Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bbe3O4Tyrosine-protein kinase JAK2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bbe3O4Tyrosine-protein kinase JAK2/1.000
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.546
4gmy0X5Tyrosine-protein kinase JAK2/0.527
4hvi19STyrosine-protein kinase JAK32.7.10.20.527
4bbfO19Tyrosine-protein kinase JAK2/0.515
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.501
4k33ACPFibroblast growth factor receptor 32.7.10.10.500
4jrnANPRhoptry kinase family protein/0.498
4jia1K3Tyrosine-protein kinase JAK2/0.496
3ormAGSSerine/threonine protein kinase/0.495
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.494
3oriAGSSerine/threonine protein kinase/0.491
4o0wADNAurora kinase A2.7.11.10.491
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.490
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.489
1yvj4STTyrosine-protein kinase JAK32.7.10.20.488
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.487
4xlvACPInsulin receptor2.7.10.10.487
4hge15VTyrosine-protein kinase JAK2/0.486
4j99ACPFibroblast growth factor receptor 2/0.486
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.486
4ez50RSCyclin-dependent kinase 62.7.11.220.485
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.484
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.484
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.483
4eooATPCyclin-dependent kinase 22.7.11.220.483
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.482
2etm7PYFocal adhesion kinase 12.7.10.20.482
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.482
5eg3ACPFibroblast growth factor receptor 2/0.482
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.481
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.481
4j95ACPFibroblast growth factor receptor 2/0.481
3c4zADPRhodopsin kinase/0.480
3t8oATPRhodopsin kinase/0.479
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.479
5e8ySTUTGF-beta receptor type-22.7.11.300.478
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.477
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.477
4j97ACPFibroblast growth factor receptor 2/0.477
1u54ACPActivated CDC42 kinase 1/0.476
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.474
2ckeIQUDeath-associated protein kinase 2/0.474
2j0m4STFocal adhesion kinase 12.7.10.20.474
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.474
5cvfATPCasein kinase II subunit alpha2.7.11.10.473
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
4hvh19RTyrosine-protein kinase JAK32.7.10.20.471
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.471
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.471
4qnyANPMitogen activated protein kinase, putative/0.471
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.470
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.470
4ic7ANPMitogen-activated protein kinase 72.7.11.240.470
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.470
4riyADPEpidermal growth factor receptor2.7.10.10.470
2v7a627Tyrosine-protein kinase ABL12.7.10.20.469
4btjATPTau-tubulin kinase 12.7.11.10.469
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.468
3lpbNVBTyrosine-protein kinase JAK2/0.468
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.467
3d7tSTUTyrosine-protein kinase CSK/0.467
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.466
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.466
4o1pANPRibonuclease L/0.466
2henADPEphrin type-B receptor 22.7.10.10.465
4bcmT7ZCyclin-dependent kinase 22.7.11.220.464
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.463
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.463
2pvnP63Casein kinase II subunit alpha2.7.11.10.463
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.463
4cd0AWJALK tyrosine kinase receptor2.7.10.10.462
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.462
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.461
4bgg844Activin receptor type-12.7.11.300.461
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.460
3zewSTUEphrin type-B receptor 42.7.10.10.460
3zh8C58Protein kinase C iota type2.7.11.130.460
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.460
2cciATPCyclin-dependent kinase 22.7.11.220.459
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.459
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.459
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.459
5av2KMPDeath-associated protein kinase 12.7.11.10.459
2ft9CHDFatty acid-binding protein 2, liver/0.458
3gu7ADPDeath-associated protein kinase 12.7.11.10.458
3oroAGSSerine/threonine protein kinase/0.458
5dt3ATPAurora kinase A2.7.11.10.458
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.457
4e6q0NVTyrosine-protein kinase JAK2/0.457
4i3zADPCyclin-dependent kinase 22.7.11.220.457
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.456
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.456
3c4wATPRhodopsin kinase/0.456
3zxtACPDeath-associated protein kinase 12.7.11.10.456
4anmWULCasein kinase II subunit alpha2.7.11.10.456
4ii5ADPCyclin-dependent kinase 22.7.11.220.456
5auvAGIDeath-associated protein kinase 12.7.11.10.456
1pmn984Mitogen-activated protein kinase 102.7.11.240.455
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.455
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.455
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.455
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.455
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.455
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.455
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.454
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.454
2iw94SPCyclin-dependent kinase 22.7.11.220.454
2x1nX1NCyclin-dependent kinase 22.7.11.220.454
3c50ADPRhodopsin kinase/0.454
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
4j98ACPFibroblast growth factor receptor 2/0.454
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.454
4ysjADPCalmodulin-like domain protein kinase/0.454
1dawANPCasein kinase II subunit alpha2.7.11.10.453
3a60STURibosomal protein S6 kinase beta-12.7.11.10.453
3a7hATPSerine/threonine-protein kinase 242.7.11.10.453
3q9xEMOCasein kinase II subunit alpha2.7.11.10.453
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.453
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.453
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.453
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.452
2p33J07Mitogen-activated protein kinase 102.7.11.240.452
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.452
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.452
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.452
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.451
5drdATPAurora kinase A2.7.11.10.451
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.450
1xjdSTUProtein kinase C theta type2.7.11.130.449
2j7t274Serine/threonine-protein kinase 102.7.11.10.449
3gu6ADPDeath-associated protein kinase 12.7.11.10.449
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.449
4aguD15Cyclin-dependent kinase-like 1/0.449
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.449
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.449
5cshATPCasein kinase II subunit alpha2.7.11.10.449
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.448
2w1fL0FAurora kinase A2.7.11.10.448
3u9eCOALmo1369 protein/0.448
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.448
4gu94GUFocal adhesion kinase 12.7.10.20.448
5cu6ATPCasein kinase II subunit alpha2.7.11.10.448
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2qoqANPEphrin type-A receptor 32.7.10.10.447
2w17I19Cyclin-dependent kinase 22.7.11.220.447
3lu7IPXSerum albumin/0.447
4deaNHIAurora kinase A2.7.11.10.447
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.447
4lfiGNPCasein kinase II subunit alpha2.7.11.10.447
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.447
1ir3ANPInsulin receptor2.7.10.10.446
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.446
2pwlACPFibroblast growth factor receptor 2/0.446
3nszANPCasein kinase II subunit alpha2.7.11.10.446
3wowANPCasein kinase II subunit alpha2.7.11.10.446
4fob0USALK tyrosine kinase receptor2.7.10.10.446
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1jklANPDeath-associated protein kinase 12.7.11.10.445
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.445
2pvhP19Casein kinase II subunit alpha2.7.11.10.445
2vu3LZECyclin-dependent kinase 22.7.11.220.445
2w2lNADD-mandelate dehydrogenase/0.445
2x6dX6DAurora kinase A2.7.11.10.445
2xngA0HAurora kinase A2.7.11.10.445
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.445
3at4CCKCasein kinase II subunit alpha2.7.11.10.445
4bcnT9NCyclin-dependent kinase 22.7.11.220.445
4ix5ANPUncharacterized protein/0.445
4lrjANPUncharacterized protein/0.445
1cm8ANPMitogen-activated protein kinase 12/0.444
1ol7ADPAurora kinase A2.7.11.10.444
1pkdUCNCyclin-dependent kinase 22.7.11.220.444
2cjmATPCyclin-dependent kinase 22.7.11.220.444
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.444
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.444
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.444
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1jnkANPMitogen-activated protein kinase 102.7.11.240.443
2vv9IM9Cyclin-dependent kinase 22.7.11.220.443
2xvdAS6Ephrin type-B receptor 42.7.10.10.443
3m9vTYDFAD-dependent oxidoreductase/0.443
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3u4uLNHCasein kinase II subunit alpha2.7.11.10.443
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.443
4gt3ATPMitogen-activated protein kinase 12.7.11.240.443
5dnrATPAurora kinase A2.7.11.10.443
1lp4ANPCasein kinase II subunit alpha2.7.11.10.442
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.442
2dcnADP2-keto-3-deoxy-gluconate kinase/0.442
2fvdLIACyclin-dependent kinase 22.7.11.220.442
2pulACPMethylthioribose kinase2.7.1.1000.442
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.442
3my5RFZCyclin-dependent kinase 22.7.11.220.442
3plsANPMacrophage-stimulating protein receptor2.7.10.10.442
4bcqTJFCyclin-dependent kinase 22.7.11.220.442
4dgnLU2Casein kinase II subunit alpha2.7.11.10.442
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.442
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.442
1dayGNPCasein kinase II subunit alpha2.7.11.10.441
2pmlANPUncharacterized protein/0.441
3lu6IMXSerum albumin/0.441
4ccbOFGALK tyrosine kinase receptor2.7.10.10.441
4eomATPCyclin-dependent kinase 22.7.11.220.441
4grb0XGCasein kinase II subunit alpha2.7.11.10.441
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.441
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4y93746Tyrosine-protein kinase/0.441
1wvxBD4Death-associated protein kinase 12.7.11.10.440
2ath3EAPeroxisome proliferator-activated receptor gamma/0.440
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.440
2puiADPMethylthioribose kinase2.7.1.1000.440
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.440
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.440
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.440
4qmySTUSerine/threonine-protein kinase 242.7.11.10.440
5av3KMPDeath-associated protein kinase 12.7.11.10.440