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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wihP48Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2wihP48Cyclin-dependent kinase 22.7.11.221.000
2wxvWXVCyclin-dependent kinase 22.7.11.220.685
1vyw292Cyclin-dependent kinase 22.7.11.220.579
2wpa889Cyclin-dependent kinase 22.7.11.220.567
1fvv107Cyclin-dependent kinase 22.7.11.220.540
2cchATPCyclin-dependent kinase 22.7.11.220.538
3bhtMFRCyclin-dependent kinase 22.7.11.220.538
4fx360KCyclin-dependent kinase 22.7.11.220.537
2iw84SPCyclin-dependent kinase 22.7.11.220.527
1oiyN41Cyclin-dependent kinase 22.7.11.220.524
3r9hZ67Cyclin-dependent kinase 22.7.11.220.522
2x1nX1NCyclin-dependent kinase 22.7.11.220.520
2uzdC85Cyclin-dependent kinase 22.7.11.220.518
3rni21ZCyclin-dependent kinase 22.7.11.220.517
2c6iDT1Cyclin-dependent kinase 22.7.11.220.516
4eok4SPCyclin-dependent kinase 22.7.11.220.516
4fkv61KCyclin-dependent kinase 22.7.11.220.513
2bkzSBCCyclin-dependent kinase 22.7.11.220.512
4qmpDKISerine/threonine-protein kinase 242.7.11.10.510
2i40BLZCyclin-dependent kinase 22.7.11.220.509
3tnwF18Cyclin-dependent kinase 22.7.11.220.509
1gih1PUCyclin-dependent kinase 22.7.11.220.507
1pkdUCNCyclin-dependent kinase 22.7.11.220.506
4fkw62KCyclin-dependent kinase 22.7.11.220.506
3rak03ZCyclin-dependent kinase 22.7.11.220.505
3rmf20ZCyclin-dependent kinase 22.7.11.220.505
2iw94SPCyclin-dependent kinase 22.7.11.220.504
3qqkX02Cyclin-dependent kinase 22.7.11.220.504
1e9hINRCyclin-dependent kinase 22.7.11.220.503
3ral04ZCyclin-dependent kinase 22.7.11.220.502
3r73X87Cyclin-dependent kinase 22.7.11.220.501
1h1s4SPCyclin-dependent kinase 22.7.11.220.499
3rk708ZCyclin-dependent kinase 22.7.11.220.498
4eor4SPCyclin-dependent kinase 22.7.11.220.498
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.497
3rk507ZCyclin-dependent kinase 22.7.11.220.497
2w17I19Cyclin-dependent kinase 22.7.11.220.496
3rpv26ZCyclin-dependent kinase 22.7.11.220.496
2c5nCK8Cyclin-dependent kinase 22.7.11.220.495
2wipP49Cyclin-dependent kinase 22.7.11.220.494
1p2a5BNCyclin-dependent kinase 22.7.11.220.493
1oi9N20Cyclin-dependent kinase 22.7.11.220.492
2c6tDT5Cyclin-dependent kinase 22.7.11.220.492
4fkr45KCyclin-dependent kinase 22.7.11.220.492
4fkt48KCyclin-dependent kinase 22.7.11.220.491
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.490
3qu0X40Cyclin-dependent kinase 22.7.11.220.489
3s1h56ZCyclin-dependent kinase 22.7.11.220.489
4fks46KCyclin-dependent kinase 22.7.11.220.488
1oguST8Cyclin-dependent kinase 22.7.11.220.487
3qzhX69Cyclin-dependent kinase 22.7.11.220.487
1v0oINRCell division control protein 2 homolog2.7.11.220.486
3qtxX43Cyclin-dependent kinase 22.7.11.220.486
1ke6LS2Cyclin-dependent kinase 22.7.11.220.485
2eufLQQCyclin-dependent kinase 62.7.11.220.485
2uzbC75Cyclin-dependent kinase 22.7.11.220.484
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.483
3qxpX64Cyclin-dependent kinase 22.7.11.220.483
4qmySTUSerine/threonine-protein kinase 242.7.11.10.483
1aq1STUCyclin-dependent kinase 22.7.11.220.482
1y91CT9Cyclin-dependent kinase 22.7.11.220.482
2btrU73Cyclin-dependent kinase 22.7.11.220.482
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.482
3s2pPMUCyclin-dependent kinase 22.7.11.220.481
1unlRRCCyclin-dependent-like kinase 52.7.11.10.480
4ek816KCyclin-dependent kinase 22.7.11.220.480
1finATPCyclin-dependent kinase 22.7.11.220.479
2bhhRYUCyclin-dependent kinase 22.7.11.220.479
3qtqX35Cyclin-dependent kinase 22.7.11.220.479
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.478
2uzeC95Cyclin-dependent kinase 22.7.11.220.478
3qtzX42Cyclin-dependent kinase 22.7.11.220.477
3t8oATPRhodopsin kinase/0.477
4eomATPCyclin-dependent kinase 22.7.11.220.477
2btsU32Cyclin-dependent kinase 22.7.11.220.476
2uzlC94Cyclin-dependent kinase 22.7.11.220.476
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.476
4qmzB49Serine/threonine-protein kinase 242.7.11.10.476
1di8DTQCyclin-dependent kinase 22.7.11.220.475
1g5sI17Cyclin-dependent kinase 22.7.11.220.475
2w06FRVCyclin-dependent kinase 22.7.11.220.475
2xmyCDKCyclin-dependent kinase 22.7.11.220.475
3lfnA27Cyclin-dependent kinase 22.7.11.220.475
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.475
2r3r6SCCyclin-dependent kinase 22.7.11.220.474
3r9dX6BCyclin-dependent kinase 22.7.11.220.474
4bgh3I6Cyclin-dependent kinase 22.7.11.220.474
2vv9IM9Cyclin-dependent kinase 22.7.11.220.473
2r3p3SCCyclin-dependent kinase 22.7.11.220.472
2vttLZDCyclin-dependent kinase 22.7.11.220.472
3dogNNNCyclin-dependent kinase 22.7.11.220.472
1dm2HMDCyclin-dependent kinase 22.7.11.220.471
2bheBRYCyclin-dependent kinase 22.7.11.220.471
2vthLZ2Cyclin-dependent kinase 22.7.11.220.471
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.471
3rk909ZCyclin-dependent kinase 22.7.11.220.471
4ek610KCyclin-dependent kinase 22.7.11.220.471
4nj32KDCyclin-dependent kinase 22.7.11.220.471
1ke9LS5Cyclin-dependent kinase 22.7.11.220.470
3rm719ZCyclin-dependent kinase 22.7.11.220.470
3ddqRRCCyclin-dependent kinase 22.7.11.220.469
3qtuX44Cyclin-dependent kinase 22.7.11.220.469
3uli1N3Cyclin-dependent kinase 22.7.11.220.469
1oitHDTCyclin-dependent kinase 22.7.11.220.468
2xnbY8LCyclin-dependent kinase 22.7.11.220.468
3ezrEZRCyclin-dependent kinase 22.7.11.220.468
4erwSTUCyclin-dependent kinase 22.7.11.220.468
1pxoCK7Cyclin-dependent kinase 22.7.11.220.467
4bcmT7ZCyclin-dependent kinase 22.7.11.220.467
4ii5ADPCyclin-dependent kinase 22.7.11.220.467
3qxoX65Cyclin-dependent kinase 22.7.11.220.466
3roy22ZCyclin-dependent kinase 22.7.11.220.466
4acm7YGCyclin-dependent kinase 22.7.11.220.466
2uzoC62Cyclin-dependent kinase 22.7.11.220.465
3fz1B98Cyclin-dependent kinase 22.7.11.220.465
3r7iX9ICyclin-dependent kinase 22.7.11.220.465
4dgo0JWCasein kinase II subunit alpha2.7.11.10.465
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.465
1h1r6CPCyclin-dependent kinase 22.7.11.220.464
1ykr628Cyclin-dependent kinase 22.7.11.220.464
3c4xATPRhodopsin kinase/0.464
3qzfX66Cyclin-dependent kinase 22.7.11.220.464
3r1yX76Cyclin-dependent kinase 22.7.11.220.464
4bcnT9NCyclin-dependent kinase 22.7.11.220.464
4eol1ROCyclin-dependent kinase 22.7.11.220.464
4fkq42KCyclin-dependent kinase 22.7.11.220.464
2c6o4SPCyclin-dependent kinase 22.7.11.220.463
3my5RFZCyclin-dependent kinase 22.7.11.220.463
4fkg4CKCyclin-dependent kinase 22.7.11.220.463
1pyePM1Cyclin-dependent kinase 22.7.11.220.462
1vyzN5BCyclin-dependent kinase 22.7.11.220.462
2b52D42Cyclin-dependent kinase 22.7.11.220.462
3r7vZ02Cyclin-dependent kinase 22.7.11.220.462
4ez30S0Cyclin-dependent kinase 22.7.11.220.462
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.461
3gxlQIGTGF-beta receptor type-12.7.11.300.461
3pj8404Cyclin-dependent kinase 22.7.11.220.461
4bcpT3CCyclin-dependent kinase 22.7.11.220.461
2r3iSCFCyclin-dependent kinase 22.7.11.220.460
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.460
1h1pCMGCyclin-dependent kinase 22.7.11.220.459
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.459
3ddpRC8Cyclin-dependent kinase 22.7.11.220.459
3r7yZ04Cyclin-dependent kinase 22.7.11.220.459
3s0o50ZCyclin-dependent kinase 22.7.11.220.459
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.459
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.458
3r8zZ63Cyclin-dependent kinase 22.7.11.220.458
4bgg844Activin receptor type-12.7.11.300.458
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.458
4eos1ROCyclin-dependent kinase 22.7.11.220.458
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.458
4gmy0X5Tyrosine-protein kinase JAK2/0.458
4i3zADPCyclin-dependent kinase 22.7.11.220.458
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.458
1oirHDYCyclin-dependent kinase 22.7.11.220.457
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.457
3le62BZCyclin-dependent kinase 22.7.11.220.457
3lfqA28Cyclin-dependent kinase 22.7.11.220.457
3r9oZ71Cyclin-dependent kinase 22.7.11.220.457
3rpy27ZCyclin-dependent kinase 22.7.11.220.457
1ke7LS3Cyclin-dependent kinase 22.7.11.220.456
1v1k3FPCyclin-dependent kinase 22.7.11.220.456
2vu3LZECyclin-dependent kinase 22.7.11.220.456
3i60E86Mitogen-activated protein kinase 12.7.11.240.456
3ql8X01Cyclin-dependent kinase 22.7.11.220.456
3sqq99ZCyclin-dependent kinase 22.7.11.220.456
3py0SU9Cyclin-dependent kinase 22.7.11.220.455
3qqfX07Cyclin-dependent kinase 22.7.11.220.455
3sw719KCyclin-dependent kinase 22.7.11.220.455
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.454
2b53D23Cyclin-dependent kinase 22.7.11.220.454
2r3lSCWCyclin-dependent kinase 22.7.11.220.454
3lfsA07Cyclin-dependent kinase 22.7.11.220.454
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.454
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.453
1pxkCK3Cyclin-dependent kinase 22.7.11.220.453
1r78FMDCyclin-dependent kinase 22.7.11.220.453
1w0xOLOCyclin-dependent kinase 22.7.11.220.453
3rkb12ZCyclin-dependent kinase 22.7.11.220.453
3qwjX6ACyclin-dependent kinase 22.7.11.220.452
3sw418KCyclin-dependent kinase 22.7.11.220.452
1ke5LS1Cyclin-dependent kinase 22.7.11.220.451
3unk0BYCyclin-dependent kinase 22.7.11.220.451
3qziX72Cyclin-dependent kinase 22.7.11.220.450
3r7uX96Cyclin-dependent kinase 22.7.11.220.450
4dgnLU2Casein kinase II subunit alpha2.7.11.10.450
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.449
3ig7EFPCyclin-dependent kinase 22.7.11.220.449
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
4eoi1ROCyclin-dependent kinase 22.7.11.220.449
3r1sX73Cyclin-dependent kinase 22.7.11.220.448
4eooATPCyclin-dependent kinase 22.7.11.220.448
1xjdSTUProtein kinase C theta type2.7.11.130.447
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.447
3mtfA3FActivin receptor type-12.7.11.300.446
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.446
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.446
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.445
3qzgX67Cyclin-dependent kinase 22.7.11.220.445
3rjc06ZCyclin-dependent kinase 22.7.11.220.445
3rm618ZCyclin-dependent kinase 22.7.11.220.445
1pxmCK5Cyclin-dependent kinase 22.7.11.220.444
1urwI1PCyclin-dependent kinase 22.7.11.220.444
1y8yCT7Cyclin-dependent kinase 22.7.11.220.444
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.444
3a7jADPSerine/threonine-protein kinase 242.7.11.10.444
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.444
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.444
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.444
4jqeANPCasein kinase II subunit alpha2.7.11.10.444
4qmlANPSerine/threonine-protein kinase 242.7.11.10.444
2uznC96Cyclin-dependent kinase 22.7.11.220.443
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.443
3r71X86Cyclin-dependent kinase 22.7.11.220.443
3raiX85Cyclin-dependent kinase 22.7.11.220.443
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.443
4fko20KCyclin-dependent kinase 22.7.11.220.443
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.443
3qruX19Cyclin-dependent kinase 22.7.11.220.442
3qwkX62Cyclin-dependent kinase 22.7.11.220.442
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.442
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
1ke8LS4Cyclin-dependent kinase 22.7.11.220.441
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.441
3iggEFQCyclin-dependent kinase 22.7.11.220.441
3lltANPProtein serine/threonine kinase-1/0.441
4anmWULCasein kinase II subunit alpha2.7.11.10.441
1gij2PUCyclin-dependent kinase 22.7.11.220.440
1oiuN76Cyclin-dependent kinase 22.7.11.220.440
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.440
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.440
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.440
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.440
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.440
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.440