sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2oy2 | ILE_ALA_GLY | Neutrophil collagenase | 3.4.24.34 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2oy2 | ILE_ALA_GLY | Neutrophil collagenase | 3.4.24.34 | 1.000 | |
| 1biw | S80 | Stromelysin-1 | 3.4.24.17 | 0.587 | |
| 1sln | INH | Stromelysin-1 | 3.4.24.17 | 0.586 | |
| 1mnc | PLH | Neutrophil collagenase | 3.4.24.34 | 0.585 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.573 | |
| 1gkc | NFH | Matrix metalloproteinase-9 | 3.4.24.35 | 0.565 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.562 | |
| 2oxw | ILE_ALA_GLY | Macrophage metalloelastase | 3.4.24.65 | 0.552 | |
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 | 0.552 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.550 | |
| 1rm8 | BAT | Matrix metalloproteinase-16 | 3.4.24 | 0.548 | |
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 | 0.547 | |
| 1bzs | BSI | Neutrophil collagenase | 3.4.24.34 | 0.542 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.540 | |
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 | 0.536 | |
| 1zs0 | EIN | Neutrophil collagenase | 3.4.24.34 | 0.534 | |
| 3kry | 3KR | Collagenase 3 | 3.4.24 | 0.534 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.532 | |
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 0.531 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.530 | |
| 1atl | 0QI | Snake venom metalloproteinase atrolysin-D | 3.4.24.42 | 0.529 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.529 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.527 | |
| 4gr0 | R4B | Macrophage metalloelastase | 3.4.24.65 | 0.527 | |
| 2d1o | FA4 | Stromelysin-1 | 3.4.24.17 | 0.526 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.526 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.523 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.518 | |
| 2ow0 | 6MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.518 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.517 | |
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.514 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.512 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.511 | |
| 1hv5 | RXP | Stromelysin-3 | 3.4.24 | 0.510 | |
| 1utt | CP8 | Macrophage metalloelastase | 3.4.24.65 | 0.510 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.509 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.508 | |
| 2ow1 | 7MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.507 | |
| 2ovz | 5MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.506 | |
| 2woa | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.504 | |
| 2ovx | 4MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.503 | |
| 3kek | 3EK | Collagenase 3 | 3.4.24 | 0.503 | |
| 3oho | Z79 | Stromelysin-1 | 3.4.24.17 | 0.501 | |
| 3aig | 0ZC | Snake venom metalloproteinase adamalysin-2 | 3.4.24.46 | 0.500 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.497 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.496 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.495 | |
| 2wo8 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.494 | |
| 1b3d | S27 | Stromelysin-1 | 3.4.24.17 | 0.491 | |
| 1g49 | 111 | Stromelysin-1 | 3.4.24.17 | 0.491 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.491 | |
| 3l0t | INN | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.488 | |
| 3lik | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.488 | |
| 2d1n | FA4 | Collagenase 3 | 3.4.24 | 0.486 | |
| 2w0d | CGS | Macrophage metalloelastase | 3.4.24.65 | 0.486 | |
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 | 0.485 | |
| 2dw0 | GM6 | Zinc metalloproteinase-disintegrin-like VAP2B | 3.4.24 | 0.485 | |
| 4iz0 | 2BI | Genome polyprotein | 2.7.7.48 | 0.485 | |
| 2jih | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | 3.4.24 | 0.484 | |
| 2wo9 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.481 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.481 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.479 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.476 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.476 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.475 | |
| 2w13 | WR2 | Snake venom metalloproteinase BaP1 | 3.4.24 | 0.475 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.474 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.473 | |
| 1d7x | SPC | Stromelysin-1 | 3.4.24.17 | 0.472 | |
| 3v2u | ATP | Protein GAL3 | / | 0.472 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.472 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.471 | |
| 1dth | BAT | Snake venom metalloproteinase atrolysin-D | 3.4.24.42 | 0.470 | |
| 2a8h | 4NH | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.470 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.470 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.469 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.468 | |
| 1v0c | ACO | AAC(6')-Ib | / | 0.467 | |
| 2e8h | SAH | Diphthine synthase | / | 0.467 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.466 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.466 | |
| 2el3 | SAH | Diphthine synthase | / | 0.466 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3u04 | BB2 | Peptide deformylase | / | 0.465 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2hpv | FMN | FMN-dependent NADH-azoreductase | 1.7 | 0.463 | |
| 2hux | SAH | Diphthine synthase | / | 0.463 | |
| 2srt | INH | Stromelysin-1 | 3.4.24.17 | 0.463 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.463 | |
| 3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.463 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.462 | |
| 3e8x | NAP | BH1520 protein | / | 0.462 | |
| 3kn0 | 3TO | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4ih7 | 1ER | Genome polyprotein | 2.7.7.48 | 0.462 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.462 | |
| 1d5j | MM3 | Stromelysin-1 | 3.4.24.17 | 0.461 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.461 | |
| 3a3b | RBF | Lumazine protein | / | 0.461 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.461 | |
| 1qrr | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.460 | |
| 1y9d | TPP | Pyruvate oxidase | 1.2.3.3 | 0.460 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.460 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.460 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.460 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.459 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.459 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.459 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.459 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.459 | |
| 3cvk | N34 | Genome polyprotein | 2.7.7.48 | 0.459 | |
| 3gol | XND | Genome polyprotein | 2.7.7.48 | 0.459 | |
| 3uph | 0C1 | Genome polyprotein | 2.7.7.48 | 0.459 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 1zxc | IH6 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.458 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.458 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.457 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.457 | |
| 3kjm | 245 | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.457 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.457 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.456 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.456 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.456 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.456 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.456 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2prb | COA | Aminoglycoside 6-N-acetyltransferase type Ib11 | / | 0.456 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.456 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.456 | |
| 3ayk | CGS | Interstitial collagenase | 3.4.24.7 | 0.456 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.456 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.456 | |
| 1fm1 | WAY | Collagenase 3 | 3.4.24 | 0.455 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.455 | |
| 2emu | SAH | Diphthine synthase | / | 0.455 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.455 | |
| 2ge3 | ACO | Probable acetyltransferase | / | 0.454 | |
| 2pk3 | GDD | GDP-6-deoxy-D-mannose reductase | / | 0.454 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.454 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.454 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.453 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.453 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.453 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.453 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.453 | |
| 3co9 | 3MS | Genome polyprotein | 2.7.7.48 | 0.453 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.452 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.452 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.452 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.452 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.452 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.452 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.451 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.451 | |
| 2p6l | SAH | Diphthine synthase | / | 0.451 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.451 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.451 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.451 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.451 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.451 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.451 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.450 | |
| 2dxw | SAH | Diphthine synthase | / | 0.450 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3u8n | 09S | Acetylcholine-binding protein | / | 0.450 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.450 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.449 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.449 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.449 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.449 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.449 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2cnt | COA | Ribosomal-protein-alanine acetyltransferase | / | 0.449 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.449 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.449 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.449 | |
| 3h98 | B5P | Genome polyprotein | 2.7.7.48 | 0.449 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.449 | |
| 3n71 | SFG | Histone-lysine N-methyltransferase Smyd1 | / | 0.449 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.449 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.448 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.448 | |
| 3kru | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.448 | |
| 3wv8 | ATP | Hmd co-occurring protein HcgE | / | 0.448 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.448 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.447 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.447 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.447 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.447 | |
| 3bi4 | 298 | Polyamine oxidase FMS1 | / | 0.447 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.447 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.447 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 4z0p | NDP | NAD-dependent dehydrogenase | / | 0.447 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.446 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.446 | |
| 2el0 | SAH | Diphthine synthase | / | 0.446 | |
| 2eld | SAH | Diphthine synthase | / | 0.446 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.446 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.446 | |
| 3gr8 | FMN | NADPH dehydrogenase | / | 0.446 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.446 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.446 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 1gc5 | ADP | ADP-dependent glucokinase | 2.7.1.147 | 0.445 | |
| 2ohv | NHL | Glutamate racemase | / | 0.445 | |
| 3ndj | JHZ | Methyltransferase | / | 0.445 | |
| 4drm | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.445 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.444 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.444 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.444 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.444 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.444 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.444 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4rel | KMP | Glycosyltransferase | / | 0.444 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.444 | |
| 4y38 | 0A9 | Endothiapepsin | 3.4.23.22 | 0.444 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.443 | |
| 2dxv | SAH | Diphthine synthase | / | 0.443 | |
| 2egl | SAH | Diphthine synthase | / | 0.443 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.443 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2pca | SAH | Diphthine synthase | / | 0.443 | |
| 2zu8 | GDD | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.443 | |
| 3dkv | AP5 | Adenylate kinase | / | 0.443 | |
| 3le9 | 727 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.443 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.443 | |
| 3t4h | MD5 | Alpha-ketoglutarate-dependent dioxygenase AlkB | 1.14.11.33 | 0.443 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.443 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.443 | |
| 4qnw | FMN | Chanoclavine-I aldehyde reductase easA | / | 0.443 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.443 | |
| 4y57 | F63 | Endothiapepsin | 3.4.23.22 | 0.443 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.442 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 1t3z | CAO | Formyl-CoA:oxalate CoA-transferase | / | 0.442 | |
| 1til | ATP | Anti-sigma F factor | / | 0.442 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2p9d | SAH | Diphthine synthase | / | 0.442 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.442 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.442 | |
| 3cso | XNI | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 3e51 | N35 | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 3nyr | MLC | Putative fatty acid synthase | / | 0.442 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.442 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.441 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.441 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3vkj | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.441 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.441 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.440 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2bwp | PLG | 5-aminolevulinate synthase | 2.3.1.37 | 0.440 | |
| 2y6d | TQJ | Matrilysin | 3.4.24.23 | 0.440 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.440 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.440 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.440 | |
| 3mp3 | HGG | Hydroxymethylglutaryl-CoA lyase, mitochondrial | 4.1.3.4 | 0.440 | |
| 3t64 | DU3 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.440 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4hr2 | ADP | Nucleoside diphosphate kinase | / | 0.440 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.440 | |
| 5dmh | ADP | 3-oxo-tetronate kinase | / | 0.440 |