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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1fcbFMNCytochrome b2, mitochondrial1.1.2.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1fcbFMNCytochrome b2, mitochondrial1.1.2.31.000
1szfFMNCytochrome b2, mitochondrial1.1.2.30.652
1kbiFMNCytochrome b2, mitochondrial1.1.2.30.640
1szgFNSCytochrome b2, mitochondrial1.1.2.30.623
1kbjFMNCytochrome b2, mitochondrial1.1.2.30.602
1goxFMNPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.564
3giyFMN(S)-mandelate dehydrogenase1.1.99.310.558
5ebuFMNLactate oxidase/0.536
2oz0FMNCytochrome b2, mitochondrial1.1.2.30.535
2e77FMNLactate oxidase/0.526
2j6xFMNLactate oxidase/0.523
2nliFMNLactate oxidase/0.515
4rjeFNRLactate oxidase/0.502
1qcwFNSCytochrome b2, mitochondrial1.1.2.30.497
4yl2FMNLactate oxidase/0.495
4qaiFMNNADPH dehydrogenase/0.486
4m5pFMNNADPH dehydrogenase/0.484
1icqFMN12-oxophytodienoate reductase 11.3.1.420.481
3p62FMNPentaerythritol tetranitrate reductase/0.480
1bwlFMNNADPH dehydrogenase 11.6.99.10.479
1h51FMNPentaerythritol tetranitrate reductase/0.478
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.477
1z44FMNNADPH dehydrogenase/0.476
3tjzGNPADP-ribosylation factor 1/0.476
2gjlFMNNitronate monooxygenase1.13.12.160.474
4df2FMNNADPH dehydrogenase/0.474
1h50FMNPentaerythritol tetranitrate reductase/0.472
2rlcCHDCholoylglycine hydrolase3.5.1.240.472
3enkUPGUDP-glucose 4-epimerase/0.471
1xe55FEPlasmepsin-23.4.23.390.470
4rnwFMNNADPH dehydrogenase 11.6.99.10.468
1vjiFMN12-oxophytodienoate reductase 11.3.1.420.467
4jicFMNGTN Reductase/0.467
2g247IGRenin3.4.23.150.466
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.466
1h63FMNPentaerythritol tetranitrate reductase/0.465
1icpFMN12-oxophytodienoate reductase 11.3.1.420.465
1me6IVSPlasmepsin-23.4.23.390.464
3f03FMNPentaerythritol tetranitrate reductase/0.464
4e2bFMNDehydrogenase/0.464
4loi1YCStimulator of interferon genes protein/0.464
2b53D23Cyclin-dependent kinase 22.7.11.220.463
2gesCOKPantothenate kinase2.7.1.330.463
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.463
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.462
4tmbFMNOld yellow enzyme/0.462
1icsFMN12-oxophytodienoate reductase 11.3.1.420.461
3c1y2BADNA integrity scanning protein DisA/0.461
2ikuLIYRenin3.4.23.150.460
2g1r3IGRenin3.4.23.150.459
2il2LIXRenin3.4.23.150.459
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.459
3p82FMNPentaerythritol tetranitrate reductase/0.459
1bwkFMNNADPH dehydrogenase 11.6.99.10.458
4lcjNADC-terminal-binding protein 2/0.458
3gkaFMNN-ethylmaleimide reductase/0.457
3hf3FMNChromate reductase/0.457
3qe2FMNNADPH--cytochrome P450 reductase/0.457
3rsv3RSBeta-secretase 13.4.23.460.457
3tjlFMNNADPH dehydrogenase/0.456
1xe65FPPlasmepsin-23.4.23.390.455
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.455
3hgrFMN12-oxophytodienoate reductase 11.3.1.420.455
1rneC60Renin3.4.23.150.454
2anb5GPGuanylate kinase2.7.4.80.453
4yaiNAIC alpha-dehydrogenase/0.453
5idwNAPShort-chain dehydrogenase/reductase SDR/0.453
1bil0IURenin3.4.23.150.452
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.452
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.452
1w6hTITPlasmepsin-23.4.23.390.452
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.452
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.452
4egbNADdTDP-glucose 4,6-dehydratase/0.452
3lqfNADGalactitol dehydrogenase/0.451
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
2xtnGTPGTPase IMAP family member 2/0.450
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.450
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.450
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.449
1s20NAD2,3-diketo-L-gulonate reductase1.1.1.1300.448
2ph6712Beta-secretase 13.4.23.460.448
2ztsADPUncharacterized protein/0.448
3hyg099A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.448
3tr05GPGuanylate kinase/0.448
4dbzNDPPutative ketoacyl reductase1.3.10.448
4rnuFMNNADPH dehydrogenase 11.6.99.10.448
4rnvFMNNADPH dehydrogenase 11.6.99.10.448
1mueCDDProthrombin3.4.21.50.447
2du2FMNLactate oxidase/0.447
2qzlIXSBeta-secretase 13.4.23.460.447
4d5gFADCyclohexane-1,2-dione hydrolase3.7.1.110.447
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.447
5cfpC2EStimulator of interferon genes protein/0.447
1mj9COAHistone acetyltransferase ESA1/0.446
2f3rG5PGuanylate kinase2.7.4.80.446
2iibC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.446
2ylxFADPhenylacetone monooxygenase1.14.13.920.446
4blrUTPNTPase P4/0.446
4c13UMLUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase/0.446
4c4oNADSADH/0.446
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.446
4xguADPPutative pachytene checkpoint protein 2/0.446
5e7oMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.446
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.445
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
3gqvNAPEnoyl reductase LovC10.445
3p74FMNPentaerythritol tetranitrate reductase/0.445
1mjbACOHistone acetyltransferase ESA1/0.444
2freFMNNAD(P)H-flavin oxidoreductase/0.444
2oapANPType II secretion system protein (GspE-2)/0.444
2omeNADC-terminal-binding protein 2/0.444
3kruFMNNADH:flavin oxidoreductase/NADH oxidase/0.444
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.444
4yagNAIC alpha-dehydrogenase/0.444
1cdoNADAlcohol dehydrogenase 11.1.1.10.443
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.443
1ma0NADAlcohol dehydrogenase class-31.1.1.10.443
1vyrFMNPentaerythritol tetranitrate reductase/0.443
2gjnFMNNitronate monooxygenase1.13.12.160.443
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.443
3b70NAPEnoyl reductase LovC10.443
3gw9VNILanosterol 14-alpha-demethylase/0.443
3nsh957Beta-secretase 13.4.23.460.443
4i0i957Beta-secretase 13.4.23.460.443
4wsoNADProbable nicotinate-nucleotide adenylyltransferase/0.443
5d3qGDPDynamin-13.6.5.50.443
1udaUFGUDP-glucose 4-epimerase5.1.3.20.442
2cftPLPPyridoxal phosphate phosphatase/0.442
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.442
2z3nPHE_ARG_TYR_LEU_GLYLeucyl/phenylalanyl-tRNA--protein transferase2.3.2.60.442
3sxpNADADP-L-glycero-D-mannoheptose-6-epimerase/0.442
1cf3FADGlucose oxidase1.1.3.40.441
2c20NADUDP-glucose 4-epimerase/0.441
2j07HDFDeoxyribodipyrimidine photo-lyase4.1.99.30.441
3to6LYS_CMCHistone acetyltransferase ESA1/0.441
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.441
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.441
4m83ERYOleandomycin glycosyltransferase2.4.10.441
1dr2TAPDihydrofolate reductase1.5.1.30.440
1f8fNADBenzyl alcohol dehydrogenase/0.440
1xvaSAMGlycine N-methyltransferase2.1.1.200.440
1z41FMNNADPH dehydrogenase/0.440
2g226IGRenin3.4.23.150.440
2q3rFMN12-oxophytodienoate reductase 11.3.1.420.440
2zevIPEGeranylgeranyl pyrophosphate synthase/0.440
3bgxTMPThymidylate synthase/0.440
3d91REMRenin3.4.23.150.440
3ingNDPHomoserine dehydrogenase related protein/0.440
3q44D50M1 family aminopeptidase3.4.110.440
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.440
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.440
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.440
4jtqNAPAldo-keto reductase family 1 member C2/0.440
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.440