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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2aqj FAD Flavin-dependent tryptophan halogenase PrnA 1.14.19.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2aqj FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 1.437
2ar8 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 1.326
4z44 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 1.228
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 1.226
2wes FADTryptophan 5-halogenase / 1.127
2jkc FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 1.085
2wet FADTryptophan 5-halogenase / 0.988
4z43 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.973
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.940
5hy5 FADTryptophan 6-halogenase / 0.816
2oal FADFlavin-dependent tryptophan halogenase RebH 1.14.19.9 0.786
3cuk FADD-amino-acid oxidase 1.4.3.3 0.780
2oa1 FADFlavin-dependent tryptophan halogenase RebH 1.14.19.9 0.760
2du8 FADD-amino-acid oxidase 1.4.3.3 0.749
1c0l FADD-amino-acid oxidase 1.4.3.3 0.735
1c0k FADD-amino-acid oxidase 1.4.3.3 0.719
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.702
3f8p NADNADH oxidase/thioredoxin reductase / 0.699
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.696
5i39 FADL-amino acid deaminase / 0.691
1kif FADD-amino-acid oxidase 1.4.3.3 0.690
3axb FADPutative oxidoreductase / 0.687
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.686
3ka7 FADPutative oxidoreductase / 0.685
4j57 FADThioredoxin reductase 2 1.8.1.9 0.685
3cnt FADPolyamine oxidase FMS1 / 0.681
4wqm FADToluene-4-monooxygenase electron transfer component 1.18.1.3 0.680
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.679
3vqr FADPutative oxidoreductase / 0.678
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.675
5j60 FADThioredoxin reductase / 0.674
1y56 ATPUncharacterized protein / 0.672
3utg FDAUDP-galactopyranose mutase / 0.672
1gaw FADFerredoxin / 0.671
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.671
1fnc FDAFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.670
3nlc FADUncharacterized protein / 0.670
2iid FADL-amino-acid oxidase 1.4.3.2 0.669
2wp5 FADTrypanothione reductase / 0.669
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.669
4yac NAIC alpha-dehydrogenase / 0.669
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.668
2e48 FADD-amino-acid oxidase 1.4.3.3 0.668
1i0s FMNFerric-chelate reductase (NAD(P)H) / 0.666
1q1r FADPutidaredoxin reductase 1.18.1.5 0.666
1ryi FADGlycine oxidase 1.4.3.19 0.666
2yg3 FADPutrescine oxidase / 0.666
3f8r NAPNADH oxidase/thioredoxin reductase / 0.666
1kf6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.664
4u8k FDAUDP-galactopyranose mutase / 0.664
4z24 FADPutative GMC-type oxidoreductase R135 1 0.664
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.664
1ger FADGlutathione reductase 1.8.1.7 0.663
4f07 FADStyrene monooxygenase component 2 / 0.663
4u8i FDAUDP-galactopyranose mutase / 0.663
4u8o FDAUDP-galactopyranose mutase / 0.663
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.663
1get FADGlutathione reductase 1.8.1.7 0.662
2hqm FADGlutathione reductase 1.8.1.7 0.662
2wow FADTrypanothione reductase / 0.661
3if9 FADGlycine oxidase 1.4.3.19 0.661
3lov FADProtoporphyrinogen oxidase / 0.661
1fec FADTrypanothione reductase 1.8.1.12 0.660
1gxf FADTrypanothione reductase 1.8.1.12 0.660
4x9n FADUncharacterized protein MG039 homolog / 0.660
1fnb FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.659
3qfc FADNADPH--cytochrome P450 reductase / 0.659
3qfr FADNADPH--cytochrome P450 reductase / 0.659
3qj4 FADRenalase / 0.659
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.659
3qe2 FADNADPH--cytochrome P450 reductase / 0.658
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.658
3atr FDAConserved Archaeal protein / 0.657
3k4c FADPyranose 2-oxidase / 0.657
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.657
3v76 FDAUncharacterized protein / 0.657
4opi FDAConserved Archaeal protein / 0.657
4tm0 NAPKtzI / 0.657
2yvf FADFerredoxin reductase / 0.656
3uth FDAUDP-galactopyranose mutase / 0.656
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.655
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.655
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.655
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.655
4i58 FADCyclohexylamine Oxidase / 0.655
1bx1 FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.654
1fnd FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.654
4cnj FADL-amino acid oxidase / 0.654
2r0c FADPutative FAD-monooxygenase / 0.653
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.653
3fpk FADFerredoxin-NADP reductase / 0.653
3k30 ADPHistamine dehydrogenase / 0.653
4u8j FDAUDP-galactopyranose mutase / 0.653
4xbf FADLysine-specific histone demethylase 1A 1 0.653
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.652
3fpz AHZThiamine thiazole synthase / 0.652
3pl8 FADPyranose 2-oxidase / 0.652
4wx1 FDAUDP-galactopyranose mutase / 0.652
2e1m FADL-glutamate oxidase / 0.651
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.651
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.651
4c3x FAD3-ketosteroid dehydrogenase / 0.651
4k5r FADOxygenase / 0.651
2qa1 FADPgaE / 0.650
4yau FADNADPH--cytochrome P450 reductase / 0.650