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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4p6xHCYGlucocorticoid receptor

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4p6xHCYGlucocorticoid receptor/1.000
4udcDEXGlucocorticoid receptor/0.604
4p6wMOFGlucocorticoid receptor/0.583
1p93DEXGlucocorticoid receptor/0.573
1m2zDEXGlucocorticoid receptor/0.565
1sr7MOFProgesterone receptor/0.539
3mnpDEXGlucocorticoid receptor/0.536
3mneDEXGlucocorticoid receptor/0.531
2w8y486Progesterone receptor/0.530
4udaDEXMineralocorticoid receptor/0.526
3bqdDAYGlucocorticoid receptor/0.522
1nhz486Glucocorticoid receptor/0.513
2ovhAS0Progesterone receptor/0.513
2ovmAS0Progesterone receptor/0.511
1ya3STRMineralocorticoid receptor/0.508
4a2jAS0Progesterone receptor/0.504
2aa2AS4Mineralocorticoid receptor/0.503
1zucT98Progesterone receptor/0.502
3vhuSNLMineralocorticoid receptor/0.496
3zr7OR8Progesterone receptor/0.496
2aa71CAMineralocorticoid receptor/0.493
3mdvCL6Cholesterol 24-hydroxylase/0.493
2pixDHTAndrogen receptor/0.492
1sqnNDRProgesterone receptor/0.491
3zrbOR8Progesterone receptor/0.491
3zrbORCProgesterone receptor/0.490
2aaxPDNMineralocorticoid receptor/0.489
4r21STRCytochrome P450 family 17 polypeptide 2/0.489
2abi1CAMineralocorticoid receptor/0.488
2w8yNDRProgesterone receptor/0.488
4lsjLSJGlucocorticoid receptor/0.486
2a3iC0RMineralocorticoid receptor/0.484
2ab2SNLMineralocorticoid receptor/0.482
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.482
4iw8KN3Estrogen receptor/0.480
2aa6STRMineralocorticoid receptor/0.479
4y8wSTRSteroid 21-hydroxylase/0.478
4apuA2KProgesterone receptor/0.476
1xddAAYIntegrin alpha-L/0.473
3mnoDEXGlucocorticoid receptor/0.473
3mdmFJZCholesterol 24-hydroxylase/0.471
3uudESTEstrogen receptor/0.470
4enhFVXCholesterol 24-hydroxylase/0.469
4oeaDHTAndrogen receptor/0.469
2oaxSNLMineralocorticoid receptor/0.468
2q9fC3SCholesterol 24-hydroxylase/0.468
4apuOR8Progesterone receptor/0.466
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.466
2po7CHDFerrochelatase, mitochondrial4.99.1.10.464
1dhjMTXDihydrofolate reductase1.5.1.30.463
1fmlRTLRetinol dehydratase/0.463
2aclREARetinoic acid receptor RXR-alpha/0.463
2iviACWIsopenicillin N synthase1.21.3.10.463
2ylqTESAndrogen receptor/0.463
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
2b03TUDPhospholipase A2, major isoenzyme3.1.1.40.462
2pioDHTAndrogen receptor/0.462
3zkyWT4Isopenicillin N synthase1.21.3.10.462
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
1dhiMTXDihydrofolate reductase1.5.1.30.461
3nx4NAPPutative oxidoreductase/0.461
4k7aDHTAndrogen receptor/0.461
1fmjRTLRetinol dehydratase/0.460
1gs4ZK5Androgen receptor/0.460
1xowR18Androgen receptor/0.460
1zky689Estrogen receptor/0.460
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.460
2pklDHTAndrogen receptor/0.460
2q7kTESAndrogen receptor/0.460
3q5kD1UHeat shock protein 83-1/0.460
4q71FADBifunctional protein PutA/0.460
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
1x8lOXRRetinol dehydratase/0.459
2aa5STRMineralocorticoid receptor/0.459
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
3vufADPGranule-bound starch synthase 1, chloroplastic/amyloplastic2.4.1.2420.459
3zraORBProgesterone receptor/0.459
4q72FADBifunctional protein PutA/0.459
1k6tXN1Gag-Pol polyprotein3.4.23.160.458
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1uzwCDHIsopenicillin N synthase1.21.3.10.458
2ylpTESAndrogen receptor/0.458
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.458
1crbRTLRetinol-binding protein 1/0.457
1dajMOTDihydrofolate reductase1.5.1.30.457
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
2uxpCLMHTH-type transcriptional regulator TtgR/0.457
3p3zP3ZPutative cytochrome P450/0.457
3vt8YI3Vitamin D3 receptor/0.457
4q73FADBifunctional protein PutA/0.457
1bk0ACVIsopenicillin N synthase1.21.3.10.456
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.456
1t88CAMCamphor 5-monooxygenase1.14.15.10.456
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.456
2q7lTESAndrogen receptor/0.456
3d90NOGProgesterone receptor/0.456
3ggfGVDSerine/threonine-protein kinase 26/0.455
4kwhNAPReductase homolog/0.455
1ywnLIFVascular endothelial growth factor receptor 22.7.10.10.454
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
2piwDHTAndrogen receptor/0.454
2y60M8FIsopenicillin N synthase1.21.3.10.454
3lqfNADGalactitol dehydrogenase/0.454
3vt9YI4Vitamin D3 receptor/0.454
4m83ERYOleandomycin glycosyltransferase2.4.10.454
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.454
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1t74DHTAndrogen receptor/0.453
1zeoC01Peroxisome proliferator-activated receptor gamma/0.453
2z97CAMCamphor 5-monooxygenase1.14.15.10.453
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
1e3kR18Progesterone receptor/0.452
1n83CLRNuclear receptor ROR-alpha/0.452
2jb4A14Isopenicillin N synthase1.21.3.10.452
3i1y33NBifunctional epoxide hydrolase 23.3.2.100.452
1dz8CAMCamphor 5-monooxygenase1.14.15.10.451
1obnASVIsopenicillin N synthase1.21.3.10.451
2amaDHTAndrogen receptor/0.451
3a3yOBNSodium/potassium-transporting ATPase subunit alpha/0.451
3vt7VDXVitamin D3 receptor/0.451
4bmpFMNProtein NrdI/0.451
4oezDHTAndrogen receptor/0.451
1zgyBRLPeroxisome proliferator-activated receptor gamma/0.450
3l8sBFFMitogen-activated protein kinase 14/0.450
4j24ESTEstrogen receptor beta/0.450
4uymVOR14-alpha sterol demethylase Cyp51B/0.450
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1hb3SCVIsopenicillin N synthase1.21.3.10.449
1xq3R18Androgen receptor/0.449
1ykdCMPAdenylate cyclase/0.449
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
3d7kD7KBenzaldehyde lyase/0.449
3q95ESLEstrogen receptor/0.449
4c9pCAMCytochrome P450/0.449
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.449
1mvsDTMDihydrofolate reductase1.5.1.30.448
1s9pDESEstrogen-related receptor gamma/0.448
2pirDHTAndrogen receptor/0.448
2piuDHTAndrogen receptor/0.448
2q70DC8Estrogen receptor/0.448
2rkvZBATrichothecene 3-O-acetyltransferase/0.448
2vd5BI8Myotonin-protein kinase2.7.11.10.448
1kzjCB3Thymidylate synthase/0.447
1t63DHTAndrogen receptor/0.447
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.447
3adaNADSubunit alpha of sarocosine oxidase/0.447
3gwfFADCyclohexanone monooxygenase/0.447
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
3l63CAMCamphor 5-monooxygenase1.14.15.10.447
3nwq2NCGag-Pol polyprotein3.4.23.160.447
3qlrNDPDihydrofolate reductase1.5.1.30.447
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.447
4jbqVX6Aurora kinase A2.7.11.10.447
4l9kEHFSerum albumin/0.447
4oilHFTAndrogen receptor/0.447
1t79DHTAndrogen receptor/0.446
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.446
2q7iTESAndrogen receptor/0.446
3dmtNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.446
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
3zoiM2WIsopenicillin N synthase1.21.3.10.446
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4hy6FJ1Heat shock protein HSP 90-alpha/0.446
4xivACPChemotaxis protein CheA2.7.13.30.446
1b2lNDCAlcohol dehydrogenase1.1.1.10.445
1gwqZTWEstrogen receptor/0.445
1iwiCAMCamphor 5-monooxygenase1.14.15.10.445
1t86CAMCamphor 5-monooxygenase1.14.15.10.445
1y9r1CAMineralocorticoid receptor/0.445
1yrcCAMCamphor 5-monooxygenase1.14.15.10.445
2nq8ZIDEnoyl-ACP reductase/0.445
3ibdCPZCytochrome P450 2B61.14.130.445
3vrwYS5Vitamin D3 receptor/0.445
1ia3TQ5Dihydrofolate reductase1.5.1.30.444
1tdrMTXDihydrofolate reductase1.5.1.30.444
1tkzH16Gag-Pol polyprotein2.7.7.490.444
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.444
2ejzSAHDiphthine synthase/0.444
2ykeYKEHeat shock protein HSP 90-alpha/0.444
3ollESTEstrogen receptor beta/0.444
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4l9q9TPSerum albumin/0.444
4tuvCPZCytochrome P450 1191.140.444
4ure1PSCyclohexanol dehydrogenase/0.444
4xldBRLPeroxisome proliferator-activated receptor gamma/0.444
1adfTADAlcohol dehydrogenase E chain1.1.1.10.443
1phePIYCamphor 5-monooxygenase1.14.15.10.443
1s9qOHTEstrogen-related receptor gamma/0.443
1t7rDHTAndrogen receptor/0.443
1wsvTHHAminomethyltransferase, mitochondrial/0.443
1yrdCAMCamphor 5-monooxygenase1.14.15.10.443
2a1nCAMCamphor 5-monooxygenase1.14.15.10.443
2f2uM77Rho-associated protein kinase 22.7.11.10.443
2qn3F55Glycogen phosphorylase, muscle form2.4.1.10.443
3cppCAMCamphor 5-monooxygenase1.14.15.10.443
4g3rCAMCamphor 5-monooxygenase1.14.15.10.443
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4ofrDHTAndrogen receptor/0.443
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.442
1culFOKAdenylate cyclase type 2/0.442
1culFOKAdenylate cyclase type 5/0.442
1drbMTXDihydrofolate reductase1.5.1.30.442
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
1hb1OCVIsopenicillin N synthase1.21.3.10.442
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1kl2FONSerine hydroxymethyltransferase/0.442
1t65DHTAndrogen receptor/0.442
1t7fDHTAndrogen receptor/0.442
1x7rGENEstrogen receptor/0.442
2azyCHDPhospholipase A2, major isoenzyme3.1.1.40.442
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2fai459Estrogen receptor/0.442
2vcmM11Isopenicillin N synthase1.21.3.10.442
2vkeTACTetracycline repressor protein class D/0.442
3hz5Z64Heat shock protein HSP 90-alpha/0.442
3nj0PYVAbscisic acid receptor PYL2/0.442
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
3u8hBHPPhospholipase A2, membrane associated/0.442
3v49PK0Androgen receptor/0.442
4a9mP9MBromodomain-containing protein 2/0.442
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4cdmFO1Deoxyribodipyrimidine photolyase/0.442
4elg52JDihydrofolate reductase/0.442
4orkGDPBifunctional AAC/APH2.3.10.442
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
1bozPRDDihydrofolate reductase1.5.1.30.441
1bygSTUTyrosine-protein kinase CSK/0.441
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2ft9CHDFatty acid-binding protein 2, liver/0.441
2g8aUMPThymidylate synthase/0.441
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.441
2qpyDHTAndrogen receptor/0.441
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.441
2y3pSM8DNA gyrase subunit A/0.441
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.441
2yloTESAndrogen receptor/0.441
3k7tFAD6-hydroxy-L-nicotine oxidase/0.441
3pqbVGPPutative oxidoreductase/0.441
4xxgFADCholesterol oxidase1.1.3.60.441
1fm4DXCMajor pollen allergen Bet v 1-L/0.440
1klkPMDDihydrofolate reductase1.5.1.30.440
1uyuCAMCamphor 5-monooxygenase1.14.15.10.440
1yb5NAPQuinone oxidoreductase1.6.5.50.440
2a1mCAMCamphor 5-monooxygenase1.14.15.10.440
2amb17HAndrogen receptor/0.440
2bfyH1NAurora kinase B-A2.7.11.10.440
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
3a60STURibosomal protein S6 kinase beta-12.7.11.10.440
3cgfJNFMitogen-activated protein kinase 102.7.11.240.440
3gyjFADCholesterol oxidase1.1.3.60.440
3uvvREARetinoic acid receptor RXR-alpha/0.440
3wixLC3Induced myeloid leukemia cell differentiation protein Mcl-1/0.440
4g1y0VOVitamin D3 receptor A/0.440
4h3ySAHtRNA (guanine-N(1)-)-methyltransferase/0.440
4j6bPLOCytochrome P450 monooxygenase/0.440
4rcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.440
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
5hs1VORLanosterol 14-alpha demethylase/0.440
5uviZMAAdenosine receptor A2a/0.440