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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3w2uROUDihydroorotate dehydrogenase (fumarate)1.3.98.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3w2uROUDihydroorotate dehydrogenase (fumarate)1.3.98.11.000
3w1rMRODihydroorotate dehydrogenase (fumarate)1.3.98.10.637
3w1tWRODihydroorotate dehydrogenase (fumarate)1.3.98.10.591
3w2nRODDihydroorotate dehydrogenase (fumarate)1.3.98.10.533
3w1xXRODihydroorotate dehydrogenase (fumarate)1.3.98.10.526
3w233RODihydroorotate dehydrogenase (fumarate)1.3.98.10.518
3w3oROEDihydroorotate dehydrogenase (fumarate)1.3.98.10.504
3w2lVRODihydroorotate dehydrogenase (fumarate)1.3.98.10.502
3enkUPGUDP-glucose 4-epimerase/0.497
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.490
2oapANPType II secretion system protein (GspE-2)/0.488
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.487
2y4gTIRTamL/0.484
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.483
2eixFADNADH-cytochrome b5 reductase/0.480
3w2mZRODihydroorotate dehydrogenase (fumarate)1.3.98.10.478
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.476
4j95ACPFibroblast growth factor receptor 2/0.476
3w2jQRODihydroorotate dehydrogenase (fumarate)1.3.98.10.474
4ebfNADPhosphonate dehydrogenase1.20.1.10.473
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.465
3p62FMNPentaerythritol tetranitrate reductase/0.465
3p82FMNPentaerythritol tetranitrate reductase/0.465
4jia1K3Tyrosine-protein kinase JAK2/0.463
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.463
3w1qYRODihydroorotate dehydrogenase (fumarate)1.3.98.10.462
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.462
1udcUFMUDP-glucose 4-epimerase5.1.3.20.460
3nl6TPSUncharacterized protein/0.460
3sopGDPNeuronal-specific septin-3/0.460
1g6kNADGlucose 1-dehydrogenase1.1.1.470.459
4tmcFMNOld yellow enzyme/0.459
1bwfATFGlycerol kinase/0.458
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.458
5d3qGDPDynamin-13.6.5.50.458
5e8wSTUTGF-beta receptor type-12.7.11.300.458
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.457
2gesCOKPantothenate kinase2.7.1.330.457
3tr05GPGuanylate kinase/0.457
4fm80UQBeta-secretase 13.4.23.460.457
2bd0NAPSepiapterin reductase/0.456
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.456
4a6nFADTetX family tetracycline inactivation enzyme/0.456
2j9gANPBiotin carboxylase6.3.4.140.455
3p74FMNPentaerythritol tetranitrate reductase/0.455
1w5tADPORC1-type DNA replication protein 2/0.454
1yw2PGJMitogen-activated protein kinase 14/0.453
2b36NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
2vtbFADCryptochrome DASH, chloroplastic/mitochondrial/0.453
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.453
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4zrnUPGUDP-glucose 4-epimerase, putative/0.452
1udaUFGUDP-glucose 4-epimerase5.1.3.20.451
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.451
2y3sTIRTamL/0.451
3p67FMNPentaerythritol tetranitrate reductase/0.451
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.451
1korANPArgininosuccinate synthase/0.450
2dcnADP2-keto-3-deoxy-gluconate kinase/0.449
2jn3JN3Fatty acid-binding protein, liver/0.449
2q3rFMN12-oxophytodienoate reductase 11.3.1.420.449
2v7a627Tyrosine-protein kinase ABL12.7.10.20.449
5cwa0GAAnthranilate synthase component 14.1.3.270.449
5ftfADPTPR domain protein/0.449
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.448
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.448
3atyFMNProstaglandin F2a synthase/0.448
4egbNADdTDP-glucose 4,6-dehydratase/0.448
4fvqATPTyrosine-protein kinase JAK2/0.448
2eudGCQRibonucleoside-diphosphate reductase large chain 11.17.4.10.447
3kb1ADPIron-sulfur cluster carrier protein/0.447
1i3nUD1UDP-glucose 4-epimerase/0.446
1w6hTITPlasmepsin-23.4.23.390.446
3t8oATPRhodopsin kinase/0.446
4eo3FMNBacterioferritin comigratory protein/NADH dehydrogenase/0.446
4uymVOR14-alpha sterol demethylase Cyp51B/0.446
1yidATPTryptophan--tRNA ligase 26.1.1.20.445
2iko7IGRenin3.4.23.150.445
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.445
2y3rTRKTamL/0.445
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.445
4ig01FGGag-Pol polyprotein2.7.7.490.445
4j2wFADKynurenine 3-monooxygenase/0.445
4jicFMNGTN Reductase/0.445
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1z44FMNNADPH dehydrogenase/0.444
2fsvNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.444
3pw8ACO1,2-phenylacetyl-CoA epoxidase, subunit A1.14.13.1490.444
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.444
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.444
4loi1YCStimulator of interferon genes protein/0.444
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.443
2xfsJ01Uncharacterized protein/0.443
3cisATPUniversal stress protein Rv2623/0.443
3nutSAHPrecorrin-3 methylase/0.443
4q72FADBifunctional protein PutA/0.443
4tqgNDPPutative dTDP-d-glucose 4 6-dehydratase/0.443
5agaANPDNA polymerase theta/0.443
1i3lGDUUDP-glucose 4-epimerase/0.442
3fr5I4AFatty acid-binding protein, adipocyte/0.442
3pftFMNFlavin reductase/0.442
4q73FADBifunctional protein PutA/0.442
1c9k5GPBifunctional adenosylcobalamin biosynthesis protein CobU/0.441
1h63FMNPentaerythritol tetranitrate reductase/0.441
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.441
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4e2bFMNDehydrogenase/0.441
4m55NADUDP-glucuronic acid decarboxylase 14.1.1.350.441
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.441
5eioNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.441
1h50FMNPentaerythritol tetranitrate reductase/0.440
1tehNADAlcohol dehydrogenase class-31.1.1.10.440
1vyrFMNPentaerythritol tetranitrate reductase/0.440
4a6rTA8Probable aminotransferase/0.440