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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rmf20ZCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3rmf20ZCyclin-dependent kinase 22.7.11.221.000
3rpy27ZCyclin-dependent kinase 22.7.11.220.684
3rak03ZCyclin-dependent kinase 22.7.11.220.647
3ral04ZCyclin-dependent kinase 22.7.11.220.646
3s1h56ZCyclin-dependent kinase 22.7.11.220.643
2w06FRVCyclin-dependent kinase 22.7.11.220.591
3sw418KCyclin-dependent kinase 22.7.11.220.584
3qtxX43Cyclin-dependent kinase 22.7.11.220.579
3rk708ZCyclin-dependent kinase 22.7.11.220.579
3uli1N3Cyclin-dependent kinase 22.7.11.220.578
1y91CT9Cyclin-dependent kinase 22.7.11.220.577
3qtzX42Cyclin-dependent kinase 22.7.11.220.567
3rni21ZCyclin-dependent kinase 22.7.11.220.566
2xmyCDKCyclin-dependent kinase 22.7.11.220.565
3qtuX44Cyclin-dependent kinase 22.7.11.220.565
3qzgX67Cyclin-dependent kinase 22.7.11.220.563
4acm7YGCyclin-dependent kinase 22.7.11.220.558
1gih1PUCyclin-dependent kinase 22.7.11.220.555
3rpv26ZCyclin-dependent kinase 22.7.11.220.553
4fkg4CKCyclin-dependent kinase 22.7.11.220.552
3rk507ZCyclin-dependent kinase 22.7.11.220.550
4fkr45KCyclin-dependent kinase 22.7.11.220.550
3qu0X40Cyclin-dependent kinase 22.7.11.220.549
3r9dX6BCyclin-dependent kinase 22.7.11.220.549
4fkv61KCyclin-dependent kinase 22.7.11.220.549
3qxpX64Cyclin-dependent kinase 22.7.11.220.548
4fkj11KCyclin-dependent kinase 22.7.11.220.548
2btsU32Cyclin-dependent kinase 22.7.11.220.547
3py0SU9Cyclin-dependent kinase 22.7.11.220.546
3r9oZ71Cyclin-dependent kinase 22.7.11.220.545
1pxmCK5Cyclin-dependent kinase 22.7.11.220.543
4fkw62KCyclin-dependent kinase 22.7.11.220.543
2bhhRYUCyclin-dependent kinase 22.7.11.220.542
1urwI1PCyclin-dependent kinase 22.7.11.220.541
3sqq99ZCyclin-dependent kinase 22.7.11.220.540
3qqkX02Cyclin-dependent kinase 22.7.11.220.539
3unk0BYCyclin-dependent kinase 22.7.11.220.539
4bgh3I6Cyclin-dependent kinase 22.7.11.220.539
1v1k3FPCyclin-dependent kinase 22.7.11.220.535
3rk909ZCyclin-dependent kinase 22.7.11.220.534
3rjc06ZCyclin-dependent kinase 22.7.11.220.533
1p2a5BNCyclin-dependent kinase 22.7.11.220.532
1w0xOLOCyclin-dependent kinase 22.7.11.220.530
2w17I19Cyclin-dependent kinase 22.7.11.220.529
1di8DTQCyclin-dependent kinase 22.7.11.220.525
1ke9LS5Cyclin-dependent kinase 22.7.11.220.521
2w1hL0FCyclin-dependent kinase 22.7.11.220.521
4fkq42KCyclin-dependent kinase 22.7.11.220.520
1ke5LS1Cyclin-dependent kinase 22.7.11.220.519
1ke6LS2Cyclin-dependent kinase 22.7.11.220.519
2a0cCK9Cyclin-dependent kinase 22.7.11.220.519
4fko20KCyclin-dependent kinase 22.7.11.220.519
4fx360KCyclin-dependent kinase 22.7.11.220.519
4ek610KCyclin-dependent kinase 22.7.11.220.518
1oitHDTCyclin-dependent kinase 22.7.11.220.517
3sw719KCyclin-dependent kinase 22.7.11.220.517
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.516
4fkt48KCyclin-dependent kinase 22.7.11.220.516
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.515
2vv9IM9Cyclin-dependent kinase 22.7.11.220.514
2bheBRYCyclin-dependent kinase 22.7.11.220.513
2c6o4SPCyclin-dependent kinase 22.7.11.220.512
3lfnA27Cyclin-dependent kinase 22.7.11.220.512
3r71X86Cyclin-dependent kinase 22.7.11.220.512
3s0o50ZCyclin-dependent kinase 22.7.11.220.512
1aq1STUCyclin-dependent kinase 22.7.11.220.509
1oiyN41Cyclin-dependent kinase 22.7.11.220.508
1gii1PUCyclin-dependent kinase 22.7.11.220.507
2w05FRTCyclin-dependent kinase 22.7.11.220.507
3r1sX73Cyclin-dependent kinase 22.7.11.220.505
2r64740Cyclin-dependent kinase 22.7.11.220.504
1oi9N20Cyclin-dependent kinase 22.7.11.220.503
1pkdUCNCyclin-dependent kinase 22.7.11.220.503
3ezvEZVCyclin-dependent kinase 22.7.11.220.501
3r9hZ67Cyclin-dependent kinase 22.7.11.220.501
4ek816KCyclin-dependent kinase 22.7.11.220.500
4ez30S0Cyclin-dependent kinase 22.7.11.220.500
2vttLZDCyclin-dependent kinase 22.7.11.220.499
3qtwX3ACyclin-dependent kinase 22.7.11.220.499
3unj0BXCyclin-dependent kinase 22.7.11.220.499
4fkpLS5Cyclin-dependent kinase 22.7.11.220.499
3r73X87Cyclin-dependent kinase 22.7.11.220.497
2iw84SPCyclin-dependent kinase 22.7.11.220.496
2r3lSCWCyclin-dependent kinase 22.7.11.220.496
3qtrX36Cyclin-dependent kinase 22.7.11.220.496
3ti1B49Cyclin-dependent kinase 22.7.11.220.496
4nj32KDCyclin-dependent kinase 22.7.11.220.496
1pxoCK7Cyclin-dependent kinase 22.7.11.220.495
1ke8LS4Cyclin-dependent kinase 22.7.11.220.494
1fvv107Cyclin-dependent kinase 22.7.11.220.493
2vthLZ2Cyclin-dependent kinase 22.7.11.220.493
2uznC96Cyclin-dependent kinase 22.7.11.220.492
3ql8X01Cyclin-dependent kinase 22.7.11.220.492
3r7iX9ICyclin-dependent kinase 22.7.11.220.492
4fki09KCyclin-dependent kinase 22.7.11.220.492
1dm2HMDCyclin-dependent kinase 22.7.11.220.490
3qxoX65Cyclin-dependent kinase 22.7.11.220.490
3wblPDYCyclin-dependent kinase 22.7.11.220.490
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.489
1g5sI17Cyclin-dependent kinase 22.7.11.220.488
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.488
1h0w207Cyclin-dependent kinase 22.7.11.220.487
1pyePM1Cyclin-dependent kinase 22.7.11.220.487
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.486
4fks46KCyclin-dependent kinase 22.7.11.220.486
1ke7LS3Cyclin-dependent kinase 22.7.11.220.485
2b55D31Cyclin-dependent kinase 22.7.11.220.485
3qqfX07Cyclin-dependent kinase 22.7.11.220.485
1oirHDYCyclin-dependent kinase 22.7.11.220.484
2c6iDT1Cyclin-dependent kinase 22.7.11.220.484
3s2pPMUCyclin-dependent kinase 22.7.11.220.484
1h1r6CPCyclin-dependent kinase 22.7.11.220.483
4qmpDKISerine/threonine-protein kinase 242.7.11.10.483
3rkb12ZCyclin-dependent kinase 22.7.11.220.482
2pvnP63Casein kinase II subunit alpha2.7.11.10.481
3iggEFQCyclin-dependent kinase 22.7.11.220.481
1pxlCK4Cyclin-dependent kinase 22.7.11.220.480
3qruX19Cyclin-dependent kinase 22.7.11.220.479
1vyw292Cyclin-dependent kinase 22.7.11.220.477
1ckpPVBCyclin-dependent kinase 22.7.11.220.476
1oguST8Cyclin-dependent kinase 22.7.11.220.476
2fvdLIACyclin-dependent kinase 22.7.11.220.476
2uzoC62Cyclin-dependent kinase 22.7.11.220.476
3fz1B98Cyclin-dependent kinase 22.7.11.220.476
3qzhX69Cyclin-dependent kinase 22.7.11.220.476
2r3kSCQCyclin-dependent kinase 22.7.11.220.475
3pxyJWSCyclin-dependent kinase 22.7.11.220.475
4dgo0JWCasein kinase II subunit alpha2.7.11.10.475
2btrU73Cyclin-dependent kinase 22.7.11.220.474
2wxvWXVCyclin-dependent kinase 22.7.11.220.474
3r7uX96Cyclin-dependent kinase 22.7.11.220.474
1h1s4SPCyclin-dependent kinase 22.7.11.220.473
2i40BLZCyclin-dependent kinase 22.7.11.220.473
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.473
3r8lZ30Cyclin-dependent kinase 22.7.11.220.473
3rpo24ZCyclin-dependent kinase 22.7.11.220.472
3qqhX0ACyclin-dependent kinase 22.7.11.220.471
3be9P04Casein kinase II subunit alpha2.7.11.10.470
3le62BZCyclin-dependent kinase 22.7.11.220.470
3qtqX35Cyclin-dependent kinase 22.7.11.220.470
3qwjX6ACyclin-dependent kinase 22.7.11.220.470
3r8zZ63Cyclin-dependent kinase 22.7.11.220.470
1fvt106Cyclin-dependent kinase 22.7.11.220.469
2c6tDT5Cyclin-dependent kinase 22.7.11.220.469
2vu3LZECyclin-dependent kinase 22.7.11.220.468
3lfsA07Cyclin-dependent kinase 22.7.11.220.468
3r7yZ04Cyclin-dependent kinase 22.7.11.220.468
2duv371Cyclin-dependent kinase 22.7.11.220.467
1vyzN5BCyclin-dependent kinase 22.7.11.220.466
3roy22ZCyclin-dependent kinase 22.7.11.220.466
2eufLQQCyclin-dependent kinase 62.7.11.220.465
1e9hINRCyclin-dependent kinase 22.7.11.220.464
3ddpRC8Cyclin-dependent kinase 22.7.11.220.464
2wihP48Cyclin-dependent kinase 22.7.11.220.463
4eok4SPCyclin-dependent kinase 22.7.11.220.463
3ddqRRCCyclin-dependent kinase 22.7.11.220.462
1m2pHNACasein kinase II subunit alpha2.7.11.10.461
1ykr628Cyclin-dependent kinase 22.7.11.220.461
2iw94SPCyclin-dependent kinase 22.7.11.220.461
3rm618ZCyclin-dependent kinase 22.7.11.220.461
3ig7EFPCyclin-dependent kinase 22.7.11.220.460
3r83Z14Cyclin-dependent kinase 22.7.11.220.460
3bhtMFRCyclin-dependent kinase 22.7.11.220.459
4anmWULCasein kinase II subunit alpha2.7.11.10.459
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.459
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.458
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.457
3lfqA28Cyclin-dependent kinase 22.7.11.220.457
1vjy460TGF-beta receptor type-12.7.11.300.456
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.456
1pxpCK8Cyclin-dependent kinase 22.7.11.220.455
3r6xX84Cyclin-dependent kinase 22.7.11.220.455
2cchATPCyclin-dependent kinase 22.7.11.220.454
3ezrEZRCyclin-dependent kinase 22.7.11.220.454
3qrtX14Cyclin-dependent kinase 22.7.11.220.454
3qwkX62Cyclin-dependent kinase 22.7.11.220.454
3r8pZ46Cyclin-dependent kinase 22.7.11.220.454
1b38ATPCyclin-dependent kinase 22.7.11.220.453
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.453
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.453
1h1pCMGCyclin-dependent kinase 22.7.11.220.452
2r3iSCFCyclin-dependent kinase 22.7.11.220.452
4dgmAGICasein kinase II subunit alpha2.7.11.10.452
1gij2PUCyclin-dependent kinase 22.7.11.220.451
2c5nCK8Cyclin-dependent kinase 22.7.11.220.451
2r3jSCJCyclin-dependent kinase 22.7.11.220.451
4bcpT3CCyclin-dependent kinase 22.7.11.220.451
4dgnLU2Casein kinase II subunit alpha2.7.11.10.450
4ez50RSCyclin-dependent kinase 62.7.11.220.450
3tnwF18Cyclin-dependent kinase 22.7.11.220.449
1r78FMDCyclin-dependent kinase 22.7.11.220.448
4aua4AUCyclin-dependent kinase 62.7.11.220.448
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
1y8yCT7Cyclin-dependent kinase 22.7.11.220.446
3gubGUBDeath-associated protein kinase 12.7.11.10.446
4eos1ROCyclin-dependent kinase 22.7.11.220.446
2x1nX1NCyclin-dependent kinase 22.7.11.220.445
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.444
3r1yX76Cyclin-dependent kinase 22.7.11.220.444
3r8vZ62Cyclin-dependent kinase 22.7.11.220.444
4eor4SPCyclin-dependent kinase 22.7.11.220.444
2j9mPY8Cyclin-dependent kinase 22.7.11.220.443
3r1qX75Cyclin-dependent kinase 22.7.11.220.443
4lyn1YGCyclin-dependent kinase 22.7.11.220.443
2wpa889Cyclin-dependent kinase 22.7.11.220.442
3pj8404Cyclin-dependent kinase 22.7.11.220.442
4eomATPCyclin-dependent kinase 22.7.11.220.442
2a4lRRCCyclin-dependent kinase 22.7.11.220.441
2vtsLZCCyclin-dependent kinase 22.7.11.220.441
3gxlQIGTGF-beta receptor type-12.7.11.300.441
4ii5ADPCyclin-dependent kinase 22.7.11.220.441
2xnbY8LCyclin-dependent kinase 22.7.11.220.440