.441
3r83Z14Cyclin-dependent kinase 22.7.11.220.441
3uylTYDProbable NDP-rhamnosyltransferase/0.441
4nxuADPMitochondrial dynamics protein MID51/0.441
4oztP1AEcdysone receptor, putative/0.441
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1lbcCYZGlutamate receptor 2/0.440
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1u3dFADCryptochrome-1/0.440
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.440
2xvdAS6Ephrin type-B receptor 42.7.10.10.440
2yxuATPPyridoxal kinase2.7.1.350.440
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.440
3dl0AP5Adenylate kinase/0.440
3gu83GUDeath-associated protein kinase 12.7.11.10.440
3nl6TPSUncharacterized protein/0.440
3zh8C58Protein kinase C iota type2.7.11.130.440
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.440
4jbsP52Endoplasmic reticulum aminopeptidase 23.4.110.440
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.440