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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5kjc NAJ Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.359
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.315
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.301
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.298
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.298
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.297
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.297
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.297
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.295
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.294
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.291
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.262
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.260
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.240
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.238
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.227
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.224
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.219
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.200
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.195
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.191
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.186
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.129
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.113
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 1.109
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.106
1h2b NAJNAD-dependent alcohol dehydrogenase / 1.022
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.993
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.989
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.967
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.951
1yqd NAPSinapyl alcohol dehydrogenase / 0.935
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.924
3jv7 NADSecondary alcohol dehydrogenase / 0.924
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.915
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.910
3two NDPMannitol dehydrogenase / 0.901
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.899
4c4o NADSADH / 0.894
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.881
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.864
3wle NAD(R)-specific carbonyl reductase / 0.860
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.846
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.841
1yqx NAPSinapyl alcohol dehydrogenase / 0.840
1u7h NADPutative ornithine cyclodeaminase / 0.838
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.833
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.831
4rqu NADAlcohol dehydrogenase class-P / 0.831
1x7d NADPutative ornithine cyclodeaminase / 0.818
1uxk NADMalate dehydrogenase / 0.810
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.807
1gv0 NADMalate dehydrogenase / 0.806
2voj NADAlanine dehydrogenase 1.4.1.1 0.798
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.797
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.794
1uxj NADMalate dehydrogenase / 0.792
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.788
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.782
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.780
2vhx NADAlanine dehydrogenase 1.4.1.1 0.777
4cpd NADAlcohol dehydrogenase / 0.776
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.775
4oaq NDPR-specific carbonyl reductase / 0.774
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.774
4j43 NADUncharacterized protein / 0.768
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.767
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.767
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.765
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.763
1pzh NADLactate dehydrogenase / 0.762
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.760
3wsw NADL-lactate dehydrogenase / 0.759
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.759
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.752
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.752
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.751
4jk3 NADUncharacterized protein / 0.751
4l0q NADAlcohol dehydrogenase class-3 / 0.751
4b7x NAPProbable oxidoreductase / 0.748
1o6z NADMalate dehydrogenase / 0.746
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.745
4i1i NADMalate dehydrogenase / 0.745
4ejm NAPPutative zinc-binding dehydrogenase / 0.744
4xqc NADHomospermidine synthase 2.5.1.44 0.741
4jji NADAlcohol dehydrogenase class-3 / 0.740
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.739
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.739
1pjc NADAlanine dehydrogenase / 0.737
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.737
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.737
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.736
4j49 NADUncharacterized protein / 0.736
3uko NADAlcohol dehydrogenase class-3 / 0.732
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.729
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.726
4xrg NADHomospermidine synthase 2.5.1.44 0.726
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.725
1ib6 NADMalate dehydrogenase / 0.724
2dph NADFormaldehyde dismutase / 0.724
2o4c NADErythronate-4-phosphate dehydrogenase / 0.724
1llu NADAlcohol dehydrogenase / 0.722
2x0i NAIMalate dehydrogenase / 0.722
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.721
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.721
3wfj NAD2-dehydropantoate 2-reductase / 0.720
1ur5 NADMalate dehydrogenase / 0.719
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.719
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.717
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.716
2y05 NAPProstaglandin reductase 1 / 0.715
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.715
3ggo NAIPrephenate dehydrogenase / 0.713
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.711
1wze NADMalate dehydrogenase / 0.711
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.711
1ie3 NADMalate dehydrogenase / 0.710
2ejv NADL-threonine 3-dehydrogenase / 0.710
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.710
2vwh NAPGlucose 1-dehydrogenase / 0.708
2xaa NADSecondary alcohol dehydrogenase / 0.708
1b8v NADMalate dehydrogenase / 0.707
1guy NADMalate dehydrogenase / 0.705
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.705
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.705
1c1d NAIPhenylalanine dehydrogenase / 0.704
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.704
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.704
4j49 NAIUncharacterized protein / 0.704
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.703
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.703
2aa3 AP0L-lactate dehydrogenase / 0.702
1sow NADL-lactate dehydrogenase 1.1.1.27 0.700
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.699
4k28 NADShikimate dehydrogenase family protein / 0.699
2fkn NADUrocanate hydratase 4.2.1.49 0.697
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.696
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.696
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.696
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.693
3abi NADUncharacterized protein / 0.693
3oet NADErythronate-4-phosphate dehydrogenase / 0.692
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.691
2v7g NADUrocanate hydratase 4.2.1.49 0.690
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.689
2x0r NADMalate dehydrogenase / 0.688
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.687
4tvb NADHomospermidine synthase 2.5.1.44 0.687
1up6 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.685
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.684
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.684
4j4b NAIUncharacterized protein / 0.684
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.683
1xag NAD3-dehydroquinate synthase / 0.683
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.683
1f8f NADBenzyl alcohol dehydrogenase / 0.682
3ikt NADRedox-sensing transcriptional repressor Rex / 0.681
5a04 NDPGlucose-fructose oxidoreductase / 0.681
2cda NAPGlucose 1-dehydrogenase / 0.680
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.678
3q2k NAIProbable oxidoreductase / 0.677
3tqh NDPQuinone oxidoreductase / 0.677
1b8u NADMalate dehydrogenase / 0.676
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.675
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.675
3x2f NAIAdenosylhomocysteinase / 0.675
3kb6 NADD-lactate dehydrogenase / 0.674
3bts NADGalactose/lactose metabolism regulatory protein GAL80 / 0.673
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.672
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.672
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.672
2dbz NAPGlyoxylate reductase 1.1.1.26 0.672
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.672
1bdm NAXMalate dehydrogenase / 0.671
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.671
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.671
1obb NADAlpha-glucosidase 3.2.1.20 0.670
4hwk NAPSepiapterin reductase 1.1.1.153 0.670
3d64 NADAdenosylhomocysteinase / 0.669
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.669
3wid NAPGlucose 1-dehydrogenase / 0.669
4ros APRMalate dehydrogenase / 0.669
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.667
1e3e NAIAlcohol dehydrogenase 4 1.1.1.1 0.665
1xq6 NAPUncharacterized protein At5g02240 / 0.665
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.664
3ggp NADPrephenate dehydrogenase / 0.664
4hnh NAPNAD-dependent epimerase/dehydratase / 0.663
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.662
2c29 NAPDihydroflavonol 4-reductase / 0.662
2cdc NAPGlucose 1-dehydrogenase / 0.662
1o0s NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.661
1rpn NDPGDP-mannose 4,6-dehydratase / 0.661
2g5c NADPrephenate dehydrogenase / 0.661
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.661
3keo NADRedox-sensing transcriptional repressor Rex / 0.661
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.661
4emi NADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.661
2yvg NADFerredoxin reductase / 0.660
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.659
2b5v NAPGlucose 1-dehydrogenase / 0.659
2gsd NADFormate dehydrogenase / 0.659
3f3s NADLambda-crystallin homolog / 0.659
4a1o AMZBifunctional purine biosynthesis protein PurH 2.1.2.3 0.658
2v92 ATP5'-AMP-activated protein kinase subunit gamma-1 / 0.657
3h4v NAPPteridine reductase 1 1.5.1.33 0.657
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.657
1bw9 NADPhenylalanine dehydrogenase / 0.656
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.656
4weq NAPNAD-dependent dehydrogenase / 0.656
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.655
1pzf A3DLactate dehydrogenase / 0.655
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.655
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.655
3gvh NADMalate dehydrogenase / 0.655
1bmd NADMalate dehydrogenase / 0.654
1hku NADC-terminal-binding protein 1 1.1.1 0.653
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.653
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.653
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.653
4ydd MGDDMSO reductase family type II enzyme, molybdopterin subunit / 0.652
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.652
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.651
1n7h GDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.651
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.651
2dfv NADL-threonine 3-dehydrogenase / 0.651
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.651
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.651
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.650
3fwr ADPTranscriptional repressor CcpN / 0.650
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.650