sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 1.000 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.621 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.601 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.552 | |
| 2gfd | RDA | Endoplasmin | / | 0.550 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.545 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.544 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.543 | |
| 2exl | GDM | Endoplasmin | / | 0.542 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.541 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.541 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.538 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.537 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.532 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.531 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.528 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.528 | |
| 2hg1 | N5O | Endoplasmin | / | 0.524 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.522 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.522 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.522 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 2esa | GDM | Endoplasmin | / | 0.516 | |
| 2gqp | PA7 | Endoplasmin | / | 0.514 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 1u0z | RDC | Endoplasmin | / | 0.513 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.513 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.511 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.511 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.510 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.507 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.507 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.505 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 4ce3 | L4V | ATP-dependent molecular chaperone HSP82 | / | 0.505 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.504 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 1ysz | NEC | Endoplasmin | / | 0.503 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.503 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.502 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.502 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.499 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.499 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 2fyp | RDE | Endoplasmin | / | 0.496 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.496 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.492 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.488 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.487 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.483 | |
| 1qy5 | NEC | Endoplasmin | / | 0.482 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.482 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.480 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.478 | |
| 2bu8 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.477 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.477 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 1u0y | PA7 | Endoplasmin | / | 0.473 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 4b7p | 9UN | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 1u2o | NEC | Endoplasmin | / | 0.470 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 1qy8 | RDI | Endoplasmin | / | 0.469 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.468 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.468 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 2hch | N5A | Endoplasmin | / | 0.467 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.461 | |
| 3ied | AN2 | HSP90 | / | 0.460 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.459 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.458 | |
| 3pej | BC2 | Endoplasmin homolog, putative | / | 0.458 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.456 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.455 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.453 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1ryw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.445 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.445 | |
| 1yt0 | ADP | Endoplasmin | / | 0.444 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3qp0 | NI8 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.444 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.443 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.442 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.442 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.442 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.442 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.441 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.441 | |
| 2fdd | 385 | Pol protein | / | 0.441 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.440 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.440 |