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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ic7ANPMitogen-activated protein kinase 72.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ic7ANPMitogen-activated protein kinase 72.7.11.241.000
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.534
4bcmT7ZCyclin-dependent kinase 22.7.11.220.519
2ojj82AMitogen-activated protein kinase 12.7.11.240.512
3c4xATPRhodopsin kinase/0.512
4b99R4LMitogen-activated protein kinase 72.7.11.240.511
3lltANPProtein serine/threonine kinase-1/0.504
4hvi19STyrosine-protein kinase JAK32.7.10.20.501
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.499
4g170VNCasein kinase I isoform gamma-32.7.11.10.499
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.495
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.495
2izsBRQCasein kinase I isoform gamma-32.7.11.10.489
2j0lANPFocal adhesion kinase 12.7.10.20.486
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.484
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.484
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.482
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.478
4jia1K3Tyrosine-protein kinase JAK2/0.478
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.478
3t8oATPRhodopsin kinase/0.476
4fv9E71Mitogen-activated protein kinase 12.7.11.240.476
3my5RFZCyclin-dependent kinase 22.7.11.220.475
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.475
1fvv107Cyclin-dependent kinase 22.7.11.220.474
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.474
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.473
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.473
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.469
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.469
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.468
3w2sW2REpidermal growth factor receptor2.7.10.10.468
2ckeIQUDeath-associated protein kinase 2/0.467
3i60E86Mitogen-activated protein kinase 12.7.11.240.467
1finATPCyclin-dependent kinase 22.7.11.220.466
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.466
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.466
4ez50RSCyclin-dependent kinase 62.7.11.220.466
2uzbC75Cyclin-dependent kinase 22.7.11.220.465
3nux3NVCyclin-dependent kinase 62.7.11.220.465
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.464
3nynSGVG protein-coupled receptor kinase 62.7.11.160.464
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
1pkdUCNCyclin-dependent kinase 22.7.11.220.461
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3fln3FNMitogen-activated protein kinase 14/0.461
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.460
3ormAGSSerine/threonine protein kinase/0.459
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.459
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.458
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.458
3c4wATPRhodopsin kinase/0.458
4j95ACPFibroblast growth factor receptor 2/0.458
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.457
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.456
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.456
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.456
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.456
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.455
2izrBRKCasein kinase I isoform gamma-32.7.11.10.455
2j0m4STFocal adhesion kinase 12.7.10.20.455
3bqr4RBDeath-associated protein kinase 3/0.455
3c4zADPRhodopsin kinase/0.455
3gc9B45Mitogen-activated protein kinase 112.7.11.240.455
3uvqFS8Mitogen-activated protein kinase 14/0.455
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2hog710Serine/threonine-protein kinase Chk12.7.11.10.454
3js2VM1Fibroblast growth factor receptor 1/0.454
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.454
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.454
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4gu94GUFocal adhesion kinase 12.7.10.20.454
4ysjADPCalmodulin-like domain protein kinase/0.454
2x9fX9FEphrin type-B receptor 42.7.10.10.453
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.453
2fvdLIACyclin-dependent kinase 22.7.11.220.452
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.452
4gmy0X5Tyrosine-protein kinase JAK2/0.452
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.452
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.451
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2xvdAS6Ephrin type-B receptor 42.7.10.10.451
3w33W19Epidermal growth factor receptor2.7.10.10.451
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.451
2ijmADPFocal adhesion kinase 12.7.10.20.450
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.450
4bcqTJFCyclin-dependent kinase 22.7.11.220.450
4fuxE75Mitogen-activated protein kinase 12.7.11.240.450
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.450
4k33ACPFibroblast growth factor receptor 32.7.10.10.450
4l9i8PRRhodopsin kinase/0.450
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.449
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.449
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4ansVGHALK tyrosine kinase receptor2.7.10.10.449
4hgs15GCasein kinase I isoform gamma-32.7.11.10.449
2etm7PYFocal adhesion kinase 12.7.10.20.448
2izuP01Casein kinase I isoform gamma-32.7.11.10.448
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.448
3tnwF18Cyclin-dependent kinase 22.7.11.220.448
4aacAAVMitogen-activated protein kinase 14/0.448
4btkDTQTau-tubulin kinase 12.7.11.10.448
4cd0AWJALK tyrosine kinase receptor2.7.10.10.448
4gk4L90Ephrin type-A receptor 32.7.10.10.448
2cchATPCyclin-dependent kinase 22.7.11.220.447
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.447
3gubGUBDeath-associated protein kinase 12.7.11.10.447
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.447
4fob0USALK tyrosine kinase receptor2.7.10.10.447
4jboWPHAurora kinase A2.7.11.10.447
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.447
2pwlACPFibroblast growth factor receptor 2/0.446
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.446
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.446
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.446
2uzdC85Cyclin-dependent kinase 22.7.11.220.445
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4eym0RXMitogen-activated protein kinase 132.7.11.240.445
4hvh19RTyrosine-protein kinase JAK32.7.10.20.445
1h1r6CPCyclin-dependent kinase 22.7.11.220.444
2btsU32Cyclin-dependent kinase 22.7.11.220.444
2vu3LZECyclin-dependent kinase 22.7.11.220.444
4aa4QC0Mitogen-activated protein kinase 14/0.444
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.444
4hnf16WCasein kinase I isoform delta2.7.11.10.444
5av2KMPDeath-associated protein kinase 12.7.11.10.444
2qoqANPEphrin type-A receptor 32.7.10.10.443
2vtqLZACyclin-dependent kinase 22.7.11.220.443
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.442
2w05FRTCyclin-dependent kinase 22.7.11.220.442
4c4g7RODual specificity protein kinase TTK2.7.12.10.442
4xhgADPUncharacterized protein/0.442
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4g160VMCasein kinase I isoform gamma-32.7.11.10.441
5auvAGIDeath-associated protein kinase 12.7.11.10.441
2itqITQEpidermal growth factor receptor2.7.10.10.440
2wouZZFTGF-beta receptor type-12.7.11.300.440
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.440
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.440
4c3pACPAurora kinase A2.7.11.10.440