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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1hyh NAD L-2-hydroxyisocaproate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 1.240
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.908
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.888
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.877
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.849
1pzh NADLactate dehydrogenase / 0.848
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.844
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.844
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.844
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.831
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.828
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.828
1uxk NADMalate dehydrogenase / 0.827
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.827
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.827
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.826
1uxj NADMalate dehydrogenase / 0.825
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.825
1ib6 NADMalate dehydrogenase / 0.822
1o6z NADMalate dehydrogenase / 0.816
1sow NADL-lactate dehydrogenase 1.1.1.27 0.815
2voj NADAlanine dehydrogenase 1.4.1.1 0.804
3wsw NADL-lactate dehydrogenase / 0.804
4c4o NADSADH / 0.803
3jv7 NADSecondary alcohol dehydrogenase / 0.802
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.802
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.798
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.795
1u7h NADPutative ornithine cyclodeaminase / 0.793
2x0i NAIMalate dehydrogenase / 0.793
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.793
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.792
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.792
1ie3 NADMalate dehydrogenase / 0.790
4oaq NDPR-specific carbonyl reductase / 0.787
3abi NADUncharacterized protein / 0.786
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.785
4j43 NADUncharacterized protein / 0.784
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.781
1x7d NADPutative ornithine cyclodeaminase / 0.779
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.777
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.776
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.776
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.773
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.773
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.772
1guy NADMalate dehydrogenase / 0.770
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.768
4j49 NADUncharacterized protein / 0.768
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.768
4ros APRMalate dehydrogenase / 0.765
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.764
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.763
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.763
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.762
2vhx NADAlanine dehydrogenase 1.4.1.1 0.761
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.760
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.760
4xq9 NADHomospermidine synthase 2.5.1.44 0.760
4xqc NADHomospermidine synthase 2.5.1.44 0.760
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.758
4plp NADHomospermidine synthase 2.5.1.44 0.757
4xrg NADHomospermidine synthase 2.5.1.44 0.757
2aa3 AP0L-lactate dehydrogenase / 0.756
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.756
4tvb NADHomospermidine synthase 2.5.1.44 0.756
1gv0 NADMalate dehydrogenase / 0.754
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.754
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.754
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.753
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.748
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.747
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.747
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.747
4l0q NADAlcohol dehydrogenase class-3 / 0.747
2dph NADFormaldehyde dismutase / 0.746
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.745
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.745
2a92 NAIL-lactate dehydrogenase / 0.744
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.743
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.743
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.742
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.742
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.742
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.742
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.742
1pzg A3DLactate dehydrogenase / 0.741
5a1t NAIL-lactate dehydrogenase / 0.741
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.739
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.737
1c1d NAIPhenylalanine dehydrogenase / 0.736
3ggp NADPrephenate dehydrogenase / 0.735
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.734
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.732
1yqd NAPSinapyl alcohol dehydrogenase / 0.731
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.730
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.729
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.728
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.728
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.727
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.727
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.726
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.726
4jk3 NADUncharacterized protein / 0.723
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.722
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.722
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.722
3ec7 NADInositol 2-dehydrogenase / 0.721
4jji NADAlcohol dehydrogenase class-3 / 0.720
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.719
3uko NADAlcohol dehydrogenase class-3 / 0.719
3wle NAD(R)-specific carbonyl reductase / 0.718
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.717
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.715
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.715
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.714
2xaa NADSecondary alcohol dehydrogenase / 0.713
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.712
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.711
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.711
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.710
2o4c NADErythronate-4-phosphate dehydrogenase / 0.710
1wze NADMalate dehydrogenase / 0.708
1pzf A3DLactate dehydrogenase / 0.707
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.706
2yy7 NADL-threonine dehydrogenase / 0.706
3two NDPMannitol dehydrogenase / 0.706
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.705
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.705
1obb NADAlpha-glucosidase 3.2.1.20 0.704
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.703
3l4s NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.702
2g82 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.700
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.699
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.699
4j49 NAIUncharacterized protein / 0.699
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.698
4uun NAIL-lactate dehydrogenase / 0.698
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.697
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.696
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.696
2hjr APRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase / 0.695
1u8x NADMaltose-6'-phosphate glucosidase 3.2.1.122 0.694
2g5c NADPrephenate dehydrogenase / 0.694
2hu2 NADC-terminal binding protein 1 / 0.694
3kve FADL-amino-acid oxidase / 0.694
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.692
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.692
3hwr NDP2-dehydropantoate 2-reductase / 0.692
1bws NDPGDP-L-fucose synthase / 0.691
2x0r NADMalate dehydrogenase / 0.691
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.690
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.690
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.689
4a99 FADTetX family tetracycline inactivation enzyme / 0.689
3m2t NADProbable dehydrogenase / 0.688
3rha FDAPutrescine oxidase / 0.688
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.688
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.687
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.687
1bw9 NADPhenylalanine dehydrogenase / 0.686
4xgi NADGlutamate dehydrogenase / 0.685
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.685
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.684
3nlc FADUncharacterized protein / 0.684
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.684
1yon A2R2-dehydropantoate 2-reductase 1.1.1.169 0.683
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.683
1i36 NAPConserved protein / 0.682
1j0x NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.682
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.682
3x2f NAIAdenosylhomocysteinase / 0.682
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.681
1b8v NADMalate dehydrogenase / 0.681
4k28 NADShikimate dehydrogenase family protein / 0.681
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.681
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.680
4wlo NAIMalate dehydrogenase, mitochondrial 1.1.1.37 0.680
1emd NADMalate dehydrogenase / 0.679
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.679
2wsb NADGalactitol dehydrogenase / 0.679
3k2b NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.679
3tqh NDPQuinone oxidoreductase / 0.679
4gl4 NAIAlcohol dehydrogenase class-3 / 0.679
3pqf NADL-lactate dehydrogenase 1.1.1.27 0.677
3qw2 NADMyo-inositol-1-phosphate synthase (Ino1) / 0.676
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.675
1pjc NADAlanine dehydrogenase / 0.674
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.674
1o9b NAIQuinate/shikimate dehydrogenase / 0.673
4b7x NAPProbable oxidoreductase / 0.673
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.672
2y05 NAPProstaglandin reductase 1 / 0.671
3q3c NADNAD-dependent L-serine dehydrogenase / 0.671
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.670
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.670
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.670
2yg5 FADPutrescine oxidase / 0.670
3d64 NADAdenosylhomocysteinase / 0.670
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.670
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.669
3bg7 FADPyranose 2-oxidase / 0.669
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.669
3gvh NADMalate dehydrogenase / 0.668
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.668
4j4b NAIUncharacterized protein / 0.668
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.667
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.667
1bdm NAXMalate dehydrogenase / 0.666
1ur5 NADMalate dehydrogenase / 0.666
2jkv NAP6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.666
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.666
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.666
3ggo NAIPrephenate dehydrogenase / 0.665
3keo NADRedox-sensing transcriptional repressor Rex / 0.665
4lcj NADC-terminal-binding protein 2 / 0.665
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.665
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.664
2dbr NAPGlyoxylate reductase 1.1.1.26 0.664
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.664
3mvq NDPGlutamate dehydrogenase 1, mitochondrial 1.4.1.3 0.664
2e37 NADL-lactate dehydrogenase / 0.663
3oet NADErythronate-4-phosphate dehydrogenase / 0.663
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.663
5bsg NAPPyrroline-5-carboxylate reductase / 0.663
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.662
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.662
5lc1 NADL-threonine 3-dehydrogenase / 0.662
1yqx NAPSinapyl alcohol dehydrogenase / 0.661
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.660
1f8r FADL-amino-acid oxidase 1.4.3.2 0.660
2c29 NAPDihydroflavonol 4-reductase / 0.660
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.660
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.660
5a05 NDPGlucose-fructose oxidoreductase / 0.660
1szj NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.659
4o63 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.659
4weq NAPNAD-dependent dehydrogenase / 0.659
1sby NADAlcohol dehydrogenase 1.1.1.1 0.658
4o9k CMKArabinose 5-phosphate isomerase / 0.658
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.658
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.657
4boy NADGlyceraldehyde-3-phosphate dehydrogenase / 0.657
4xb2 NDP319aa long hypothetical homoserine dehydrogenase / 0.657
3ikt NADRedox-sensing transcriptional repressor Rex / 0.656
3zcx NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
2yjz NAPMetalloreductase STEAP4 1.16.1 0.655
3gvi ADPMalate dehydrogenase / 0.655
3ket NADRedox-sensing transcriptional repressor Rex / 0.655
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.655
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.655
2cda NAPGlucose 1-dehydrogenase / 0.654
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.654
1b8u NADMalate dehydrogenase / 0.653
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.653
1zmd NAIDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.653
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.653
3tri NAPPyrroline-5-carboxylate reductase / 0.653
4i1i NADMalate dehydrogenase / 0.653
2iid FADL-amino-acid oxidase 1.4.3.2 0.652
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.652
4y1b NAPAntE / 0.652
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.651
3doc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.651
3icp NADNAD-dependent epimerase/dehydratase / 0.651
3ko8 NADNAD-dependent epimerase/dehydratase / 0.651
3nx4 NAPPutative oxidoreductase / 0.651
4xb1 NDP319aa long hypothetical homoserine dehydrogenase / 0.651
4y0k NAPAntE / 0.651
4yac NAIC alpha-dehydrogenase / 0.651
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.651
2dvm NAD439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme] / 0.650
2p5y NADUDP-glucose 4-epimerase / 0.650
4egb NADdTDP-glucose 4,6-dehydratase / 0.650
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.650
4tm1 FDAKtzI / 0.650