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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ic7ANPMitogen-activated protein kinase 72.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ic7ANPMitogen-activated protein kinase 72.7.11.241.000
3c4xATPRhodopsin kinase/0.524
2ojj82AMitogen-activated protein kinase 12.7.11.240.522
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.522
3lltANPProtein serine/threonine kinase-1/0.521
4bcmT7ZCyclin-dependent kinase 22.7.11.220.521
4hvi19STyrosine-protein kinase JAK32.7.10.20.513
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.505
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.504
2j0lANPFocal adhesion kinase 12.7.10.20.497
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.496
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.494
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.494
3t8oATPRhodopsin kinase/0.493
2izsBRQCasein kinase I isoform gamma-32.7.11.10.491
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.487
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.487
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.484
4ez50RSCyclin-dependent kinase 62.7.11.220.484
1finATPCyclin-dependent kinase 22.7.11.220.482
4jia1K3Tyrosine-protein kinase JAK2/0.482
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.480
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.479
3i60E86Mitogen-activated protein kinase 12.7.11.240.479
4j95ACPFibroblast growth factor receptor 2/0.479
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
3c4wATPRhodopsin kinase/0.477
3c4zADPRhodopsin kinase/0.475
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.475
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.475
2uzbC75Cyclin-dependent kinase 22.7.11.220.474
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.474
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.473
1pkdUCNCyclin-dependent kinase 22.7.11.220.471
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.471
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.471
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.471
4b99R4LMitogen-activated protein kinase 72.7.11.240.470
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.469
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.469
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.469
4qnyANPMitogen activated protein kinase, putative/0.469
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
1yvj4STTyrosine-protein kinase JAK32.7.10.20.468
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
2izrBRKCasein kinase I isoform gamma-32.7.11.10.467
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.467
4l9i8PRRhodopsin kinase/0.467
1fvv107Cyclin-dependent kinase 22.7.11.220.466
2fvdLIACyclin-dependent kinase 22.7.11.220.466
2j0m4STFocal adhesion kinase 12.7.10.20.466
3nynSGVG protein-coupled receptor kinase 62.7.11.160.466
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.465
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.465
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.465
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.464
3w2sW2REpidermal growth factor receptor2.7.10.10.464
2ckeIQUDeath-associated protein kinase 2/0.462
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.462
4gmy0X5Tyrosine-protein kinase JAK2/0.462
2ijmADPFocal adhesion kinase 12.7.10.20.461
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.461
3fln3FNMitogen-activated protein kinase 14/0.461
3ormAGSSerine/threonine protein kinase/0.461
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.459
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.459
3my5RFZCyclin-dependent kinase 22.7.11.220.458
4bcqTJFCyclin-dependent kinase 22.7.11.220.458
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.458
2w05FRTCyclin-dependent kinase 22.7.11.220.457
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.457
3bqr4RBDeath-associated protein kinase 3/0.457
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.457
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.457
4ysjADPCalmodulin-like domain protein kinase/0.457
1h1r6CPCyclin-dependent kinase 22.7.11.220.456
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.456
2cchATPCyclin-dependent kinase 22.7.11.220.456
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.455
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4fob0USALK tyrosine kinase receptor2.7.10.10.455
4k33ACPFibroblast growth factor receptor 32.7.10.10.454
4otiMI1Serine/threonine-protein kinase N1/0.454
3dfcANPDeath-associated protein kinase 12.7.11.10.453
3gubGUBDeath-associated protein kinase 12.7.11.10.453
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.453
4hgs15GCasein kinase I isoform gamma-32.7.11.10.453
4hvh19RTyrosine-protein kinase JAK32.7.10.20.453
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.452
2pwlACPFibroblast growth factor receptor 2/0.452
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.452
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.452
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.451
2itqITQEpidermal growth factor receptor2.7.10.10.451
2vtqLZACyclin-dependent kinase 22.7.11.220.451
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.451
3qc9ADPRhodopsin kinase/0.451
3w33W19Epidermal growth factor receptor2.7.10.10.451
4deeADPAurora kinase A2.7.11.10.451
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.451
4gk4L90Ephrin type-A receptor 32.7.10.10.451
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3sheI85MAP kinase-activated protein kinase 32.7.11.10.450
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.450
1jklANPDeath-associated protein kinase 12.7.11.10.449
5av2KMPDeath-associated protein kinase 12.7.11.10.449
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.448
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2qoqANPEphrin type-A receptor 32.7.10.10.448
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.448
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.448
3nux3NVCyclin-dependent kinase 62.7.11.220.448
4bbe3O4Tyrosine-protein kinase JAK2/0.448
4fmqANPMitogen-activated protein kinase 12.7.11.240.448
1e9hINRCyclin-dependent kinase 22.7.11.220.447
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2hog710Serine/threonine-protein kinase Chk12.7.11.10.447
3c50ADPRhodopsin kinase/0.447
3uvqFS8Mitogen-activated protein kinase 14/0.447
4hvg19QTyrosine-protein kinase JAK32.7.10.20.447
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
4o0wADNAurora kinase A2.7.11.10.447
4fv6E57Mitogen-activated protein kinase 12.7.11.240.446
4qmlANPSerine/threonine-protein kinase 242.7.11.10.446
2yn8STUEphrin type-B receptor 42.7.10.10.445
3nup3NUCyclin-dependent kinase 62.7.11.220.445
4cd0AWJALK tyrosine kinase receptor2.7.10.10.445
1qmzATPCyclin-dependent kinase 22.7.11.220.444
2etm7PYFocal adhesion kinase 12.7.10.20.444
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.444
2uzdC85Cyclin-dependent kinase 22.7.11.220.444
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.444
4gk3L87Ephrin type-A receptor 32.7.10.10.444
5av3KMPDeath-associated protein kinase 12.7.11.10.444
2izuP01Casein kinase I isoform gamma-32.7.11.10.443
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2vu3LZECyclin-dependent kinase 22.7.11.220.443
3igoANPCalmodulin-domain protein kinase 1, putative/0.443
3tnwF18Cyclin-dependent kinase 22.7.11.220.443
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.443
4h3qANPMitogen-activated protein kinase 12.7.11.240.443
5e8ySTUTGF-beta receptor type-22.7.11.300.443
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.442
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.442
2wihP48Cyclin-dependent kinase 22.7.11.220.442
2x1nX1NCyclin-dependent kinase 22.7.11.220.442
4c3pACPAurora kinase A2.7.11.10.442
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.442
4nks2M2Fibroblast growth factor receptor 1/0.442
4xhgADPUncharacterized protein/0.442
5eg3ACPFibroblast growth factor receptor 2/0.442
2yaaATPDeath-associated protein kinase 2/0.441
3gu7ADPDeath-associated protein kinase 12.7.11.10.441
3ortAGSSerine/threonine protein kinase/0.441
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.441
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.440
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2vd5BI8Myotonin-protein kinase2.7.11.10.440
2xvdAS6Ephrin type-B receptor 42.7.10.10.440
3a62STURibosomal protein S6 kinase beta-12.7.11.10.440
4bcnT9NCyclin-dependent kinase 22.7.11.220.440
4wsqKSAAP2-associated protein kinase 12.7.11.10.440
5dnrATPAurora kinase A2.7.11.10.440