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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ap3 FAD Steroid monooxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ap3 FADSteroid monooxygenase / 1.265
4aos FADSteroid monooxygenase / 1.141
4aox FADSteroid monooxygenase / 1.009
4ap1 FADSteroid monooxygenase / 1.002
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.819
2gv8 FADThiol-specific monooxygenase 1.14.13 0.818
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.813
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.813
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.809
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.803
3gwf FADCyclohexanone monooxygenase / 0.793
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.782
2gvc FADThiol-specific monooxygenase 1.14.13 0.780
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.780
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.766
4mok FADPyranose 2-oxidase / 0.766
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.764
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.752
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.750
3pl8 FADPyranose 2-oxidase / 0.750
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.749
3gwd FADCyclohexanone monooxygenase / 0.749
1get FADGlutathione reductase 1.8.1.7 0.746
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.744
2ign FADPyranose 2-oxidase / 0.738
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.728
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.728
4usr FADMonooxygenase / 0.727
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.726
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.723
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.723
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.723
3k30 ADPHistamine dehydrogenase / 0.721
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.718
4tm3 FADKtzI / 0.717
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.717
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.716
2yg7 FADPutrescine oxidase / 0.715
4tlz FADKtzI / 0.714
4d7e FADPutative lysine-N-oxygenase / 0.709
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.708
3lsh FADPyranose 2-oxidase / 0.707
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.706
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.706
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.706
3mj4 FADUDP-galactopyranose mutase / 0.703
3lsi FADPyranose 2-oxidase / 0.702
2yqu FADDihydrolipoyl dehydrogenase / 0.701
1qo8 FADFumarate reductase flavoprotein subunit / 0.700
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.699
2tpr FADTrypanothione reductase 1.8.1.12 0.697
3k4c FADPyranose 2-oxidase / 0.697
4gcm FADThioredoxin reductase 1.8.1.9 0.696
4gut FADLysine-specific histone demethylase 1B 1 0.696
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.695
4cnk FADL-amino acid oxidase / 0.695
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.695
5hxw FADL-amino acid deaminase / 0.695
2x3n FADProbable FAD-dependent monooxygenase / 0.694
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.693
2jk6 FADTrypanothione reductase / 0.693
5br7 FADUDP-galactopyranose mutase / 0.693
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.692
2eq6 FADDihydrolipoyl dehydrogenase / 0.692
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.690
3urh FADDihydrolipoyl dehydrogenase / 0.690
4b68 FADL-ornithine N(5)-monooxygenase / 0.689
4nzh FADL-ornithine N(5)-monooxygenase / 0.689
2xvf FADPutative flavin-containing monooxygenase / 0.688
1bzl FADTrypanothione reductase 1.8.1.12 0.687
2b9y FADPutative aminooxidase / 0.686
3kve FADL-amino-acid oxidase / 0.686
4b65 FADL-ornithine N(5)-monooxygenase / 0.686
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.685
4jq9 FADDihydrolipoyl dehydrogenase / 0.685
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.685
2cul FADGidA-related protein / 0.684
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.684
2yg3 FADPutrescine oxidase / 0.683
2yg4 FADPutrescine oxidase / 0.682
4fwf FADLysine-specific histone demethylase 1B 1 0.682
3cty FADProbable thioredoxin reductase / 0.681
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.681
4mih FADPyranose 2-oxidase 1.1.3.10 0.681
4z24 FADPutative GMC-type oxidoreductase R135 1 0.681
2igo FADPyranose 2-oxidase / 0.680
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.678
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.678
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.678
4j57 FADThioredoxin reductase 2 1.8.1.9 0.678
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.677
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.676
3lsm SFDPyranose 2-oxidase / 0.676
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.676
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.674
4la1 FADThioredoxin glutathione reductase / 0.674
2r9z FADGlutathione amide reductase / 0.673
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.673
3t37 FADPyridoxine 4-oxidase / 0.673
4hb9 FADUncharacterized protein / 0.673
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.672
1yy5 FADPolyamine oxidase FMS1 / 0.672
4c3x FAD3-ketosteroid dehydrogenase / 0.672
4yac NAIC alpha-dehydrogenase / 0.672
1f8r FADL-amino-acid oxidase 1.4.3.2 0.671
4fwe FADLysine-specific histone demethylase 1B 1 0.671
4tm4 FDAKtzI / 0.671
1nhq FADNADH peroxidase 1.11.1.1 0.670
2q7v FADThioredoxin reductase / 0.670
2wba FADTrypanothione reductase 1.8.1.12 0.670
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.670
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.670
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.669
2dw4 FADLysine-specific histone demethylase 1A 1 0.669
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.669
2xvh FADPutative flavin-containing monooxygenase / 0.669
2eq7 NADDihydrolipoyl dehydrogenase / 0.668
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.668
4fwj FADLysine-specific histone demethylase 1B 1 0.668
1joa FADNADH peroxidase 1.11.1.1 0.667
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.667
2q0l FADThioredoxin reductase 1.8.1.9 0.667
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.666
2vqb FADPutative flavin-containing monooxygenase / 0.666
3f8p NADNADH oxidase/thioredoxin reductase / 0.666
4gur FADLysine-specific histone demethylase 1B 1 0.666
4qi5 FADCellobiose dehydrogenase / 0.666
2xvi FADPutative flavin-containing monooxygenase / 0.665
3he3 FADUDP-galactopyranose mutase / 0.665
4hsu FADLysine-specific histone demethylase 1B 1 0.665
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.664
1npx FADNADH peroxidase 1.11.1.1 0.663
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.663
1fea FADTrypanothione reductase 1.8.1.12 0.662
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.662
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.662
2eq8 FADDihydrolipoyl dehydrogenase / 0.662
3f8d FADNADH oxidase/thioredoxin reductase / 0.662
4b69 FADL-ornithine N(5)-monooxygenase / 0.662
4ysh FADGlycine oxidase / 0.661
1ojt FADDihydrolipoyl dehydrogenase / 0.660
2hko FADLysine-specific histone demethylase 1A 1 0.660
3icr FADCoenzyme A disulfide reductase / 0.660
3rfx NADUronate dehydrogenase / 0.660
4dna FADProbable glutathione reductase / 0.660
4qi7 FADCellobiose dehydrogenase / 0.660
1nhr FADNADH peroxidase 1.11.1.1 0.659
4b63 FADL-ornithine N(5)-monooxygenase / 0.659
1ges FADGlutathione reductase 1.8.1.7 0.658
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.658
1y56 ATPUncharacterized protein / 0.658
5cku FADL-ornithine N(5)-monooxygenase / 0.658
4cnj FADL-amino acid oxidase / 0.657
1f8s FADL-amino-acid oxidase 1.4.3.2 0.656
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.656
2bab FADPutative aminooxidase / 0.655
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.655
3q9t FAYUncharacterized protein / 0.655
1nhp FADNADH peroxidase 1.11.1.1 0.654
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.654
3hdy FADUDP-galactopyranose mutase / 0.654
2iid FADL-amino-acid oxidase 1.4.3.2 0.653
2xls FADPutative flavin-containing monooxygenase / 0.653
3sz0 FADSulfide-quinone reductase / 0.651
1fec FADTrypanothione reductase 1.8.1.12 0.650
2hqm FADGlutathione reductase 1.8.1.7 0.650
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.650