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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2r3r6SCCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2r3r6SCCyclin-dependent kinase 22.7.11.221.000
2r3o2SCCyclin-dependent kinase 22.7.11.220.660
2r3iSCFCyclin-dependent kinase 22.7.11.220.658
2c6iDT1Cyclin-dependent kinase 22.7.11.220.599
2r3gSC9Cyclin-dependent kinase 22.7.11.220.599
4ek816KCyclin-dependent kinase 22.7.11.220.586
2c6mDT5Cyclin-dependent kinase 22.7.11.220.569
4fkt48KCyclin-dependent kinase 22.7.11.220.569
2r3q5SCCyclin-dependent kinase 22.7.11.220.568
3r73X87Cyclin-dependent kinase 22.7.11.220.549
4kd11QKCyclin-dependent kinase 22.7.11.220.549
2c69CT8Cyclin-dependent kinase 22.7.11.220.545
3rni21ZCyclin-dependent kinase 22.7.11.220.545
2r3p3SCCyclin-dependent kinase 22.7.11.220.544
2r3fSC8Cyclin-dependent kinase 22.7.11.220.542
3r8vZ62Cyclin-dependent kinase 22.7.11.220.539
1w8cN69Cyclin-dependent kinase 22.7.11.220.538
2r3mSCXCyclin-dependent kinase 22.7.11.220.537
2w05FRTCyclin-dependent kinase 22.7.11.220.536
3r71X86Cyclin-dependent kinase 22.7.11.220.536
3rahO1ZCyclin-dependent kinase 22.7.11.220.531
3r8pZ46Cyclin-dependent kinase 22.7.11.220.530
3rm719ZCyclin-dependent kinase 22.7.11.220.527
1vyzN5BCyclin-dependent kinase 22.7.11.220.526
2btrU73Cyclin-dependent kinase 22.7.11.220.525
1pxmCK5Cyclin-dependent kinase 22.7.11.220.523
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.521
4fkr45KCyclin-dependent kinase 22.7.11.220.521
2j9mPY8Cyclin-dependent kinase 22.7.11.220.520
3qxpX64Cyclin-dependent kinase 22.7.11.220.516
2r3kSCQCyclin-dependent kinase 22.7.11.220.513
2uzoC62Cyclin-dependent kinase 22.7.11.220.512
3lfqA28Cyclin-dependent kinase 22.7.11.220.512
1ykr628Cyclin-dependent kinase 22.7.11.220.511
3qx2X63Cyclin-dependent kinase 22.7.11.220.511
3sw719KCyclin-dependent kinase 22.7.11.220.511
2uznC96Cyclin-dependent kinase 22.7.11.220.509
3r1yX76Cyclin-dependent kinase 22.7.11.220.509
3raiX85Cyclin-dependent kinase 22.7.11.220.509
4bgh3I6Cyclin-dependent kinase 22.7.11.220.509
2c6o4SPCyclin-dependent kinase 22.7.11.220.508
1w0xOLOCyclin-dependent kinase 22.7.11.220.507
2fvdLIACyclin-dependent kinase 22.7.11.220.507
3lfnA27Cyclin-dependent kinase 22.7.11.220.507
3qqlX03Cyclin-dependent kinase 22.7.11.220.507
3qtrX36Cyclin-dependent kinase 22.7.11.220.507
4ek610KCyclin-dependent kinase 22.7.11.220.507
2bhhRYUCyclin-dependent kinase 22.7.11.220.506
3s2pPMUCyclin-dependent kinase 22.7.11.220.506
3rm618ZCyclin-dependent kinase 22.7.11.220.505
1gih1PUCyclin-dependent kinase 22.7.11.220.504
2vtsLZCCyclin-dependent kinase 22.7.11.220.504
4fkq42KCyclin-dependent kinase 22.7.11.220.504
3qqhX0ACyclin-dependent kinase 22.7.11.220.503
3qwjX6ACyclin-dependent kinase 22.7.11.220.503
3rpo24ZCyclin-dependent kinase 22.7.11.220.503
3r7iX9ICyclin-dependent kinase 22.7.11.220.502
3r7yZ04Cyclin-dependent kinase 22.7.11.220.502
3r9nZ68Cyclin-dependent kinase 22.7.11.220.502
1ke5LS1Cyclin-dependent kinase 22.7.11.220.501
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.501
3qtuX44Cyclin-dependent kinase 22.7.11.220.501
3r9hZ67Cyclin-dependent kinase 22.7.11.220.501
1oitHDTCyclin-dependent kinase 22.7.11.220.500
1y8yCT7Cyclin-dependent kinase 22.7.11.220.500
2w1hL0FCyclin-dependent kinase 22.7.11.220.498
3r8uZ31Cyclin-dependent kinase 22.7.11.220.498
3rpv26ZCyclin-dependent kinase 22.7.11.220.498
3rk909ZCyclin-dependent kinase 22.7.11.220.497
1h0w207Cyclin-dependent kinase 22.7.11.220.496
1ke7LS3Cyclin-dependent kinase 22.7.11.220.496
2r3lSCWCyclin-dependent kinase 22.7.11.220.496
4fko20KCyclin-dependent kinase 22.7.11.220.496
2a4lRRCCyclin-dependent kinase 22.7.11.220.494
3rak03ZCyclin-dependent kinase 22.7.11.220.494
4fx360KCyclin-dependent kinase 22.7.11.220.494
3qruX19Cyclin-dependent kinase 22.7.11.220.493
3r7uX96Cyclin-dependent kinase 22.7.11.220.493
1fvt106Cyclin-dependent kinase 22.7.11.220.492
1h0vUN4Cyclin-dependent kinase 22.7.11.220.491
2r64740Cyclin-dependent kinase 22.7.11.220.491
3qxoX65Cyclin-dependent kinase 22.7.11.220.491
3ral04ZCyclin-dependent kinase 22.7.11.220.491
2a0cCK9Cyclin-dependent kinase 22.7.11.220.490
3qu0X40Cyclin-dependent kinase 22.7.11.220.490
3r28XA0Cyclin-dependent kinase 22.7.11.220.490
1e1xNW1Cyclin-dependent kinase 22.7.11.220.489
3qtzX42Cyclin-dependent kinase 22.7.11.220.489
3ig7EFPCyclin-dependent kinase 22.7.11.220.488
3qtxX43Cyclin-dependent kinase 22.7.11.220.488
1g5sI17Cyclin-dependent kinase 22.7.11.220.487
3r7vZ02Cyclin-dependent kinase 22.7.11.220.487
3sqq99ZCyclin-dependent kinase 22.7.11.220.487
3qqkX02Cyclin-dependent kinase 22.7.11.220.486
3r9dX6BCyclin-dependent kinase 22.7.11.220.486
2c6lDT4Cyclin-dependent kinase 22.7.11.220.485
2r3jSCJCyclin-dependent kinase 22.7.11.220.485
2vttLZDCyclin-dependent kinase 22.7.11.220.484
4fkpLS5Cyclin-dependent kinase 22.7.11.220.484
4fkv61KCyclin-dependent kinase 22.7.11.220.484
3iggEFQCyclin-dependent kinase 22.7.11.220.483
3lfsA07Cyclin-dependent kinase 22.7.11.220.482
3roy22ZCyclin-dependent kinase 22.7.11.220.482
3s1h56ZCyclin-dependent kinase 22.7.11.220.482
2wxvWXVCyclin-dependent kinase 22.7.11.220.481
3r8lZ30Cyclin-dependent kinase 22.7.11.220.481
4eor4SPCyclin-dependent kinase 22.7.11.220.481
2c68CT6Cyclin-dependent kinase 22.7.11.220.480
2w17I19Cyclin-dependent kinase 22.7.11.220.480
3ezvEZVCyclin-dependent kinase 22.7.11.220.480
3r83Z14Cyclin-dependent kinase 22.7.11.220.480
4fkw62KCyclin-dependent kinase 22.7.11.220.480
1ke6LS2Cyclin-dependent kinase 22.7.11.220.479
3rk708ZCyclin-dependent kinase 22.7.11.220.478
1h1s4SPCyclin-dependent kinase 22.7.11.220.477
3qwkX62Cyclin-dependent kinase 22.7.11.220.477
3r6xX84Cyclin-dependent kinase 22.7.11.220.477
1aq1STUCyclin-dependent kinase 22.7.11.220.476
4fks46KCyclin-dependent kinase 22.7.11.220.476
1p2a5BNCyclin-dependent kinase 22.7.11.220.475
2vu3LZECyclin-dependent kinase 22.7.11.220.475
3qtqX35Cyclin-dependent kinase 22.7.11.220.475
3rkb12ZCyclin-dependent kinase 22.7.11.220.475
3sw418KCyclin-dependent kinase 22.7.11.220.475
1pxpCK8Cyclin-dependent kinase 22.7.11.220.473
2b55D31Cyclin-dependent kinase 22.7.11.220.473
4ez30S0Cyclin-dependent kinase 22.7.11.220.472
4fkg4CKCyclin-dependent kinase 22.7.11.220.472
3qzhX69Cyclin-dependent kinase 22.7.11.220.470
1gz8MBPCyclin-dependent kinase 22.7.11.220.469
1ke8LS4Cyclin-dependent kinase 22.7.11.220.469
2x1nX1NCyclin-dependent kinase 22.7.11.220.469
3pj8404Cyclin-dependent kinase 22.7.11.220.469
3qziX72Cyclin-dependent kinase 22.7.11.220.469
4acm7YGCyclin-dependent kinase 22.7.11.220.469
1h1r6CPCyclin-dependent kinase 22.7.11.220.468
3rmf20ZCyclin-dependent kinase 22.7.11.220.468
1ke9LS5Cyclin-dependent kinase 22.7.11.220.467
1y91CT9Cyclin-dependent kinase 22.7.11.220.467
3wblPDYCyclin-dependent kinase 22.7.11.220.467
2c6kDT2Cyclin-dependent kinase 22.7.11.220.466
1v0pPVBCell division control protein 2 homolog2.7.11.220.465
3le62BZCyclin-dependent kinase 22.7.11.220.465
2wpa889Cyclin-dependent kinase 22.7.11.220.463
3rpr25ZCyclin-dependent kinase 22.7.11.220.463
1di8DTQCyclin-dependent kinase 22.7.11.220.462
2b54D05Cyclin-dependent kinase 22.7.11.220.462
2xmyCDKCyclin-dependent kinase 22.7.11.220.462
3pxyJWSCyclin-dependent kinase 22.7.11.220.462
4fki09KCyclin-dependent kinase 22.7.11.220.462
2b52D42Cyclin-dependent kinase 22.7.11.220.461
2iw84SPCyclin-dependent kinase 22.7.11.220.461
3qtsX46Cyclin-dependent kinase 22.7.11.220.461
3qzfX66Cyclin-dependent kinase 22.7.11.220.461
1unlRRCCyclin-dependent-like kinase 52.7.11.10.460
3r1sX73Cyclin-dependent kinase 22.7.11.220.460
1v1k3FPCyclin-dependent kinase 22.7.11.220.459
2wihP48Cyclin-dependent kinase 22.7.11.220.459
3rk507ZCyclin-dependent kinase 22.7.11.220.458
3unk0BYCyclin-dependent kinase 22.7.11.220.458
1oguST8Cyclin-dependent kinase 22.7.11.220.457
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.457
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.456
3ddpRC8Cyclin-dependent kinase 22.7.11.220.456
3rzb02ZCyclin-dependent kinase 22.7.11.220.456
3qqfX07Cyclin-dependent kinase 22.7.11.220.455
2bheBRYCyclin-dependent kinase 22.7.11.220.454
1vyw292Cyclin-dependent kinase 22.7.11.220.453
3ezrEZRCyclin-dependent kinase 22.7.11.220.452
3unj0BXCyclin-dependent kinase 22.7.11.220.452
1gii1PUCyclin-dependent kinase 22.7.11.220.451
3rjc06ZCyclin-dependent kinase 22.7.11.220.451
1ckpPVBCyclin-dependent kinase 22.7.11.220.450
1pxlCK4Cyclin-dependent kinase 22.7.11.220.450
1pxkCK3Cyclin-dependent kinase 22.7.11.220.449
4erwSTUCyclin-dependent kinase 22.7.11.220.449
2w06FRVCyclin-dependent kinase 22.7.11.220.448
4qmpDKISerine/threonine-protein kinase 242.7.11.10.448
3ti1B49Cyclin-dependent kinase 22.7.11.220.447
1pkdUCNCyclin-dependent kinase 22.7.11.220.446
3qtwX3ACyclin-dependent kinase 22.7.11.220.446
1urwI1PCyclin-dependent kinase 22.7.11.220.445
3r1qX75Cyclin-dependent kinase 22.7.11.220.445
4lyn1YGCyclin-dependent kinase 22.7.11.220.445
1fvv107Cyclin-dependent kinase 22.7.11.220.444
2btsU32Cyclin-dependent kinase 22.7.11.220.444
3qzgX67Cyclin-dependent kinase 22.7.11.220.444
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.443
3ddqRRCCyclin-dependent kinase 22.7.11.220.442
3ggfGVDSerine/threonine-protein kinase 26/0.442
3s00Z60Cyclin-dependent kinase 22.7.11.220.442
1pyePM1Cyclin-dependent kinase 22.7.11.220.441
2b53D23Cyclin-dependent kinase 22.7.11.220.441
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.441
3my5RFZCyclin-dependent kinase 22.7.11.220.441
4eok4SPCyclin-dependent kinase 22.7.11.220.441
1oirHDYCyclin-dependent kinase 22.7.11.220.440
3sheI85MAP kinase-activated protein kinase 32.7.11.10.440