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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4e1bTXAThreonylcarbamoyl-AMP synthase2.7.7.87

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4e1bTXAThreonylcarbamoyl-AMP synthase2.7.7.871.000
1kgjFL8Transthyretin/0.511
4hwkNAPSepiapterin reductase1.1.1.1530.508
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.505
3ajeANPThreonylcarbamoyl-AMP synthase2.7.7.870.501
3vthAPCCarbamoyltransferase/0.495
3zc3NAPFerredoxin--NADP reductase1.18.1.20.491
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.488
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.488
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.487
1ictT44Transthyretin/0.487
2bx8AZQSerum albumin/0.487
3wdlATP4-phosphopantoate--beta-alanine ligase6.3.2.360.487
4qvtACOAcetyltransferase YpeA2.3.10.487
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.485
2pd7FADVivid PAS protein VVD/0.484
2rghFADAlpha-Glycerophosphate Oxidase/0.482
2yutNAPPutative short-chain oxidoreductase/0.482
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.482
1ipeNDPTropinone reductase 21.1.1.2360.480
8catNDPCatalase1.11.1.60.479
3h86AP5Adenylate kinase/0.478
4l9q9TPSerum albumin/0.478
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.477
3d72FADVivid PAS protein VVD/0.476
3ntdCOAFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.476
2pg0FADAcyl-CoA dehydrogenase/0.475
4b6cB5UDNA gyrase subunit B/0.475
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.474
4en4ATPPyridoxal kinase2.7.1.350.473
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.472
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
3lu7IPXSerum albumin/0.471
4bwxAGSPAB-dependent poly(A)-specific ribonuclease subunit pan3/0.471
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.470
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.470
4ii5ADPCyclin-dependent kinase 22.7.11.220.470
4ki8ADP60 kDa chaperonin/0.470
3tqcADPPantothenate kinase/0.469
4i9aNCNNicotinate-nucleotide pyrophosphorylase [carboxylating]/0.469
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.468
2ev9NAPShikimate dehydrogenase (NADP(+))/0.468
2gsdNADFormate dehydrogenase/0.468
2ym2NAPPhenylacetone monooxygenase1.14.13.920.468
5idwNAPShort-chain dehydrogenase/reductase SDR/0.468
7catNDPCatalase1.11.1.60.468
1pmn984Mitogen-activated protein kinase 102.7.11.240.466
1ryeNDPGlucose--fructose oxidoreductase1.1.99.280.466
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.466
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.465
3okxSAMS-adenosyl-L-methionine-binding protein RPA0152/0.465
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.465
3rusADPChaperonin/0.465
3sjzGNPTranslation initiation factor 2 subunit gamma/0.465
4e37NDPCatalase1.11.1.60.465
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.464
1sx4ADP60 kDa chaperonin/0.464
1w87NAPFerredoxin--NADP reductase1.18.1.20.464
1xq6NAPUncharacterized protein At5g02240/0.464
2x0iNAIMalate dehydrogenase/0.464
3fhyATPPyridoxal kinase2.7.1.350.464
3hjiFADVivid PAS protein VVD/0.464
3lu6IMXSerum albumin/0.464
1o6kANPRAC-beta serine/threonine-protein kinase2.7.11.10.463
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.463
3hjkFADVivid PAS protein VVD/0.463
1gjrNAPFerredoxin--NADP reductase1.18.1.20.462
2ebaFADPutative glutaryl-CoA dehydrogenase/0.462
2g78REACellular retinoic acid-binding protein 2/0.462
2q4bNAPUncharacterized protein At5g02240/0.462
3ad9NADSubunit alpha of sarocosine oxidase/0.462
3idcANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
3nt6COAFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.462
5hwsNAP2-dehydropantoate 2-reductase/0.462
1f20NAPNitric oxide synthase, brain1.14.13.390.461
1ofgNDPGlucose--fructose oxidoreductase1.1.99.280.461
2xb5I7TTetracycline repressor protein class D/0.461
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.461
4b8wNAPGDP-L-fucose synthase1.1.1.2710.461
4mb2ATPUncharacterized protein/0.461
1oaaNAPSepiapterin reductase1.1.1.1530.460
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.460
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.460
4idgNADPutative UDP-glucose 4-epimerase/0.460
1h6bNDPGlucose--fructose oxidoreductase1.1.99.280.459
2vqdAP2Biotin carboxylase6.3.4.140.459
2yxuATPPyridoxal kinase2.7.1.350.459
4gt3ATPMitogen-activated protein kinase 12.7.11.240.459
4jtqNAPAldo-keto reductase family 1 member C2/0.459
4l8u9AZSerum albumin/0.459
2c3qGTXGlutathione S-transferase theta-12.5.1.180.458
3cukFADD-amino-acid oxidase1.4.3.30.458
3k5uPFQAurora kinase A2.7.11.10.458
1kk4ACOStreptogramin A acetyltransferase2.3.10.457
2bacFADPutative aminooxidase/0.457
2cmvNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.457
2f1kNAPPrephenate dehydrogenase/0.457
3q30D61Squalene synthase2.5.1.210.457
4dpwAGSMevalonate diphosphate decarboxylase/0.457
4oknNAIL-lactate dehydrogenase A chain1.1.1.270.457
5c1oANPD-alanine--D-alanine ligase/0.457
2aazCB3Thymidylate synthase2.1.1.450.456
2ojj82AMitogen-activated protein kinase 12.7.11.240.456
2v92ATP5'-AMP-activated protein kinase subunit gamma-1/0.456
3tqhNDPQuinone oxidoreductase/0.456
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.456
4n9iPCGCatabolite expression activator/0.456
4s33ANPMitogen-activated protein kinase 12.7.11.240.456
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.456
5l8lADPAurora kinase A2.7.11.10.456
1n1eNDEGlycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal1.1.1.80.455
4at9UTPInterleukin enhancer-binding factor 2/0.455
4cpdNADAlcohol dehydrogenase/0.455
4jbqVX6Aurora kinase A2.7.11.10.455
4kcfAKMFAD-dependent oxidoreductase/0.455
4lx9ACON-alpha-acetyltransferase2.3.10.455
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
1ie4T44Transthyretin/0.454
1yb5NAPQuinone oxidoreductase1.6.5.50.454
1z7eUGABifunctional polymyxin resistance protein ArnA/0.454
3bazNAPHydroxyphenylpyruvate reductase1.1.1.2370.454
3f1kNAPUncharacterized oxidoreductase YciK10.454
3pjuC2EDiguanylate cyclase/phosphodiesterase/0.454
3pkpDTPGlucose-1-phosphate thymidylyltransferase2.7.7.240.454
3uwqU5POrotidine 5'-phosphate decarboxylase/0.454
4gddFADUDP-galactopyranose mutase/0.454
4ku5DCC3-oxoacyl-[ACP] synthase III/0.454
4qnyANPMitogen activated protein kinase, putative/0.454
5kf8ACOPredicted acetyltransferase/0.454
1qmzATPCyclin-dependent kinase 22.7.11.220.453
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.453
3p2eSAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.453
4deeADPAurora kinase A2.7.11.10.453
4n9wGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.453
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.453
1ht0NADAlcohol dehydrogenase 1C1.1.1.10.452
1wwkNAD307aa long hypothetical phosphoglycerate dehydrogenase/0.452
2vhwNAIAlanine dehydrogenase1.4.1.10.452
3cgdCOACoenzyme A disulfide reductase/0.452
3mddFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.452
3uteFADUDP-galactopyranose mutase/0.452
4fdpFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.452
4o1pANPRibonuclease L/0.452
5a3bAPRSIR2 family protein/0.452
1aj8COACitrate synthase/0.451
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.451
1t9a1TBAcetolactate synthase catalytic subunit, mitochondrial2.2.1.60.451
2dbrNAPGlyoxylate reductase1.1.1.260.451
2obyNAPQuinone oxidoreductase PIG310.451
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.451
3keuATPPyridoxal kinase2.7.1.350.451
3wecAUICytochrome P450/0.451
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4g1cCNANAD-dependent protein deacylase sirtuin-5, mitochondrial/0.451
4y9qC2EUncharacterized protein/0.451
1okkGCPSignal recognition particle protein/0.450
1okkGCPSignal recognition particle receptor FtsY/0.450
3efwAK8Aurora kinase A2.7.11.10.450
3ictCOACoenzyme A disulfide reductase/0.450
3kmwATPIntegrin-linked protein kinase2.7.11.10.450
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.450
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.450
4j7uNAPSepiapterin reductase1.1.1.1530.450
1j39UPGDNA beta-glucosyltransferase/0.449
1kifFADD-amino-acid oxidase1.4.3.30.449
2bsmBSMHeat shock protein HSP 90-alpha/0.449
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.449
2excJNKMitogen-activated protein kinase 102.7.11.240.449
3nwlNDPCatalase1.11.1.60.449
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.449
4s32ANPMitogen-activated protein kinase 12.7.11.240.449
5ahsCOAAcyl-CoA dehydrogenase/0.449
5ayzNCNNicotinate-nucleotide pyrophosphorylase [carboxylating]2.4.2.190.449
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.449
1i44ACPInsulin receptor2.7.10.10.448
1m75NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.448
2c6eHPMAurora kinase A2.7.11.10.448
2j3iNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.448
2r26CMCCitrate synthase2.3.3.160.448
3rf7NADIron-containing alcohol dehydrogenase/0.448
4fk1FADPutative thioredoxin reductase/0.448
4xnhACON-terminal acetyltransferase A complex subunit NAT52.3.10.448
4xwrFADCholesterol oxidase1.1.3.60.448
4zlaBESCytosol aminopeptidase3.4.11.10.448
5a3cNADSIR2 family protein/0.448
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.447
1h6dNDPGlucose--fructose oxidoreductase1.1.99.280.447
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.447
1mabATPATP synthase subunit alpha, mitochondrial/0.447
1orkATCTetracycline repressor protein class D/0.447
1tz8DESTransthyretin/0.447
3nf7CIWGag-Pol polyprotein/0.447
3pjtC2EDiguanylate cyclase/phosphodiesterase/0.447
3ttiKBIMitogen-activated protein kinase 102.7.11.240.447
5jlaNADPutative short-chain dehydrogenase/reductase/0.447
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.446
1y4lSVRBasic phospholipase A2 homolog 2/0.446
1ybmNAPUncharacterized protein At5g02240/0.446
2acuNAPAldose reductase1.1.1.210.446
2c91NAPAflatoxin B1 aldehyde reductase member 2/0.446
2clpNDPAflatoxin B1 aldehyde reductase member 3/0.446
2j8zNAPQuinone oxidoreductase PIG310.446
3gu7ADPDeath-associated protein kinase 12.7.11.10.446
3pb3SAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.446
3s79ASDAromatase1.14.14.140.446
5iqiGNPBifunctional AAC/APH2.3.10.446
1do8NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.445
1f8sFADL-amino-acid oxidase1.4.3.20.445
1hldNADAlcohol dehydrogenase E chain1.1.1.10.445
1k3yGTXGlutathione S-transferase A12.5.1.180.445
1nsfATPVesicle-fusing ATPase3.6.4.60.445
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.445
2babFADPutative aminooxidase/0.445
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.445
2r9eSDXCitrate synthase2.3.3.160.445
2rc3NADCBS domain/0.445
2xpwOTCTetracycline repressor protein class D/0.445
3adaNADSubunit alpha of sarocosine oxidase/0.445
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.445
3eofFMNPutative oxidase/0.445
3lnv1ZZSaframycin Mx1 synthetase B/0.445
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.445
3och2MXDihydrofolate reductase1.5.1.30.445
3w18N13Aurora kinase A2.7.11.10.445
4ma628EAra h 8 allergen/0.445
4s34ANPMitogen-activated protein kinase 12.7.11.240.445
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.445
4wriOKAOkadaic acid binding protein 2-alpha/0.445
5caeCOASuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial6.2.1.40.445
1b87ACOAac(6')-Ii protein/0.444
1efpFADElectron transfer flavoprotein subunit alpha/0.444
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.444
2bpoNAPNADPH--cytochrome P450 reductase/0.444
2e48FADD-amino-acid oxidase1.4.3.30.444
2xrwANPMitogen-activated protein kinase 82.7.11.240.444
3fql79ZGenome polyprotein2.7.7.480.444
3ge6FMNNitroreductase/0.444
3kkjFADRenalase/0.444
3p4tFAOPutative acyl-CoA dehydrogenase/0.444
3rv9RVDSalicylate synthase/0.444
3stxBKAMethylketone synthase I/0.444
4gyy12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.444
4hi0GDPUrease accessory protein UreG/0.444
4xxgFADCholesterol oxidase1.1.3.60.444
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.444
1j7uANPAminoglycoside 3'-phosphotransferase2.7.1.950.443
1tj0FADBifunctional protein PutA1.5.5.20.443
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.443
2hf8GSPProbable hydrogenase nickel incorporation protein HypB/0.443
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.443
2imkGTXAGAP009194-PA/0.443
2qrdADP5'-AMP-activated protein kinase subunit gamma/0.443
2xpvMIYTetracycline repressor protein class D/0.443
3efvNADPutative succinate-semialdehyde dehydrogenase/0.443
3oibFDAPutative acyl-CoA dehydrogenase/0.443
4jd3COAAlpha-pyrone synthesis polyketide synthase-like Pks112.3.10.443
4xyeNADFormate dehydrogenase/0.443
1agnNADAlcohol dehydrogenase class 4 mu/sigma chain1.1.1.10.442
1h6aNDPGlucose--fructose oxidoreductase1.1.99.280.442
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.442
2b9yFADPutative aminooxidase/0.442
2pdtFADVivid PAS protein VVD/0.442
2r0pK2CPutative FAD-monooxygenase/0.442
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.442
2ywwATPAspartate carbamoyltransferase regulatory chain/0.442
3nf4FADAcyl-CoA dehydrogenase domain-containing protein/0.442
4c77N01Phenylacetone monooxygenase1.14.13.920.442
4dpmCOAMalonyl-CoA reductase1.2.1.750.442
4ele31IDihydrofolate reductase/0.442
4k88HFGBifunctional glutamate/proline--tRNA ligase6.1.1.150.442
5dnrATPAurora kinase A2.7.11.10.442
5fklTDCTetracycline repressor protein class D/0.442
5kf2ACOPredicted acetyltransferase/0.442
1dorFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.441
1obbNADAlpha-glucosidase3.2.1.200.441
1w82L10Mitogen-activated protein kinase 14/0.441
2b9xFADPutative aminooxidase/0.441
2jb1FADL-amino acid oxidase/0.441
2jn3JN3Fatty acid-binding protein, liver/0.441
2vrx447Aurora kinase B-A2.7.11.10.441
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.441
3b8z294A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.441
3ge1ADPGlycerol kinase/0.441
3uceNDPDehydrogenase/0.441
4burFADApoptosis-inducing factor 1, mitochondrial1.1.10.441
4f4qFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.441
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.441
4mokFADPyranose 2-oxidase/0.441
8dfrNDPDihydrofolate reductase1.5.1.30.441
1ae1NAPTropinone reductase 1/0.440
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.440
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.440
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.440
2cahNDPCatalase1.11.1.60.440
2pmdGNPTranslation initiation factor 2 subunit gamma/0.440
2qocANPEphrin type-A receptor 32.7.10.10.440
3b70NAPEnoyl reductase LovC10.440
3cgcCOACoenzyme A disulfide reductase/0.440
3erkSB4Mitogen-activated protein kinase 12.7.11.240.440
3i59N6SCRP-like cAMP-activated global transcriptional regulator/0.440
3i99FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.440
3ix9MTXDihydrofolate reductase1.5.1.30.440
3lpbNVBTyrosine-protein kinase JAK2/0.440
3thrC2FGlycine N-methyltransferase2.1.1.200.440
3twoNDPMannitol dehydrogenase/0.440
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.440
3wfjNAD2-dehydropantoate 2-reductase/0.440
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.440
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.440
4rflNDPGlycerol-1-phosphate dehydrogenase [NAD(P)+]/0.440
4uuxAPRCinA-like protein/0.440