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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2c6kDT2Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2c6kDT2Cyclin-dependent kinase 22.7.11.221.000
3r71X86Cyclin-dependent kinase 22.7.11.220.587
2r3iSCFCyclin-dependent kinase 22.7.11.220.586
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.586
2c6lDT4Cyclin-dependent kinase 22.7.11.220.575
4fklCK2Cyclin-dependent kinase 22.7.11.220.565
3r8vZ62Cyclin-dependent kinase 22.7.11.220.561
1y8yCT7Cyclin-dependent kinase 22.7.11.220.559
3lfqA28Cyclin-dependent kinase 22.7.11.220.554
1oitHDTCyclin-dependent kinase 22.7.11.220.553
2c6mDT5Cyclin-dependent kinase 22.7.11.220.553
2vtsLZCCyclin-dependent kinase 22.7.11.220.545
1pxjCK2Cyclin-dependent kinase 22.7.11.220.544
3lfnA27Cyclin-dependent kinase 22.7.11.220.539
2r64740Cyclin-dependent kinase 22.7.11.220.538
3r7yZ04Cyclin-dependent kinase 22.7.11.220.536
3rahO1ZCyclin-dependent kinase 22.7.11.220.535
3s2pPMUCyclin-dependent kinase 22.7.11.220.532
4ek816KCyclin-dependent kinase 22.7.11.220.532
1e1xNW1Cyclin-dependent kinase 22.7.11.220.531
2vtqLZACyclin-dependent kinase 22.7.11.220.530
1h0w207Cyclin-dependent kinase 22.7.11.220.525
2exmZIPCyclin-dependent kinase 22.7.11.220.525
2r3lSCWCyclin-dependent kinase 22.7.11.220.525
3rni21ZCyclin-dependent kinase 22.7.11.220.525
2c6o4SPCyclin-dependent kinase 22.7.11.220.523
3r73X87Cyclin-dependent kinase 22.7.11.220.523
3r83Z14Cyclin-dependent kinase 22.7.11.220.523
2ds11CDCyclin-dependent kinase 22.7.11.220.522
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.522
3s1h56ZCyclin-dependent kinase 22.7.11.220.522
3sqq99ZCyclin-dependent kinase 22.7.11.220.521
1oirHDYCyclin-dependent kinase 22.7.11.220.520
2a4lRRCCyclin-dependent kinase 22.7.11.220.520
2c6iDT1Cyclin-dependent kinase 22.7.11.220.520
2vthLZ2Cyclin-dependent kinase 22.7.11.220.520
1g5sI17Cyclin-dependent kinase 22.7.11.220.516
4fkv61KCyclin-dependent kinase 22.7.11.220.514
1w8cN69Cyclin-dependent kinase 22.7.11.220.513
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.513
2r3jSCJCyclin-dependent kinase 22.7.11.220.512
2w06FRVCyclin-dependent kinase 22.7.11.220.512
2uzoC62Cyclin-dependent kinase 22.7.11.220.511
2r3gSC9Cyclin-dependent kinase 22.7.11.220.505
1pxmCK5Cyclin-dependent kinase 22.7.11.220.503
2b52D42Cyclin-dependent kinase 22.7.11.220.503
3qqkX02Cyclin-dependent kinase 22.7.11.220.502
3rpo24ZCyclin-dependent kinase 22.7.11.220.502
1gih1PUCyclin-dependent kinase 22.7.11.220.501
1ke7LS3Cyclin-dependent kinase 22.7.11.220.501
4kd11QKCyclin-dependent kinase 22.7.11.220.501
2w05FRTCyclin-dependent kinase 22.7.11.220.500
3r1sX73Cyclin-dependent kinase 22.7.11.220.500
1h1s4SPCyclin-dependent kinase 22.7.11.220.499
3qtuX44Cyclin-dependent kinase 22.7.11.220.499
3r8uZ31Cyclin-dependent kinase 22.7.11.220.497
1oguST8Cyclin-dependent kinase 22.7.11.220.496
1pxlCK4Cyclin-dependent kinase 22.7.11.220.496
3qx2X63Cyclin-dependent kinase 22.7.11.220.496
3r7iX9ICyclin-dependent kinase 22.7.11.220.495
1v0pPVBCell division control protein 2 homolog2.7.11.220.494
3raiX85Cyclin-dependent kinase 22.7.11.220.494
3pj8404Cyclin-dependent kinase 22.7.11.220.492
3r8lZ30Cyclin-dependent kinase 22.7.11.220.492
3nynSGVG protein-coupled receptor kinase 62.7.11.160.491
4acm7YGCyclin-dependent kinase 22.7.11.220.491
1oiyN41Cyclin-dependent kinase 22.7.11.220.490
1y91CT9Cyclin-dependent kinase 22.7.11.220.490
3le62BZCyclin-dependent kinase 22.7.11.220.490
3nieANPMitogen-activated protein kinase/0.490
1hckATPCyclin-dependent kinase 22.7.11.220.488
3qtxX43Cyclin-dependent kinase 22.7.11.220.488
3qtzX42Cyclin-dependent kinase 22.7.11.220.488
2b53D23Cyclin-dependent kinase 22.7.11.220.487
2duv371Cyclin-dependent kinase 22.7.11.220.487
2uznC96Cyclin-dependent kinase 22.7.11.220.487
4fko20KCyclin-dependent kinase 22.7.11.220.487
2y9qANPMitogen-activated protein kinase 12.7.11.240.486
2iw84SPCyclin-dependent kinase 22.7.11.220.485
3rk909ZCyclin-dependent kinase 22.7.11.220.485
3rm618ZCyclin-dependent kinase 22.7.11.220.485
4fks46KCyclin-dependent kinase 22.7.11.220.485
3ezrEZRCyclin-dependent kinase 22.7.11.220.484
3rk708ZCyclin-dependent kinase 22.7.11.220.484
1w0xOLOCyclin-dependent kinase 22.7.11.220.483
3r9nZ68Cyclin-dependent kinase 22.7.11.220.483
3rmf20ZCyclin-dependent kinase 22.7.11.220.483
3sw719KCyclin-dependent kinase 22.7.11.220.482
1h0vUN4Cyclin-dependent kinase 22.7.11.220.481
3ddpRC8Cyclin-dependent kinase 22.7.11.220.481
3ezvEZVCyclin-dependent kinase 22.7.11.220.481
3lfsA07Cyclin-dependent kinase 22.7.11.220.481
3qzhX69Cyclin-dependent kinase 22.7.11.220.481
4fkq42KCyclin-dependent kinase 22.7.11.220.481
4fkw62KCyclin-dependent kinase 22.7.11.220.481
2b54D05Cyclin-dependent kinase 22.7.11.220.480
2r3fSC8Cyclin-dependent kinase 22.7.11.220.480
3r7uX96Cyclin-dependent kinase 22.7.11.220.480
3ral04ZCyclin-dependent kinase 22.7.11.220.480
4fkr45KCyclin-dependent kinase 22.7.11.220.480
2vv9IM9Cyclin-dependent kinase 22.7.11.220.479
2x1nX1NCyclin-dependent kinase 22.7.11.220.479
3sw418KCyclin-dependent kinase 22.7.11.220.479
1ke9LS5Cyclin-dependent kinase 22.7.11.220.478
2r3r6SCCyclin-dependent kinase 22.7.11.220.478
3rpv26ZCyclin-dependent kinase 22.7.11.220.478
1aq1STUCyclin-dependent kinase 22.7.11.220.477
1urwI1PCyclin-dependent kinase 22.7.11.220.477
1ykr628Cyclin-dependent kinase 22.7.11.220.477
3qqhX0ACyclin-dependent kinase 22.7.11.220.477
3r9dX6BCyclin-dependent kinase 22.7.11.220.477
1v1k3FPCyclin-dependent kinase 22.7.11.220.476
3r7vZ02Cyclin-dependent kinase 22.7.11.220.476
3qqlX03Cyclin-dependent kinase 22.7.11.220.475
2a0cCK9Cyclin-dependent kinase 22.7.11.220.474
2r3kSCQCyclin-dependent kinase 22.7.11.220.474
3rak03ZCyclin-dependent kinase 22.7.11.220.474
3roy22ZCyclin-dependent kinase 22.7.11.220.474
3rk507ZCyclin-dependent kinase 22.7.11.220.473
4bgh3I6Cyclin-dependent kinase 22.7.11.220.473
1oiqHDUCyclin-dependent kinase 22.7.11.220.472
1pyePM1Cyclin-dependent kinase 22.7.11.220.470
2r3p3SCCyclin-dependent kinase 22.7.11.220.470
3r9hZ67Cyclin-dependent kinase 22.7.11.220.468
3qxpX64Cyclin-dependent kinase 22.7.11.220.467
4eor4SPCyclin-dependent kinase 22.7.11.220.467
5cnoANPEpidermal growth factor receptor2.7.10.10.467
1pxkCK3Cyclin-dependent kinase 22.7.11.220.465
2w1hL0FCyclin-dependent kinase 22.7.11.220.465
3wblPDYCyclin-dependent kinase 22.7.11.220.465
3qqfX07Cyclin-dependent kinase 22.7.11.220.464
3rkb12ZCyclin-dependent kinase 22.7.11.220.464
1eh4IC1Casein kinase I homolog 12.7.11.10.463
3qx4X4BCyclin-dependent kinase 22.7.11.220.463
1ke6LS2Cyclin-dependent kinase 22.7.11.220.461
1xjdSTUProtein kinase C theta type2.7.11.130.461
3r8pZ46Cyclin-dependent kinase 22.7.11.220.461
3iggEFQCyclin-dependent kinase 22.7.11.220.459
3r1qX75Cyclin-dependent kinase 22.7.11.220.459
3rjc06ZCyclin-dependent kinase 22.7.11.220.459
1dm2HMDCyclin-dependent kinase 22.7.11.220.458
1gij2PUCyclin-dependent kinase 22.7.11.220.458
3fz1B98Cyclin-dependent kinase 22.7.11.220.458
1h1r6CPCyclin-dependent kinase 22.7.11.220.457
2w17I19Cyclin-dependent kinase 22.7.11.220.457
4erwSTUCyclin-dependent kinase 22.7.11.220.456
2bhhRYUCyclin-dependent kinase 22.7.11.220.455
2vtrLZBCyclin-dependent kinase 22.7.11.220.455
4eok4SPCyclin-dependent kinase 22.7.11.220.455
1gii1PUCyclin-dependent kinase 22.7.11.220.454
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
4a4qUX9Pol protein/0.454
2c5yMTWCyclin-dependent kinase 22.7.11.220.453
4eon1ROCyclin-dependent kinase 22.7.11.220.453
4fkt48KCyclin-dependent kinase 22.7.11.220.453
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.452
3s0o50ZCyclin-dependent kinase 22.7.11.220.452
3qu0X40Cyclin-dependent kinase 22.7.11.220.451
3qwkX62Cyclin-dependent kinase 22.7.11.220.451
3r7eX88Cyclin-dependent kinase 22.7.11.220.451
2uzbC75Cyclin-dependent kinase 22.7.11.220.449
3zpuM8BGag-Pol polyprotein3.4.23.160.449
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2iw94SPCyclin-dependent kinase 22.7.11.220.448
2uzlC94Cyclin-dependent kinase 22.7.11.220.448
5cnnANPEpidermal growth factor receptor2.7.10.10.448
1pxoCK7Cyclin-dependent kinase 22.7.11.220.446
2b55D31Cyclin-dependent kinase 22.7.11.220.446
2vu3LZECyclin-dependent kinase 22.7.11.220.446
3r1yX76Cyclin-dependent kinase 22.7.11.220.446
1b38ATPCyclin-dependent kinase 22.7.11.220.445
1c6yMK1Protease/0.445
1hpxKNIGag-Pol polyprotein/0.444
2bkzSBCCyclin-dependent kinase 22.7.11.220.444
2i40BLZCyclin-dependent kinase 22.7.11.220.444
3qruX19Cyclin-dependent kinase 22.7.11.220.444
3ti1B49Cyclin-dependent kinase 22.7.11.220.444
1pxpCK8Cyclin-dependent kinase 22.7.11.220.443
3sheI85MAP kinase-activated protein kinase 32.7.11.10.443
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.443
4qnyANPMitogen activated protein kinase, putative/0.443
2xmyCDKCyclin-dependent kinase 22.7.11.220.442
3el51UNGag-Pol polyprotein/0.442
3qrtX14Cyclin-dependent kinase 22.7.11.220.442
1b39ATPCyclin-dependent kinase 22.7.11.220.441
1p2a5BNCyclin-dependent kinase 22.7.11.220.441
3zpsEQMGag-Pol polyprotein3.4.23.160.441
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.441
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.441
2b7aIZATyrosine-protein kinase JAK2/0.440
2c68CT6Cyclin-dependent kinase 22.7.11.220.440
2r3mSCXCyclin-dependent kinase 22.7.11.220.440
3ddqRRCCyclin-dependent kinase 22.7.11.220.440
3oroAGSSerine/threonine protein kinase/0.440