sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.760 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.755 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.720 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.713 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.705 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.705 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.694 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.688 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.684 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.680 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.677 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.676 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.675 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.672 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.671 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.661 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.653 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.652 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.650 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.643 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.634 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.634 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.629 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.628 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.627 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.616 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.615 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.607 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.604 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.597 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.593 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.591 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.588 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.585 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.578 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.575 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.572 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.563 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.556 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.552 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.540 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.532 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.529 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.523 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.515 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.515 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.508 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.494 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.493 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.489 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.487 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.483 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.479 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.475 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.472 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 4nh9 | 2LC | Endoplasmin | / | 0.471 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.470 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.470 | |
| 1qy5 | NEC | Endoplasmin | / | 0.469 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.468 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.466 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.463 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.460 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.457 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.456 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.454 | |
| 3zuy | TCH | Transporter | / | 0.454 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.452 | |
| 2esa | GDM | Endoplasmin | / | 0.452 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.452 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.451 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1sej | F89 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.451 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.451 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.451 | |
| 3q5l | KX2 | Heat shock protein 83-1 | / | 0.450 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.449 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.449 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.449 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.448 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.448 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1r2j | FAD | FkbI | / | 0.447 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.446 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.446 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.446 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.445 | |
| 1eio | GCH | Gastrotropin | / | 0.444 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.444 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 2zdx | P4A | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.444 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.444 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.442 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 1fml | RTL | Retinol dehydratase | / | 0.441 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.440 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.440 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 |