sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1qy8 | RDI | Endoplasmin |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1qy8 | RDI | Endoplasmin | / | 1.000 | |
| 1qy5 | NEC | Endoplasmin | / | 0.630 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.599 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.564 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.560 | |
| 1u0z | RDC | Endoplasmin | / | 0.554 | |
| 1ysz | NEC | Endoplasmin | / | 0.551 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.551 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.551 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.545 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.543 | |
| 1u0y | PA7 | Endoplasmin | / | 0.541 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.540 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.537 | |
| 2gqp | PA7 | Endoplasmin | / | 0.531 | |
| 2hch | N5A | Endoplasmin | / | 0.531 | |
| 2hg1 | N5O | Endoplasmin | / | 0.530 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.530 | |
| 1u2o | NEC | Endoplasmin | / | 0.528 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.525 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.523 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.520 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 2fyp | RDE | Endoplasmin | / | 0.517 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.517 | |
| 2gfd | RDA | Endoplasmin | / | 0.515 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.510 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.507 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.506 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.503 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.503 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.499 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.497 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.497 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.496 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.493 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.490 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 2o1u | ANP | Endoplasmin | / | 0.488 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.488 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.487 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.483 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.482 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.482 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.481 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.479 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.479 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 3t0z | ATP | Heat shock protein HSP 90-alpha | / | 0.477 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.477 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.476 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.474 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.471 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.468 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.468 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.467 | |
| 3q5l | KX2 | Heat shock protein 83-1 | / | 0.467 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.466 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 3ied | AN2 | HSP90 | / | 0.465 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.464 | |
| 2bu8 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.462 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.461 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 2esa | GDM | Endoplasmin | / | 0.459 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.458 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.455 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.454 | |
| 2yi5 | YI5 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.453 | |
| 2o1v | ADP | Endoplasmin | / | 0.452 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.452 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.452 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.451 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.451 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.450 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.450 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 1yt0 | ADP | Endoplasmin | / | 0.448 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.448 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3eof | FMN | Putative oxidase | / | 0.448 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1gjv | AGS | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | 2.7.11.4 | 0.445 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.445 | |
| 2exl | GDM | Endoplasmin | / | 0.444 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.444 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.444 | |
| 2zkj | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.442 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.440 |