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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3fln3FNMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3fln3FNMitogen-activated protein kinase 14/1.000
3fklFKLMitogen-activated protein kinase 14/0.748
3flzFLZMitogen-activated protein kinase 14/0.720
3fmkFMKMitogen-activated protein kinase 14/0.681
3flyFLYMitogen-activated protein kinase 14/0.678
3flwFLWMitogen-activated protein kinase 14/0.671
3fmh533Mitogen-activated protein kinase 14/0.667
3nww3NWMitogen-activated protein kinase 14/0.655
3fi4FI4Mitogen-activated protein kinase 14/0.634
3fskRO6Mitogen-activated protein kinase 14/0.626
4aa4QC0Mitogen-activated protein kinase 14/0.616
2balPQAMitogen-activated protein kinase 14/0.614
3hl7I47Mitogen-activated protein kinase 14/0.614
3dt1P40Mitogen-activated protein kinase 14/0.609
3iphG11Mitogen-activated protein kinase 14/0.606
4lopSB4Mitogen-activated protein kinase 14/0.596
4aa5NQBMitogen-activated protein kinase 14/0.593
4aacAAVMitogen-activated protein kinase 14/0.591
3mpt1GKMitogen-activated protein kinase 14/0.589
3hvcGG5Mitogen-activated protein kinase 14/0.584
3ocgOCGMitogen-activated protein kinase 14/0.563
2rg6287Mitogen-activated protein kinase 14/0.562
4kip1R9Mitogen-activated protein kinase 14/0.561
4looSB4Mitogen-activated protein kinase 14/0.560
2rg5279Mitogen-activated protein kinase 14/0.557
4kiq1RAMitogen-activated protein kinase 14/0.557
3uyt0CKCasein kinase I isoform delta2.7.11.10.551
4kin1M8Mitogen-activated protein kinase 14/0.548
2qd9LGFMitogen-activated protein kinase 14/0.547
1ywrLI9Mitogen-activated protein kinase 14/0.545
4loqSB4Mitogen-activated protein kinase 14/0.542
3hllI45Mitogen-activated protein kinase 14/0.541
3s4qNK0Mitogen-activated protein kinase 14/0.541
3fmn530Mitogen-activated protein kinase 14/0.537
3mvl38PMitogen-activated protein kinase 14/0.535
3u8w09JMitogen-activated protein kinase 14/0.532
1ouk084Mitogen-activated protein kinase 14/0.530
2ghlLIBMitogen-activated protein kinase 14/0.530
4ewqMWLMitogen-activated protein kinase 14/0.528
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.525
3mvm39PMitogen-activated protein kinase 14/0.521
1zz2B11Mitogen-activated protein kinase 14/0.519
3flsFLSMitogen-activated protein kinase 14/0.518
4ic7ANPMitogen-activated protein kinase 72.7.11.240.518
3roc29AMitogen-activated protein kinase 14/0.516
4hnf16WCasein kinase I isoform delta2.7.11.10.515
1zyjBI5Mitogen-activated protein kinase 14/0.510
4eh60ONMitogen-activated protein kinase 14/0.509
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.508
4kbk1QGCasein kinase I isoform delta2.7.11.10.502
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.500
3l8xN4DMitogen-activated protein kinase 14/0.498
3uvqFS8Mitogen-activated protein kinase 14/0.497
3gfeP37Mitogen-activated protein kinase 14/0.496
4eh70OOMitogen-activated protein kinase 14/0.494
3o8tBMUMitogen-activated protein kinase 14/0.493
3uibSB2Putative mitogen-activated protein kinase/0.493
3hx4ANPCalmodulin-domain protein kinase 1/0.490
3fkoFKOMitogen-activated protein kinase 14/0.487
3mpaSB2Mitogen-activated protein kinase 14/0.487
3w33W19Epidermal growth factor receptor2.7.10.10.487
3kf7L9GMitogen-activated protein kinase 14/0.486
1bl6SB6Mitogen-activated protein kinase 14/0.485
3gw9VNILanosterol 14-alpha-demethylase/0.484
3fl4FL4Mitogen-activated protein kinase 14/0.483
4kbc1QJCasein kinase I isoform delta2.7.11.10.480
2xa4AZ5Tyrosine-protein kinase JAK2/0.479
3fknFKNMitogen-activated protein kinase 14/0.477
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.477
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
3gc9B45Mitogen-activated protein kinase 112.7.11.240.475
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.475
4kb81QNCasein kinase I isoform delta2.7.11.10.474
3uvp048Mitogen-activated protein kinase 14/0.473
2xikJ60Serine/threonine-protein kinase 252.7.11.10.472
1xjdSTUProtein kinase C theta type2.7.11.130.471
3hp552PMitogen-activated protein kinase 14/0.471
3sa0NRAMitogen-activated protein kinase 12.7.11.240.470
1k6cMK1Gag-Pol polyprotein3.4.23.160.469
1nzdUPGDNA beta-glucosyltransferase/0.469
2vd5BI8Myotonin-protein kinase2.7.11.10.469
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.469
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.468
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.468
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.468
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.468
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.467
1xl5190Gag-Pol polyprotein3.4.23.160.466
1ywnLIFVascular endothelial growth factor receptor 22.7.10.10.466
2y6o1N1Ephrin type-A receptor 42.7.10.10.466
3mdvCL6Cholesterol 24-hydroxylase/0.466
4i22IREEpidermal growth factor receptor2.7.10.10.466
1yw2PGJMitogen-activated protein kinase 14/0.465
3vjoANPEpidermal growth factor receptor2.7.10.10.465
2itpAEEEpidermal growth factor receptor2.7.10.10.464
2izsBRQCasein kinase I isoform gamma-32.7.11.10.464
2zb0GK3Mitogen-activated protein kinase 14/0.464
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.464
4nka2K7Fibroblast growth factor receptor 1/0.464
4yuqKS1Calmodulin-like domain protein kinase/0.464
3w32W32Epidermal growth factor receptor2.7.10.10.463
4f650S9Fibroblast growth factor receptor 1/0.463
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.462
2znq401Peroxisome proliferator-activated receptor delta/0.462
3bv3P39Mitogen-activated protein kinase 14/0.462
2wouZZFTGF-beta receptor type-12.7.11.300.461
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.461
1iwiCAMCamphor 5-monooxygenase1.14.15.10.460
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.460
3gubGUBDeath-associated protein kinase 12.7.11.10.460
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.460
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.459
3gc7B45Mitogen-activated protein kinase 14/0.459
4b99R4LMitogen-activated protein kinase 72.7.11.240.459
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.459
4g170VNCasein kinase I isoform gamma-32.7.11.10.459
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.458
4kba1QMCasein kinase I isoform delta2.7.11.10.458
1phePIYCamphor 5-monooxygenase1.14.15.10.457
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.457
2j5xGSPADP-ribosylation factor 6/0.457
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.457
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.457
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.457
4i231C9Epidermal growth factor receptor2.7.10.10.457
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.457
1py5PY1TGF-beta receptor type-12.7.11.300.456
2izrBRKCasein kinase I isoform gamma-32.7.11.10.456
2of2547Tyrosine-protein kinase Lck2.7.10.20.456
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.456
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.456
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.456
1gih1PUCyclin-dependent kinase 22.7.11.220.455
1m7qDQOMitogen-activated protein kinase 14/0.455
1zrzBI1Protein kinase C iota type2.7.11.130.455
2ittAEEEpidermal growth factor receptor2.7.10.10.455
2of4979Tyrosine-protein kinase Lck2.7.10.20.455
3itzP66Mitogen-activated protein kinase 14/0.455
4fod0UVALK tyrosine kinase receptor2.7.10.10.455
4g160VMCasein kinase I isoform gamma-32.7.11.10.455
5e8wSTUTGF-beta receptor type-12.7.11.300.455
1vikBAYGag-Pol polyprotein/0.454
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.454
1dz6CAMCamphor 5-monooxygenase1.14.15.10.453
2gtmLIDMitogen-activated protein kinase 14/0.453
4erkOLOMitogen-activated protein kinase 12.7.11.240.453
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.453
1ouy094Mitogen-activated protein kinase 14/0.452
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.452
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.452
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.452
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.452
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.452
4tuvCPZCytochrome P450 1191.140.452
1di8DTQCyclin-dependent kinase 22.7.11.220.451
2nmtNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.451
2q9fC3SCholesterol 24-hydroxylase/0.451
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.451
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.451
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.451
4jrvKJVEpidermal growth factor receptor2.7.10.10.451
4kkyCAMCamphor 5-monooxygenase1.14.15.10.451
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.451
1cdeGARPhosphoribosylglycinamide formyltransferase/0.450
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.450
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.450
2itzIREEpidermal growth factor receptor2.7.10.10.450
3fmjFMJMitogen-activated protein kinase 14/0.450
3tucFPWTyrosine-protein kinase SYK2.7.10.20.450
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.450
4gk3L87Ephrin type-A receptor 32.7.10.10.450
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.449
1t87CAMCamphor 5-monooxygenase1.14.15.10.449
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
2ftoCB3Thymidylate synthase/0.449
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.449
4hgs15GCasein kinase I isoform gamma-32.7.11.10.449
4hni16WCasein kinase I isoform epsilon2.7.11.10.449
1t88CAMCamphor 5-monooxygenase1.14.15.10.448
2cig1DGDihydrofolate reductase1.5.1.30.448
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.448
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
4g3jVNTLanosterol 14-alpha-demethylase/0.448
5eccNAPDehydrofolate reductase type I/0.448
1cdeDZFPhosphoribosylglycinamide formyltransferase/0.447
1k6tXN1Gag-Pol polyprotein3.4.23.160.447
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.447
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.447
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.447
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.447
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.447
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.447
1bdlIM1Gag-Pol polyprotein3.4.23.160.446
1booSAHModification methylase PvuII2.1.1.1130.446
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.446
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.446
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.446
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4g2fC07Ephrin type-A receptor 32.7.10.10.446
4gk2L66Ephrin type-A receptor 32.7.10.10.446
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
4y93746Tyrosine-protein kinase/0.446
4y95746Tyrosine-protein kinase/0.446
1xkkFMMEpidermal growth factor receptor2.7.10.10.445
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.445
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.445
3fwiCAMCamphor 5-monooxygenase1.14.15.10.445
3zkyWT4Isopenicillin N synthase1.21.3.10.445
4c02TAKActivin receptor type-12.7.11.300.445
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.445
1c1dNAIPhenylalanine dehydrogenase/0.444
1fnnADPORC1-type DNA replication protein/0.444
1hb1OCVIsopenicillin N synthase1.21.3.10.444
1idb0DOGag-Pol polyprotein/0.444
1jpaANPEphrin type-B receptor 22.7.10.10.444
1k6vXN2Gag-Pol polyprotein3.4.23.160.444
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.444
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.444
3zewSTUEphrin type-B receptor 42.7.10.10.444
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.444
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4hnc0UTMandelate racemase/0.444
4kb81QOCasein kinase I isoform delta2.7.11.10.444
4kl9NDPDihydrofolate reductase1.5.1.30.444
1bygSTUTyrosine-protein kinase CSK/0.443
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.443
1u4dDBQActivated CDC42 kinase 1/0.443
2wotZZGTGF-beta receptor type-12.7.11.300.443
3pvuQRWBeta-adrenergic receptor kinase 12.7.11.150.443
3zmmF9JTyrosine-protein kinase JAK2/0.443
4nks2M2Fibroblast growth factor receptor 1/0.443
1bxoPP7Penicillopepsin-13.4.23.200.442
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.442
1phgMYTCamphor 5-monooxygenase1.14.15.10.442
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.442
2znnS44Peroxisome proliferator-activated receptor alpha/0.442
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.442
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.442
3iok1P6Tyrosine-protein kinase JAK2/0.442
3oom507Activin receptor type-12.7.11.300.442
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.441
2ghmLICMitogen-activated protein kinase 14/0.441
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.441
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.441
3fc152PMitogen-activated protein kinase 14/0.441
3l63CAMCamphor 5-monooxygenase1.14.15.10.441
3poz03PEpidermal growth factor receptor2.7.10.10.441
4c9oCAMCytochrome P450/0.441
4fuxE75Mitogen-activated protein kinase 12.7.11.240.441
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.441
4g3rCAMCamphor 5-monooxygenase1.14.15.10.441
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.441
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.441
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1x2hLPALipoate-protein ligase A6.3.1.200.440
1xe55FEPlasmepsin-23.4.23.390.440
2b7aIZATyrosine-protein kinase JAK2/0.440
2fsvNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.440
2hk51BMTyrosine-protein kinase HCK2.7.10.20.440
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.440
2p3c3TLProtease/0.440
2q7vFADThioredoxin reductase/0.440
2zaxCAMCamphor 5-monooxygenase1.14.15.10.440
2znpK55Peroxisome proliferator-activated receptor delta/0.440
3ac1KZITyrosine-protein kinase Lck2.7.10.20.440
3ac2KSETyrosine-protein kinase Lck2.7.10.20.440
3d7zGK5Mitogen-activated protein kinase 14/0.440
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
3iqzH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.440
3nr4PYVAbscisic acid receptor PYL2/0.440
3wrmCAMCamphor 5-monooxygenase1.14.15.10.440
4ienCOAPutative acyl-CoA hydrolase/0.440
4riyADPEpidermal growth factor receptor2.7.10.10.440
5cp4CAMCamphor 5-monooxygenase1.14.15.10.440