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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2r3iSCFCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2r3iSCFCyclin-dependent kinase 22.7.11.221.000
2c6iDT1Cyclin-dependent kinase 22.7.11.220.691
2r3r6SCCyclin-dependent kinase 22.7.11.220.646
2r3q5SCCyclin-dependent kinase 22.7.11.220.640
2r3p3SCCyclin-dependent kinase 22.7.11.220.637
4fkt48KCyclin-dependent kinase 22.7.11.220.637
2r3fSC8Cyclin-dependent kinase 22.7.11.220.636
4ek816KCyclin-dependent kinase 22.7.11.220.634
2r3o2SCCyclin-dependent kinase 22.7.11.220.626
2r3gSC9Cyclin-dependent kinase 22.7.11.220.607
2r3jSCJCyclin-dependent kinase 22.7.11.220.578
4fkr45KCyclin-dependent kinase 22.7.11.220.577
2r3lSCWCyclin-dependent kinase 22.7.11.220.575
3s2pPMUCyclin-dependent kinase 22.7.11.220.574
2r3mSCXCyclin-dependent kinase 22.7.11.220.573
2vtsLZCCyclin-dependent kinase 22.7.11.220.572
2c6kDT2Cyclin-dependent kinase 22.7.11.220.560
1pxjCK2Cyclin-dependent kinase 22.7.11.220.559
2r64740Cyclin-dependent kinase 22.7.11.220.558
2uznC96Cyclin-dependent kinase 22.7.11.220.557
4fko20KCyclin-dependent kinase 22.7.11.220.557
1oitHDTCyclin-dependent kinase 22.7.11.220.555
2btrU73Cyclin-dependent kinase 22.7.11.220.555
1w8cN69Cyclin-dependent kinase 22.7.11.220.554
2vv9IM9Cyclin-dependent kinase 22.7.11.220.554
3r73X87Cyclin-dependent kinase 22.7.11.220.554
3r1yX76Cyclin-dependent kinase 22.7.11.220.552
3r8vZ62Cyclin-dependent kinase 22.7.11.220.552
4fkq42KCyclin-dependent kinase 22.7.11.220.552
2w05FRTCyclin-dependent kinase 22.7.11.220.551
3rni21ZCyclin-dependent kinase 22.7.11.220.551
3r83Z14Cyclin-dependent kinase 22.7.11.220.549
2j9mPY8Cyclin-dependent kinase 22.7.11.220.548
4fks46KCyclin-dependent kinase 22.7.11.220.548
3lfqA28Cyclin-dependent kinase 22.7.11.220.546
1h0vUN4Cyclin-dependent kinase 22.7.11.220.541
1ke7LS3Cyclin-dependent kinase 22.7.11.220.540
4fklCK2Cyclin-dependent kinase 22.7.11.220.540
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.538
3sqq99ZCyclin-dependent kinase 22.7.11.220.538
3sw418KCyclin-dependent kinase 22.7.11.220.538
1ke6LS2Cyclin-dependent kinase 22.7.11.220.536
2a0cCK9Cyclin-dependent kinase 22.7.11.220.536
1gih1PUCyclin-dependent kinase 22.7.11.220.535
2c6mDT5Cyclin-dependent kinase 22.7.11.220.535
2w17I19Cyclin-dependent kinase 22.7.11.220.534
3sw719KCyclin-dependent kinase 22.7.11.220.533
2b54D05Cyclin-dependent kinase 22.7.11.220.532
3qtxX43Cyclin-dependent kinase 22.7.11.220.532
4acm7YGCyclin-dependent kinase 22.7.11.220.532
3qtuX44Cyclin-dependent kinase 22.7.11.220.531
3rpv26ZCyclin-dependent kinase 22.7.11.220.531
1y8yCT7Cyclin-dependent kinase 22.7.11.220.529
4bgh3I6Cyclin-dependent kinase 22.7.11.220.529
2uzoC62Cyclin-dependent kinase 22.7.11.220.528
3qqhX0ACyclin-dependent kinase 22.7.11.220.528
3r71X86Cyclin-dependent kinase 22.7.11.220.528
1g5sI17Cyclin-dependent kinase 22.7.11.220.527
1h0w207Cyclin-dependent kinase 22.7.11.220.526
1w0xOLOCyclin-dependent kinase 22.7.11.220.526
2c6lDT4Cyclin-dependent kinase 22.7.11.220.526
3s1h56ZCyclin-dependent kinase 22.7.11.220.525
3qqfX07Cyclin-dependent kinase 22.7.11.220.524
3qzfX66Cyclin-dependent kinase 22.7.11.220.524
1ykr628Cyclin-dependent kinase 22.7.11.220.523
1pxmCK5Cyclin-dependent kinase 22.7.11.220.522
3qtzX42Cyclin-dependent kinase 22.7.11.220.522
3qzhX69Cyclin-dependent kinase 22.7.11.220.522
3r1sX73Cyclin-dependent kinase 22.7.11.220.522
3rm719ZCyclin-dependent kinase 22.7.11.220.522
3raiX85Cyclin-dependent kinase 22.7.11.220.521
3r7uX96Cyclin-dependent kinase 22.7.11.220.520
3r8lZ30Cyclin-dependent kinase 22.7.11.220.520
3rjc06ZCyclin-dependent kinase 22.7.11.220.520
1urwI1PCyclin-dependent kinase 22.7.11.220.519
3lfnA27Cyclin-dependent kinase 22.7.11.220.519
3pj8404Cyclin-dependent kinase 22.7.11.220.519
3r8uZ31Cyclin-dependent kinase 22.7.11.220.519
3roy22ZCyclin-dependent kinase 22.7.11.220.519
1p2a5BNCyclin-dependent kinase 22.7.11.220.518
2c6o4SPCyclin-dependent kinase 22.7.11.220.516
3r7yZ04Cyclin-dependent kinase 22.7.11.220.516
3pxyJWSCyclin-dependent kinase 22.7.11.220.515
3qxpX64Cyclin-dependent kinase 22.7.11.220.515
2b52D42Cyclin-dependent kinase 22.7.11.220.514
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.514
1pxkCK3Cyclin-dependent kinase 22.7.11.220.513
1pxlCK4Cyclin-dependent kinase 22.7.11.220.511
2fvdLIACyclin-dependent kinase 22.7.11.220.511
4kd11QKCyclin-dependent kinase 22.7.11.220.511
2a4lRRCCyclin-dependent kinase 22.7.11.220.509
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.509
3le62BZCyclin-dependent kinase 22.7.11.220.509
1oguST8Cyclin-dependent kinase 22.7.11.220.508
3rak03ZCyclin-dependent kinase 22.7.11.220.508
1h1s4SPCyclin-dependent kinase 22.7.11.220.506
3rm618ZCyclin-dependent kinase 22.7.11.220.506
2r3kSCQCyclin-dependent kinase 22.7.11.220.505
3rk708ZCyclin-dependent kinase 22.7.11.220.504
3qu0X40Cyclin-dependent kinase 22.7.11.220.503
3qxoX65Cyclin-dependent kinase 22.7.11.220.503
3rk909ZCyclin-dependent kinase 22.7.11.220.503
4fkw62KCyclin-dependent kinase 22.7.11.220.503
3rk507ZCyclin-dependent kinase 22.7.11.220.502
4fkv61KCyclin-dependent kinase 22.7.11.220.502
1vyzN5BCyclin-dependent kinase 22.7.11.220.501
3qx2X63Cyclin-dependent kinase 22.7.11.220.501
4ez30S0Cyclin-dependent kinase 22.7.11.220.501
4fkpLS5Cyclin-dependent kinase 22.7.11.220.501
3r9oZ71Cyclin-dependent kinase 22.7.11.220.500
3s00Z60Cyclin-dependent kinase 22.7.11.220.500
3ezvEZVCyclin-dependent kinase 22.7.11.220.499
4fx360KCyclin-dependent kinase 22.7.11.220.499
1oiqHDUCyclin-dependent kinase 22.7.11.220.498
1di8DTQCyclin-dependent kinase 22.7.11.220.497
2xmyCDKCyclin-dependent kinase 22.7.11.220.497
3r7vZ02Cyclin-dependent kinase 22.7.11.220.497
3r9hZ67Cyclin-dependent kinase 22.7.11.220.497
3rmf20ZCyclin-dependent kinase 22.7.11.220.497
1aq1STUCyclin-dependent kinase 22.7.11.220.495
2w1hL0FCyclin-dependent kinase 22.7.11.220.495
3rahO1ZCyclin-dependent kinase 22.7.11.220.495
2w06FRVCyclin-dependent kinase 22.7.11.220.494
3r9dX6BCyclin-dependent kinase 22.7.11.220.494
1fvt106Cyclin-dependent kinase 22.7.11.220.493
2c69CT8Cyclin-dependent kinase 22.7.11.220.492
2xnbY8LCyclin-dependent kinase 22.7.11.220.492
3r7eX88Cyclin-dependent kinase 22.7.11.220.492
3r7iX9ICyclin-dependent kinase 22.7.11.220.492
4ek610KCyclin-dependent kinase 22.7.11.220.492
2bhhRYUCyclin-dependent kinase 22.7.11.220.491
2c6tDT5Cyclin-dependent kinase 22.7.11.220.491
2vttLZDCyclin-dependent kinase 22.7.11.220.491
2x1nX1NCyclin-dependent kinase 22.7.11.220.491
1pyePM1Cyclin-dependent kinase 22.7.11.220.490
3ral04ZCyclin-dependent kinase 22.7.11.220.490
3ti1B49Cyclin-dependent kinase 22.7.11.220.490
1oiyN41Cyclin-dependent kinase 22.7.11.220.489
3nynSGVG protein-coupled receptor kinase 62.7.11.160.489
3unj0BXCyclin-dependent kinase 22.7.11.220.489
3unk0BYCyclin-dependent kinase 22.7.11.220.489
1pxpCK8Cyclin-dependent kinase 22.7.11.220.486
2iw84SPCyclin-dependent kinase 22.7.11.220.486
1e1xNW1Cyclin-dependent kinase 22.7.11.220.485
1ke5LS1Cyclin-dependent kinase 22.7.11.220.485
1ke9LS5Cyclin-dependent kinase 22.7.11.220.485
2exmZIPCyclin-dependent kinase 22.7.11.220.484
2wihP48Cyclin-dependent kinase 22.7.11.220.484
1oirHDYCyclin-dependent kinase 22.7.11.220.483
2b53D23Cyclin-dependent kinase 22.7.11.220.481
3fz1B98Cyclin-dependent kinase 22.7.11.220.481
1vyw292Cyclin-dependent kinase 22.7.11.220.480
2wpa889Cyclin-dependent kinase 22.7.11.220.480
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.480
3qqlX03Cyclin-dependent kinase 22.7.11.220.480
2vu3LZECyclin-dependent kinase 22.7.11.220.479
3iggEFQCyclin-dependent kinase 22.7.11.220.479
4eor4SPCyclin-dependent kinase 22.7.11.220.479
3ddpRC8Cyclin-dependent kinase 22.7.11.220.478
1unlRRCCyclin-dependent-like kinase 52.7.11.10.477
1v0pPVBCell division control protein 2 homolog2.7.11.220.477
3r28XA0Cyclin-dependent kinase 22.7.11.220.477
2wxvWXVCyclin-dependent kinase 22.7.11.220.476
3qwjX6ACyclin-dependent kinase 22.7.11.220.476
3r1qX75Cyclin-dependent kinase 22.7.11.220.476
3rpo24ZCyclin-dependent kinase 22.7.11.220.476
4lyn1YGCyclin-dependent kinase 22.7.11.220.476
1fvv107Cyclin-dependent kinase 22.7.11.220.475
3uli1N3Cyclin-dependent kinase 22.7.11.220.475
4eok4SPCyclin-dependent kinase 22.7.11.220.475
4erwSTUCyclin-dependent kinase 22.7.11.220.475
1v1k3FPCyclin-dependent kinase 22.7.11.220.474
3qzgX67Cyclin-dependent kinase 22.7.11.220.474
4qmpDKISerine/threonine-protein kinase 242.7.11.10.474
1pxoCK7Cyclin-dependent kinase 22.7.11.220.473
2vthLZ2Cyclin-dependent kinase 22.7.11.220.472
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.471
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.471
3qruX19Cyclin-dependent kinase 22.7.11.220.471
3qwkX62Cyclin-dependent kinase 22.7.11.220.470
4eomATPCyclin-dependent kinase 22.7.11.220.470
3r6xX84Cyclin-dependent kinase 22.7.11.220.468
1y91CT9Cyclin-dependent kinase 22.7.11.220.467
3ddqRRCCyclin-dependent kinase 22.7.11.220.467
3lfsA07Cyclin-dependent kinase 22.7.11.220.467
4fki09KCyclin-dependent kinase 22.7.11.220.467
1h1r6CPCyclin-dependent kinase 22.7.11.220.466
2iw94SPCyclin-dependent kinase 22.7.11.220.466
3qziX72Cyclin-dependent kinase 22.7.11.220.466
4bcmT7ZCyclin-dependent kinase 22.7.11.220.466
1eh4IC1Casein kinase I homolog 12.7.11.10.465
1gii1PUCyclin-dependent kinase 22.7.11.220.465
3ezrEZRCyclin-dependent kinase 22.7.11.220.465
3sheI85MAP kinase-activated protein kinase 32.7.11.10.465
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.463
3py0SU9Cyclin-dependent kinase 22.7.11.220.462
1b39ATPCyclin-dependent kinase 22.7.11.220.461
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.461
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.461
2uzbC75Cyclin-dependent kinase 22.7.11.220.461
3qtrX36Cyclin-dependent kinase 22.7.11.220.461
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.460
1gij2PUCyclin-dependent kinase 22.7.11.220.459
3r8pZ46Cyclin-dependent kinase 22.7.11.220.459
3r9nZ68Cyclin-dependent kinase 22.7.11.220.459
2bheBRYCyclin-dependent kinase 22.7.11.220.458
3r8zZ63Cyclin-dependent kinase 22.7.11.220.458
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.458
1oi9N20Cyclin-dependent kinase 22.7.11.220.457
3s0o50ZCyclin-dependent kinase 22.7.11.220.457
1b38ATPCyclin-dependent kinase 22.7.11.220.456
2c5yMTWCyclin-dependent kinase 22.7.11.220.456
3rzb02ZCyclin-dependent kinase 22.7.11.220.456
3ggfGVDSerine/threonine-protein kinase 26/0.455
3rkb12ZCyclin-dependent kinase 22.7.11.220.454
1ke8LS4Cyclin-dependent kinase 22.7.11.220.453
2btsU32Cyclin-dependent kinase 22.7.11.220.453
1dm2HMDCyclin-dependent kinase 22.7.11.220.452
2b55D31Cyclin-dependent kinase 22.7.11.220.452
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.452
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.451
2c5nCK8Cyclin-dependent kinase 22.7.11.220.451
3i60E86Mitogen-activated protein kinase 12.7.11.240.451
3qtqX35Cyclin-dependent kinase 22.7.11.220.451
2c68CT6Cyclin-dependent kinase 22.7.11.220.450
2uzlC94Cyclin-dependent kinase 22.7.11.220.450
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.450
1ckpPVBCyclin-dependent kinase 22.7.11.220.449
2eufLQQCyclin-dependent kinase 62.7.11.220.448
3qrtX14Cyclin-dependent kinase 22.7.11.220.448
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.448
1e9hINRCyclin-dependent kinase 22.7.11.220.447
3qtsX46Cyclin-dependent kinase 22.7.11.220.447
2uzeC95Cyclin-dependent kinase 22.7.11.220.446
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.446
5cnoANPEpidermal growth factor receptor2.7.10.10.446
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.445
3rpy27ZCyclin-dependent kinase 22.7.11.220.445
2bkzSBCCyclin-dependent kinase 22.7.11.220.444
2uzdC85Cyclin-dependent kinase 22.7.11.220.444
3tnwF18Cyclin-dependent kinase 22.7.11.220.444
4fkg4CKCyclin-dependent kinase 22.7.11.220.444
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.443
2xngA0HAurora kinase A2.7.11.10.443
1xjdSTUProtein kinase C theta type2.7.11.130.442
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.442
4i8zG08Gag-Pol polyprotein3.4.23.160.442
2dwbANPAurora kinase A2.7.11.10.441
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.441
2duv371Cyclin-dependent kinase 22.7.11.220.440
2i40BLZCyclin-dependent kinase 22.7.11.220.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
4bcpT3CCyclin-dependent kinase 22.7.11.220.440
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.440