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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fks46KCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fks46KCyclin-dependent kinase 22.7.11.221.000
4acm7YGCyclin-dependent kinase 22.7.11.220.715
2r3jSCJCyclin-dependent kinase 22.7.11.220.636
4fkt48KCyclin-dependent kinase 22.7.11.220.634
4ek816KCyclin-dependent kinase 22.7.11.220.620
2vv9IM9Cyclin-dependent kinase 22.7.11.220.618
2xmyCDKCyclin-dependent kinase 22.7.11.220.614
3iggEFQCyclin-dependent kinase 22.7.11.220.613
3rpv26ZCyclin-dependent kinase 22.7.11.220.610
2r3lSCWCyclin-dependent kinase 22.7.11.220.604
1y91CT9Cyclin-dependent kinase 22.7.11.220.602
2c6iDT1Cyclin-dependent kinase 22.7.11.220.588
2btrU73Cyclin-dependent kinase 22.7.11.220.583
4fkv61KCyclin-dependent kinase 22.7.11.220.580
3sw719KCyclin-dependent kinase 22.7.11.220.577
3rni21ZCyclin-dependent kinase 22.7.11.220.572
2w17I19Cyclin-dependent kinase 22.7.11.220.571
2uznC96Cyclin-dependent kinase 22.7.11.220.568
3r1yX76Cyclin-dependent kinase 22.7.11.220.568
2r3kSCQCyclin-dependent kinase 22.7.11.220.567
2a0cCK9Cyclin-dependent kinase 22.7.11.220.566
3sw418KCyclin-dependent kinase 22.7.11.220.565
4fkq42KCyclin-dependent kinase 22.7.11.220.562
1pxlCK4Cyclin-dependent kinase 22.7.11.220.561
3py0SU9Cyclin-dependent kinase 22.7.11.220.561
3qtuX44Cyclin-dependent kinase 22.7.11.220.559
3qtxX43Cyclin-dependent kinase 22.7.11.220.558
3qzgX67Cyclin-dependent kinase 22.7.11.220.558
4ek610KCyclin-dependent kinase 22.7.11.220.558
2vtrLZBCyclin-dependent kinase 22.7.11.220.557
4fkr45KCyclin-dependent kinase 22.7.11.220.557
1g5sI17Cyclin-dependent kinase 22.7.11.220.555
3r8lZ30Cyclin-dependent kinase 22.7.11.220.554
1oitHDTCyclin-dependent kinase 22.7.11.220.553
2b52D42Cyclin-dependent kinase 22.7.11.220.553
1ykr628Cyclin-dependent kinase 22.7.11.220.552
3rjc06ZCyclin-dependent kinase 22.7.11.220.552
3rk708ZCyclin-dependent kinase 22.7.11.220.552
4fkpLS5Cyclin-dependent kinase 22.7.11.220.552
1pxmCK5Cyclin-dependent kinase 22.7.11.220.550
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.550
1pxoCK7Cyclin-dependent kinase 22.7.11.220.548
4fko20KCyclin-dependent kinase 22.7.11.220.548
3qu0X40Cyclin-dependent kinase 22.7.11.220.547
3rak03ZCyclin-dependent kinase 22.7.11.220.547
3s1h56ZCyclin-dependent kinase 22.7.11.220.547
1oirHDYCyclin-dependent kinase 22.7.11.220.545
2r3iSCFCyclin-dependent kinase 22.7.11.220.545
3lfqA28Cyclin-dependent kinase 22.7.11.220.545
1ckpPVBCyclin-dependent kinase 22.7.11.220.542
3qtrX36Cyclin-dependent kinase 22.7.11.220.541
1ke5LS1Cyclin-dependent kinase 22.7.11.220.540
3pj8404Cyclin-dependent kinase 22.7.11.220.540
3rk909ZCyclin-dependent kinase 22.7.11.220.539
4fkw62KCyclin-dependent kinase 22.7.11.220.538
2c6o4SPCyclin-dependent kinase 22.7.11.220.537
4fki09KCyclin-dependent kinase 22.7.11.220.537
3lfnA27Cyclin-dependent kinase 22.7.11.220.536
3rmf20ZCyclin-dependent kinase 22.7.11.220.536
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.535
1y8yCT7Cyclin-dependent kinase 22.7.11.220.534
2c6lDT4Cyclin-dependent kinase 22.7.11.220.532
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.532
3qtzX42Cyclin-dependent kinase 22.7.11.220.532
2c6kDT2Cyclin-dependent kinase 22.7.11.220.529
2vthLZ2Cyclin-dependent kinase 22.7.11.220.529
2w1hL0FCyclin-dependent kinase 22.7.11.220.529
2w06FRVCyclin-dependent kinase 22.7.11.220.527
1ke7LS3Cyclin-dependent kinase 22.7.11.220.526
2uzoC62Cyclin-dependent kinase 22.7.11.220.526
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.525
3ezvEZVCyclin-dependent kinase 22.7.11.220.525
3r1sX73Cyclin-dependent kinase 22.7.11.220.525
4fkg4CKCyclin-dependent kinase 22.7.11.220.525
1ke6LS2Cyclin-dependent kinase 22.7.11.220.522
2eufLQQCyclin-dependent kinase 62.7.11.220.522
3r8vZ62Cyclin-dependent kinase 22.7.11.220.522
2duv371Cyclin-dependent kinase 22.7.11.220.521
3rk507ZCyclin-dependent kinase 22.7.11.220.521
2b53D23Cyclin-dependent kinase 22.7.11.220.519
1vyzN5BCyclin-dependent kinase 22.7.11.220.517
2r3mSCXCyclin-dependent kinase 22.7.11.220.517
3s2pPMUCyclin-dependent kinase 22.7.11.220.516
1fvv107Cyclin-dependent kinase 22.7.11.220.515
3unk0BYCyclin-dependent kinase 22.7.11.220.515
4bgh3I6Cyclin-dependent kinase 22.7.11.220.515
1urwI1PCyclin-dependent kinase 22.7.11.220.514
3r9oZ71Cyclin-dependent kinase 22.7.11.220.514
2c6tDT5Cyclin-dependent kinase 22.7.11.220.513
2btsU32Cyclin-dependent kinase 22.7.11.220.512
3qqhX0ACyclin-dependent kinase 22.7.11.220.512
1gih1PUCyclin-dependent kinase 22.7.11.220.511
3rm618ZCyclin-dependent kinase 22.7.11.220.511
2r3p3SCCyclin-dependent kinase 22.7.11.220.510
1w0xOLOCyclin-dependent kinase 22.7.11.220.509
1p2a5BNCyclin-dependent kinase 22.7.11.220.508
1oguST8Cyclin-dependent kinase 22.7.11.220.507
2a4lRRCCyclin-dependent kinase 22.7.11.220.507
3ezrEZRCyclin-dependent kinase 22.7.11.220.506
1di8DTQCyclin-dependent kinase 22.7.11.220.504
1ke9LS5Cyclin-dependent kinase 22.7.11.220.502
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.500
3r7yZ04Cyclin-dependent kinase 22.7.11.220.500
3pxyJWSCyclin-dependent kinase 22.7.11.220.499
2ds11CDCyclin-dependent kinase 22.7.11.220.498
3qxoX65Cyclin-dependent kinase 22.7.11.220.498
3unj0BXCyclin-dependent kinase 22.7.11.220.498
1gii1PUCyclin-dependent kinase 22.7.11.220.497
1h1r6CPCyclin-dependent kinase 22.7.11.220.497
2x1nX1NCyclin-dependent kinase 22.7.11.220.497
3qzhX69Cyclin-dependent kinase 22.7.11.220.496
1pxpCK8Cyclin-dependent kinase 22.7.11.220.493
3fz1B98Cyclin-dependent kinase 22.7.11.220.493
1hckATPCyclin-dependent kinase 22.7.11.220.491
3ral04ZCyclin-dependent kinase 22.7.11.220.491
3r73X87Cyclin-dependent kinase 22.7.11.220.490
1ke8LS4Cyclin-dependent kinase 22.7.11.220.489
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.488
2iw84SPCyclin-dependent kinase 22.7.11.220.488
1fvt106Cyclin-dependent kinase 22.7.11.220.487
1oi9N20Cyclin-dependent kinase 22.7.11.220.487
1v1k3FPCyclin-dependent kinase 22.7.11.220.486
3r7uX96Cyclin-dependent kinase 22.7.11.220.486
1h1s4SPCyclin-dependent kinase 22.7.11.220.485
3ddpRC8Cyclin-dependent kinase 22.7.11.220.485
3qwjX6ACyclin-dependent kinase 22.7.11.220.485
4fklCK2Cyclin-dependent kinase 22.7.11.220.484
2vttLZDCyclin-dependent kinase 22.7.11.220.483
3r71X86Cyclin-dependent kinase 22.7.11.220.482
4fkj11KCyclin-dependent kinase 22.7.11.220.482
1pyePM1Cyclin-dependent kinase 22.7.11.220.481
2exmZIPCyclin-dependent kinase 22.7.11.220.481
1oiyN41Cyclin-dependent kinase 22.7.11.220.480
3rpy27ZCyclin-dependent kinase 22.7.11.220.479
3uli1N3Cyclin-dependent kinase 22.7.11.220.479
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.479
3rpo24ZCyclin-dependent kinase 22.7.11.220.478
2bhhRYUCyclin-dependent kinase 22.7.11.220.476
2iw94SPCyclin-dependent kinase 22.7.11.220.475
1h0w207Cyclin-dependent kinase 22.7.11.220.474
3qqlX03Cyclin-dependent kinase 22.7.11.220.474
3rm719ZCyclin-dependent kinase 22.7.11.220.474
3sqq99ZCyclin-dependent kinase 22.7.11.220.474
4anmWULCasein kinase II subunit alpha2.7.11.10.474
4fx360KCyclin-dependent kinase 22.7.11.220.474
2b55D31Cyclin-dependent kinase 22.7.11.220.473
4lyn1YGCyclin-dependent kinase 22.7.11.220.473
1h0vUN4Cyclin-dependent kinase 22.7.11.220.471
1pxkCK3Cyclin-dependent kinase 22.7.11.220.471
1aq1STUCyclin-dependent kinase 22.7.11.220.470
3qqkX02Cyclin-dependent kinase 22.7.11.220.470
3r83Z14Cyclin-dependent kinase 22.7.11.220.470
2pvlP55Casein kinase II subunit alpha2.7.11.10.469
2vtsLZCCyclin-dependent kinase 22.7.11.220.469
2r3q5SCCyclin-dependent kinase 22.7.11.220.468
3r7vZ02Cyclin-dependent kinase 22.7.11.220.468
3rzb02ZCyclin-dependent kinase 22.7.11.220.468
4dgo0JWCasein kinase II subunit alpha2.7.11.10.468
3r9hZ67Cyclin-dependent kinase 22.7.11.220.467
4eor4SPCyclin-dependent kinase 22.7.11.220.467
2vtqLZACyclin-dependent kinase 22.7.11.220.465
2wihP48Cyclin-dependent kinase 22.7.11.220.465
3lfsA07Cyclin-dependent kinase 22.7.11.220.464
4dgnLU2Casein kinase II subunit alpha2.7.11.10.464
1e1xNW1Cyclin-dependent kinase 22.7.11.220.463
3qruX19Cyclin-dependent kinase 22.7.11.220.463
3r8pZ46Cyclin-dependent kinase 22.7.11.220.463
4aua4AUCyclin-dependent kinase 62.7.11.220.463
2xnbY8LCyclin-dependent kinase 22.7.11.220.462
2r3gSC9Cyclin-dependent kinase 22.7.11.220.461
2r3r6SCCyclin-dependent kinase 22.7.11.220.461
1oiuN76Cyclin-dependent kinase 22.7.11.220.460
3r6xX84Cyclin-dependent kinase 22.7.11.220.459
3roy22ZCyclin-dependent kinase 22.7.11.220.459
1b39ATPCyclin-dependent kinase 22.7.11.220.458
3raiX85Cyclin-dependent kinase 22.7.11.220.458
4eok4SPCyclin-dependent kinase 22.7.11.220.458
4kd11QKCyclin-dependent kinase 22.7.11.220.458
3qtqX35Cyclin-dependent kinase 22.7.11.220.457
3sheI85MAP kinase-activated protein kinase 32.7.11.10.457
1dm2HMDCyclin-dependent kinase 22.7.11.220.456
1b38ATPCyclin-dependent kinase 22.7.11.220.455
2pvnP63Casein kinase II subunit alpha2.7.11.10.455
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.455
3wblPDYCyclin-dependent kinase 22.7.11.220.455
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.455
1gij2PUCyclin-dependent kinase 22.7.11.220.454
2uzeC95Cyclin-dependent kinase 22.7.11.220.454
2uzlC94Cyclin-dependent kinase 22.7.11.220.454
3ggfGVDSerine/threonine-protein kinase 26/0.454
3ddqRRCCyclin-dependent kinase 22.7.11.220.453
4qmpDKISerine/threonine-protein kinase 242.7.11.10.453
1rw8580TGF-beta receptor type-12.7.11.300.452
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.452
4ivb1J5Tyrosine-protein kinase JAK1/0.452
4nj32KDCyclin-dependent kinase 22.7.11.220.452
1vjy460TGF-beta receptor type-12.7.11.300.451
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.451
3rahO1ZCyclin-dependent kinase 22.7.11.220.450
3r1qX75Cyclin-dependent kinase 22.7.11.220.449
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.449
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.449
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.448
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.448
3tnwF18Cyclin-dependent kinase 22.7.11.220.448
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.447
4eon1ROCyclin-dependent kinase 22.7.11.220.446
1vyw292Cyclin-dependent kinase 22.7.11.220.445
2vu3LZECyclin-dependent kinase 22.7.11.220.445
3hmm855TGF-beta receptor type-12.7.11.300.445
3nynSGVG protein-coupled receptor kinase 62.7.11.160.445
3r28XA0Cyclin-dependent kinase 22.7.11.220.445
4qysPLRTryptophan synthase beta chain 24.2.1.200.445
1qmzATPCyclin-dependent kinase 22.7.11.220.443
2i40BLZCyclin-dependent kinase 22.7.11.220.443
3be9P04Casein kinase II subunit alpha2.7.11.10.443
3ig7EFPCyclin-dependent kinase 22.7.11.220.443
4eomATPCyclin-dependent kinase 22.7.11.220.443
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.443
1pkdUCNCyclin-dependent kinase 22.7.11.220.442
1xjdSTUProtein kinase C theta type2.7.11.130.442
2cchATPCyclin-dependent kinase 22.7.11.220.442
3qrtX14Cyclin-dependent kinase 22.7.11.220.442
3r7eX88Cyclin-dependent kinase 22.7.11.220.442
3zuyTCHTransporter/0.442
3bhtMFRCyclin-dependent kinase 22.7.11.220.441
3qqgX06Cyclin-dependent kinase 22.7.11.220.441
4dgmAGICasein kinase II subunit alpha2.7.11.10.441
1om1IQACasein kinase II subunit alpha2.7.11.10.440
1w8cN69Cyclin-dependent kinase 22.7.11.220.440
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.440
2uzbC75Cyclin-dependent kinase 22.7.11.220.440
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.440
3pe2E1BCasein kinase II subunit alpha2.7.11.10.440
3qqfX07Cyclin-dependent kinase 22.7.11.220.440
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.440