sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.710 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.676 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.671 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.671 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.670 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.664 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.661 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.656 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.654 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.650 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.644 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.627 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.627 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.627 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.626 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.625 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.624 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.623 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.616 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.612 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.611 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.611 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.610 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.605 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.604 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.599 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.597 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.596 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.594 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.592 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.590 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.589 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.587 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.579 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.578 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.569 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.557 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.556 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.554 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.549 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.544 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.542 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.525 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.522 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.507 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.504 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.503 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.499 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.498 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.497 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.493 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.491 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.491 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.490 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.490 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.490 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.489 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.488 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.487 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.487 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.486 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.486 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.485 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.484 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.482 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.479 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.478 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.477 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.477 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.477 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.477 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.475 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.473 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.473 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.473 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.470 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.469 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.468 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.468 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.467 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.466 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.466 | |
| 1fml | RTL | Retinol dehydratase | / | 0.465 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.465 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.465 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.464 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.463 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.462 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.461 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 5a3c | NAD | SIR2 family protein | / | 0.460 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.459 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.457 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.457 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.456 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.456 | |
| 4h6p | FMN | Chromate reductase | / | 0.456 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.455 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.455 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.455 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.454 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.454 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.453 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.453 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.453 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.452 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.451 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.450 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.450 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.450 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.450 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.450 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.450 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.450 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.449 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.449 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.449 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.449 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.449 | |
| 4jic | FMN | GTN Reductase | / | 0.449 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.448 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.448 | |
| 3eej | 53R | Uncharacterized protein | / | 0.448 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.448 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.447 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.447 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2y3r | TRK | TamL | / | 0.446 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2hmy | SAM | Modification methylase HhaI | 2.1.1.37 | 0.445 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.445 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.445 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.445 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.445 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.445 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.444 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.444 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.444 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.444 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1tv8 | SAM | GTP 3',8-cyclase | 4.1.99.18 | 0.443 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.443 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2wd9 | IBP | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.442 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.442 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.442 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.441 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.441 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.441 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.441 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.440 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.440 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4dja | FAD | (6-4) photolyase | / | 0.440 | |
| 4ewq | MWL | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 |