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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3kbz2T4Fructose-1,6-bisphosphatase 13.1.3.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3kbz2T4Fructose-1,6-bisphosphatase 13.1.3.111.000
3kc02T5Fructose-1,6-bisphosphatase 13.1.3.110.662
2y5kYCUFructose-1,6-bisphosphatase 13.1.3.110.559
3kc12T6Fructose-1,6-bisphosphatase 13.1.3.110.552
3a292T0Fructose-1,6-bisphosphatase 13.1.3.110.550
1levCLIFructose-1,6-bisphosphatase 13.1.3.110.539
2jjkR15Fructose-1,6-bisphosphatase 13.1.3.110.528
2fhyA37Fructose-1,6-bisphosphatase 13.1.3.110.525
2wbdRO5Fructose-1,6-bisphosphatase 13.1.3.110.504
1nzdUPGDNA beta-glucosyltransferase/0.492
2wbbRO3Fructose-1,6-bisphosphatase 13.1.3.110.486
1rfvADPPyridoxal kinase2.7.1.350.483
4ryvZEAProtein LlR18A/0.475
1ie3NADMalate dehydrogenase/0.470
1j39UPGDNA beta-glucosyltransferase/0.470
2dcnADP2-keto-3-deoxy-gluconate kinase/0.470
2o12FMNChorismate synthase/0.470
4q71FADBifunctional protein PutA/0.469
1nzfUPGDNA beta-glucosyltransferase/0.468
1a8rGTPGTP cyclohydrolase 13.5.4.160.465
3lqfNADGalactitol dehydrogenase/0.465
4q73FADBifunctional protein PutA/0.465
2cmvNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.464
5hwsNAP2-dehydropantoate 2-reductase/0.464
3opdHIEHeat shock protein 83/0.460
2x9fX9FEphrin type-B receptor 42.7.10.10.459
3oqkS52Renin3.4.23.150.459
4gk3L87Ephrin type-A receptor 32.7.10.10.458
4azmT4BFatty acid-binding protein, epidermal/0.457
2pv7NADT-protein1.3.1.120.456
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.456
4gk2L66Ephrin type-A receptor 32.7.10.10.456
1aj8COACitrate synthase/0.455
1b16NAQAlcohol dehydrogenase1.1.1.10.455
3tqhNDPQuinone oxidoreductase/0.455
4cukNAID-lactate dehydrogenase/0.455
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
2itvANPEpidermal growth factor receptor2.7.10.10.454
2v1aFMNNPH1-1/0.454
3ak4NADNADH-dependent quinuclidinone reductase/0.454
2y6o1N1Ephrin type-A receptor 42.7.10.10.453
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4cdmFADDeoxyribodipyrimidine photolyase/0.453
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.452
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.452
2npaMMBPeroxisome proliferator-activated receptor alpha/0.452
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.452
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.452
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.452
4ctaATPCinA-like protein/0.452
4q72FADBifunctional protein PutA/0.452
2q4bNAPUncharacterized protein At5g02240/0.451
2v58LZJBiotin carboxylase6.3.4.140.451
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.451
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.451
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.451
3zk5Z18Cytochrome P450 monooxygenase PikC/0.451
4oznATPAmmonium transporter/0.451
2znnS44Peroxisome proliferator-activated receptor alpha/0.450
3p3zP3ZPutative cytochrome P450/0.450
4a6nFADTetX family tetracycline inactivation enzyme/0.450
1v9oADPSignaling protein/0.449
2hfuMEVMevalonate kinase/0.449
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.449
2xvu9DNSerum albumin/0.449
3mdvCL6Cholesterol 24-hydroxylase/0.449
3slkNDPPolyketide synthase extender module 2/0.449
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.449
4n6hEJ4Delta-type opioid receptor/0.449
5a3bAPRSIR2 family protein/0.449
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.448
2ejvNADL-threonine 3-dehydrogenase/0.448
2p20PRXAcetyl-coenzyme A synthetase/0.448
3uyt0CKCasein kinase I isoform delta2.7.11.10.448
4bb432WEphrin type-B receptor 42.7.10.10.448
4u0mGTPCyclic GMP-AMP synthase/0.448
5a3cNADSIR2 family protein/0.448
1cqp803Integrin alpha-L/0.447
1n3rGTPGTP cyclohydrolase 13.5.4.160.447
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4dkv0KWEnvelope glycoprotein gp160/0.447
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1rfuADPPyridoxal kinase2.7.1.350.446
2z1mNDPGDP-mannose 4,6-dehydratase/0.446
3nx4NAPPutative oxidoreductase/0.446
3sdkP3NProteasome subunit beta type-53.4.25.10.446
3sdkP3NProteasome subunit beta type-63.4.25.10.446
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.446
1fm4DXCMajor pollen allergen Bet v 1-L/0.445
1kzjCB3Thymidylate synthase/0.445
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.445
2c27ACOMycothiol acetyltransferase2.3.1.1890.445
2gtnLIEMitogen-activated protein kinase 14/0.445
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.445
3bc3OPTCathepsin L13.4.22.150.445
3il1B5DGlutamate receptor 2/0.445
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.445
1bwsNDPGDP-L-fucose synthase/0.444
1gqtACPRibokinase/0.444
1tj0FADBifunctional protein PutA1.5.5.20.444
2jcxNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.444
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.444
3s1dZIRCytokinin dehydrogenase 11.5.99.120.444
4bfwZVWPantothenate kinase2.7.1.330.444
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.444
1e3eNAIAlcohol dehydrogenase 41.1.1.10.443
2rkvZBATrichothecene 3-O-acetyltransferase/0.443
3fd6ADPSelenide, water dikinase 12.7.9.30.443
3gobHXXDdmC/0.443
4dfrMTXDihydrofolate reductase1.5.1.30.443
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
2gjnFMNNitronate monooxygenase1.13.12.160.442
2h55DZ8Heat shock protein HSP 90-alpha/0.442
2qo9ANPEphrin type-A receptor 32.7.10.10.442
2vww7X2Ephrin type-B receptor 42.7.10.10.442
3d8vUD1Bifunctional protein GlmU/0.442
3drcMTXDihydrofolate reductase1.5.1.30.442
3o0iP54Heat shock protein HSP 90-alpha/0.442
3pqbVGPPutative oxidoreductase/0.442
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.442
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.442
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
2qocANPEphrin type-A receptor 32.7.10.10.441
2vesGVRUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.441
2zgzGNPPlasmid segregation protein ParM/0.441
3ddw055Glycogen phosphorylase, liver form2.4.1.10.441
3lu8IQXSerum albumin/0.441
4bfxZVXPantothenate kinase2.7.1.330.441
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.441
4l04NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
1bl6SB6Mitogen-activated protein kinase 14/0.440
1gcoNADGlucose 1-dehydrogenase1.1.1.470.440
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1zeoC01Peroxisome proliferator-activated receptor gamma/0.440
2r0cFADPutative FAD-monooxygenase/0.440
2vkeTACTetracycline repressor protein class D/0.440
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.440
3u4cNDPNADPH-dependent reductase BacG/0.440
3zuyTCHTransporter/0.440
4bfsZVSPantothenate kinase2.7.1.330.440
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.440
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.440
4hneADPPhosphatidylinositol 4-kinase type 2-alpha/0.440