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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5kcp NAJ Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.357
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.321
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.321
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.321
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.320
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.320
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.320
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.320
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.319
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.319
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.319
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.319
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.318
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.315
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.298
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.285
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.276
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.274
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.261
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.261
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.251
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.247
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.233
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.215
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.207
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.203
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.194
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.192
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.173
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.136
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 1.099
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.073
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.955
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.941
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.936
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.923
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.914
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.909
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.905
1yqd NAPSinapyl alcohol dehydrogenase / 0.903
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.902
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.892
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.870
4c4o NADSADH / 0.868
2xaa NADSecondary alcohol dehydrogenase / 0.865
3jv7 NADSecondary alcohol dehydrogenase / 0.862
3two NDPMannitol dehydrogenase / 0.862
4rqu NADAlcohol dehydrogenase class-P / 0.857
4oaq NDPR-specific carbonyl reductase / 0.851
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.847
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.845
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.839
1yqx NAPSinapyl alcohol dehydrogenase / 0.831
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.827
4cpd NADAlcohol dehydrogenase / 0.825
1uxk NADMalate dehydrogenase / 0.824
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.823
3wle NAD(R)-specific carbonyl reductase / 0.814
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.813
1gv0 NADMalate dehydrogenase / 0.805
1u7h NADPutative ornithine cyclodeaminase / 0.805
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.805
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.804
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.799
1uxj NADMalate dehydrogenase / 0.797
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.797
1o6z NADMalate dehydrogenase / 0.795
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.787
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.787
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.774
4jji NADAlcohol dehydrogenase class-3 / 0.774
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.766
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.763
4l0q NADAlcohol dehydrogenase class-3 / 0.763
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.761
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.758
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.755
4i1i NADMalate dehydrogenase / 0.755
4jk3 NADUncharacterized protein / 0.754
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.751
4ejm NAPPutative zinc-binding dehydrogenase / 0.749
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.748
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.743
4b7x NAPProbable oxidoreductase / 0.742
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.741
2o4c NADErythronate-4-phosphate dehydrogenase / 0.740
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.739
4gl4 NAIAlcohol dehydrogenase class-3 / 0.739
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.738
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.736
4j49 NADUncharacterized protein / 0.736
1ur5 NADMalate dehydrogenase / 0.734
4j43 NADUncharacterized protein / 0.734
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.732
1llu NADAlcohol dehydrogenase / 0.729
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.728
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.727
1x7d NADPutative ornithine cyclodeaminase / 0.724
1pzh NADLactate dehydrogenase / 0.723
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.722
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.722
2dph NADFormaldehyde dismutase / 0.722
3uko NADAlcohol dehydrogenase class-3 / 0.722
3wsw NADL-lactate dehydrogenase / 0.722
4plp NADHomospermidine synthase 2.5.1.44 0.722
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.721
2voj NADAlanine dehydrogenase 1.4.1.1 0.719
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.719
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.717
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.716
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.715
4xq9 NADHomospermidine synthase 2.5.1.44 0.715
2y05 NAPProstaglandin reductase 1 / 0.714
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.713
3wfj NAD2-dehydropantoate 2-reductase / 0.712
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.711
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.711
1wze NADMalate dehydrogenase / 0.709
2vhx NADAlanine dehydrogenase 1.4.1.1 0.709
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.706
1b8v NADMalate dehydrogenase / 0.705
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.705
3oet NADErythronate-4-phosphate dehydrogenase / 0.705
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.704
4xrg NADHomospermidine synthase 2.5.1.44 0.704
4k28 NADShikimate dehydrogenase family protein / 0.703
1up6 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.701
2ejv NADL-threonine 3-dehydrogenase / 0.700
1ie3 NADMalate dehydrogenase / 0.698
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.696
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.695
1pjc NADAlanine dehydrogenase / 0.694
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.692
3abi NADUncharacterized protein / 0.692
2x0i NAIMalate dehydrogenase / 0.691
4xqc NADHomospermidine synthase 2.5.1.44 0.691
2aa3 AP0L-lactate dehydrogenase / 0.690
1c1d NAIPhenylalanine dehydrogenase / 0.689
4tvb NADHomospermidine synthase 2.5.1.44 0.689
2vwh NAPGlucose 1-dehydrogenase / 0.688
4j4b NAIUncharacterized protein / 0.688
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.688
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.687
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.687
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.685
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.684
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.683
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.682
3x2f NAIAdenosylhomocysteinase / 0.680
1b8u NADMalate dehydrogenase / 0.679
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.679
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.679
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.678
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.677
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.677
2fkn NADUrocanate hydratase 4.2.1.49 0.676
2x0r NADMalate dehydrogenase / 0.676
4y0k NAPAntE / 0.676
2cda NAPGlucose 1-dehydrogenase / 0.675
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.674
3hl0 NADMaleylacetate reductase / 0.674
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.672
1i3l NADUDP-glucose 4-epimerase / 0.672
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.672
3kb6 NADD-lactate dehydrogenase / 0.672
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.672
1sow NADL-lactate dehydrogenase 1.1.1.27 0.671
3f3s NADLambda-crystallin homolog / 0.671
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.671
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.671
2d8a NADL-threonine 3-dehydrogenase / 0.670
1emd NADMalate dehydrogenase / 0.669
3q2k NAIProbable oxidoreductase / 0.669
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.667
1ib6 NADMalate dehydrogenase / 0.667
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.667
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.667
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.667
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.667
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.667
4yag NAIC alpha-dehydrogenase / 0.666
3d64 NADAdenosylhomocysteinase / 0.665
5a04 NDPGlucose-fructose oxidoreductase / 0.665
3pqf NADL-lactate dehydrogenase 1.1.1.27 0.664
4ros APRMalate dehydrogenase / 0.664
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.663
2cdc NAPGlucose 1-dehydrogenase / 0.663
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.663
1f8f NADBenzyl alcohol dehydrogenase / 0.662
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.662
2rir NAPDipicolinate synthase subunit A / 0.662
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.661
3wid NAPGlucose 1-dehydrogenase / 0.661
2g5c NADPrephenate dehydrogenase / 0.660
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.659
4j49 NAIUncharacterized protein / 0.659
2b5v NAPGlucose 1-dehydrogenase / 0.658
1e5q NDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming] 1.5.1.10 0.657
1pzg A3DLactate dehydrogenase / 0.657
3ggp NADPrephenate dehydrogenase / 0.657
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.657
5jy1 NADPutative short-chain dehydrogenase/reductase / 0.657
3ikt NADRedox-sensing transcriptional repressor Rex / 0.656
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.656
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.656
3keo NADRedox-sensing transcriptional repressor Rex / 0.655
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.655
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.654
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.654
4weq NAPNAD-dependent dehydrogenase / 0.654
5br7 FADUDP-galactopyranose mutase / 0.654
1hku NADC-terminal-binding protein 1 1.1.1 0.653
2yvg NADFerredoxin reductase / 0.653
3l4s NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.653
3ec7 NADInositol 2-dehydrogenase / 0.652
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.652
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.651
3tqh NDPQuinone oxidoreductase / 0.651
5a1t NAIL-lactate dehydrogenase / 0.651
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.650
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.650
4hnh NAPNAD-dependent epimerase/dehydratase / 0.650
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.650
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.650