sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.570 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.549 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.548 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.540 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.534 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.530 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.528 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.528 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.528 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.520 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.518 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.517 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.517 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.515 | |
| 3qly | 55V | Uncharacterized protein | / | 0.514 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.513 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.511 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.511 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.510 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.509 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.509 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.508 | |
| 3eej | 53R | Uncharacterized protein | / | 0.508 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.502 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3eel | 53T | Uncharacterized protein | / | 0.501 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.498 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.498 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.496 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.496 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.495 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.492 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.490 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1nw3 | SAM | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.488 | |
| 3cse | N22 | Uncharacterized protein | / | 0.488 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.488 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.487 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.487 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 2c3u | 2TP | Pyruvate synthase | / | 0.486 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.486 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.485 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.485 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.485 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.484 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.484 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.483 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.482 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.482 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.482 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.482 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.479 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.479 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.477 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.477 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.475 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.474 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.473 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.473 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.473 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4ysw | NAI | Xanthine dehydrogenase/oxidase | / | 0.472 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.470 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.469 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.469 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1lhw | ESM | Sex hormone-binding globulin | / | 0.468 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.468 | |
| 4bgb | ADP | Predicted molecular chaperone distantly related to HSP70-fold metalloproteases | / | 0.467 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.466 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.466 | |
| 4kxl | 6C6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.466 | |
| 1lud | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.465 | |
| 3eek | 53S | Uncharacterized protein | / | 0.465 | |
| 3g8d | ADP | Biotin carboxylase | 6.3.4.14 | 0.465 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.465 | |
| 1rh3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 5kf2 | ACO | Predicted acetyltransferase | / | 0.464 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.463 | |
| 4b8u | IBK | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase | 4.2.1.59 | 0.463 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.463 | |
| 4l9q | 9TP | Serum albumin | / | 0.463 | |
| 4zas | TYD | CalS13 | / | 0.463 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.463 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4imu | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.462 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4gg5 | 0J3 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.461 | |
| 3i58 | 7NA | 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | / | 0.460 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 4l8u | 9AZ | Serum albumin | / | 0.460 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.460 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1psd | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.459 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.459 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.459 | |
| 5kgh | ACO | Predicted acetyltransferase | / | 0.459 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.458 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3eem | 53V | Uncharacterized protein | / | 0.458 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1ewy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.457 | |
| 1xws | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.457 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.457 | |
| 3cgy | RDC | Virulence sensor histidine kinase PhoQ | 2.7.13.3 | 0.457 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.457 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.457 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.456 | |
| 2pda | TPP | Pyruvate synthase | / | 0.456 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.456 | |
| 2wkm | PFY | Hepatocyte growth factor receptor | 2.7.10.1 | 0.456 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.456 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.456 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4j4v | SVR | Nucleocapsid protein | / | 0.456 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1dtn | APG | Mandelate racemase | / | 0.455 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.455 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.454 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.454 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.454 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.453 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.453 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.453 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.453 | |
| 4lm5 | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.453 | |
| 4lmu | QUE | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.453 | |
| 2olc | ADP | Methylthioribose kinase | 2.7.1.100 | 0.452 | |
| 2pun | ACP | Methylthioribose kinase | 2.7.1.100 | 0.452 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.452 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.451 | |
| 1sez | OMN | Protoporphyrinogen oxidase, mitochondrial | 1.3.3.4 | 0.451 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4bub | ADP | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase | / | 0.451 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4mv3 | ACP | Biotin carboxylase | 6.3.4.14 | 0.451 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.451 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1z0z | NAD | NAD kinase | / | 0.450 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.450 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.450 | |
| 2q3e | UPG | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.450 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.450 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.450 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.450 | |
| 4at2 | ASD | Possible succinate dehydrogenase | / | 0.450 | |
| 4bwa | N0B | Pyrrolysine--tRNA ligase | / | 0.450 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.450 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1lwx | AZD | Nucleoside diphosphate kinase, cytosolic | 2.7.4.6 | 0.449 | |
| 2ay3 | MPP | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.449 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.449 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.449 | |
| 3sr5 | Q12 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.449 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.448 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1tae | NAD | DNA ligase | / | 0.448 | |
| 1tez | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.448 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.448 | |
| 3jpv | 1DR | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 3uix | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.448 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.447 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3qar | QAR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.447 | |
| 4rd2 | GNP | Translation initiation factor 2 subunit gamma | / | 0.447 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.446 | |
| 1s64 | 778 | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.446 | |
| 2bsw | CAO | Probable acetyltransferase | / | 0.446 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.446 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.446 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.446 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.446 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.445 | |
| 1t47 | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.445 | |
| 1wpg | ADP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.445 | |
| 1yi4 | ADN | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.445 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.445 | |
| 4ag7 | COA | Glucosamine 6-phosphate N-acetyltransferase | / | 0.445 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.445 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4uog | YYY | Nucleoside diphosphate kinase | / | 0.445 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.444 | |
| 1q3g | UDA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.444 | |
| 2ati | IHU | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.444 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.444 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.444 | |
| 3fgo | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.444 | |
| 3ldf | SAH | Uncharacterized protein | / | 0.444 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.444 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.444 | |
| 4cry | ACO | PanD regulatory factor | / | 0.444 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.444 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.444 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2c3o | TPP | Pyruvate synthase | / | 0.443 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.443 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4ffr | ATP | Uncharacterized protein | / | 0.443 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 4ma6 | 28E | Ara h 8 allergen | / | 0.443 | |
| 5kgj | ACO | Predicted acetyltransferase | / | 0.443 | |
| 1bwk | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.442 | |
| 1v79 | FR7 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 2cl5 | BIE | Catechol O-methyltransferase | 2.1.1.6 | 0.442 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.442 | |
| 3k3k | A8S | Abscisic acid receptor PYR1 | / | 0.442 | |
| 3r02 | UNM | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.442 | |
| 1dre | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.441 | |
| 1xpc | AIT | Estrogen receptor | / | 0.441 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 2xae | ADP | Kinesin-like protein KIF11 | / | 0.441 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.441 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.440 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.440 | |
| 2uza | HTL | Pyruvate synthase | / | 0.440 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.440 | |
| 3zp4 | TSA | Chorismate mutase AroH | 5.4.99.5 | 0.440 | |
| 4a7c | E46 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 4dm8 | REA | Retinoic acid receptor beta | / | 0.440 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 5kf8 | ACO | Predicted acetyltransferase | / | 0.440 |