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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3anxMTAPolyamine aminopropyltransferase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3anxMTAPolyamine aminopropyltransferase/1.000
3bc3OPTCathepsin L13.4.22.150.507
3oibFDAPutative acyl-CoA dehydrogenase/0.497
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.488
4q73FADBifunctional protein PutA/0.487
4q71FADBifunctional protein PutA/0.483
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.478
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
3t2kFADSulfide-quinone reductase/0.477
1eh4IC1Casein kinase I homolog 12.7.11.10.476
1me6IVSPlasmepsin-23.4.23.390.476
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.476
3d8vUD1Bifunctional protein GlmU/0.475
1hncGDNGlutathione S-transferase Mu 22.5.1.180.472
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.472
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.471
1rm4NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.469
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.469
2vkeTACTetracycline repressor protein class D/0.468
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.467
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.466
2cig1DGDihydrofolate reductase1.5.1.30.465
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.465
3lsiFADPyranose 2-oxidase/0.465
4q72FADBifunctional protein PutA/0.465
2ath3EAPeroxisome proliferator-activated receptor gamma/0.463
4jalSAHtRNA (cytidine(34)-2'-O)-methyltransferase/0.463
1dnpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.461
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.461
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.460
3qlsNDPDihydrofolate reductase1.5.1.30.460
4djhJDCKappa-type opioid receptor/0.460
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
4l9kEHFSerum albumin/0.458
4v2gITCTetracycline repressor protein class D/0.458
1h74AGSHomoserine kinase2.7.1.390.457
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.457
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.457
1ia3TQ5Dihydrofolate reductase1.5.1.30.456
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.456
2p5uNADUDP-glucose 4-epimerase/0.456
2xx91NFGlutamate receptor 2/0.456
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.455
3ijdC2FMethylenetetrahydrofolate reductase/0.455
1drhNAPDihydrofolate reductase1.5.1.30.454
4an2EUIDual specificity mitogen-activated protein kinase kinase 12.7.12.20.454
4an35Y0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.454
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.454
1fm4DXCMajor pollen allergen Bet v 1-L/0.453
3clyACPFibroblast growth factor receptor 2/0.453
3i59N6SCRP-like cAMP-activated global transcriptional regulator/0.453
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.453
1kvkATPMevalonate kinase2.7.1.360.452
1m17AQ4Epidermal growth factor receptor2.7.10.10.452
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
2wotZZGTGF-beta receptor type-12.7.11.300.452
4u03GTPCyclic GMP-AMP synthase/0.452
4y8wSTRSteroid 21-hydroxylase/0.452
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.452
1ay0TPPTransketolase 12.2.1.10.451
2dteNAIGlucose 1-dehydrogenase related protein/0.451
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.451
3k4vROCGag-Pol polyprotein3.4.23.160.451
3zxsFADDeoxyribodipyrimidine photolyase-related protein/0.451
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.451
4j95ACPFibroblast growth factor receptor 2/0.451
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.451
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1x1cSAHC-20 methyltransferase/0.450
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.450
2gmjFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.450
3gw9VNILanosterol 14-alpha-demethylase/0.450
3ii43IIDihydrolipoyl dehydrogenase1.8.1.40.450
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.450
3u4cNDPNADPH-dependent reductase BacG/0.450
4f650S9Fibroblast growth factor receptor 1/0.450
4y95746Tyrosine-protein kinase/0.450
1h1s4SPCyclin-dependent kinase 22.7.11.220.449
1pjkANPCasein kinase II subunit alpha2.7.11.10.449
1w6hTITPlasmepsin-23.4.23.390.449
2ijgFADCryptochrome DASH, chloroplastic/mitochondrial/0.449
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.449
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.449
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.449
3qyw6PBMitogen-activated protein kinase 12.7.11.240.449
4fnzNZFALK tyrosine kinase receptor2.7.10.10.449
4jbqVX6Aurora kinase A2.7.11.10.449
4mwhATPCasein kinase II subunit alpha2.7.11.10.449
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.449
1nvfADPPentafunctional AROM polypeptide/0.448
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.448
2f8lSAMLmo1582 protein/0.448
2iw84SPCyclin-dependent kinase 22.7.11.220.448
2jn3JN3Fatty acid-binding protein, liver/0.448
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.448
3u9eCOALmo1369 protein/0.448
3uwqU5POrotidine 5'-phosphate decarboxylase/0.448
4e5yNDPGDP-L-fucose synthase1.1.1.2710.448
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.448
4nmdFDABifunctional protein PutA/0.448
4obwSAM2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial/0.448
1ai9NDPDihydrofolate reductase1.5.1.30.447
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.447
2am22LGUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.447
2c27ACOMycothiol acetyltransferase2.3.1.1890.447
2x7hPFNProstaglandin reductase 310.447
2zbaZBATrichothecene 3-O-acetyltransferase/0.447
3qlrNDPDihydrofolate reductase1.5.1.30.447
3uteFADUDP-galactopyranose mutase/0.447
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.447
1nzdUPGDNA beta-glucosyltransferase/0.446
1rl8RITGag-Pol polyprotein3.4.23.160.446
1t7j478Gag-Pol polyprotein3.4.23.160.446
2btsU32Cyclin-dependent kinase 22.7.11.220.446
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.446
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.446
4enhFVXCholesterol 24-hydroxylase/0.446
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4z44FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.446
1lf2R37Plasmepsin-23.4.23.390.445
2j5xGSPADP-ribosylation factor 6/0.445
2rkgAB1Pol protein/0.445
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.445
3btsNADGalactose/lactose metabolism regulatory protein GAL80/0.445
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.445
4a6bQG8Gag-Pol polyprotein3.4.23.160.445
4anmWULCasein kinase II subunit alpha2.7.11.10.445
4h3qANPMitogen-activated protein kinase 12.7.11.240.445
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.445
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
5eccNAPDehydrofolate reductase type I/0.445
3sn6P0GBeta-2 adrenergic receptor/0.445
1dz4CAMCamphor 5-monooxygenase1.14.15.10.444
1e3eNAIAlcohol dehydrogenase 41.1.1.10.444
1nzfUPGDNA beta-glucosyltransferase/0.444
1sx4ADP60 kDa chaperonin/0.444
1t85CAMCamphor 5-monooxygenase1.14.15.10.444
1u3cFADCryptochrome-1/0.444
1zdwFLVPrenyltransferase/0.444
2om9AJAPeroxisome proliferator-activated receptor gamma/0.444
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2wq6FADRE11660p/0.444
2y9qANPMitogen-activated protein kinase 12.7.11.240.444
2yyuC5POrotidine 5'-phosphate decarboxylase/0.444
3coy53HPantothenate synthetase6.3.2.10.444
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4f9fGDPPutative glycosyltransferase/0.444
4ly91YYGlucokinase regulatory protein/0.444
4m6jNDPDihydrofolate reductase1.5.1.30.444
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1ia4TQ6Dihydrofolate reductase1.5.1.30.443
1o76CAMCamphor 5-monooxygenase1.14.15.10.443
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.443
2gsdNADFormate dehydrogenase/0.443
3bbrBHYGlutamate receptor 2/0.443
3hazFADBifunctional protein PutA/0.443
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.443
3mdmFJZCholesterol 24-hydroxylase/0.443
3uylTYDProbable NDP-rhamnosyltransferase/0.443
3w32W32Epidermal growth factor receptor2.7.10.10.443
4fi1ATPCasein kinase II subunit alpha2.7.11.10.443
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.443
4u8iFDAUDP-galactopyranose mutase/0.443
4wx1FDAUDP-galactopyranose mutase/0.443
4xgxADPFAD:protein FMN transferase/0.443
1dg8NDPDihydrofolate reductase1.5.1.30.442
1f4fTP3Thymidylate synthase/0.442
1h73ANPHomoserine kinase2.7.1.390.442
1phhFADp-hydroxybenzoate hydroxylase/0.442
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.442
2v7a627Tyrosine-protein kinase ABL12.7.10.20.442
2xrlDXTTetracycline repressor protein class D/0.442
2zdu446Mitogen-activated protein kinase 102.7.11.240.442
3d84NDPDihydrofolate reductase1.5.1.30.442
3eljGS7Mitogen-activated protein kinase 82.7.11.240.442
3ey9TDPPyruvate dehydrogenase [ubiquinone]1.2.5.10.442
3l63CAMCamphor 5-monooxygenase1.14.15.10.442
3r83Z14Cyclin-dependent kinase 22.7.11.220.442
4djr0KJPol polyprotein/0.442
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
1bygSTUTyrosine-protein kinase CSK/0.441
1dr3TAPDihydrofolate reductase1.5.1.30.441
1oiyN41Cyclin-dependent kinase 22.7.11.220.441
1osvCHCBile acid receptor/0.441
1xddAAYIntegrin alpha-L/0.441
2uxuNARHTH-type transcriptional regulator TtgR/0.441
2xa4AZ5Tyrosine-protein kinase JAK2/0.441
3gobHXXDdmC/0.441
3p62FMNPentaerythritol tetranitrate reductase/0.441
3wb2YGPUncharacterized protein MJ0488/0.441
4fmqANPMitogen-activated protein kinase 12.7.11.240.441
4fod0UVALK tyrosine kinase receptor2.7.10.10.441
4h3ySAHtRNA (guanine-N(1)-)-methyltransferase/0.441
4hvh19RTyrosine-protein kinase JAK32.7.10.20.441
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.441
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4mv8ACPBiotin carboxylase6.3.4.140.441
1dhrNADDihydropteridine reductase1.5.1.340.440
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.440
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.440
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.440
2z1mNDPGDP-mannose 4,6-dehydratase/0.440
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.440
3ggaGGWGag-Pol polyprotein/0.440
3p8zSAHGenome polyprotein2.1.1.560.440
3uvqFS8Mitogen-activated protein kinase 14/0.440
3vt8YI3Vitamin D3 receptor/0.440
4a99FADTetX family tetracycline inactivation enzyme/0.440
4njoNADD-3-phosphoglycerate dehydrogenase, putative/0.440