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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1t40ID5Aldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1t40ID5Aldose reductase1.1.1.211.000
2pdmZSTAldose reductase1.1.1.210.778
1z8962PAldose reductase1.1.1.210.761
2iki388Aldose reductase1.1.1.210.742
1z3n3NAAldose reductase1.1.1.210.732
2dv0ZSTAldose reductase1.1.1.210.703
2ikj393Aldose reductase1.1.1.210.702
2hv5ZSTAldose reductase1.1.1.210.699
3g5eQ74Aldose reductase1.1.1.210.680
2fz9ZSTAldose reductase1.1.1.210.674
2i16LDTAldose reductase1.1.1.210.669
2duxZSTAldose reductase1.1.1.210.662
1t41ID5Aldose reductase1.1.1.210.659
2fz8ZSTAldose reductase1.1.1.210.656
2qxwLDTAldose reductase1.1.1.210.656
3lqlLDTAldose reductase1.1.1.210.653
4gca2X9Aldose reductase1.1.1.210.652
2pdxZSTAldose reductase1.1.1.210.651
3m4h388Aldose reductase1.1.1.210.650
2ikhLITAldose reductase1.1.1.210.646
4yu153NAldose reductase1.1.1.210.645
2pdc393Aldose reductase1.1.1.210.644
3ld5LDTAldose reductase1.1.1.210.639
3lboLDTAldose reductase1.1.1.210.638
3mb9ZSTAldose reductase1.1.1.210.637
2pdu393Aldose reductase1.1.1.210.636
2pdp393Aldose reductase1.1.1.210.635
3ghuLDTAldose reductase1.1.1.210.633
2pdfZSTAldose reductase1.1.1.210.625
2i17LDTAldose reductase1.1.1.210.622
3t423T4Aldose reductase1.1.1.210.622
1pwlBFIAldose reductase1.1.1.210.618
1us0LDTAldose reductase1.1.1.210.614
2pdh47DAldose reductase1.1.1.210.612
2pdbZSTAldose reductase1.1.1.210.611
3ghrLDTAldose reductase1.1.1.210.611
2pzn393Aldose reductase1.1.1.210.610
3lenZSTAldose reductase1.1.1.210.609
3lz5LDTAldose reductase1.1.1.210.605
3m0iZSTAldose reductase1.1.1.210.602
3mc5393Aldose reductase1.1.1.210.602
3m64393Aldose reductase1.1.1.210.601
3ghtLDTAldose reductase1.1.1.210.600
2hvnZSTAldose reductase1.1.1.210.598
2duzZSTAldose reductase1.1.1.210.587
2pdg47DAldose reductase1.1.1.210.582
2pd5ZSTAldose reductase1.1.1.210.578
3ghsLDTAldose reductase1.1.1.210.578
2pdj393Aldose reductase1.1.1.210.572
1ieiZESAldose reductase1.1.1.210.571
2pdiZSTAldose reductase1.1.1.210.571
2pdn47DAldose reductase1.1.1.210.571
2agtFIDAldose reductase1.1.1.210.558
1frbZSTAldose reductase-related protein 2/0.557
2pdq47DAldose reductase1.1.1.210.547
1zuaTOLAldo-keto reductase family 1 member B101.1.10.526
2fzdTOLAldose reductase1.1.1.210.524
1ah3TOLAldose reductase1.1.1.210.523
2pdlTOLAldose reductase1.1.1.210.515
2hvoZSTAldose reductase1.1.1.210.513
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.513
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.508
2pdwFIDAldose reductase1.1.1.210.501
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.496
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.493
4u163C0Muscarinic acetylcholine receptor M3/0.493
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.491
4e0u0MVCyclic dipeptide N-prenyltransferase/0.489
4dbw511Aldo-keto reductase family 1 member C3/0.487
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.484
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.483
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.480
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.480
4phlPILPhosphodiesterase/0.477
2cbqTH2Neocarzinostatin/0.476
2f2kTGGAldose reductase1.1.1.210.476
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.475
3f3y4OABile salt sulfotransferase2.8.2.140.474
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.473
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.472
1yw7A41Methionine aminopeptidase 2/0.470
2iqdLPAAldose reductase1.1.1.210.470
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
1ry0PG2Aldo-keto reductase family 1 member C3/0.469
1ry8RUTAldo-keto reductase family 1 member C3/0.469
1xf0ASDAldo-keto reductase family 1 member C3/0.469
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
1lnmDTXBilin-binding protein/0.468
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.467
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.467
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.466
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.466
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.465
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
2f3815MAldo-keto reductase family 1 member C3/0.465
4li61XOTankyrase-12.4.2.300.465
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.464
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.464
5liu388Aldo-keto reductase family 1 member B101.1.10.464
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
2aouCQAHistamine N-methyltransferase2.1.1.80.462
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.462
3sn6P0GBeta-2 adrenergic receptor/0.462
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.460
2zsdCOAPantothenate kinase2.7.1.330.460
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.460
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
2ea4F79Methionine aminopeptidase 2/0.459
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
3q9bB3NAcetylpolyamine amidohydrolase/0.459
3uweVJJAldo-keto reductase family 1 member C3/0.459
1ekoI84Aldose reductase1.1.1.210.458
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.458
2cmfF11Acetylcholinesterase3.1.1.70.458
2qx7NAPEugenol synthase 11.1.1.3180.458
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4b65NDPL-ornithine N(5)-monooxygenase/0.458
4fam0SZAldo-keto reductase family 1 member C3/0.458
5d5aCAUBeta-2 adrenergic receptor/0.458
2oazI96Methionine aminopeptidase 2/0.457
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1hb1OCVIsopenicillin N synthase1.21.3.10.456
1u65CP0Acetylcholinesterase3.1.1.70.456
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.456
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.456
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.456
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4hmn16JAldo-keto reductase family 1 member C3/0.456
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.455
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.455
5ctoNTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.455
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.454
2aot2PMHistamine N-methyltransferase2.1.1.80.454
2aovC2MHistamine N-methyltransferase2.1.1.80.454
2xuiTZ5Acetylcholinesterase3.1.1.70.454
3abxRCBGlucanase/0.454
3af2ACPPantothenate kinase2.7.1.330.454
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.454
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.454
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.454
4xwtU5PRibonuclease J/0.454
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3b82NADExotoxin A2.4.2.360.453
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.453
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.452
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.452
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3v94WYQPhosphodiesterase/0.452
4dbuBT9Aldo-keto reductase family 1 member C3/0.452
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.451
1tfz8694-hydroxyphenylpyruvate dioxygenase1.13.11.270.451
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.451
4bj9UHBTankyrase-22.4.2.300.451
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
2ckmAA7Acetylcholinesterase3.1.1.70.450
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.450
3pn1IVHDNA ligase/0.450
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.450
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4kmzFOLFolate receptor beta/0.450
4wevSUZAldo-keto reductase family 1 member B101.1.10.450
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1zgcA2EAcetylcholinesterase3.1.1.70.449
2cekN8TAcetylcholinesterase3.1.1.70.449
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.449
2qimZEAClass 10 plant pathogenesis-related protein/0.449
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.449
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
4li81XQTankyrase-12.4.2.300.449
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.447
5a8eXTKBeta-1 adrenergic receptor/0.447
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.446
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.446
2ga2A19Methionine aminopeptidase 2/0.446
3v35NTIAldose reductase1.1.1.210.446
3zoiM2WIsopenicillin N synthase1.21.3.10.446
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.446
1hb3SCVIsopenicillin N synthase1.21.3.10.445
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2jf6S55Strictosidine-O-beta-D-glucosidase3.2.1.1050.445
3elePLPAminotransferase/0.445
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.445
4hcy0YNTransketolase/0.445
4jtrIBPAldo-keto reductase family 1 member C2/0.445
1fmlRTLRetinol dehydratase/0.444
1yw9A84Methionine aminopeptidase 2/0.444
2fzbTOLAldose reductase1.1.1.210.444
2xufTZ4Acetylcholinesterase3.1.1.70.444
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.444
3zkyWT4Isopenicillin N synthase1.21.3.10.444
4bvnP32Beta-1 adrenergic receptor/0.444
4dvi2IWTankyrase-12.4.2.300.444
1q23FUAChloramphenicol acetyltransferase2.3.1.280.443
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
2w6cBM4Acetylcholinesterase3.1.1.70.443
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4bfvZVVPantothenate kinase2.7.1.330.443
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4jq1NPSAldo-keto reductase family 1 member C2/0.443
1blzACVIsopenicillin N synthase1.21.3.10.442
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.442
3gsiTHGDimethylglycine oxidase1.5.3.100.442
4jq3ZOMAldo-keto reductase family 1 member C2/0.442
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.442
1p0pBCHCholinesterase3.1.1.80.441
1ut6A8NAcetylcholinesterase3.1.1.70.441
1x8lOXRRetinol dehydratase/0.441
1zgbA1EAcetylcholinesterase3.1.1.70.441
2bjsACVIsopenicillin N synthase1.21.3.10.441
2jb4A14Isopenicillin N synthase1.21.3.10.441
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.441
3dr4G4MGDP-perosamine synthase/0.441
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.441
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.441
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.441
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4nv10FXFormyl transferase/0.441
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.441
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.441
5bn4ANPV-type ATP synthase alpha chain/0.441
2v0mKLNCytochrome P450 3A4/0.440
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.440
3r8hZOMAldo-keto reductase family 1 member C3/0.440
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.440
4b2gV1NUncharacterized protein/0.440
4dbs0HVAldo-keto reductase family 1 member C3/0.440
4jtrIZPAldo-keto reductase family 1 member C2/0.440