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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.261.000
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.637
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.606
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.592
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.581
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.580
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.574
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.562
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.560
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.557
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.556
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.553
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.530
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.525
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.515
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.514
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.512
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.511
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.509
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.505
4bcmT7ZCyclin-dependent kinase 22.7.11.220.501
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.500
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.497
3i60E86Mitogen-activated protein kinase 12.7.11.240.497
4bchT7ZCyclin-dependent kinase 92.7.11.220.497
3rak03ZCyclin-dependent kinase 22.7.11.220.496
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.494
3du8553Glycogen synthase kinase-3 beta2.7.11.260.494
3my5RFZCyclin-dependent kinase 22.7.11.220.494
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.493
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.493
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.488
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.488
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.488
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.486
3eb0DRKUncharacterized protein/0.486
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.485
2fvdLIACyclin-dependent kinase 22.7.11.220.484
4bgg844Activin receptor type-12.7.11.300.484
4jboWPHAurora kinase A2.7.11.10.484
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.482
4wsqKSAAP2-associated protein kinase 12.7.11.10.481
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.479
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.478
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.476
4ix6ADPUncharacterized protein/0.476
5cvfATPCasein kinase II subunit alpha2.7.11.10.476
1fvv107Cyclin-dependent kinase 22.7.11.220.475
4o0wADNAurora kinase A2.7.11.10.475
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.474
3mtfA3FActivin receptor type-12.7.11.300.473
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.472
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.472
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.472
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.472
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
3s1h56ZCyclin-dependent kinase 22.7.11.220.471
4dymIYZActivin receptor type-12.7.11.300.471
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.470
2ijmADPFocal adhesion kinase 12.7.10.20.469
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.469
4jia1K3Tyrosine-protein kinase JAK2/0.469
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.469
5e8ySTUTGF-beta receptor type-22.7.11.300.469
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.468
4grb0XGCasein kinase II subunit alpha2.7.11.10.468
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.467
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.467
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.466
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
2itpAEEEpidermal growth factor receptor2.7.10.10.465
2xvdAS6Ephrin type-B receptor 42.7.10.10.465
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.465
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.465
4jbpYPHAurora kinase A2.7.11.10.465
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.464
3rkb12ZCyclin-dependent kinase 22.7.11.220.464
4dgnLU2Casein kinase II subunit alpha2.7.11.10.464
4hvi19STyrosine-protein kinase JAK32.7.10.20.464
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.464
2cchATPCyclin-dependent kinase 22.7.11.220.463
3axwTIDCasein kinase II subunit alpha2.7.11.10.463
3zdu38RCyclin-dependent kinase-like 32.7.11.220.463
4aguD15Cyclin-dependent kinase-like 1/0.463
4ez50RSCyclin-dependent kinase 62.7.11.220.463
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.462
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.462
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.462
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.460
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.460
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.460
3nux3NVCyclin-dependent kinase 62.7.11.220.459
3w2sW2REpidermal growth factor receptor2.7.10.10.459
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.459
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.458
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.458
2uzdC85Cyclin-dependent kinase 22.7.11.220.457
3bqr4RBDeath-associated protein kinase 3/0.457
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.457
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.456
2hog710Serine/threonine-protein kinase Chk12.7.11.10.456
2wouZZFTGF-beta receptor type-12.7.11.300.456
4ic7ANPMitogen-activated protein kinase 72.7.11.240.456
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.455
4qo9627Serine/threonine-protein kinase 242.7.11.10.455
2w05FRTCyclin-dependent kinase 22.7.11.220.454
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.454
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.453
2x9fX9FEphrin type-B receptor 42.7.10.10.453
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.453
2i0ePDSProtein kinase C beta type2.7.11.130.452
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.452
3pe2E1BCasein kinase II subunit alpha2.7.11.10.452
4bgq38RCyclin-dependent kinase-like 52.7.11.220.452
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.452
4g1wG1WMitogen-activated protein kinase 82.7.11.240.452
4xf7ACPCarbohydrate/pyrimidine kinase, PfkB family/0.452
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3be9P04Casein kinase II subunit alpha2.7.11.10.451
3js2VM1Fibroblast growth factor receptor 1/0.451
1jklANPDeath-associated protein kinase 12.7.11.10.450
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.450
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.450
4btkDTQTau-tubulin kinase 12.7.11.10.450
4fv6E57Mitogen-activated protein kinase 12.7.11.240.450
5av2KMPDeath-associated protein kinase 12.7.11.10.450
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.450
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.449
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.449
4j95ACPFibroblast growth factor receptor 2/0.449
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.448
1finATPCyclin-dependent kinase 22.7.11.220.447
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.447
4e730NRMitogen-activated protein kinase 82.7.11.240.447
4fuxE75Mitogen-activated protein kinase 12.7.11.240.447
4g170VNCasein kinase I isoform gamma-32.7.11.10.447
5av3KMPDeath-associated protein kinase 12.7.11.10.447
1u4dDBQActivated CDC42 kinase 1/0.446
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2vttLZDCyclin-dependent kinase 22.7.11.220.446
3vf9477Tyrosine-protein kinase SYK2.7.10.20.446
2j9mPY8Cyclin-dependent kinase 22.7.11.220.445
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3qxpX64Cyclin-dependent kinase 22.7.11.220.445
3zh8C58Protein kinase C iota type2.7.11.130.445
1gii1PUCyclin-dependent kinase 22.7.11.220.444
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.444
2btsU32Cyclin-dependent kinase 22.7.11.220.444
2ckeIQUDeath-associated protein kinase 2/0.444
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.444
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.444
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.444
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.444
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.443
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.443
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.443
4gk4L90Ephrin type-A receptor 32.7.10.10.443
4qmySTUSerine/threonine-protein kinase 242.7.11.10.443
4y93746Tyrosine-protein kinase/0.443
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.442
3q9xEMOCasein kinase II subunit alpha2.7.11.10.442
3sheI85MAP kinase-activated protein kinase 32.7.11.10.442
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.442
3zep1NXTyrosine-protein kinase JAK32.7.10.20.442
4c62XWWTyrosine-protein kinase JAK2/0.442
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.442
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.442
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.442
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.441
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.441
2vv9IM9Cyclin-dependent kinase 22.7.11.220.441
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.441
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.441
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.441
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.440
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.440
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.440
2zjwREFCasein kinase II subunit alpha2.7.11.10.440
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.440
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.440
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.440
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.440
4hys1BJMitogen-activated protein kinase 82.7.11.240.440