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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1lld NAD L-lactate dehydrogenase 2 1.1.1.27

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1lld NADL-lactate dehydrogenase 2 1.1.1.27 1.087
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.851
1uxj NADMalate dehydrogenase / 0.845
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.819
1uxk NADMalate dehydrogenase / 0.805
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.798
4jk3 NADUncharacterized protein / 0.797
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.792
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.786
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.784
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.781
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.780
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.780
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.778
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.776
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.776
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.774
4j49 NADUncharacterized protein / 0.772
1ib6 NADMalate dehydrogenase / 0.768
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.768
1o6z NADMalate dehydrogenase / 0.761
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.758
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.757
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.757
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.757
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.756
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.756
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.756
2o4c NADErythronate-4-phosphate dehydrogenase / 0.755
4j4b NAIUncharacterized protein / 0.755
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.753
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.752
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.751
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.747
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.747
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.746
1gv0 NADMalate dehydrogenase / 0.743
3abi NADUncharacterized protein / 0.743
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.742
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.742
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.741
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.741
4ros APRMalate dehydrogenase / 0.740
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.739
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.739
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.738
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.733
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.733
3wsw NADL-lactate dehydrogenase / 0.733
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.732
3d64 NADAdenosylhomocysteinase / 0.732
2vhx NADAlanine dehydrogenase 1.4.1.1 0.731
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.731
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.729
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.728
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.728
4j43 NADUncharacterized protein / 0.728
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.728
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.727
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.725
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.725
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.725
4j49 NAIUncharacterized protein / 0.725
1guy NADMalate dehydrogenase / 0.724
1pzh NADLactate dehydrogenase / 0.724
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.723
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.722
2voj NADAlanine dehydrogenase 1.4.1.1 0.722
1sow NADL-lactate dehydrogenase 1.1.1.27 0.721
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.721
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.720
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.720
4xqc NADHomospermidine synthase 2.5.1.44 0.720
4xrg NADHomospermidine synthase 2.5.1.44 0.720
2dvm NAD439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme] / 0.719
4c4o NADSADH / 0.718
4xq9 NADHomospermidine synthase 2.5.1.44 0.717
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.713
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.713
4gl4 NAIAlcohol dehydrogenase class-3 / 0.713
2x0i NAIMalate dehydrogenase / 0.712
3jv7 NADSecondary alcohol dehydrogenase / 0.712
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.712
1pzg A3DLactate dehydrogenase / 0.711
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.710
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.710
4cpd NADAlcohol dehydrogenase / 0.709
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.707
1emd NADMalate dehydrogenase / 0.706
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.706
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.706
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.705
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.705
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.705
2dph NADFormaldehyde dismutase / 0.704
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.703
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.703
4tvb NADHomospermidine synthase 2.5.1.44 0.703
1ie3 NADMalate dehydrogenase / 0.702
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.702
1ur5 NADMalate dehydrogenase / 0.702
2y05 NAPProstaglandin reductase 1 / 0.701
4oaq NDPR-specific carbonyl reductase / 0.701
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.700
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.700
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.700
1bw9 NADPhenylalanine dehydrogenase / 0.697
1yqd NAPSinapyl alcohol dehydrogenase / 0.697
4ejm NAPPutative zinc-binding dehydrogenase / 0.697
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.697
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.696
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.696
2g5c NADPrephenate dehydrogenase / 0.696
3wle NAD(R)-specific carbonyl reductase / 0.696
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.695
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.694
3x2f NAIAdenosylhomocysteinase / 0.694
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.694
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.692
1c1d NAIPhenylalanine dehydrogenase / 0.691
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.691
1f8f NADBenzyl alcohol dehydrogenase / 0.690
3kb6 NADD-lactate dehydrogenase / 0.690
3oet NADErythronate-4-phosphate dehydrogenase / 0.690
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.690
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.690
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.690
4plp NADHomospermidine synthase 2.5.1.44 0.689
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.688
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.688
1x7d NADPutative ornithine cyclodeaminase / 0.687
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.687
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.685
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.685
2gsd NADFormate dehydrogenase / 0.684
2x0r NADMalate dehydrogenase / 0.684
3gvi ADPMalate dehydrogenase / 0.684
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.684
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.682
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.682
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.681
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.681
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.681
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.681
4kug NAD3-hydroxybutyryl-CoA dehydrogenase / 0.681
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.681
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.681
1yqx NAPSinapyl alcohol dehydrogenase / 0.679
2e37 NADL-lactate dehydrogenase / 0.679
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.679
3two NDPMannitol dehydrogenase / 0.679
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.679
1pjc NADAlanine dehydrogenase / 0.678
2npx NADNADH peroxidase 1.11.1.1 0.678
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.678
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.676
3ikt NADRedox-sensing transcriptional repressor Rex / 0.676
1vi2 NADQuinate/shikimate dehydrogenase / 0.675
4lcj NADC-terminal-binding protein 2 / 0.675
3nx4 NAPPutative oxidoreductase / 0.674
3qvt NAIMyo-inositol-1-phosphate synthase (Ino1) / 0.674
4yag NAIC alpha-dehydrogenase / 0.674
2nad NADFormate dehydrogenase / 0.673
3x2e NAIAdenosylhomocysteinase / 0.673
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.673
3m2t NADProbable dehydrogenase / 0.672
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.671
1wze NADMalate dehydrogenase / 0.671
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.671
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.671
1ptj SNDNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.670
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.670
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.670
4yac NAIC alpha-dehydrogenase / 0.670
4k28 NADShikimate dehydrogenase family protein / 0.669
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.668
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.668
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.668
4i1i NADMalate dehydrogenase / 0.668
1ky4 NADAdenosylhomocysteinase 3.3.1.1 0.667
4ebf NADPhosphonate dehydrogenase 1.20.1.1 0.667
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.666
4y1b NAPAntE / 0.666
4yai NAIC alpha-dehydrogenase / 0.666
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.665
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.665
2qg4 NADUDP-glucose 6-dehydrogenase 1.1.1.22 0.665
3pqf NADL-lactate dehydrogenase 1.1.1.27 0.665
4jji NADAlcohol dehydrogenase class-3 / 0.665
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.665
5bsg NAPPyrroline-5-carboxylate reductase / 0.665
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.664
3qw2 NADMyo-inositol-1-phosphate synthase (Ino1) / 0.664
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.663
3tqh NDPQuinone oxidoreductase / 0.663
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.662
1ebu NDAHomoserine dehydrogenase 1.1.1.3 0.661
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.660
1pzf A3DLactate dehydrogenase / 0.660
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.660
2cdc NAPGlucose 1-dehydrogenase / 0.660
4l0q NADAlcohol dehydrogenase class-3 / 0.660
4oqy NDP(S)-imine reductase / 0.660
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.659
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.659
1pdh FASp-hydroxybenzoate hydroxylase / 0.658
1dc6 NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.657
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.657
2ome NADC-terminal-binding protein 2 / 0.657
3ggp NADPrephenate dehydrogenase / 0.657
1hku NADC-terminal-binding protein 1 1.1.1 0.656
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.656
1bmd NADMalate dehydrogenase / 0.655
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.655
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.655
2hu2 NADC-terminal binding protein 1 / 0.655
3f3s NADLambda-crystallin homolog / 0.655
3t4e NADQuinate/shikimate dehydrogenase / 0.655
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.654
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.654
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.654
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.654
4wlo NAIMalate dehydrogenase, mitochondrial 1.1.1.37 0.654
1hzz NADNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.653
2cda NAPGlucose 1-dehydrogenase / 0.653
2vyn NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.653
3kve FADL-amino-acid oxidase / 0.653
4cr8 NADN-acylmannosamine 1-dehydrogenase 1.1.1.233 0.653
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.652
3tri NAPPyrroline-5-carboxylate reductase / 0.652
4rqu NADAlcohol dehydrogenase class-P / 0.652
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.652
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.651
2yjz NAPMetalloreductase STEAP4 1.16.1 0.651
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.651
3wyc NAPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.651
2xaa NADSecondary alcohol dehydrogenase / 0.650
2yy7 NADL-threonine dehydrogenase / 0.650
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.650
4b7x NAPProbable oxidoreductase / 0.650
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.650