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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ka0MK3MAP kinase-activated protein kinase 22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ka0MK3MAP kinase-activated protein kinase 22.7.11.11.000
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.518
3nup3NUCyclin-dependent kinase 62.7.11.220.498
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.497
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.491
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.490
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.488
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.486
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.483
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.483
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.482
4aguD15Cyclin-dependent kinase-like 1/0.480
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.480
2vd5BI8Myotonin-protein kinase2.7.11.10.479
3zh8C58Protein kinase C iota type2.7.11.130.479
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.479
2c4g514Cyclin-dependent kinase 22.7.11.220.478
3sheI85MAP kinase-activated protein kinase 32.7.11.10.478
4bcmT7ZCyclin-dependent kinase 22.7.11.220.478
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.478
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.477
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.477
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.475
4ez50RSCyclin-dependent kinase 62.7.11.220.475
4fv8E63Mitogen-activated protein kinase 12.7.11.240.475
4qnaX11Serine/threonine-protein kinase 242.7.11.10.475
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.474
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.474
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.473
2uzbC75Cyclin-dependent kinase 22.7.11.220.473
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.472
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.472
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
1pkdUCNCyclin-dependent kinase 22.7.11.220.470
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.470
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.469
1di8DTQCyclin-dependent kinase 22.7.11.220.468
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.468
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.468
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.468
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.468
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.467
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.467
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.467
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.466
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.466
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.466
4hgs15GCasein kinase I isoform gamma-32.7.11.10.466
2j0j4STFocal adhesion kinase 12.7.10.20.465
3nux3NVCyclin-dependent kinase 62.7.11.220.465
3q9xEMOCasein kinase II subunit alpha2.7.11.10.465
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.465
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.464
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.463
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.463
3at4CCKCasein kinase II subunit alpha2.7.11.10.463
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.463
4dgo0JWCasein kinase II subunit alpha2.7.11.10.463
4fv9E71Mitogen-activated protein kinase 12.7.11.240.463
4nmbFADBifunctional protein PutA/0.463
1oiyN41Cyclin-dependent kinase 22.7.11.220.462
3axwTIDCasein kinase II subunit alpha2.7.11.10.462
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.462
5cu6ATPCasein kinase II subunit alpha2.7.11.10.462
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.461
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.461
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.461
3u4uLNHCasein kinase II subunit alpha2.7.11.10.461
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.461
2ckeIQUDeath-associated protein kinase 2/0.460
3a62STURibosomal protein S6 kinase beta-12.7.11.10.460
3bqr4RBDeath-associated protein kinase 3/0.460
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.460
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.459
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.459
2zjwREFCasein kinase II subunit alpha2.7.11.10.459
1e9hINRCyclin-dependent kinase 22.7.11.220.458
1j39UPGDNA beta-glucosyltransferase/0.458
2btsU32Cyclin-dependent kinase 22.7.11.220.458
3ezrEZRCyclin-dependent kinase 22.7.11.220.458
4b99R4LMitogen-activated protein kinase 72.7.11.240.458
4grb0XGCasein kinase II subunit alpha2.7.11.10.458
4kbc1QJCasein kinase I isoform delta2.7.11.10.458
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.457
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.457
2w05FRTCyclin-dependent kinase 22.7.11.220.457
1fvv107Cyclin-dependent kinase 22.7.11.220.456
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.456
2ojj82AMitogen-activated protein kinase 12.7.11.240.456
2pvmP29Casein kinase II subunit alpha2.7.11.10.456
3uvqFS8Mitogen-activated protein kinase 14/0.455
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.455
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.454
1v1k3FPCyclin-dependent kinase 22.7.11.220.454
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.454
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.454
3my5RFZCyclin-dependent kinase 22.7.11.220.454
4fki09KCyclin-dependent kinase 22.7.11.220.454
4ogrADNCyclin-dependent kinase 92.7.11.220.454
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.453
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.453
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.453
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.453
2pvnP63Casein kinase II subunit alpha2.7.11.10.453
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.453
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.453
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.453
4bcnT9NCyclin-dependent kinase 22.7.11.220.453
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.453
4jqeANPCasein kinase II subunit alpha2.7.11.10.453
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.453
2iw84SPCyclin-dependent kinase 22.7.11.220.452
3gc9B45Mitogen-activated protein kinase 112.7.11.240.452
3lfnA27Cyclin-dependent kinase 22.7.11.220.452
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.452
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.452
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
1zrzBI1Protein kinase C iota type2.7.11.130.451
2c475IDCasein kinase I isoform gamma-2/0.451
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.451
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.451
4fv6E57Mitogen-activated protein kinase 12.7.11.240.451
1oi9N20Cyclin-dependent kinase 22.7.11.220.450
2fvdLIACyclin-dependent kinase 22.7.11.220.450
4aqc88ATyrosine-protein kinase JAK2/0.450
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.450
5dr2ATPAurora kinase A2.7.11.10.450
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.449
3i60E86Mitogen-activated protein kinase 12.7.11.240.449
3r7yZ04Cyclin-dependent kinase 22.7.11.220.449
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.449
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.448
1r78FMDCyclin-dependent kinase 22.7.11.220.448
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.448
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.448
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.448
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.448
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.448
4xhgADPUncharacterized protein/0.448
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
1oguST8Cyclin-dependent kinase 22.7.11.220.447
2hog710Serine/threonine-protein kinase Chk12.7.11.10.447
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.447
3pe2E1BCasein kinase II subunit alpha2.7.11.10.447
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.447
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.446
2wotZZGTGF-beta receptor type-12.7.11.300.446
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.446
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4hgt15GCasein kinase I isoform delta2.7.11.10.446
4wkqIREEpidermal growth factor receptor2.7.10.10.446
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.445
2c3qGTXGlutathione S-transferase theta-12.5.1.180.445
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.445
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.445
3lpbNVBTyrosine-protein kinase JAK2/0.445
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.445
3r1sX73Cyclin-dependent kinase 22.7.11.220.445
4bcoT6QCyclin-dependent kinase 22.7.11.220.445
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.445
4dgnLU2Casein kinase II subunit alpha2.7.11.10.445
4fuxE75Mitogen-activated protein kinase 12.7.11.240.445
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.445
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
1gih1PUCyclin-dependent kinase 22.7.11.220.444
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.444
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.444
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.444
3eb0DRKUncharacterized protein/0.444
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.444
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.444
1gii1PUCyclin-dependent kinase 22.7.11.220.443
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.443
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.443
2izuP01Casein kinase I isoform gamma-32.7.11.10.443
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.443
2vv9IM9Cyclin-dependent kinase 22.7.11.220.443
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.443
3rkb12ZCyclin-dependent kinase 22.7.11.220.443
3vf80JETyrosine-protein kinase SYK2.7.10.20.443
4anmWULCasein kinase II subunit alpha2.7.11.10.443
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.443
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
5e8xSTUTGF-beta receptor type-12.7.11.300.443
1ke7LS3Cyclin-dependent kinase 22.7.11.220.442
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.442
1v9aSAHUncharacterized protein/0.442
2iw94SPCyclin-dependent kinase 22.7.11.220.442
2pvlP55Casein kinase II subunit alpha2.7.11.10.442
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3ggpNADPrephenate dehydrogenase/0.442
4iaq2GM5-hydroxytryptamine receptor 1B/0.442
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.442
1aq1STUCyclin-dependent kinase 22.7.11.220.441
1eh4IC1Casein kinase I homolog 12.7.11.10.441
1ke9LS5Cyclin-dependent kinase 22.7.11.220.441
1oiqHDUCyclin-dependent kinase 22.7.11.220.441
1rfvADPPyridoxal kinase2.7.1.350.441
3gubGUBDeath-associated protein kinase 12.7.11.10.441
3zsh469Mitogen-activated protein kinase 14/0.441
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.441
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.441
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.441
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.441
4h3qANPMitogen-activated protein kinase 12.7.11.240.441
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4c62XWWTyrosine-protein kinase JAK2/0.440
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.440
4kbk1QGCasein kinase I isoform delta2.7.11.10.440
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4lrzADPPEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL2.70.440
4wboANWRhodopsin kinase/0.440
5e8ySTUTGF-beta receptor type-22.7.11.300.440