sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2wi2 | ZZ3 | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2wi2 | ZZ3 | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 2wi1 | ZZ2 | Heat shock protein HSP 90-alpha | / | 0.627 | |
| 2uwd | 2GG | Heat shock protein HSP 90-alpha | / | 0.626 | |
| 2yi6 | 6QM | Heat shock protein HSP 90-alpha | / | 0.623 | |
| 4egh | 0OY | Heat shock protein HSP 90-alpha | / | 0.612 | |
| 2ye4 | 2FY | Heat shock protein HSP 90-alpha | / | 0.607 | |
| 2ye9 | 2D4 | Heat shock protein HSP 90-alpha | / | 0.605 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.598 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.594 | |
| 2vci | 2GJ | Heat shock protein HSP 90-alpha | / | 0.591 | |
| 2yjw | YJW | Heat shock protein HSP 90-alpha | / | 0.589 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.588 | |
| 2cct | 2E1 | Heat shock protein HSP 90-alpha | / | 0.584 | |
| 2yec | XQ0 | Heat shock protein HSP 90-alpha | / | 0.579 | |
| 2yi7 | BZ8 | Heat shock protein HSP 90-alpha | / | 0.572 | |
| 3ft5 | MO8 | Heat shock protein HSP 90-alpha | / | 0.562 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.559 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.553 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.543 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.540 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.537 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.533 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.525 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.524 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.523 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.519 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.519 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.515 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.513 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.505 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.501 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.501 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.492 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.490 | |
| 2xjj | L81 | Heat shock protein HSP 90-alpha | / | 0.487 | |
| 4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.485 | |
| 2xjg | XJG | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.483 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.479 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.478 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.477 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.477 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.476 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.473 | |
| 1u0z | RDC | Endoplasmin | / | 0.472 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 2c5n | CK8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.470 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 2xnb | Y8L | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.468 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.468 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.467 | |
| 1ogu | ST8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.466 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.466 | |
| 1z5a | ADP | Type 2 DNA topoisomerase 6 subunit B | / | 0.466 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.466 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.466 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 3rlp | 3RP | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.465 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.465 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.464 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.464 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.463 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.463 | |
| 3ral | 04Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.463 | |
| 3dnd | LL2 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.462 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.461 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.461 | |
| 4dee | ADP | Aurora kinase A | 2.7.11.1 | 0.461 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 1hk5 | T44 | Serum albumin | / | 0.460 | |
| 2uze | C95 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 2uzl | C94 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.459 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.459 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.459 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.459 | |
| 1ci7 | UMP | Thymidylate synthase | 2.1.1.45 | 0.458 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.458 | |
| 2xhx | T5M | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.458 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.458 | |
| 3mt8 | 17T | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.458 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.458 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.458 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.457 | |
| 2ovm | AS0 | Progesterone receptor | / | 0.457 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.457 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.457 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.456 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 3gds | VAL_TYR_TYR_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.456 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.456 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.456 | |
| 1ywn | LIF | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.455 | |
| 2gfd | RDA | Endoplasmin | / | 0.455 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.455 | |
| 2q5o | PPY | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.455 | |
| 3bhh | 5CP | Calcium/calmodulin-dependent protein kinase type II subunit beta | 2.7.11.17 | 0.455 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 4j1r | I5R | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.455 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.455 | |
| 1nvr | STU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.454 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.454 | |
| 1ezv | UQ6 | Cytochrome b | / | 0.453 | |
| 1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.453 | |
| 1iy8 | NAD | Levodione reductase | / | 0.453 | |
| 1z5c | ADP | Type 2 DNA topoisomerase 6 subunit B | / | 0.453 | |
| 2euf | LQQ | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.453 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 2ivv | PP1 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.453 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.453 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.453 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.453 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.453 | |
| 3uli | 1N3 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 4b7p | 9UN | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 4eom | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 4ivd | 15T | Tyrosine-protein kinase JAK1 | / | 0.453 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.453 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.453 | |
| 4xvr | GNP | GTPase HRas | / | 0.453 | |
| 1hpx | KNI | Gag-Pol polyprotein | / | 0.452 | |
| 1pkd | UCN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.452 | |
| 3igo | ANP | Calmodulin-domain protein kinase 1, putative | / | 0.452 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.452 | |
| 3rk5 | 07Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.452 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.451 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.451 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.451 | |
| 3r7i | X9I | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.451 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.451 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.451 | |
| 4ft0 | HK9 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 4qmz | B49 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.451 | |
| 5dt3 | ATP | Aurora kinase A | 2.7.11.1 | 0.451 | |
| 1jg0 | DDT | Thymidylate synthase | / | 0.450 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.450 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.450 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.450 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.450 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.450 | |
| 4fx3 | 60K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 1nf7 | RVP | Inosine-5'-monophosphate dehydrogenase 2 | / | 0.449 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2w1f | L0F | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.449 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.449 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3kjm | 245 | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.449 | |
| 3od0 | PCG | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.449 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.449 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.449 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.448 | |
| 2ym7 | YM7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.448 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.448 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.448 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.448 | |
| 3oy4 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3sw4 | 18K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.448 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.447 | |
| 1gij | 2PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.447 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.447 | |
| 2fav | APR | Nonstructural polyprotein pp1a | / | 0.447 | |
| 3qpj | N4I | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.447 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 1u0y | PA7 | Endoplasmin | / | 0.446 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.446 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.446 | |
| 3nta | COA | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.446 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.446 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.446 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 5dn3 | ATP | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 1msn | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 2o2y | TCL | Enoyl-ACP reductase | / | 0.445 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 3a20 | FMN | FMN-binding protein | / | 0.445 | |
| 3fr0 | AJB | Glucokinase | 2.7.1.2 | 0.445 | |
| 3fr8 | NDP | Ketol-acid reductoisomerase, chloroplastic | 1.1.1.86 | 0.445 | |
| 3n0t | OPY | Dipeptidyl peptidase 2 | 3.4.14.2 | 0.445 | |
| 3qtz | X42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3saa | 77F | Protease | / | 0.445 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.445 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.445 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.444 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.444 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2egs | SAH | Diphthine synthase | / | 0.444 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.444 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2qi6 | MZ8 | Gag-Pol polyprotein | / | 0.444 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.444 | |
| 2xch | CKG | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.444 | |
| 3bkb | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.444 | |
| 3bv3 | P39 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.444 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.444 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.444 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.444 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.444 | |
| 4wbo | ANW | Rhodopsin kinase | / | 0.444 | |
| 1il0 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 1py5 | PY1 | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.443 | |
| 2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.443 | |
| 2i4x | KGQ | Protease | / | 0.443 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2vo6 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2ym6 | YM6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.443 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.443 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.443 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3lad | FAD | Dihydrolipoyl dehydrogenase | / | 0.443 | |
| 3ow3 | SMY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3r1s | X73 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3sa8 | K83 | Protease | / | 0.443 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.443 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.443 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.443 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.443 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1eio | GCH | Gastrotropin | / | 0.442 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2o1v | ADP | Endoplasmin | / | 0.442 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.442 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 2vwz | 7X6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.442 | |
| 2wgj | VGH | Hepatocyte growth factor receptor | 2.7.10.1 | 0.442 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.442 | |
| 3o99 | K13 | Pol polyprotein | / | 0.442 | |
| 3qd3 | 3Q5 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3qtq | X35 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3vfa | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 4c62 | XWW | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 4cki | ADN | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.442 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.442 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.442 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.442 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2etr | Y27 | Rho-associated protein kinase 1 | 2.7.11.1 | 0.441 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.441 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.441 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2o2s | TCL | Enoyl-acyl carrier reductase | / | 0.441 | |
| 2qi0 | MZ3 | Gag-Pol polyprotein | / | 0.441 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3k4v | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.441 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.441 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4nfh | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.441 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 1unl | RRC | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.440 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.440 | |
| 2b60 | RIT | Pol polyprotein | / | 0.440 | |
| 2bro | DF2 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.440 | |
| 2wpx | ACO | Orf14 | / | 0.440 | |
| 2xb7 | GUI | ALK tyrosine kinase receptor | 2.7.10.1 | 0.440 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.440 | |
| 3iqe | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.440 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.440 | |
| 3qx4 | X4B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.440 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.440 | |
| 4h4q | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.440 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4okx | 198 | Androgen receptor | / | 0.440 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.440 | |
| 5auu | LU2 | Death-associated protein kinase 1 | 2.7.11.1 | 0.440 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 |