Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3fklFKLMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3fklFKLMitogen-activated protein kinase 14/1.000
3fln3FNMitogen-activated protein kinase 14/0.746
3flwFLWMitogen-activated protein kinase 14/0.697
3fskRO6Mitogen-activated protein kinase 14/0.680
3flyFLYMitogen-activated protein kinase 14/0.668
3flzFLZMitogen-activated protein kinase 14/0.656
3nww3NWMitogen-activated protein kinase 14/0.652
4aa4QC0Mitogen-activated protein kinase 14/0.652
3fmh533Mitogen-activated protein kinase 14/0.648
3iphG11Mitogen-activated protein kinase 14/0.627
4aacAAVMitogen-activated protein kinase 14/0.625
3fmkFMKMitogen-activated protein kinase 14/0.618
4aa5NQBMitogen-activated protein kinase 14/0.618
4kip1R9Mitogen-activated protein kinase 14/0.614
3fi4FI4Mitogen-activated protein kinase 14/0.603
3s4qNK0Mitogen-activated protein kinase 14/0.601
2balPQAMitogen-activated protein kinase 14/0.598
3hl7I47Mitogen-activated protein kinase 14/0.595
4kiq1RAMitogen-activated protein kinase 14/0.595
3u8w09JMitogen-activated protein kinase 14/0.587
3mpt1GKMitogen-activated protein kinase 14/0.586
3dt1P40Mitogen-activated protein kinase 14/0.583
4lopSB4Mitogen-activated protein kinase 14/0.574
4kin1M8Mitogen-activated protein kinase 14/0.572
3ocgOCGMitogen-activated protein kinase 14/0.564
2rg6287Mitogen-activated protein kinase 14/0.561
4looSB4Mitogen-activated protein kinase 14/0.541
3l8xN4DMitogen-activated protein kinase 14/0.539
2rg5279Mitogen-activated protein kinase 14/0.533
3gw9VNILanosterol 14-alpha-demethylase/0.531
3hvcGG5Mitogen-activated protein kinase 14/0.531
3gfeP37Mitogen-activated protein kinase 14/0.529
3hllI45Mitogen-activated protein kinase 14/0.529
2ghlLIBMitogen-activated protein kinase 14/0.528
3flsFLSMitogen-activated protein kinase 14/0.522
3roc29AMitogen-activated protein kinase 14/0.522
3mvl38PMitogen-activated protein kinase 14/0.520
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.519
3uibSB2Putative mitogen-activated protein kinase/0.519
4loqSB4Mitogen-activated protein kinase 14/0.516
3mvm39PMitogen-activated protein kinase 14/0.515
2qd9LGFMitogen-activated protein kinase 14/0.514
4eh60ONMitogen-activated protein kinase 14/0.514
1zz2B11Mitogen-activated protein kinase 14/0.513
1ouk084Mitogen-activated protein kinase 14/0.510
3gc9B45Mitogen-activated protein kinase 112.7.11.240.507
1ywrLI9Mitogen-activated protein kinase 14/0.505
1zrzBI1Protein kinase C iota type2.7.11.130.505
3itzP66Mitogen-activated protein kinase 14/0.503
2zb0GK3Mitogen-activated protein kinase 14/0.501
4nk92K5Fibroblast growth factor receptor 1/0.500
1zyjBI5Mitogen-activated protein kinase 14/0.497
3uvqFS8Mitogen-activated protein kinase 14/0.493
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.491
2qo9ANPEphrin type-A receptor 32.7.10.10.489
3w33W19Epidermal growth factor receptor2.7.10.10.489
4kb81QOCasein kinase I isoform delta2.7.11.10.489
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.488
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.488
3zh8C58Protein kinase C iota type2.7.11.130.488
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.485
4nka2K7Fibroblast growth factor receptor 1/0.484
2y6o1N1Ephrin type-A receptor 42.7.10.10.483
3bv3P39Mitogen-activated protein kinase 14/0.483
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.483
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.481
3fmn530Mitogen-activated protein kinase 14/0.481
3mpaSB2Mitogen-activated protein kinase 14/0.481
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.480
2gfsPQBMitogen-activated protein kinase 14/0.478
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.478
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.478
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.478
1yw2PGJMitogen-activated protein kinase 14/0.477
2vd5BI8Myotonin-protein kinase2.7.11.10.477
4g3jVNTLanosterol 14-alpha-demethylase/0.477
4nks2M2Fibroblast growth factor receptor 1/0.477
4qms1N1Serine/threonine-protein kinase 242.7.11.10.477
3uyt0CKCasein kinase I isoform delta2.7.11.10.475
3w32W32Epidermal growth factor receptor2.7.10.10.474
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.474
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.474
4f650S9Fibroblast growth factor receptor 1/0.474
4g7gVFVLanosterol 14-alpha-demethylase/0.474
4gk2L66Ephrin type-A receptor 32.7.10.10.474
1u4dDBQActivated CDC42 kinase 1/0.473
3wmxNADNAD dependent epimerase/dehydratase/0.473
2itpAEEEpidermal growth factor receptor2.7.10.10.472
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.472
2jedLG8Protein kinase C theta type2.7.11.130.471
4i231C9Epidermal growth factor receptor2.7.10.10.471
4g2fC07Ephrin type-A receptor 32.7.10.10.470
4ic7ANPMitogen-activated protein kinase 72.7.11.240.470
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.469
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.469
3hp552PMitogen-activated protein kinase 14/0.468
3sz0FADSulfide-quinone reductase/0.468
4eh70OOMitogen-activated protein kinase 14/0.468
2zb1GK4Mitogen-activated protein kinase 14/0.466
4qmzB49Serine/threonine-protein kinase 242.7.11.10.466
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.465
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.465
1vjy460TGF-beta receptor type-12.7.11.300.464
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
3atzFMNProstaglandin F2a synthase/0.464
2ittAEEEpidermal growth factor receptor2.7.10.10.463
3poz03PEpidermal growth factor receptor2.7.10.10.463
1bygSTUTyrosine-protein kinase CSK/0.462
2acxANPG protein-coupled receptor kinase 62.7.11.160.462
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
2fgiPD1Fibroblast growth factor receptor 1/0.462
2itnANPEpidermal growth factor receptor2.7.10.10.462
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
1m17AQ4Epidermal growth factor receptor2.7.10.10.461
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.461
3vjoANPEpidermal growth factor receptor2.7.10.10.461
4gk3L87Ephrin type-A receptor 32.7.10.10.461
2itqITQEpidermal growth factor receptor2.7.10.10.460
2wotZZGTGF-beta receptor type-12.7.11.300.460
4c02TAKActivin receptor type-12.7.11.300.460
3gubGUBDeath-associated protein kinase 12.7.11.10.459
4erkOLOMitogen-activated protein kinase 12.7.11.240.459
3b6zCO7Enoyl reductase LovC10.458
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.458
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.457
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
4ewqMWLMitogen-activated protein kinase 14/0.457
4jr3KJREpidermal growth factor receptor2.7.10.10.457
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.457
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.457
1cf3FADGlucose oxidase1.1.3.40.456
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.456
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.456
2of2547Tyrosine-protein kinase Lck2.7.10.20.456
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.456
3d8bADPFidgetin-like protein 13.6.40.456
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.456
1v9aSAHUncharacterized protein/0.455
2qoqANPEphrin type-A receptor 32.7.10.10.455
3vs3VSETyrosine-protein kinase HCK2.7.10.20.455
4yuqKS1Calmodulin-like domain protein kinase/0.455
1gypNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.454
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.454
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.454
3fknFKNMitogen-activated protein kinase 14/0.454
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.454
3qaiXNNKetohexokinase/0.454
4gk4L90Ephrin type-A receptor 32.7.10.10.454
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.453
2gtnLIEMitogen-activated protein kinase 14/0.453
2izrBRKCasein kinase I isoform gamma-32.7.11.10.453
3ac2KSETyrosine-protein kinase Lck2.7.10.20.453
4riyADPEpidermal growth factor receptor2.7.10.10.453
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
3lshFADPyranose 2-oxidase/0.452
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.452
5e8wSTUTGF-beta receptor type-12.7.11.300.452
1gd1NADGlyceraldehyde-3-phosphate dehydrogenase/0.451
1jpaANPEphrin type-B receptor 22.7.10.10.451
2cig1DGDihydrofolate reductase1.5.1.30.451
2eb3ANPEpidermal growth factor receptor2.7.10.10.451
3fmmXI2Mitogen-activated protein kinase 14/0.451
3kf7L9GMitogen-activated protein kinase 14/0.451
3t2zFADSulfide-quinone reductase/0.451
4jq7KJQEpidermal growth factor receptor2.7.10.10.451
1nq5NADGlyceraldehyde-3-phosphate dehydrogenase/0.450
2zazGK1Mitogen-activated protein kinase 14/0.450
3b70NAPEnoyl reductase LovC10.450
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
4nfn2KCTau-tubulin kinase 12.7.11.10.450
4y8wSTRSteroid 21-hydroxylase/0.450
2y5kYCUFructose-1,6-bisphosphatase 13.1.3.110.449
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.449
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.449
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.449
4hjoAQ4Epidermal growth factor receptor2.7.10.10.449
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.448
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.448
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.448
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.448
4jbiNDPAlcohol dehydrogenase (Zinc)/0.448
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.448
1jkx138Phosphoribosylglycinamide formyltransferase/0.447
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2itzIREEpidermal growth factor receptor2.7.10.10.447
2rkvZBATrichothecene 3-O-acetyltransferase/0.447
2vyvNADGlyceraldehyde-3-phosphate dehydrogenase A/0.447
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.447
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.447
4i22IREEpidermal growth factor receptor2.7.10.10.447
4kbk1QGCasein kinase I isoform delta2.7.11.10.447
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.447
1g1aNADdTDP-glucose 4,6-dehydratase/0.446
1ml3NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.446
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.446
1py5PY1TGF-beta receptor type-12.7.11.300.446
1s0xC3SNuclear receptor ROR-alpha/0.446
2g82NADGlyceraldehyde-3-phosphate dehydrogenase/0.446
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
3e5rNADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic1.2.1.120.446
3gu83GUDeath-associated protein kinase 12.7.11.10.446
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.446
3l0lHC3Nuclear receptor ROR-gamma/0.446
3lqfNADGalactitol dehydrogenase/0.446
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.446
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.446
4b8uIBK3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase4.2.1.590.446
4fob0USALK tyrosine kinase receptor2.7.10.10.446
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.446
1k6cMK1Gag-Pol polyprotein3.4.23.160.445
1nqoNADGlyceraldehyde-3-phosphate dehydrogenase/0.445
1ywnLIFVascular endothelial growth factor receptor 22.7.10.10.445
2lbaCHOFatty acid binding protein 6/0.445
2om9AJAPeroxisome proliferator-activated receptor gamma/0.445
2vwx7X4Ephrin type-B receptor 42.7.10.10.445
3gqvNAPEnoyl reductase LovC10.445
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.445
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.445
3qlrNDPDihydrofolate reductase1.5.1.30.445
3uvp048Mitogen-activated protein kinase 14/0.445
3w2sW2REpidermal growth factor receptor2.7.10.10.445
4ambDUDPutative glycosyl transferase/0.445
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.444
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.444
2itwITQEpidermal growth factor receptor2.7.10.10.444
3d7zGK5Mitogen-activated protein kinase 14/0.444
3k9vCPS1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial/0.444
3ksdNADGlyceraldehyde-3-phosphate dehydrogenase 1/0.444
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.444
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.444
3tucFPWTyrosine-protein kinase SYK2.7.10.20.444
4btkDTQTau-tubulin kinase 12.7.11.10.444
4jq8KJ8Epidermal growth factor receptor2.7.10.10.444
4kb81QNCasein kinase I isoform delta2.7.11.10.444
5a3bAPRSIR2 family protein/0.444
1gih1PUCyclin-dependent kinase 22.7.11.220.443
2c475IDCasein kinase I isoform gamma-2/0.443
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.443
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
2vx07X7Ephrin type-B receptor 42.7.10.10.443
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.443
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.443
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.443
3i59N6SCRP-like cAMP-activated global transcriptional regulator/0.443
3iw4LW4Protein kinase C alpha type2.7.11.130.443
3t2kFADSulfide-quinone reductase/0.443
4dymIYZActivin receptor type-12.7.11.300.443
4hnf16WCasein kinase I isoform delta2.7.11.10.443
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.443
1nptNADGlyceraldehyde-3-phosphate dehydrogenase/0.442
2c0cNAPProstaglandin reductase 310.442
2g5cNADPrephenate dehydrogenase/0.442
3ggpNADPrephenate dehydrogenase/0.442
3nbwTR4Ketohexokinase/0.442
3u4cNDPNADPH-dependent reductase BacG/0.442
4g160VMCasein kinase I isoform gamma-32.7.11.10.442
4ipw1G7Mycocyclosin synthase1.14.21.90.442
4yaoFMNNADPH--cytochrome P450 reductase/0.442
1bl6SB6Mitogen-activated protein kinase 14/0.441
1k6pXN3Gag-Pol polyprotein3.4.23.160.441
1yb5NAPQuinone oxidoreductase1.6.5.50.441
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
2ftoCB3Thymidylate synthase/0.441
2yn8STUEphrin type-B receptor 42.7.10.10.441
3bx5304Mitogen-activated protein kinase 14/0.441
3fkoFKOMitogen-activated protein kinase 14/0.441
3gobHXXDdmC/0.441
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.441
4ansVGHALK tyrosine kinase receptor2.7.10.10.441
4id71G0Activated CDC42 kinase 1/0.441
4kbc1QJCasein kinase I isoform delta2.7.11.10.441
1agwSU2Fibroblast growth factor receptor 1/0.440
1idb0DOGag-Pol polyprotein/0.440
1ie3NADMalate dehydrogenase/0.440
1m7qDQOMitogen-activated protein kinase 14/0.440
2xvdAS6Ephrin type-B receptor 42.7.10.10.440
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.440
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.440
4qnaX11Serine/threonine-protein kinase 242.7.11.10.440
5dp2NAPCurF/0.440